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| Research progress of immune regulation mediated by PD-1/PD-L1 immune whistle in rheumatoid arthritis |
| LIU Lu XU Yuansheng HUANG Weiqian CHEN Jianmin LIU Guoyin▲ |
| Department of Orthopaedics, Qinhuai District Medical Area of Eastern Theater Command of Chinese People’s Liberation Army, Jiangsu Province, Nanjing 210002, China |
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Abstract programmed death receptor-1 (PD-1) / programmed death ligand-1(PD-L1) immune whistle is a negative immunomodulatory signal, which is activated or suppressed according to the immune status. Targeted drugs based on PD-1 and PD-L1 have been used in tumor immunotherapy at home and abroad and achieved remarkable effects. However, the relevant therapeutic effects of this target in rheumatoid arthritis (RA) are still divergent. Based on the latest research progress, the pathogenesis of RA induced by immune regulation mediated by PD-1/PD-L1 immune whistle is summarized as follows: With the progression of RA and the repeated changes between active and quiescent phases, persistent and/or high expression of PD-1/PD-L1→impaired or depleted immune cell function→disorder of immune tolerance and immune balance→enhanced immune response→promoted or aggravated the progression of RA. This article reviews the role of immune regulation mediated by PD-1/PD-L1 immune whistle in RA.
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