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2022 Vol. 19, No. 25 Published: 2022-09-05

	5	Visual analysis of coronary heart disease complicated with erectile dysfunction using CiteSpace and VOSviewer software
		WANG Jisheng1 WANG Xian2 LI Haisong1 FENG Junlong1 DENG Sheng1 WANG Lu1 LI Haiyan2 LI Yiming2
		DOI: 10.20047/j.issn1673-7210.2022.25.01
		Objective To explore the research status, hot spots, and trends in the field of coronary heart disease and erectile dysfunction in the past 20 years, and to use CiteSpace and VOSviewer software for visual analysis. Methods Taking Web of Science Core Aggregate Database as the data source, the visual analysis software CiteSpace and VOSviewer were used to visually analyze the related researches on coronary heart disease and erectile dysfunction from January 2004 to October 2021, and the authors, countries/institutions distribution of related researches, and keywords were analyzed. Results A total of 549 papers were included, the number of documents issued showed a fluctuating upward trend before 2012, and a downward trend after 2012. There were obvious differences in by each country, and 12 of the top 15 countries by the number of issued documents were from Europe, America, and developed countries. Several stable cooperative teams had been formed among authors/institutions, but the cooperation between the teams was not close. Keyword analysis found multi-dimensional and multi-level research types involving drug treatment, clinical trials, meta-analyses, and outcome indicators. Conclusion In the past 20 years, the research content on coronary heart disease and erectile dysfunction is relatively rich. The current research hotspot trend is to summarize clinical experience and literature research, and the underlying mechanism needs to be further explored.
		2022 Vol. 19 (25): 5-9 [Abstract] ( 19 ) HTML (1 KB) PDF (2120 KB) ( 58 )

	10	Effect of Shengxian Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy
		JIANG Cuihong1 LYU Yutong1 ZHAO Zhizheng2
		DOI: 10.20047/j.issn1673-7210.2022.25.02
		Objective To investigate the effect of Shengxin Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy. Methods A total of 102 patients with oncogenic fatigue admitted to the Southern District of Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences from May 2018 to February 2022 were selected, according to the random number table method, they were divided into control group and combined group, with 51 cases in each group. The control group was given albumin Paclitaxel + Platinum, on this basis, the combined group was treated with Shengxian Decoction. The degree of cancer-related fatigue were compared between the two groups, the pulmonary function, quality of life and immune function of the two groups were compared before and after treatment, and the side effects of the two groups were observed, and the treatment compliance of the two groups was compared. Results After treatment, the improvement of cancer-related fatigue in the combined group was better than that in the control group (P ＜ 0.05). After treatment, forced expiratory volume in one second, forced vital capacity ratio and maximum peak expiratory flow rate in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P ＜ 0.05); the scores of quality of life in the two group were higher than those before treatment, and the combined group was higher than that in the control group (P ＜ 0.05). CD3+, CD4+, and CD4+/CD8+ in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P ＜ 0.05). The treatment compliance of the combined group was better than that of the control group (P ＜ 0.05). The incidence of side effects in combination group was lower than that in control group (P ＜ 0.05). Conclusion Shengxian Decoction can improve the quality of life of patients with oncogenic fatigue in lung cancer chemotherapy, improve the immune function and degree of cancer-related fatigue, and with less toxic side effects, high compliance, which is worthy of further clinical promotion.
		2022 Vol. 19 (25): 10-14 [Abstract] ( 36 ) HTML (1 KB) PDF (667 KB) ( 105 )

