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2022 Vol. 19, No. 32 Published: 2022-11-15

	5	Study on the medication rule of traditional Chinese medicine in the treatment of breast cancer aromatase inhibitor-related osteoporosis
		MENG Hui YU Mingwei WANG Xiaomin CHEN Yuhan ZHANG Jiahui
		DOI: 10.20047/j.issn1673-7210.2022.32.01
		Objective To study the prescription medication rules of breast cancer aromatase inhibitor-related osteoporosis based on hospital information system. Methods The diagnosis and treatment information of breast cancer patients with aromatase inhibitor-related osteoporosis was collected from the information system of Beijing Traditional Chinese Medicine Hospital, Capital Medical University from January 2019 to October 2021. The overall use of traditional Chinese medicine was analyzed, and association rule analysis and cluster analysis were performed for traditional Chinese medicine. Results A total of 184 breast cancer patients with aromatase inhibitor-related osteoporosis were included. The most common traditional Chinese medicine syndroms were syndrome of healthy qi deficiency and toxin accumulation, syndrome of stagnation of liver qi and spleen deficiency, syndrome of intermin-gled phlegm and blood stasis, etc. All the prescriptions involved 298 kinds of traditional Chinese medicine, and the four nature of traditional Chinese medicine were mainly warm and calm drugs. Five flavours to sweet, bitter, bitter drugs more common. The main channel tropism of drugs was liver channel. The most frequently used drug category is the drugs for promoting blood circulation for removing blood stasis. Association rule analysis showed that the drug combinations with the highest confidence and support were Bupleuri Radix-Curcumae Radix, Atractylodis Macrocephalae Rhizoma-Herba Hedyotis-Radix, respectively. The drugs were grouped into four groups by cluster analysis. Conclusion The traditional Chinese medicine treatment of breast cancer aromatase inhibitor-related osteoporosis is to regulate liver and regulate qi, remove stasis, remove obstruction in collaterals, and relieve pain as the main treatment, supplemented by yiqi and detoxification.
		2022 Vol. 19 (32): 5-9 [Abstract] ( 18 ) HTML (1 KB) PDF (1158 KB) ( 90 )

	10	Effect and mechanism of cytosolic carboxypeptidase 1 on the proliferation of mouse primary spermatocyte GC-2 cells
		ZHANG Ting1 WANG Wanlun1 LIU Tongjia1 LIU Shuang1 BIAN Yanchao1 ZHANG Chuanling2 XIAO Rui1
		DOI: 10.20047/j.issn1673-7210.2022.32.02
		Objective To investigate the role of cytosolic carboxypeptidase 1(CCP1) in the proliferation of mouse testicular primary spermatocytes (GC-2) and its molecular mechanism. Methods GC-2 cells of mouse were cultured in vitro, the cells of negative control group (NC group) and CCP1 overexpression group(GC-2+CCP1 group) were constructed by infecting GC-2 cells with lentivirus containing empty plasmid and CCP1 recombinant plasmid. The influence of CCP1 overexpression on the proliferation and cycle of GC-2 cells were detected by CCK-8 and flow cytometry; the changes of cycle key regulatory proteins in GC-2+CCP1 cells, including cyclin-dependent kinase 2(Cdk2), cyclin B1(Ccnb1) and cyclin D1(Ccnd1) were detected by real-time fluorescence quantitative PCR; the changes of Cdk2 in GC-2+CCP1 cells were analyzed by Western blot. Results CCK-8 and flow cytometry showed that the proliferation ability of GC-2+CCP1 cells in vitro was lower than NC group and cycle of GC-2+CCP1 cells arrest in G2/M phase, the differences were statistically significant (P ＜ 0.05). The mRNA and protein of Cdk2 in GC-2+CCP1 cells was higher than NC group and Cyclin B1 and Cyclin D1 mRNA were lower, the differences were statistically significant (P ＜ 0.05). Conclusion Overexpression of CCP1 can block GC-2 cells in G2/M phase, inhibit the proliferation of GC-2 cells in vitro and affect the expression of Cdk2, Cyclin B1, and Cyclin D1.
		2022 Vol. 19 (32): 10-13,30 [Abstract] ( 27 ) HTML (1 KB) PDF (1236 KB) ( 33 )

	14	PK/PD analysis of Qiguiyin Decoction on Levofloxacin against drug- resistant Pseudomonas aeruginosa in semivivo in rats #br#
		ZHANG Wanqiao1* LI Yanling1* WU Jun2 LIU Qingquan3 XU Guang1 QIN Ming1 JI Li1 MA Qun1
		DOI: 10.20047/j.issn1673-7210.2022.32.03
		Objective To explore the effect of Qiguiyin Decoction on Levofloxacin (LVFX) against drug-resistant Pseudomonas aeruginosa (PA) by establishing the pharmacokinetic/pharmacodynamic (PK/PD) model of LVFX alone and LVFX combined with Qiguiyin Decoction. Methods Fifteen male Wistar rats aged 6-7 weeks were divided into three groups, with five rats in each group. The single group was gavaged with 0.01 g/ml LVFX, the combined group was gavaged with 1 g/ml Qiguiyin Decoction and 0.01 g/ml LVFX, and the blank group was gavaged with the same volume of distilled water for five days. Blood was collected from orbit at 0, 0.25, 0.50, 1.00, 1.50, 2.00, 4.00, 8.00, 12.00, and 24.00 h after the last administration. After sample treatment, the PK parameters were calculated by DAS 2.0 software, the bacteriostasis rate of drug-resistant PA was measured with drug-containing serum, and the hemibody PK/PD model was established. Results The mean residence time, peak time of the combine group were longer than those of control group, and clearance rate of the combined group were higher than those of the single group, the area under the curve and the maximum plasma concentration were lower than those of the single group (P ＜ 0.05). The initial value of serum bacteriostasis rate was higher than that of the single group, and the time to reach the maximum bacteriostasis rate in the combined group were longer than that in the single group (P ＜ 0.05). The semivivo PK/PD models of the single group and the combined group were E = (63.80×C2.96)/(0.94 + C2.96) and E = 34.72 + (57.88×C3.04)/(66.63 + C3.04). Conclusion Qiguiyin Decoction may enhance the effect of LVFX against PA by affecting LVFX blood drug concentration in rats.
		2022 Vol. 19 (32): 14-17 [Abstract] ( 14 ) HTML (1 KB) PDF (793 KB) ( 40 )

	18	Visual analysis of CiteSpace knowledge map visualization analysis of acupuncture treatment for dementia in recent ten years
		LI Hui1 QIAO Haifa1 WANG Qiang1 GUO Ting1 HE Ling1 XU Lei1 YANG Huan2 WANG Yuan1
		DOI: 10.20047/j.issn1673-7210.2022.32.04
		Objective To make a visual analysis of the relevant literature on acupuncture treatment of dementia in the past ten years based on CiteSpace. Methods Chinese literatures related to acupuncture intervention for dementia from January 2013 to February 2022 were retrieved from China Journal Full-text Database, the CiteSpace 5.8 R3 were used to analyze the annual publication volume and the fund-funded projects, and visualization analysis of the authors, institutions and keywords. Results A total of 896 papers were included, of which 216 papers were funded; 319 authors, 32 core authors, 149 institutions, and 300 keywords were included. Zhang Xuezhu is the author with the most published articles; the institution with the most publications is Anhui University of Chinese Medicine, “acupuncture” was used more frequently; “acupuncture therapy” appeared more strongly; “acupuncture” cluster clustering effect was better; acupuncture group cluster appeared earlier and more stable. Conclusion Acupuncture intervention in the development of dementia has received more and more work, and it should be strongly supported in the future, strengthen collaboration and innovate development.
		2022 Vol. 19 (32): 18-21 [Abstract] ( 19 ) HTML (1 KB) PDF (2780 KB) ( 36 )

	22	The value of dual-energy CT iodography in the assessment of radiotherapy efficacy in non-small cell lung cancer
		WANG Danfeng LIN Daiying▲ XIAO Jianning ZHANG Xiaoqin ZHUANG Qiaowei HU Zehuan
		DOI: 10.20047/j.issn1673-7210.2022.32.05
		Objective To investigate the clinical value of dual-source CT dual-energy iodography imaging to assess the efficacy of radiotherapy for non-small cell lung cancer. Methods Seventy-nine patients with pathologically confirmed non-small cell lung cancer from October 2018 to October 2021 were collected from Shantou Central Hospital. All patients underwent dual-source CT dual-energy scans within a week before radiotherapy and at five weeks after radiotherapy. The results of five weeks review were divided into treatment-ineffective and treatment-effective groups according to the RECIST solid tumor criteria, and the change values of clinical target arteries (CTA), clinical target venous (CTV), normalized iodine concentration in the arterial phase (NICAP), normalized iodine concentration in the arterial venous phase (NICVP) of lesions before and after treatment were recorded in both groups. Results The number of patients enrolled was 47 in the treatment effective group and 32 in the treatment ineffective group. After treatment, CTA, CTV, NICAP, and NICVP in the effective group were lower than before treatment, and each indexs were lower than those in the ineffective group, and the differences were statistically significant (P ＜ 0.05). The rate of change of NICAP, CTA, NICVP, and maximum diameter of lesion in the effective group were higher than those in the ineffective group, and the differences were statistically significant (P ＜ 0.05). The rate of change of the maximum diameter of the lesion was positively correlated with the rate of change of CTA, NICAP, CTV, and NICVP (r ＞ 0, P ＜ 0.05). After radiotherapy, the ROC curve areas of CTA and NICAP change rates to assess the efficacy of NSCLC were 0.817 and 0.882, respectively. Conclusion Dual-energy CT iodography imaging can predict the therapeutic effect of radiotherapy for non-small cell lung cancer and provide a reference basis for precise clinical treatment.
		2022 Vol. 19 (32): 22-25 [Abstract] ( 16 ) HTML (1 KB) PDF (1214 KB) ( 83 )

	26	Visual analysis of traditional Chinese medicine functional exercise in the treatment of lumbar disc herniation based on CiteSpace
		DAI Wenhao1 GUO Bingqing1 XIE Qiang1 LIU Yibing1 CHNAG Junjie1 GAO Jun1 ZHANG Xi2
		DOI: 10.20047/j.issn1673-7210.2022.32.06
		Objective To explore the research status and frontier hotspots of traditional Chinese medicine functional exercise in the treatment of lumbar disc herniation (LDH) by the visualization software CiteSpace. Methods Literatures on the prevention and treatment of LDH by traditional Chinese medicine functional exercise from the inception to February 2022 in CNKI was retrieved. CiteSpace software was used to analyze the publication time, authors, research institutions, and keywords of the literatures, and visual knowledge maps were drew. Results Finally, 62 literatures were included, and the overall number of publications in this field showed a fluctuating upward trend. Two core research teams led by Zhu Qingguang and Zhang Weizhong were formed respectively. The main research institutions were Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicined, Wujiang Hospital of Traditional Chinese Medicine in Suzhou, Jiangsu Province, etc. High frequency keywords included LDH, Baduanjin, Taijiquan, Wuqinxi, curative effect, etc. At present, the research focus in this field were clinical efficacy and rehabilitation therapy. Conclusion Traditional Chinese medicine has great advantages and prospects in the prevention and treatment of LDH. It is necessary to strengthen communication and cooperation among research groups. Future research hotspots may tend to focus on mechanism exploration, efficacy standards, technical specifications, etc.
		2022 Vol. 19 (32): 26-30 [Abstract] ( 19 ) HTML (1 KB) PDF (1579 KB) ( 68 )

	31	Advances in antitumor and antibacterial activities of N-heterocyclic carbine-metal complexes
		LU Qianqian1,2* LIU Ying1,2* YAN Mi1,2 LIU Binbin1,2 CAI Yi1,2 WANG Jun1,3 ZOU Lili1,2
		DOI: 10.20047/j.issn1673-7210.2022.32.07
		Since Arduengo’s first successful isolation of stable free N-heterocyclic carbinol compounds (NHC) in 1991, its research as a novel ligand for transition metal complexes has developed rapidly. NHC metal complexes deserve special attention for their therapeutic applications in addition to their wide range of applications in catalysis, synthesis and materials. Recent studies have revealed that NHC-metal complexes exhibit good biological activities in anti-tumor and anti-microbial aspects and have great application prospects. Based on this, a brief review of the anti-malignant proliferative activity of NHC-gold (Au), NHC-silver (Ag), NHC-palladium (Pd), and NHC-platinum and the anti-microbial activity of NHC-Au, NHC-Ag, and NHC-Pd is presented.
		2022 Vol. 19 (32): 31-34,46 [Abstract] ( 9 ) HTML (1 KB) PDF (565 KB) ( 133 )

	35	Research progress of immune regulation mediated by PD-1/PD-L1 immune whistle in rheumatoid arthritis
		LIU Lu XU Yuansheng HUANG Weiqian CHEN Jianmin LIU Guoyin▲
		DOI: 10.20047/j.issn1673-7210.2022.32.08
		programmed death receptor-1 (PD-1) / programmed death ligand-1(PD-L1) immune whistle is a negative immunomodulatory signal, which is activated or suppressed according to the immune status. Targeted drugs based on PD-1 and PD-L1 have been used in tumor immunotherapy at home and abroad and achieved remarkable effects. However, the relevant therapeutic effects of this target in rheumatoid arthritis (RA) are still divergent. Based on the latest research progress, the pathogenesis of RA induced by immune regulation mediated by PD-1/PD-L1 immune whistle is summarized as follows: With the progression of RA and the repeated changes between active and quiescent phases, persistent and/or high expression of PD-1/PD-L1→impaired or depleted immune cell function→disorder of immune tolerance and immune balance→enhanced immune response→promoted or aggravated the progression of RA. This article reviews the role of immune regulation mediated by PD-1/PD-L1 immune whistle in RA.
		2022 Vol. 19 (32): 35-38,50 [Abstract] ( 13 ) HTML (1 KB) PDF (610 KB) ( 69 )

	39	Research progress of medical imaging technology in osteoporosis
		LI Luqin1 SUN Zhongyang2
		DOI: 10.20047/j.issn1673-7210.2022.32.09
		Osteoporosis is a metabolic bone disease with high incidence. Millions of people suffer from fragility fractures every year, most of which can be prevented. Therefore, early diagnosis and accurate evaluation of osteoporosis have become a research hotspot. With the rapid development of medical imaging technology, it has gradually become the core method of diagnosis and evaluation of osteoporosis. Medical imaging technology commonly used in clinic, such as X-ray, dual energy X-ray absorptiometry, ultrasound, computed tomography, and magnetic resonance imaging have played a vital role in the diagnosis and evaluation of osteoporosis. This paper will briefly summarize the new progress of medical imaging technology used in the study of osteoporosis, in order to provide theoretical basis for the diagnosis and evaluation of osteoporosis and expand the understanding of the occurrence and development of osteoporosis.
		2022 Vol. 19 (32): 39-42 [Abstract] ( 11 ) HTML (1 KB) PDF (484 KB) ( 82 )

	43	Research progress on the correlation between sedentary behavior and cognitive impairment in the elderly
		LIAN Xuan1 WANG Feng1 LIU Yuewen2 GUO Qi2 YU Ying1▲
		DOI: 10.20047/j.issn1673-7210.2022.32.10
		Cognitive impairment is common in the elderly, which has many influencing factors. Among these factors, sedentary behavior is gradually becoming a research hotspot in recent years. This article reviews the overview of sedentary behavior and cognitive impairment, the relationship between sedentary behavior and cognitive impairment, the possible mechanism, and the inspiration for clinical medical work, in order to provide a theoretical basis for the prevention and delay of cognitive impairment in the elderly.
		2022 Vol. 19 (32): 43-46 [Abstract] ( 22 ) HTML (1 KB) PDF (492 KB) ( 51 )

	47	Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of slow transit constipation
		SHI Min LIU Fulin XIA Xuting LIAO Chenmin
		DOI: 10.20047/j.issn1673-7210.2022.32.11
		Based on the relationship between intestinal flora and slow transit constipation, this paper discusses the mechanism of traditional Chinese medicine regulating intestinal flora in the treatment of this disease, and believes that the physiological function of intestinal flora is consistent with the holism of traditional medicine and the theory of yin and yang balance. The onset of slow transit constipation is related to intestinal flora imbalance. Traditional Chinese medicine can promote gastrointestinal motility by regulating metabolites of intestinal flora, intestinal neurotransmitters, and intestinal immune response, so as to improve slow transit constipation. This paper reveals the mechanism of traditional Chinese medicine regulating intestinal flora in the treatment of slow transit constipation, and provides theoretical reference for the clinical and scientific research of traditional Chinese medicine in the prevention and treatment of this disease.
		2022 Vol. 19 (32): 47-50 [Abstract] ( 56 ) HTML (1 KB) PDF (547 KB) ( 88 )

	51	Research progress of drug-coated balloon in the treatment of coronary artery disease
		WU Zhihao1 WANG Si1 PENG Yangwei1 XIE Junmin1 JIA Xinwei2
		DOI: 10.20047/j.issn1673-7210.2022.32.12
		Drug-coated balloon (DCB), as a new type of coronary intervention, for in-stent restenosis and small vessel disease, DCB alone has been accepted by domestic experts and foreign guidelines as an alternative therapy for drug-eluting stent. In addition, studies have found that DCB also shows corresponding advantages in the treatment of primary macrovascular disease, bifurcation disease, chronic total occlusion disease, and other lesions. This paper introduces the characteristics and mechanism of DCB, analyzes and summarizes the clinical application and advantages of DCB in the lesions of large vessels in situ, bifurcation, acute myocardial infarction, chronic total occlusion, calcification, etc., and provides a new idea for the interventional treatment of DCB in coronary heart disease.
		2022 Vol. 19 (32): 51-54,58 [Abstract] ( 23 ) HTML (1 KB) PDF (625 KB) ( 199 )