	15	Effect of Baicalin on chronic pulmonary infection of multidrug resistant Pseudomonas aeruginosa in rats
		LI Lei1* WANG Jing2* CUI Lanfeng3* LYU Siyuan1 GUO Yufei1 QIN Xinxin1 WANG Chengxiang1
		DOI: 10.20047/j.issn1673-7210.2022.25.03
		Objective To study the effect of Baicalin on chronic pulmonary infection of multidrug resistant Pseudomonas aeruginosa (MDRPA) in rats. Methods Thirty-two SPF male SD rats (6-8 weeks old, weight 180-220 g) were randomly divided into blank group, model group, western medicine group, and Baicalin group, with eight rats in each group. Among them, the model group, western medicine group, and the Baicalin group were injected with MDRPA alginate coated body through ortracheal intubation to establish the rat model of MDRPA chronic pulmonary infection. The Baicalin group was given 0.8 g/(kg·d) Baicalin by gavage, and the western medicine group was given 0.8 g/(kg·d) Piperacillin Tazobactam Sodium intramuscular injection. The blank group and the model group were given the same amount of normal saline as the Baicalin group by gavage. After 14 days of intervention, serum and lung tissues of the four groups were collected, and the lung tissues were observed by hematoxylin-eosin staining. The levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in serum were detected by enzyme-linked immunosorbent assay. The mRNA expressions of Toll-like receptor 4 (TLR4) and nuclear factor κB (p65 subunit) (NF-κB p65) in lung tissue were detected by quantitative polymerase chain reaction. Results The lung tissue of blank group was normal. In the model group, a large number of inflammatory cells were infiltrated and the alveolar wall was significantly thickened. In Baicalin group, there were fewer inflammatory cells and thinner alveolar wall in lung tissues. The levels of serum TNF-α and the levels of TLR4 and NF-κB p65 mRNA in lung tissues in the model group were higher than those in the blank group, and the level of serum IL-10 was lower than that in the blank group (P ＜ 0.05). The levels of serum TNF-α and the levels of TLR4 and NF-κB p65 mRNA in lung tissues in Baicalin group were lower than those in model group, and the level of serum IL-10 was higher than that in model group (P ＜ 0.05). Conclusion Baicalin can reduce the inflammatory injury of lung tissues in rats with MDRPA chronic lung infection, and the mechanism may be related to the inhibition of TLR4/NF-κB pathway activation.
		2022 Vol. 19 (25): 15-18 [Abstract] ( 18 ) HTML (1 KB) PDF (1174 KB) ( 23 )

	19	Comparison of three rat models of coronary microvascular dysfunction induced by sodium laurate
		ZHU Jinxian FAN Yawen GONG Shenglan ZHUANG Yuanfei LIU Chungui TANG Xinzheng
		DOI: 10.20047/j.issn1673-7210.2022.25.04
		Objective To evaluate the optimal scheme of three coronary microcirculation dysfunction models in SD rats induced by sodium laurate. Methods A total of 50 male SD rats aged 6-8 weeks were divided into blank group, sham operation group, and model group 1-3 by random number table method, with ten rats in each group. The blank group did not receive any intervention; in model group 1, the heart was extruded after intercostal expansion and sodium laurate (1 mg/kg) was injected into the apex of the heart once; in model group 2, the heart was extruded after intercostal expansion and sodium laurate (1 mg/kg) was injected into the apex of the heart twice; in model group 3, the heart was extruded after intercostal expansion, the aortic root was clipped and the apex of the heart was injected with sodium laurate (1 mg/kg) once; the sham operation group performed the same operation as model group 2, but the same amount of normal saline was injected. Echocardiogram was used to evaluate cardiac function after 72 h of continuous feeding. The pathological changes of myocardial tissue were observed by HE staining, Heidenhain staining, and Carstairs staining. Results The mortality rate of operational rats was 17.5% (7/40). There was no significant difference in left ventricular ejection fraction (LVEF) between sham operation group and blank group (P > 0.05). Compared with the sham operation group, the LVEF of the model group 1-3 was decreased (P < 0.05); compared with model group 2, LVEF in model group 1 and 3 was increased (P < 0.05). HE staining showed that myocardial cell lysis, rupture, and inflammatory cell infiltration, coronary microvascular thrombosis in different degrees were observed in model group 1-3. Heidenhain staining showed that different degrees of dot, sheet, and mass black staining could be seen in the myocardial fibers of model group 1-3. Carstairs staining showed that purple thrombus which consists of overlapping platelets and fibrin could be seen in the coronary microvascular of model group 1-3. Conclusion Three modeling methods can establish the model of coronary microvascular dysfunction, and the model established by squeezed out the heart after expanding the intercostal space and injecting sodium laurate (1 mg/kg) into the apex twice is more stable and reliable.
		2022 Vol. 19 (25): 19-23 [Abstract] ( 12 ) HTML (1 KB) PDF (1652 KB) ( 54 )