	55	Analysis of risk factors in patients with polycystic ovary syndrome of reproductive age in Wenzhou Hospital of Traditional Chinese Medicine
		YING Haiqiong ZHU Xiaoli JI Shuangshuang XU Jing HU Xinxin
		DOI: 10.20047/j.issn1673-7210.2022.32.13
		Objective To investigate the risk factors in patients with polycystic ovary syndrome of reproductive age in Wenzhou Hospital of Traditional Chinese Medicine. Methods A total of 1 530 medical examiners of childbearing age who were examined in Wenzhou Hospital of Traditional Chinese Medicine from May 2019 to February 2021 were selected for the study, and the detection rate of polycystic ovary syndrome was counted and the risk factors for the occurrence of polycystic ovary syndrome were analyzed. Results A total of 1 530 questionnaires were sent out in this survey and 1 300 were returned, with a return rate of 84.80%. The detection rate of polycystic ovary syndrome in 1 300 persons of reproductive age was 38.46%. Univariate analysis showed that the occurrence of polycystic ovary syndrome in reproductive age was associated with age, body mass index, family history of hypertension, family history of obesity, time taken from menarche to regular menstruation, hirsutism, and acne, with statistically significant differences (P ＜ 0.05). Logistic regression analysis showed that age 18 -＜ 26 years, body mass index ≥25 kg/m2, family history of hypertension, family history of obesity, time taken from menarche to regular menstruation ＞2 years, hirsute F-G ≥6 points, and acne >10 were risk factors for the formation of polycystic ovary syndrome of the reproductive age (OR ＞ 1, P ＜ 0.05). Conclusion The development of polycystic ovary syndrome in reproductive age is mainly influenced by age, body mass index, family history of hypertension, hirsutism, family history of obesity, time taken from menarche to regular menstruation, acne, and other factors. Effective prevention of risk factors can reduce the occurrence of polycystic ovary syndrome.
		2022 Vol. 19 (32): 55-58 [Abstract] ( 14 ) HTML (1 KB) PDF (526 KB) ( 25 )

	59	Survey on the current situation of undergraduate anesthesiology students applying the Internet to enhance their independent learning ability
		LIN Hongyu1 ZHONG Hongge2 WANG Boqing3 YANG Zhongyu4 ZHENG Qi4 YANG Tianyu4 REN Yanghao4 WANG Tianhai1
		DOI: 10.20047/j.issn1673-7210.2022.32.14
		Objective To investigate the objective conditions and subjective recognition of the application of the Internet to enhance independent learning among undergraduate anesthesiology students. Methods The undergraduate education students enrolled in the Department of Anesthesiology of Xinjiang Medical University from 2017 to 2021 were selected as the respondents, and the survey was conducted from September 23 to 27, 2021 using a questionnaire star. The categorical questions in the questionnaire was used to evaluated the students’ objective conditions of the school’s provision of Internet hardware, students’ Internet learning style, habits, and motivation; the quantitative questions was used to evaluated the students’ acceptance of using the Internet to enhance their independent learning skills. Results A total of 285 valid papers were issued, and the effective return rate of the questionnaire was 100%, Six valid questions were statistically screened among the quantitative questions with a mean score of 1.3, and the difference was statistically significant when compared with the median 1 (P ＜ 0.01). The classification questions showed that only 2.1% of students use foreign language databases to find professional knowledge; for extracurricular knowledge, 72.6% of students use the Internet to obtain relevant knowledge; only 1.8% of students pay little attention to Internet learning resources; 62.8% of students’ intrinsic drive for independent learning needs to come from the arrangement of teachers; 67.4% of students think that the Internet resources provided by their schools can meet their learning needs. Conclusion Students have a positive attitude toward the recognition of using the Internet to enhance their learning ability, and are satisfied with the hardware facilities and network resources provided by the school; however, they still do not have a good grasp of the usage methods and make full use of the available Internet resources as a whole. Students also need to improve their independent learning ability under the guidance of the course or the relevant teacher, to reduce the adverse interference of the Internet to students, to mobilize their subjective initiative, and to achieve the ability to improve independent learning using the Internet.
		2022 Vol. 19 (32): 59-62 [Abstract] ( 14 ) HTML (1 KB) PDF (576 KB) ( 15 )

	63	Application of dynamic electrocardiogram ST segment and T wave changes combined with coronary CT angiography in the diagnosis of coronary heart disease
		HU Fuqu1 YAN Weiguo2 PENG Jiecheng2 WU Wanshi2 LIU Guodong2
		DOI: 10.20047/j.issn1673-7210.2022.32.15
		Objective To study the application effect of dynamic electrocardiogram ST segment and T wave changes combined with coronary CT angiography (CTA) in the diagnosis of coronary heart disease (CHD). Methods A total of 80 patients with suspected CHD who were diagnosed and treated in Anqing First People’s Hospital of Anhui Province from February 2019 to December 2021 were selected as the research subjects. All patients underwent dynamic electrocardiogram, coronary CTA, and coronary angiography. The results of coronary angiography were used as the gold standard, the diagnostic efficacy and consistency of dynamic electrocardiogram, coronary CTA, and their combination in detecting CHD were compared. Results A total of 69 (86.25%) of 80 suspected CHD patients were positive. The accuracy rate of dynamic electrocardiogram in diagnosing CHD was 67.50%, and the Kappa value was 0.520, the consistency was ideal; the accuracy rate of coronary CTA in diagnosing CHD was 81.25%, and the Kappa value was 0.768, the consistency was good; the accuracy of combined diagnosis of CHD was 92.50%, and the Kappa value was 0.918, the consistency was good. Conclusion Dynamic electrocardiogram ST segment and T wave changes combined with coronary CTA have higher value in the diagnosis of CHD.
		2022 Vol. 19 (32): 63-66 [Abstract] ( 16 ) HTML (1 KB) PDF (902 KB) ( 28 )

	67	Mesh meta-analysis of the efficacy and safety of multiple interventions in the treatment of mild to moderate Alzheimer’s disease
		HAN Nana1 JI Bo1 FANG Yang1 ZHAO Guozhen2 LIU Yitian1 WANG Yifei1 WU Le1 GUO Tingting1
		DOI: 10.20047/j.issn1673-7210.2022.32.16
		Objective To evaluate the efficacy and safety of multiple interventions based on drug and non-drug therapy in the treatment of mild to moderate Alzheimer’s disease (AD) by mesh meta-analysis. Methods PubMed, Embase, Cochrane Library, CBM, VIP, CNKI, and Wanfang Data were searched for randomized controlled trials on drug and non-drug measures for the treatment of mild to moderate AD published from the inception to September 2021. RevMan 5.3 software was used to evaluate the quality of the included literatures, and Stata 15.0 software was used for network meta-analysis. Results A total of 62 literatures including 10 934 patients were included. The results of mesh meta-analysis showed that in terms of improving the mini-mental state examination (MMSE) score, the surface under the cumulative ranking (SUCRA) of each intervention in descending order was acupuncture (92.4%) ＞ transcranial direct current stimulation (85.5%) ＞ cognitive therapy (70.7%) ＞ Mementin (60.6%) ＞ Huperzine A (56.0%) ＞ Carbalatine (50.9%) ＞ Donepezil (41.4%) ＞ Ginkgo biloba extraction (26.7%) ＞ placebo (13.3%) ＞ Galantamine (2.4%). In terms of safety, the SUCRA of each intervention in descending order was Ginkgo biloba extraction (85.0%) ＞ acupuncture (74.7%) ＞ placebo (67.4%) ＞ Mementin (65.0%) ＞ Huperzine A (49.3%) ＞ Donepezil (27.5%) ＞ Galantamine (21.8%) ＞ Carbalatine (9.4%). The funnel plots of MMSE score and the total incidence of adverse events were relatively symmetric, suggesting that there was no significant publication bias. Conclusion This study analyzed the effectiveness of multiple interventions in the treatment of mild to moderate AD, which can help clinicians and policy makers make better decisions.
		2022 Vol. 19 (32): 67-74,79 [Abstract] ( 22 ) HTML (1 KB) PDF (2399 KB) ( 116 )

	75	Mediating effects of fall efficacy and walking ability on balance function and activity ability in foot drop patients with stroke
		LI Jingjing WANG Ningning MIAO Tianyu PARIDA Maimaiti
		DOI: 10.20047/j.issn1673-7210.2022.32.17
		Objective To study the correlation between fall efficacy, walking ability, balance function, and activity ability in foot drop patients with stroke. Methods From December 2020 to October 2021, 159 foot drop inpatients with stroke in the Department of Rehabilitation Medicine, the First Affiliated Hospital of Xinjiang Medical University were selected by convenience sampling method, and the fall efficacy, walking ability, balance function, and activities of daily living were measured. Pearson correlation was used, and the SPSS was used for statistical analysis. Results Balance function was positively correlated with walking ability and activity ability (r = 0.819, 0.789, P ＜ 0.01), and negatively correlated with fall efficacy (r = -0.712, P ＜ 0.01). Walking ability was positively correlated with activity ability (r = 0.722, P ＜ 0.01). The fall efficacy was negatively correlated with activity ability (r = -0.621, P ＜ 0.01). The fall efficacy and walking ability of stroke patients with foot drop had a mediating effect between balance function and activity ability, and the mediating effect accounted for 37.58% of the total effect. Conclusion The fall efficacy and walking ability play a partial mediating effect between balance function and activities of daily living.
		2022 Vol. 19 (32): 75-79 [Abstract] ( 15 ) HTML (1 KB) PDF (853 KB) ( 34 )