	24	Discussion on the effect of Yiqi Shengji Mixture combined with Triethanolamine Cream on skin lesions and serum inflammatory factors in pressure ulcer rat model based on p38 MARK signaling pathway
		TANG Yuli1 LIU Xin1 LIAO Ruoyi2
		DOI: 10.20047/j.issn1673-7210.2022.25.05
		Objective To investigate the effect and mechanism of Yiqi Shengji Mixture combined with Triethanolamine Cream on skin lesions and serum inflammatory factors in a rat model of pressure ulcer. Methods Fifty SPF SD rats (half male and half male, 6-7 weeks old, 180-200 g) were divided into sham operation group, model group, Triethanolamine Cream group, Yiqi Shengji group, and combined medication group by random number table method, with 10 rats in each group. The model group, Triethanolamine Cream group, Yiqi Shengji group, combined medication group were simulated by ischemia-reperfusion method. in the sham operation group, the magnet was only embedded in the same site without pressure. Sham operation group and model group were given normal saline 0.4 ml by gavage; Triethanolamine Cream group was given Triethanolamine Cream for external use; Yiqi Shengji group was given 12.98 g/(kg·d) Yiqi Shengji Mixture by gavage; combined medication group received Triethanolamine Cream for external use and Yiqi Shengji Mixture by gavage, all groups were given for eight days. Wound conditions, serum inflammatory factor levels, and wound P38 MARK signaling pathway related protein expression were recorded in each group. Results The skin lesion area of Triethanolamine Cream group, Yiqi Shengji group, and combined medication group on the 8th day of modeling was lower than that of model group, and the skin lesion area of combined medication group on the 8th day of modeling was lower than that of Triethanolamine Cream group and Yiqi Shengji group(P ＜ 0.05). The serum levels of interleukin (IL)-2, IL-12, and C-reactive protein (CRP) in the model group were higher than those in the sham operation group (P ＜ 0.05). The serum inflammatory factor levels of IL-2, IL-12, and CRP in Triethanolamine Cream group, Yiqi Shengji group and combined medication were lower than those in model group, and the serum inflammatory factor levels of IL-2, IL-12, and CRP in combined medication group were lower than those in Triethanolamine Cream group and Yiqi Shengji group (P ＜ 0.05). The protein expressions of p38mitogen-activatedproteinkinase (p38 MARK), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMP-9) in the skin lesions of the sham operation group were lower than those of the model group (P ＜ 0.05). The protein expression levels of p38 MARK, VEGF, and MMP-9 in skin lesions in Triethanolamine Cream group, Yiqi Shengji group and combination drug group were lower than those in model group, and the protein expression levels of p38 MARK, VEGF, and MMP-9 in skin lesions in combination drug group were lower than those in Triethanolamine Cream group and Yiqi Shengji group (P ＜ 0.05). Conclusion The combination of Yiqi Shengji Mixture and Triethanolamine Cream can effectively repair the skin lesions of the pressure ulcer rat model and reduce the level of serum inflammatory factors.
		2022 Vol. 19 (25): 24-27,37 [Abstract] ( 16 ) HTML (1 KB) PDF (1211 KB) ( 111 )

	28	Visual analysis of knowledge map of traditional Chinese medicine on thyroid research in domestic and foreign literature in recent 20 years
		LI Xinyi1 SHANG Jianwei1 CHEN Xiaoheng1 LI Zhe1 DING Zhiguo2 QI Shuo2
		DOI: 10.20047/j.issn1673-7210.2022.25.06
		Objective To make a visual analysis of the knowledge map of traditional Chinese medicine ont thyroid research in domestic and foreign literature in recent 20 years. Methods The Web of Science core collection database and China National Knowledge Infrastructure were used as data sources for the search, and the search time limit was from October 2002 to October 2021. The obtained data were imported into CiteSpace software to remove the weight, and the author, institution and keywords were compared and analyzed. Results A total of 4 279 literatures were included, including 4 217 in Chinese and 62 in English. There were four teams of Chinese literatures research authors. The cooperation form of institutions was mainly the university of traditional Chinese medicine and its secondary units. Meanwhile, there were cross regional and cross unit cooperation forms. Most of the research hotspots were clinical research on clinical efficacy, etiology, and pathogenesis, syndrome differentiation, and traditional Chinese medicine constitution. However, foreign literatures had not yet formed a relatively stable cooperation team which the main research institutions were in China, and the research focus on basic research. Conclusion In recent 20 years, there have been more research results on thyroid in domestic literature than in foreign literature, the formation of research teams and institutions is stable, and the research hot spots are different. It is suggested that domestic and foreign scholars strengthen cooperation and learn from each other to make joint efforts for research and exploration in this field.
		2022 Vol. 19 (25): 28-32 [Abstract] ( 16 ) HTML (1 KB) PDF (1870 KB) ( 33 )