	80	Effect of repetitive transcranial magnetic stimulation in the treatment of cognitive dysfunction after ischemic stroke
		LI Jing1 CUI Yu1 JIA Meiyan2▲
		DOI: 10.20047/j.issn1673-7210.2022.32.18
		Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive dysfunction after ischemic stroke. Methods A total of 82 patients with cognitive dysfunction after ischemic stroke admitted to the Fifth People’s Hospital of Wuxi, Jiangsu Province from March 2018 to March 2021 were selected. According to the random number table method, they were divided into single group (Nimodipine, four consecutive weeks) and combined group (rTMS+ Nimodipine, four consecutive weeks), with 41 cases in each group. The Montreal cognitive assessment (MoCA) score, cerebral circulation dynamics index, modified Barthel index (MBI), and stroke specific quality of life (SS-QOL) scale score before and after four weeks of treatment were analyzed. Results Among the 82 patients, five dropped out and the remaining 77 cases were included, including 40 cases in the single group and 37 cases in the combined group. After four weeks of treatment, the scores of MoCA, MBI, SS-QOL, mean cerebral blood flow, and mean cerebral flow velocity in the two groups were higher than those before treatment, and the vascular resistance was lower than that before treatment; the scores of MoCA, MBI, SS-QOL, mean cerebral blood flow, and mean velocity in the combined group were higher than those in the single group, and the vascular resistance was lower than that in the single group (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion rTMS is effective in the treatment of cognitive dysfunction after ischemic stroke, which can effectively improve the cognitive function of patients and promote the increase of cerebral blood flow, with good safety, and can be popularized in clinical practice.
		2022 Vol. 19 (32): 80-83 [Abstract] ( 20 ) HTML (1 KB) PDF (549 KB) ( 44 )

	84	Efficacy of sequential therapy of Butylphthalide combined with dual antiplatelet therapy in patients with acute cerebral infarction complicated with atherosclerosis and its effects on neurological function, serum Hcy and hs-CRP levels
		WANG Can HOU Huanxi HUANG Wei LIU Hongli
		DOI: 10.20047/j.issn1673-7210.2022.32.19
		Objective To investigate the effect of sequential therapy of Butylphthalide combined with dual antiplatelet therapy on patients with acute cerebral infarction (ACI) complicated with atherosclerosis (AS) and its effects on neurological function, serum homocysteine (Hcy), and high-sensitivity C-reactive protein ( hs-CRP) levels. Methods A total of 82 patients with ACI complicated with AS who were treated in Huaibei Miners General Hospital of Anhui Province from July 2019 to June 2021 were selected as the research objects, and they were divided into the control group (odd number) and the study group (even number) according to the odd and even number method, with 41 in each group. The patients in the control group received routine and dual antiplatelet intervention, and the patients in the study group received sequential therapy intervention of Butylphthalide based on the control group. After 90 days of treatment, the clinical efficacy, Hcy, hs-CRP levels, and NIHSS score were compared between the two groups. Results The clinical effect of the study group was better than the control group (P ＜ 0.05). Before treatment, there were no significant differences in NIHSS score, Hcy, and hs-CRP levels between the two groups (P ＞ 0.05); after treatment, the levels of Hcy, hs-CRP, and NIHSS in the two groups were lower than those before treatment, and those in the study group were lower than the control group (P ＜ 0.05). Conclusion Butylphthalide sequential therapy combined with dual antiplatelet therapy in the treatment of ACI complicated with AS can significantly improve the curative effect, improve neurological function, and also effectively reduce serum Hcy and hs-CRP levels.
		2022 Vol. 19 (32): 84-87 [Abstract] ( 18 ) HTML (1 KB) PDF (589 KB) ( 37 )

	88	Correlation analysis of peripheral blood miR-155 expression with Th1/Th17 cells and related cytokines in children with atopic dermatitis
		ZHOU Xiaoyu LUO Ting WANG Runchao
		DOI: 10.20047/j.issn1673-7210.2022.32.20
		Objective To investigate the correlation of peripheral blood microRNA (miR-155) expression with T helper (Th)1/Th17 cells and to related cytokines in children with atopic dermatitis (AD). Methods A total of 89 AD children admitted to Taihe Hospital, Hubei Province (hereinafter referred to as “our hospital”) from February 2018 to September 2021 were selected as AD group, and according to the score of scoring atopic dermatitis, they were divided into mild group (28 cases), moderate group (37 cases), and severe group ( 24 cases). Another 25 healthy children who underwent physical examination during the same period were selected as control group. The levels of miR-155 in peripheral blood, Th1/Th17 cells, and related cytokines of each group were compared, and the correlation between the expression of miR-155 in peripheral blood and Th1, Th17, and related cytokine levels in children with AD were analyzed. Results The expression of miR-155, the proportion of Th17 cell, interleukin (IL)-17, and IL-23 in AD group were higher than those in control group, and the proportion of Th1 cell, Th1/Th17, interferon-γ (IFN-γ), IL-2, and IFN-γ/IL-17 were lower than those in control group (P ＜ 0.05). The expression of miR-155, the proportion of Th17 cell, IL-17, and IL-23 in severe group were higher than those in mild group and moderate group, while the proportion of Th1 cell, Th1/Th17, IFN-γ, IL-2, and IFN-γ/IL-17 were lower than those in mild group and moderate group (P ＜ 0.05). The expression of miR-155, the proportion of Th17 cell, IL-17, and IL-23 in moderate group were higher than those in mild group, and the proportion of Th1 cell, Th1/Th17, IFN-γ, IL-2, and IFN-γ/IL-17 in moderate group were lower than those in mild group (P ＜ 0.05). The expression of miR-155 in peripheral blood of AD children was positively correlated with the proportion of Th17 cell, serum IL-17 and IL-23 (r ＞ 0, P ＜ 0.05), and negatively correlated with the proportion of Th1 cell, Th1/Th17, IFN-γ, IL-2, and IFN-γ/IL-17 (r ＜ 0, P ＜ 0.05). Conclusion The expression of miR-155 in peripheral blood of AD children is increased, and it is related to the imbalance of Th1/Th17. The miR-155 may participate in the pathogenesis of AD by regulating Th1/Th17.
		2022 Vol. 19 (32): 88-91 [Abstract] ( 17 ) HTML (1 KB) PDF (523 KB) ( 19 )

	92	Relationship analysis of serum lipid level and lipid combine index with wheezing diseases in children
		ZHAO Yidong YAO Jiaqi ZHAO Xuan GUI Jingjing ZHU Linjie JIN Aquan ZHANG Liwen HUANG Zhiying▲
		DOI: 10.20047/j.issn1673-7210.2022.32.21
		Objective To explore the relationship of serum lipid level and lipid combine index (LCI) with wheezing diseases in children. Methods A total of 6 311 children hospitalized in the Department of Pediatrics, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University from July 2016 to June 2021 were selected for blood lipid analysis. The children were divided into wheezing group (1 707 cases) and non-wheezing group (4 604 cases) according to whether they had wheezing symptoms or signs at admission; according to body mass index (BMI), the children were divided into overweight-obese wheezing group (466 cases) and overweight-obese non-wheezing group (722 cases). The general data and blood lipid indexes of the children were collected, and LCI was calculated; the correlation between serum lipid level, LCI and asthmatic diseases in children were analyzed. Results There were significant differences in gender, age, BMI, previous history of asthma, breastfeeding alone, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol, high density lipoprotein cholesterol (HDL-C), and LCI between wheezing group and non-wheezing group (P ＜ 0.05). Gender, age, BMI, previous history of asthma, and TC were the influencing factors of asthmatic diseases in children (P ＜ 0.05). There were significant differences in gender, age, BMI, previous history of asthma, TC, TG, HDL-C, and LCI between overweight-obese wheezing group and overweight-obese non-wheezing group (P ＜ 0.05). Gender, age, previous history of asthma, TC, TG, and LCI were the influencing factors of asthmatic diseases in overweight-obese children (P ＜ 0.05). Conclusion Lipid levels is associated with wheezing in children, but not with LCI.
		2022 Vol. 19 (32): 92-95 [Abstract] ( 26 ) HTML (1 KB) PDF (424 KB) ( 29 )

	96	Analysis of risk factors and avoidance paths of accidental injury in children
		YE Hongman ZHU Ting ZHU Hui
		DOI: 10.20047/j.issn1673-7210.2022.32.22
		Objective To analyze the risk factors of accidental injury in children, and to explore effective avoidance paths to avoid them. Methods A total of 158 children who visited the Department of Pediatrics, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from March 2018 to March 2020 were selected. The case data were collected and the risk factors of accidental injury in children were analyzed. Results Among the 158 children, 100 cases were accidental injuries, and the most common types of accidental injuries were fall injury, traffic injury, and poisoning. Home, kindergarten, and residential community were common places of accidental injury. After treatment, 8 cases died and 92 cases recovered. There were statistically significant differences in the incidence of accidental injury among children of different ages, genders, family harmony, orderlies’ education level, and social and economic development level (P ＜ 0.05). Age, family harmony, and orderlies’ education level were the protective factors of children’s accidental injury (OR ＜ 1, P ＜ 0.05). Conclusion The occurrence of accidental injury to children is unpredictable. Age, family harmony, and parental education are protective factors. In order to avoid the occurrence of accidental injury to children, it should be paid more attention to strengthening science popularization and education, improving public health management and enhancing orderlies’ awareness of prevention.
		2022 Vol. 19 (32): 96-99 [Abstract] ( 26 ) HTML (1 KB) PDF (510 KB) ( 133 )