	33	Research progress on the therapeutical effect of exosomes in ischemia reperfusion injury in important organs
		ZENG Kejun1 YANG Yuhui1 HU Zhe2▲
		DOI: 10.20047/j.issn1673-7210.2022.25.07
		Ischemia reperfusion injury (IRI) is a multi-step chain process from potential risk factors to obvious clinical diseases. Vascular cells, blood cells, cardiomyocytes, and stem cells all participate in pathophysiology through continuous and multiple crosstalk. As a powerful carrier of cell-cell communication, exosomes has always been the focus of basic and clinical research. A large amount of evidence shows that exosomes are involved in the evolution of IRI to a large extent, but their actual therapeutical effect is still controversial. The clinical role of exosomes in cell-cell communication at different stages of disease is still poorly understood. This article reviews the latest research on the application of exosomes in IRI of important organs, and focus on the clinical application prospect of their targeted modification.
		2022 Vol. 19 (25): 33-37 [Abstract] ( 17 ) HTML (1 KB) PDF (657 KB) ( 216 )

	38	Research progress on the mechanism of macrophages in metabolic associated fatty liver disease
		TAN Liting1 ZENG Shenglan1 CHEN Weiyu1 CAO Yanggang1 HU Jin1 LONG Xiaorong1 TAO Ran1 MAO Dewen2
		DOI: 10.20047/j.issn1673-7210.2022.25.08
		The global prevalence of metabolic associated fatty liver disease (MAFLD) is on the rise, and MAFLD has now become a global health problem. Macrophages have the ability to scavenge pathogenic microorganisms, antigen presentation, and promote or inhibit the hepatic inflammatory response and are directly involved in the development of liver diseases and injury repair. The mechanism of macrophage in MAFLD and its clinical significance have gradually become a current medical research hotspot. Recent studies have shown that macrophages may become new therapeutic tools and therapeutic targets for MAFLD. In this paper, the classification and function of macrophages and their role in different stages of MAFLD pathogenesis are discussed and summarized in order to provide relevant ideas and new perspectives for clinical prevention and treatment of MAFLD.
		2022 Vol. 19 (25): 38-42 [Abstract] ( 13 ) HTML (1 KB) PDF (542 KB) ( 60 )

	43	Research status on the slicing while fresh in the origin of Salvia miltiorrh iz a
		LU Mingyue1 LIU Qian1 ZHANG Yongqing1 ZHANG Li2 YANG Hanbing2
		DOI: 10.20047/j.issn1673-7210.2022.25.09
		Salvia miltiorrhiza belongs to a large and commonly used Chinese medicinal materials, both clinical formula and production and feeding need to be sliced first. Traditional slicing is to moisten the dried medicinal materials with water and then slice them, and the process is complicated, time-consuming, and easy to lose active ingredients. If it can be slice while fresh in the origin, it will effectively solve the above problems, which is conducive to ensure the quality of decoction pieces and improve the efficiency. This paper summarizes the research status of slice while fresh in the origin in Salvia miltiorrhiza, and the main contents include the comparison of slice while fresh with traditional slices, the selection of soil removal method, non-medicinal parts removal, the water control of medicinal materials before slicing, the classification of medicinal materials, drying method selection, and drying temperature control. The research results show that it is feasible to slice while fresh of Salvia miltiorrhiza, but it need careful study and strengthen management.
		2022 Vol. 19 (25): 43-46,67 [Abstract] ( 12 ) HTML (1 KB) PDF (673 KB) ( 136 )

	47	Research progress of Guanxin Shutong Capsules in prevention and treatment of cardiovascular disease
		FANG Huanle1 ZHOU Yaming1 CHEN Yanbin2
		DOI: 10.20047/j.issn1673-7210.2022.25.10
		Guanxin Shutong Capsules are a modern traditional Chinese medicine preparation mainly composed of jujube, salvia, clove, borneol, and Tianzhuhuang. Modern research has found that it can produce pharmacological effects such as resisting cardiomyocyte apoptosis, increasing myocardial energy metabolism, regulating blood lipids, reducing inflammation levels, and anti-oxidative stress. In clinical practice, it is usually combined with routine administration to treat cardiovascular disease, which can significantly improve clinical efficacy, reduce adverse reactions, and improve complications. This paper summarizes the pharmacological mechanism of Guanxin Shutong Capsules and its clinical application, and provides a theoretical reference for the drug to reveal its scientific connotation and expand its clinical application.
		2022 Vol. 19 (25): 47-50 [Abstract] ( 14 ) HTML (1 KB) PDF (613 KB) ( 37 )