	100	Risk factors of intestinal obstruction after total hysterectomy for endometrial cancer
		YANG Ying LI Ming WANG Yuan LU Yun▲
		DOI: 10.20047/j.issn1673-7210.2022.32.23
		Objective To analyze the risk factors of intestinal obstruction after total hysterectomy for endometrial cancer, so as to provide an important basis for the prevention of postoperative intestinal obstruction. Methods A total of 110 patients with endometrial cancer who underwent hysterectomy in Huai’an First People’s Hospital of Jiangsu Province from August 2017 to August 2021 were selected. They were divided into the non-occurrence group and the occurrence group. The risk factors of intestinal obstruction after total hysterectomy for endometrial cancer were analyzed. Results Among the 110 patients, 9 patients had intestinal obstruction, the incidence rate was 8.18%. There were significant differences in body mass index, history of pelvic surgery, history of dysmenorrhea, pelvic adhesion, opioid application, operation method, postoperative blood potassium, pelvic infection, operation time, and postoperative fasting time between the two groups (P ＜ 0.05). Pelvic adhesion (OR = 2.630, 95%CI: 1.175-5.886), opioid application (OR = 2.396, 95%CI: 1.397-4.108), postoperative blood potassium (OR = 2.373, 95%CI: 1.183-4.758) were independent influencing factor of intestinal obstruction after total hysterectomy for endometrial cancer. Conclusion Pelvic adhesion, opioid application, and postoperative blood potassium level are important factors leading to the occurrence of intestinal obstruction. Clinical attention should be paid to the above factors, and corresponding preventive measures should be taken to reduce the occurrence of intestinal obstruction and promote postoperative rehabilitation.
		2022 Vol. 19 (32): 100-103 [Abstract] ( 21 ) HTML (1 KB) PDF (571 KB) ( 33 )

	104	Knowledge map analysis of studies related to caloric restriction in delaying aging
		LI Yuan1 ZHOU Yu1 WEI Yi2 HU Yuanhui2
		DOI: 10.20047/j.issn1673-7210.2022.32.24
		Objective To visually analyze the research literature on caloric restriction in delaying aging in the past decade, and to explore the research status and hot spots in this field. Methods The relevant literature of Web of Science core collection database from January 2012 to December 2021 was retrieved. CiteSpace 5.8 R3 software was used to conduct knowledge graph analysis on the authors, institutions, countries, keywords, and co-cited literatures and authors of the selected literatures. Results A total of 2 986 literatures were included. The main research country and institution was the National Institute on Aging in the United States; the most published and cited authors were RAFAEL DE CABO and FONTANA L; hot keywords were calorie restriction, oxidative stress, gene expression, insulin resistance, and obesity, etc. Conclusion In the past decade, the trend of annual publications on caloric restriction delaying aging research has been relatively stable. Exploring the potential mechanism of caloric restriction delaying aging and discovering more drug targets and interventions are the research hotspots in this field.
		2022 Vol. 19 (32): 104-107,116 [Abstract] ( 23 ) HTML (1 KB) PDF (2291 KB) ( 40 )

	108	Hotspots and trends of magnetic resonance research of acupuncture based on CiteSpace visual analysis
		WANG Yue WANG Liping WANG Yahui CHEN Chen YU Xin WU Linlu ZOU Yihuai
		DOI: 10.20047/j.issn1673-7210.2022.32.25
		Objective To make a visual analysis of the English literature on magnetic resonance research of acupuncture and show the research hotspots and trends in this field. Methods The literatures on acupuncture based on magnetic resonance published in the core database of Web of Science from January 2004 to April 2022 were obtained. The co-occurrence, clustering or emergence analysis of countries, authors, keywords, and co-cited references were performed using CiteSpace software, and the visual map was drawn. Results A total of 696 literatures were included, and the number of annual publications showed an overall upward trend. The number of publications from China was dominant, while the importance of publications from the United States was dominant. The top five authors were Jie Tian, Jian Kong, Wei Qin, Fanrong Liang, and Lijun Bai. The author with the highest centrality ranking was Jian Kong. The top five high-frequency keywords were functional magnetic resonance imaging, stimulation, pain, acupuncture, and electro-acupuncture. The keyword with the highest centrality ranking was functional magnetic resonance imaging. Keywords clustering results were cortex, randomized controlled trials, functional connectivity, anterior cingulate cortex, neural regeneration, human brain, rehabilitation, systematic review, brain activity, case reports. Meta analysis, default mode network, curative effect and so on were the key words that had emerged and lasted till now. The clustering results of co-cited references were pinprick specificity, depression, chronic low back pain, needle sensation, amygdala, migraine without aura, placebo, external closure, exercise, and subcortical stroke. Conclusion The research hotspots of magnetic resonance imaging of acupuncture include physiological response and acupoint specificity, therapeutic effect of acupuncture in diseases, systematic review and meta- analysis of previous literatures. Gratifying achievements have been made in this field in the past two decades, but there are still many gaps. In the future, more studies with rigorous design, wide range of diseases, and advanced analytical and modeling methods will emerge.
		2022 Vol. 19 (32): 108-111,121 [Abstract] ( 17 ) HTML (1 KB) PDF (1932 KB) ( 32 )

	112	Treatment of internal hemorrhoid hemorrhage and prolapse with Yizi Decoction based on “the ascending and descending theory” of traditional Chinese medicine#br#
		YUAN Run1 JIANG Yun2 LEI Li2 LI Huashan1
		DOI: 10.20047/j.issn1673-7210.2022.32.26
		The ascending and descending theory is of great clinical significance in the theory system of traditional Chinese medicine, and is widely used in various systemic diseases. Although internal hemorrhoid hemorrhage and prolapse is a local disease, its internal mechanism reflects the dynamic imbalance of the whole qi, blood, yin, and yang. Clinical treatment of internal hemorrhoids in traditional Chinese medicine often card the rise and fall of qi machine. Yizi Decoction is regarded as an excellent prescription for hemorrhoids and also used for many kinds of anorectal diseases because of adjusting the disturbance in ascending and descending, which contains the meaning of acrid opening and bitter downbearing, clearing cooperate with scattering. Modern doctors based on the ascending and descending theory as the guiding ideology, the modified treatment of internal hemorrhoids hemorrhage and prolapse based on the Yizi Decoction, flexible use and achieved good results. This paper introduces the long history of traditional Chinese medicine in understanding internal hemorrhoids and the valuable experience in the formulation of Yizi Decoction under the guidance of ascending and descending theory, and expounds the clinical application of Yizi Decoction in the treatment of internal haemorrhoid hemorrhage and prolapse，inherits and excavates the thinking of traditional Chinese medicine clinical syndrome differentiation and treatment for internal haemorrhoid hemorrhage and prolapse, and enriches the internal treatment methods of anorectal diseases.
		2022 Vol. 19 (32): 112-116 [Abstract] ( 25 ) HTML (1 KB) PDF (831 KB) ( 31 )

	117	Clinical characteristics and distribution of traditional Chinese medicine syndrome elements of Sangqi Qingxuan Granules in treating hypertension
		REN Weiquan1 FAN Jiarong2 ZHANG Gaoyu2 HE Qing2 LIAO Jiangquan3 HUANG Li3 LI Lin3▲
		DOI: 10.20047/j.issn1673-7210.2022.32.27
		Objective To evaluate the clinical characteristics and distribution of traditional Chinese medicine syndrome elements of patients with hypertension treated by Sangqi Qingxuan Granules. Methods From January 2018 to December 2019, a total of 150 hypertensive patients who were treated with Sangqi Qingxuan Granules by Professor Huang Li in China-Japan Friendship Hospital were selected for the collection of clinical general data and syndrome element evaluation. The distribution of symptoms, tongue and pulse, syndrome elements were observed. Results A total of 150 questionnaires were distributed and 122 valid questionnaires were collected. The gender distribution of the population was mostly male (62 cases, accounting for 50.8%), the age distribution was mostly patients under 60 years old (78 cases, 63.93%), the body weight was more obese (54 cases, accounting for 44.26%), and the hypertension grade was more common in grade 1 (74 cases, accounting for 60.66%). In terms of traditional Chinese medicine syndromes, dizziness, headache, poor sleep, more dreams and dry stools were the most common symptoms. The patients were mostly characterized by pink tongue, thin fur, stringy and thready pulse, and syndrome of hyperactivity of yang. Cluster analysis showed three patterns of combination of syndrome elements: hyperactivity of yang; yin deficiency; blood stasis, qi deficiency, qi stagnation, phlegm, dampness, heat. Conclusion Sangqi Qingxuan Granules is effective in the treatment of grade 1 hypertension, especially for patients with syndrome of yin deficiency of liver and kidney and syndrome of upper hyperactivity of liver yang.
		2022 Vol. 19 (32): 117-121 [Abstract] ( 14 ) HTML (1 KB) PDF (914 KB) ( 29 )

	122	Discussion on principle-method-recipe-medicines of treating pulmonary nodules based on “deficiency, phlegm, stasis, toxicity”
		DANG Shuyuan1 SHAO Cancan1 MENG Pengfei2 LI Liangping2 XU Liran2
		DOI: 10.20047/j.issn1673-7210.2022.32.28
		The unified and standardized theoretical system is the prerequisite for theoretical innovation and breakthrough, and also the cornerstone and key to improve clinical efficacy. Based on the comprehensive and systematic analysis of modern physicians’ discussion on principle-method-recipe-medicines of pulmonary nodules and the summary of experts’ experience, this paper summarizes principle-method-recipe-medicines of traditional Chinese medicine in treating pulmonary nodules. It is believed that “deficiency, phlegm, stasis, toxicity” are the core pathogenesis of pulmonary nodules. Different constitutions and different periods of pathogenesis have different manifestations and focuses, but generally speaking, its pathogenesis can be summarized as cold and hot. The syndrome differentiation and classification of pulmonary nodules mainly focus on deficiency syndrome, phlegm syndrome, stasis syndrome, and toxicity syndrome. The treatment of pulmonary nodules mainly focuses on the treatment of lung, spleen, liver and kidney, and mainly focuses on ventilating the lung qi, strengthening the spleen, and regulating the cold and heat.
		2022 Vol. 19 (32): 122-125 [Abstract] ( 18 ) HTML (1 KB) PDF (606 KB) ( 19 )

	126	Discussion on prolonging the protection period of traditional knowledge of traditional Chinese medicine
		WANG Shiheng QIN Peijie WANG Liuqing ZHAO Zhupei SHI Xueqin ZHANG Fengxia LIU Qian LIU Jianfeng
		DOI: 10.20047/j.issn1673-7210.2022.32.29
		Traditional knowledge of traditional Chinese medicine has great economic and social value, and it is a treasure of the Chinese nation. Its most important feature is inheritance and continuity. At present, the protection of traditional knowledge of traditional Chinese medicine in my country mostly uses the modern intellectual property protection system, and the protection period is short, which is contrary to the inheritance and continuity of traditional Chinese medicine, and cannot achieve the purpose of better protection of traditional knowledge of traditional Chinese medicine. At present, the protection of traditional knowledge of traditional Chinese medicine is facing many difficulties and challenges, and the lack of inheritance and protection has led to the imminent loss of many traditional knowledge of traditional Chinese medicine. Many problems with traditional knowledge of traditional Chinese medicine need to be solved urgently. Therefore, formulating a protection system that conforms to the characteristics of traditional Chinese medicine and extending the protection period are of great significance for protecting traditional knowledge of traditional Chinese medicine and promoting the achievement of the goal of a healthy China.
		2022 Vol. 19 (32): 126-129 [Abstract] ( 26 ) HTML (1 KB) PDF (547 KB) ( 21 )

	130	New idea of traditional Chinese medical comprehensive intervention for moderate and severe degenerative lumbar spinal stenosis
		AN Yi1 CHEN Hong2 WANG Xiyou2 ZHOU Yanji1 ZHANG Yang2 JIA Shouguo2 LIU Changxin2▲ YU Changhe2▲
		DOI: 10.20047/j.issn1673-7210.2022.32.30
		Degenerative lumbar spinal stenosis is a disease frequently occurring in the elderly. Conservative treatment of moderate and severe degenerative lumbar spinal stenosis is recommended as the first treatment strategy in the guidelines, but there is no specific high-quality evidence to recommend conservative treatment of Chinese medicine. According to the Chinese medicine theory of “yi jin dai gu” as the treatment principle, a new idea of Chinese medicine comprehensive plan for intervention of moderate and severe lumbar spinal stenosis is explored, that is, a new idea of Chinese medicine conservative treatment plan of “heterozygosity and treatment”. On the basis of the pricking blood treatment and medicine cupping therapy, combined with acupotomology, ointment rubbing, Chinese medicine decoction and other treatment methods as one of the comprehensive therapy. Oral Chinese medicine is used to recuperate the patient’s body and mind, acupotomology is used to increase the intensity of treatment, and ointment rubbing is used to promote tissue repair, forming a four-dimensional integrated therapy of “bamboocuppingas the main therapy, acupotomology as the assist therapy, ointment rubbing as the repair therapy, and Chinese medicine decoction as to improve physical condition”.
		2022 Vol. 19 (32): 130-132,137 [Abstract] ( 23 ) HTML (1 KB) PDF (820 KB) ( 29 )

	133	Professor Wen Qinghan’s clinical experience and academic thoughts on massage therapy for tendon injuries
		MO Wenli TIAN Jun WU Peng YANG Hanchao PU Yaohui WEN Qinghan FAN Yun
		DOI: 10.20047/j.issn1673-7210.2022.32.31
		In more than 50 years of clinical practice of massage, Professor Wen Qinghan has been able to integrate the western and traditional Chinese medicine. He has drawn on the strengths of various schools, has formed a unique experience and academic ideological system for treating tendon and injuries. Professor Wen strictly followed the traditional principles which emphasize the characteristics of “tendon prefering softness instead of rigidity”, focusing on the inheritance of traditional massage therapy and closely integrating modern medical theory. In the clinical treatment of tendon injuries, Professor Wen emphasizes the application of myofascial chain and muscle starting point therapy, stressing that the practitioner not only needs to be based on the whole body and focus on the local area, but also has to identify the meridian to take the points as well as distinguish the anatomical structure to help who patients restore the mechanical balance of the body and achieve a status of balance between yin and yang. In addition, Professor Wen attaches importance to clinical efficacy, advocates flexible manipulation, opposes excessive massage, and holds the view that practitioners need to continuously strengthen their own manipulations. Professor Wen’s clinical treatment effectiveness is excellent, which deserves learning, refering, inheritance and development.
		2022 Vol. 19 (32): 133-137 [Abstract] ( 15 ) HTML (1 KB) PDF (750 KB) ( 38 )

	138	Effect of scalp acupuncture combined with sensory perception training in the treatment of autism
		REN Ting1 LI Hongyu2 ZHANG Chunyan3 ZHU Luwen4 TANG Qiang4 WANG Hongxu5 LI Zhigang5 LI Baolong3
		DOI: 10.20047/j.issn1673-7210.2022.32.32
		Objective To explore the effect of scalp acupuncture combined with sensory perception training in the treatment of autism. Methods Seventy-two autistic children aged two to ten years admitted to the outpatient department and ward of Department of Rehabilitation, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2020 to October 2021 were selected and allocated. According to the computer-generated randomization procedure, the children who met the inclusion criteria were assigned to the combination group, the perception training group and the head acupuncture group according to 1∶1∶1, with 24 cases in each group. The combination group was treated with scalp acupuncture combined with sensory perception training. The perception training group was treated with hearing, touch, proprioception and perception training. The scalp acupuncture group was treated with long retaining needle of scalp acupuncture in the functional area of Yu’s seven zone division method. Childhood autism rating scale (CARS) and autism behavior checklist (ABC) scores before and after treatment in each group were compared. Results The overall analysis showed that there were statistically significant differences in group comparison, time point comparison and interaction of CARS and ABC scores (P < 0.05). Further pairwise comparison, intra group comparison: the CARS and ABC scores of the three groups after 16 and 32 weeks of treatment were lower than those before treatment, the CARS and ABC scores of the three groups after 32 weeks of treatment were lower than those after 16 weeks of treatment, the differences were statistically significant (P < 0.05). The group comparison: the CARS and ABC scores in the combination group were lower than those in the perception training group and the scalp acupuncture group after 16 and 32 weeks of treatment, the differences were statistically significant (P < 0.05). Conclusion The effect of scalp acupuncture combined with sensory perception training in the treatment of autistic children is significantly better than that of simple sensory perception training and simple scalp acupuncture, which is more conducive to the early recovery of autistic children.
		2022 Vol. 19 (32): 138-141,146 [Abstract] ( 18 ) HTML (1 KB) PDF (675 KB) ( 76 )

	142	Analysis of the academic value of the Complete Works of Chishui Xuanzhu
		MENG Xiaoyu GAO Xiaoqin ZHOU Yadong
		DOI: 10.20047/j.issn1673-7210.2022.32.33
		This paper summarizes the academic value and diagnosis and treatment characteristics reflected in the Complete Works of Chishui Xuanzhu by Sun Yikui, a representative physician in Xin’an area. From the analysis and excavation of the historical prescription medicines, clinical evidence experience, medical theories, and specific medical cases referred to by Sun Shi in the Complete Works of Chishui Xuanzhu, it is concluded that the academic value of the Complete Works of Chishui Xuanzhu is concretely manifested in: the law follows the evidence, the first heavy evidence; evidence-based administration, treatment has positioning; poor reasom and mingxin, medical easy integration; solid foundation peiyuan, prevention and control of transmission of four parts. Sun Yikui is guided by the classical theories of the sages, but some academic ideas transcend the classics and benefit future generations. The Complete Works of Chishui Xuanzhu has high reference value for excavating and sorting out the study of medicine in the motherland, local medicine and guiding clinical practice.
		2022 Vol. 19 (32): 142-146 [Abstract] ( 41 ) HTML (1 KB) PDF (810 KB) ( 30 )