	51	Progress in the mechanism of massage treatment of lumbar intervertebral disc prolapse
		ZHANG Yupu JI Dengjun ZHANG Yan ZHANG Yu MA Ji GU Fei
		DOI: 10.20047/j.issn1673-7210.2022.25.11
		The mechanism of massage treatment in lumbar disc herniation can be explained from three aspects. First of all, massage has a direct improving effect on the lumbar bony structure and its dynamic relationship by adjusting the tension of muscles and soft tissues, restoring spino-balance of three dimension, reducing nerve stimulation symptoms. Secondly, in fascia theory, massage can improve autonomic nerve over reaction by relieving abnormal electrophysiology nervous impulse and increasing the microcirculation perfusion. Finally, massage can promote the spontaneous absorption of lumbar disc herniation and regulate inflammation and immune factors.
		2022 Vol. 19 (25): 51-54 [Abstract] ( 18 ) HTML (1 KB) PDF (599 KB) ( 103 )

	55	Research progress on antibiotic resistance of pathogenic Escherichia coli
		REN Chenyin1 FU Yixiu2▲
		DOI: 10.20047/j.issn1673-7210.2022.25.12
		Pathogenic Escherichia coli can infect important tissues and organs through various infection routes in clinical practice. The irregular use of antibiotics leads to the accumulation and spread of bacterial resistance. Recent studies have shown that antibiotic resistance of pathogenic Escherichia coli is becoming increasingly severe. This article discusses the current status of drug resistance of common pathogenic Escherichia coli in clinical practice, and summarizes the drug resistance mechanisms of pathogenic Escherichia coli from the aspects of mobile genetic elements, target mutation and modification, and inactivated enzymes, explore the genetic engineering or molecular biology, Chinese medicine and some other novel non-antibiotic therapy methods, in order to provide reference information for alleviating the drug resistance of pathogenic Escherichia coli.
		2022 Vol. 19 (25): 55-58 [Abstract] ( 18 ) HTML (1 KB) PDF (524 KB) ( 150 )

	59	Exploration of “Med-lab escape” in the cultivation of practical ability of basic medical research
		XIONG Yanlu1 CHEN Huiyu2▲
		DOI: 10.20047/j.issn1673-7210.2022.25.13
		The cultivation of basic research practical ability in medical teaching is of great significance, and the teaching method is the key to the effective cultivation. Serious game is a new type of teaching method, widely used and effective. Based on the practice of basic medical research, this paper designed a serious game——“Med-lab escape” based on the common laboratory pattern. Through the story line, the learners make a breakthrough “escape”, and complete the cultivation of the practical ability of five kinds of classical basic medical research under the feedback of rewards and punishments. “Med-lab escape” has a good effect in the internal preliminary test, but there are still some shortcomings. It needs to be further optimized in the aspects of scheme design, hardware equipment, operation details, evaluation, and management.
		2022 Vol. 19 (25): 59-62 [Abstract] ( 14 ) HTML (1 KB) PDF (809 KB) ( 61 )

	63	Application of case-based learning based on virtual learning platform in basic nursing course
		TAO Jie1 JIANG Xiaojian1 LONG Yanjun2
		DOI: 10.20047/j.issn1673-7210.2022.25.14
		Objective To explore the application effect of case-based learning (CBL) based on virtual learning platform in the teaching of basic nursing. Methods The cluster sampling method was used to randomly select two classes of students from four classes of higher vocational nursing major of grade 2020 in Yongzhou Vocational Technology College as the experimental group (62 students), and the other two classes as the control group (61 students). The experimental group was taught with CBL based on virtual learning platform, while the control group was taught with traditional teaching method. The teaching time of both groups was 12 class hours. After teaching, the assessment scores, autonomous learning ability, and learning effect evaluation were compared between the two groups. Results The scores of multiple choice questions, case analysis questions, theoretical scores, operation scores, and the total score of examination in the experimental group were higher than those in the control group (P ＜ 0.05). The scores of learning motivation, self-management, learning cooperation, information literacy, and self-learning ability of the experimental group were higher than those of the control group (P ＜ 0.05). The self-evaluation scores of interpersonal communication ability, humanistic care ability, clinical thinking ability, teamwork ability, and nursing comprehensive ability of the experimental group were higher than those of the control group (P ＜ 0.05). Conclusion The application of CBL based on virtual learning platform in the teaching of basic nursing courses is helpful to promote the innovation of CBL teaching model, improve the assessment scores of students, cultivate students’ autonomous learning ability, improve the learning effect, and help cultivate students’ comprehensive ability.
		2022 Vol. 19 (25): 63-67 [Abstract] ( 16 ) HTML (1 KB) PDF (986 KB) ( 52 )