	147	Impact of personalized psychological care on disease uncertainty and prognosis in patients with nutcracker syndrome treated with 3D printed extravascular stent implantation
		WAN Xiaoqiong ZHANG Bo LI Sha CUI Dong YAN Fengqi LAN Hua CHEN Qian▲
		DOI: 10.20047/j.issn1673-7210.2022.32.34
		Objective To investigate the impact of personalized psychological care on disease uncertainty and prognosis in patients with 3D printed extravascular stent implantation for nutcracker syndrome. Methods Seventy-two patients with nutcracker syndrome who underwent 3D printed extravascular stent implantation at the Second Affiliated Hospital of the Chinese People’s Liberation Army Air Force Military Medical University from December 2019 to September 2021 were selected for the study, and the patients were divided into control group and observation group of 36 cases each according to the random number table method. The control group implemented conventional care, while the observation group implemented personalized psychological care. Comparison of disease uncertainty, psychological status, pain, comfort, and sleep quality scores between the two groups was carried out before and after care. Results After care, the disease uncertainty, anxiety, and depression scores of both groups were lower than before care, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). After care, the pain scores and sleep quality scores of both groups were lower than before care, while those of the observation group were lower than those of the control group; the comfort scores of both groups were higher than before care, and while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Personalized psychological care can effectively improve the psychological status of patients with nutcracker syndrome during the perioperative period of 3D printed extravascular stent implantation, reduce their disease uncertainty, and alleviate pain, enhance somatic comfort and improve sleep quality.
		2022 Vol. 19 (32): 147-150 [Abstract] ( 16 ) HTML (1 KB) PDF (564 KB) ( 25 )

	151	Effectiveness of comprehensive nursing care based on Omaha theory for traumatic paraplegic patients
		XIANG Rui1 XU Fengqin2 JI Lili1 YIN Zhaoyang3 XU Qin4▲
		DOI: 10.20047/j.issn1673-7210.2022.32.35
		Objective To explore the analysis of the effectiveness of comprehensive care based on the Omaha system for patients with traumatic paraplegia. Methods Eighty-four patients with traumatic paraplegia treated at Lianyungang Clinical Medical College, Nanjing Medical University from January 2020 to June 2021 were selected and divided into basic group and combined group by the random number table method, with 42 cases in each group. The basic group was given conventional care, while the combined group was given comprehensive care under the guidance of Omaha system theory during hospitalization and after discharge, and negative emotions, sleep quality and recovery of limb function were assessed before and after care in both groups. The adverse reactions were recorded. Results After comprehensive care, the independence rating scale and Fugl-Meyer scores were higher in both groups than before care, while those of the combined group were higher than those of the control group, with statistically significant differences (P ＜ 0.05). After care, the dimensions of Nottingham health questionnaire scores were lower in both groups than before care, while the combined group had lower energy, pain, sleep, social, and physical scores than the base group, with statistically significant differences (P ＜ 0.05). After care, the scores on the self-rating sleep status scale, the self-rating anxiety scale, and the self-rating depression scale in both groups were lower than before care, while in those the combined group were lower than those in the basic group, with statistically significant differences (P ＜ 0.05). The incidences of muscle atrophy and joint stiffness during care were lower in the combined group than in the basic group, and the differences were statistically significant (P ＜ 0.05). Conclusion Comprehensive care based on the Omaha system can significantly improve somatic and motor functions, increase quality of life, and reduce psychological stress in patients with traumatic paraplegia.
		2022 Vol. 19 (32): 151-154,163 [Abstract] ( 20 ) HTML (1 KB) PDF (610 KB) ( 56 )

	155	Effect of King standard theoretical nursing intervention on postoperative physical function rehabilitation training of brain tumor patients in the motor area
		LI Yuanyuan1 WANG Lei2 ZHANG Qing1▲
		DOI: 10.20047/j.issn1673-7210.2022.32.36
		Objective To investigate the effect of King standard theoretical nursing intervention on the functional rehabilitation training of the limbs in patients. Methods Eighty-two patients with brain tumors in the motor area treated at Wuhan University Central South Hospital from September 2020 to February 2022 were selected as study subjects and divided into observation group and control group according to the random number table method, with 41 cases each. The control group was given conventional interventions while the observation group was given King standard theoretical nursing theory nursing interventions. The rehabilitation effects and motor function scale scores were compared between the two groups. Results After the intervention, the excellent recovery rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The proportions of upper limb muscle strength and lower limb muscle strength grade Ⅲ and above were higher in the observation group than in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the Fugl-Meyer score was higher in the observation group compared with the control group, and the difference was statistically significant (P ＜ 0.05). The role, somatic, social, emotional, and cognitive function scores in the observation group were higher than those in the control group after the intervention, with statistically significant differences (P ＜ 0.05). Conclusion The adoption of King standard theoretical nursing intervention for brain tumor patients in the motor area can effectively improve the rehabilitation effect, and improve the limb motor function and quality of life, which is worthy of clinical promotion and application.
		2022 Vol. 19 (32): 155-158 [Abstract] ( 19 ) HTML (1 KB) PDF (558 KB) ( 51 )

	159	High risk factors for complications after CT-guided percutaneous lung aspiration biopsy and nursing intervention countermeasures
		SONG Yu1 CAI Limei2 LIU Jing1 TU Yanhui3 LIU Zhao1 HE Jingrui1
		DOI: 10.20047/j.issn1673-7210.2022.32.37
		Objective To explore and analyze the high-risk factors of complications after CT-guided percutaneous lung aspiration biopsy and nursing intervention countermeasures. Methods From May 2018 to October 2021, the clinical data of 196 cases in Tangshan People's Hospital, Hebei Province was retrospectively analyzed. All patients underwent CT-guided percutaneous lung aspiration biopsy for the diagnosis of the disease, and those with postoperative complications were classified as the complication group (42 patients) and the non-complication group (154 patients). The success rate of puncture biopsy and the type of complications in patients were observed, and the high-risk factors affecting complications after CT-guided percutaneous lung puncture biopsy were analyzed. Results The success rate of one-time puncture biopsy in patients was 98.98%, the rate of two punctures was 1.02%, and the complication rate was 21.43%. The differences were statistically significant when comparing the combined COPD, lesion diameter, lesion distance from the chest wall, and puncture needle dwell time between the two groups (P ＜ 0.05). Multifactorial logistic regression analysis showed that combined chronic obstructive pulmonary disease, lesion diameter, lesion distance from the chest wall, and puncture needle dwell time were high risk factors for complications after CT-guided percutaneous lung aspiration biopsy (OR ＞ 1, P ＜ 0.05). Conclusion CT-guided percutaneous lung aspiration biopsy has a high success rate during operation; the high-risk factors of postoperative complications after CT-guided percutaneous lung aspiration biopsy include combined chronic obstructive pulmonary disease, lesion diameter, lesion distance from the chest wall, and puncture needle dwell time, and the analysis of the high-risk factors and the development of effective nursing interventions may reduce the adverse effects of postoperative complications on patients’ health.
		2022 Vol. 19 (32): 159-163 [Abstract] ( 17 ) HTML (1 KB) PDF (641 KB) ( 72 )

	164	Perioperative nursing and effect of robot assisted radical prostatectomy for patients with prostate cancer
		TANG Yan ZHANG Xueyan TANG Xiaojuan
		DOI: 10.20047/j.issn1673-7210.2022.32.38
		Objective To explore the perioperative nursing intervention measures and effect of robot assisted radical prostatectomy. Methods A total of 74 prostate cancer patients who underwent radical resection in the First Affiliated Hospital of Guangxi Medical University from July 2020 to August 2021 were selected. They were divided into control group and observation group by random number table method, with 37 cases in each group. The control group was given routine nursing intervention, while the observation group was given fine perioperative nursing intervention. After intervention, the relevant surgical indicators, postoperative complications, and the improvement of quality of life were observed in the two groups. Results After intervention, operation time, postoperative exclusion, extubation, and hospital stay in the observation group were shorter than those in the control group, and the amount of blood loss, and operation cost were less than those in the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The scores of short form of quality of life measurement scale of the two groups were higher than those before the intervention, and the scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion During the treatment of prostate cancer patients undergoing robot assisted radical resection, strengthen fine perioperative nursing intervention, can shorten the rehabilitation process of patients and help to improve their quality of life.
		2022 Vol. 19 (32): 164-167,183 [Abstract] ( 22 ) HTML (1 KB) PDF (700 KB) ( 66 )

	168	Bibliometric analysis on the research hotspots of mother-infant bedside nursing in China
		ZHONG Hui YANG Rong LIU Wei
		DOI: 10.20047/j.issn1673-7210.2022.32.39
		Objective To explore the research hotspots of mother-infant bedside nursing in China by bibliometrics method. Methods CNKI, Wanfang Data, and VIP were searched with “mother- infant”, “bedside”, and “nursing” as the keywords. The retrieval period was from the establishment of the database to December 2021. SPSS 26.0, CiteSpace V, and CNKI literature visualization analysis system software were used to conduct cluster analysis and draw bar graphs and network graphs. Results A total of 437 literatures were included, of which only three were funded. The top ten journals with the most publications of literatures were all general journals. The distribution of publishing units of literatures in this field was relatively uniform in China. The most common keyword is “nursing quality”, and the most frequently cited literature is Application and effect of mother-infant bedside nursing model in obstetrics published in Chinese Journal of Nursing. Conclusion This paper systematically analyzes the literature publication, fund support, keyword co-occurrence, and literature citation of mother-infant bedside nursing, and analyzes the current research focus in this field as nursing content, nursing object, and nursing quality evaluation index, which has certain reference significance for relevant medical staff.
		2022 Vol. 19 (32): 168-171,188 [Abstract] ( 17 ) HTML (1 KB) PDF (1620 KB) ( 16 )

	172	Effect of cross theoretical model cognitive intervention on health behavior and self-care ability of patients with acute ischemic stroke after thrombectomy
		XUE Yingying ZHANG Xiaoxi LI Hongyue ZHENG Jing GAN Lifen▲
		DOI: 10.20047/j.issn1673-7210.2022.32.40
		Objective To explore the effect of cross theoretical model cognitive intervention on health behavior and self-care ability with acute ischemic stroke after thrombectomy. Methods A total of 100 patients with acute ischemic stroke who received thrombectomy in Shanghai Changhai Hospital from September 2020 to September 2021 were selected as the research subjects. They were divided into control group (50 cases) and observation group (50 cases) by random number table method. The control group was treated with routine nursing, and the observation group was treated with cognitive intervention of cross theoretical model, both groups were intervened for six months. The healthy behavior and self-care ability of two groups before and after intervention were compared. Results After six months of intervention, the scores of health-promoting lifestyle profile-Ⅱ and activity of daily living in both groups were increased than those before intervention, and observation group was higher than control group (P ＜ 0.05). Conclusion The cognitive intervention of cross theoretical model has a good application effect in patients with acute ischemic stroke after thrombectomy, and can effectively improve their healthy behavior and self-care ability.
		2022 Vol. 19 (32): 172-175 [Abstract] ( 19 ) HTML (1 KB) PDF (535 KB) ( 29 )

	176	Application effect and safety of non-invasive sputum suction technique in nursing of bronchopneumonia
		WU Jingxian WANG Junqin
		DOI: 10.20047/j.issn1673-7210.2022.32.41
		Objective To explore the effect and safety of non-invasive sputum suction technique in nursing of children with bronchopneumonia. Methods A total of 86 children with bronchopneumonia admitted to Bengbu Third People’s Hospital, Anhui Province from April 2021 to March 2022 were selected and divided into control group and observation group by random number table method. During the nursing period, the children in the control group (43 cases) were given traditional sputum suction, and the children in the observation group (43 cases) were given non-invasive sputum suction. The effect of sputum suction, the degree of sputum suction cooperation, the incidence of sputum suction complications, and the recovery indicators of physical signs were observed and compared between the two groups. Results The sputum suction effect and the degree of sputum suction coordination of the observation group were better than those of the control group, and the total incidence of complications was lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). The time of antipyretic, cough, lung rales disappeared, asthma disappeared, and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Non-invasive sputum suction in the nursing of children with bronchopneumonia can effectively improve the overall effect of sputum suction, improve the cooperation degree of children, significantly reduce sputum suction related complications, and help shorten the recovery time of children.
		2022 Vol. 19 (32): 176-179 [Abstract] ( 22 ) HTML (1 KB) PDF (549 KB) ( 72 )

	180	Application effect and prognosis of magnetic nursing concept in surgical nursing of placenta previa
		ZHANG Hang HAN Yue▲
		DOI: 10.20047/j.issn1673-7210.2022.32.42
		Objective To explore the application effect of magnetic nursing concept in cesarean section of placenta previa. Methods A total of 120 pregnant women with placenta previa undergoing cesarean section in the Second Affiliated Hospital of Air Force Military Medical University from February 2019 to February 2021, according to the random number table method, the patients were divided into control group (60 cases, routine nursing intervention were received) and study group (60 cases, magnetic nursing intervention were received). The scores of self rating anxiety scale (SAS), perinatal complications, maternal and infant pregnancy outcomes and Hamilton depression scale (HAMD) were compared between the two groups. Results After the intervention, the SAS and HAMD scores of the two groups were lower than those before the intervention, and those of the study group were lower than the control group (P ＜ 0.05). The incidence of perinatal complications in the study group was significantly lower than that in the control group (P ＜ 0.05). There was no significant difference in the total incidence of adverse pregnancy outcomes between the two groups (P ＞ 0.05). Conclusion Magnetic nursing concept can reduce the risk of perinatal complications of cesarean section with placenta previa and improve the psychological negative emotion of pregnant women.
		2022 Vol. 19 (32): 180-183 [Abstract] ( 16 ) HTML (1 KB) PDF (564 KB) ( 16 )

	184	A case of allergic cheilitis caused by tetrodotoxin poisoning treated by Professor Lü Wenliang from the perspective of “internal retention of wind-toxicity”
		YAO Ziang1 QIANG Rui2 ZHANG Lili2 LYU Wenliang2
		DOI: 10.20047/j.issn1673-7210.2022.32.43
		Puffer fish poisoning is a relatively rare type of food poisoning. At present, there is no specific antidote for puffer fish poisoning. It is necessary to induce vomiting, gastric lavage, and diuresis as soon as possible to promote the discharge of toxins and symptomatic treatment. This case reports a rare case of recurrent allergic cheilitis due to puffer fish poisoning in a patient without a previous history of food allergy. Professor Lü Wenliang clinically combined with his medical history and pathogenesis, and proposed that the traditional Chinese medicine syndrome differentiation characteristics of tetrodotoxin should be “wind-toxin mainly, and with fire carries dampness”, with “the residual toxin is not clear, the wind toxin is embedded” as the pathogenesis, with “softening liver and dispelling pathogenic wind” as the core treatment method, taking into account “clearing heat and removing toxicity, invigorating spleen for eliminating dampness”, and using traditional Chinese medicine to treat allergic cheilitis secondary to tetrodotoxin poisoning. This case is relatively rare and has remarkable curative effect. It is hereby reported for the benefit of colleagues, aiming to supplement and enlighten the traditional Chinese medicine treatment of allergic cheilitis secondary to puffer fish poisoning.
		2022 Vol. 19 (32): 184-188 [Abstract] ( 18 ) HTML (1 KB) PDF (851 KB) ( 35 )

	189	Treatment of thymus malignant melanoma with PD-1 inhibitors：a case report and review of the literature
		SONG Yipeng1 SUN Sanyuan1 HAN Liang1 LIU Wei1 HUANG Liu2
		DOI: 10.20047/j.issn1673-7210.2022.32.44
		Thymic malignant melanoma is a rare ectopic thymic tumor with high invasivity. For patients with advanced thymic tumor that cannot be surgically resected, radiotherapy and chemotherapy are the traditional treatment methods, but the effect is poor. Recently, immune checkpoint inhibitors have shown good anti-tumor effects. According to previous reports, the use of immune checkpoint inhibitors in the treatment of thymic tumors and thymic carcinoma causes a high proportion of serious immune-related adverse reactions. There has been no report of immune checkpoint inhibitors in the treatment of thymic malignant melanoma. This case on October 4, 2021 in the Xuzhou Central Hospital, Jiangsu Province, by biopsy and gene detects the definite diagnosis of primary melanoma of the thymus gland malignant, after six cycles of Tririplizumab treatment, chest tightness and wheezing symptoms were relieved, and the tumor was reduced, the treatment effect was evaluated as partial remission, and the patient is still under treatment and follow-up. This article through to the patient’s diagnosis, treatment and follow-up process, review and summarize the related literatures, the thymus gland malignant melanoma is relatively rare, need to identify with other thymic tumor pathologically, using immune checkpoint inhibitors in thymus treatment in patients with malignant melanoma may show a good effect, immune related adverse reaction probability than other thymic tumor is low, it can provide treatment ideas for similar cases in the future.
		2022 Vol. 19 (32): 189-192 [Abstract] ( 20 ) HTML (1 KB) PDF (1210 KB) ( 43 )

	193	Risk prevention and control analysis of human genetic resources management and countermeasures in clinical trials
		LI Qin* ZHOU Yan* LIU Lin ZAHNG Qian LI Na HE Yan
		DOI: 10.20047/j.issn1673-7210.2022.32.45
		Human genetic resources are the key resources to carry out life science research. It is very important to standardize the management of human genetic resources in clinical research. Based on the self-examination of human genetic resources management and the accumulation of daily work experience, the Affiliated Hospital of Guizhou Medical University found the following risk points of human genetic resources management in clinical studies: lack of awareness of sponsors/researchers in reporting and unclear types of reporting; the estimate of the number of biological samples required for the test is unreasonable, the collection purpose is not specific, and the supervision of the use is not comprehensive; the rationality of clinical research intellectual property ownership is not in-depth, and the fairness of the distribution of experimental results needs to be enhanced. Based on the above risks point analysis, strengthen the education of the human genetic resources, enhance the consciousness of the declaration, improve the level of scrutiny, clear responsibilities, strengthen the daily supervision, from the four stage of clinical research project initation, start, development and completion, establish and improve the human genetic resources to further improve human genetic resources management system.
		2022 Vol. 19 (32): 193-196 [Abstract] ( 17 ) HTML (1 KB) PDF (591 KB) ( 111 )

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