	68	Construction and practice of pharmaceutics curriculum system under the background of new medicine
		LIU Daozhou HUAN Menglei WANG Wei CHENG Ying YE Weiliang LIU Miao ZHANG Bangle ZHOU Siyuan
		DOI: 10.20047/j.issn1673-7210.2022.25.15
		Pharmaceutics is a comprehensive and applied technology science, and it is also the core and main courses of pharmacy major, which plays an important role in the cultivation of pharmaceutical talents. The course structure of traditional curriculum system of pharmaceutics is unreasonable, and teaching resources are lacking. The cultivation of students’ innovation ability and practical ability is insufficient. In order to adapt to new medical requirements of pharmaceutical education, starting from the optimization of the curriculum system, the teaching and research section has constructed a a new system of pharmacy courses, which based on the pharmacy curriculum, the cross-integration of the biopharmaceutical and pharmacokinetics curriculum, the innovative practice of the pharmacy and pharmacokinetics experimental curriculum, and the expansion and improvement of the new progress of pharmacy research curriculum, it aims to comprehensively improve the quality of pharmaceutical talents training and make contributions to the training of innovative, compound and applied pharmaceutical talents.
		2022 Vol. 19 (25): 68-71,80 [Abstract] ( 12 ) HTML (1 KB) PDF (733 KB) ( 196 )

	72	Application of intelligent simulation technology combined with case-based learning in difficult airway teaching for anesthesiologists
		WANG Huijun1 XIONG Jun2 BAO Yin1 WANG Guyan1▲
		DOI: 10.20047/j.issn1673-7210.2022.25.16
		Objective To explore and evaluate the application value of combined application of intelligent difficult airway management simulator assessment system and case-based learning (CBL) in the teaching for anesthesiologists to deal with difficult airway. Methods Forty anesthesiologists trained in the Department of Anesthesiology, Beijing Tongren Hospital from September 2021 to February 2022 were divided into control group and observation group, by block randomization grouping method, with 20 anesthesiologists in each group. The control group trained by the traditional teaching methods of skill operation theory training and clinical practice training, the observation group was taught by CBL with intelligent difficult airway management simulator assessment system for teaching and training. The training content included the treatment of four different difficult airway modes: normal airway, closed teeth, stiff neck and mandibular deformity, and the application of airway tools. Evaluate The effect of teaching and training was evaluated by relevant theoy, clinical operation assessment and satisfaction questionnaire. Results There were no significant differences between the two groups in the theoretical examination results, the operation results of normal airway, and the examination results of using airway tools (P ＞ 0.05); the scores of the observation group in the three difficult airway modes of closed teeth, stiff neck, and mandibular deformity was higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The satisfaction of the observation group was higher than that of the control group in enhancing the awareness of airway management, deepening the understanding of treatment principles, improving clinical operation self-confidence, improving clinical treatment ability, and enhancing learning interest, and the differences were statistically significant(P ＜ 0.05). Conclusion Combination of intelligent simulation technology and CBL is effective to improve the interest and enthusiasm of anesthesiologists in difficult airway training, and further improve their ability to deal with difficult airway.
		2022 Vol. 19 (25): 72-75 [Abstract] ( 11 ) HTML (1 KB) PDF (576 KB) ( 28 )

	76	Evaluation of the effect of applying case-based learning combined with problem-based learning method in the practice teaching of thoracic surgery
		LUO Dongbo Adili·Salai LYU Hongbo WANG Yang GAO Yunfei CHU Jianhu
		DOI: 10.20047/j.issn1673-7210.2022.25.17
		Objective To explore and analyze the effect of applying case-based learning (CBL) combined with problem-based learning (PBL) in the practice teaching of thoracic surgery. Methods From April 2018 to April 2021, 230 medical students who received thoracic surgery practice teaching in the Second Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University were selected as the research objects, and they were divided into control group and observation group by random number table method, with 115 students in each group. The control group was given the conventional teaching method, and the observation group was given CBL combined with PBL teaching on the basis of the control group, both groups were taught for four consecutive months. The examination results, self-learning performance, teaching effect, and knowledge application of the two groups were compared under different teaching methods. Results The scores of theoretical course examination and practice examination in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of careful searching for data, active speaking, clear personal views, good cooperation with students and teachers, and good overall personal performance in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The satisfaction of stimulating learning enthusiasm and initiative, enlightening to students’ thinking, association and innovation,improve students’ ability to comprehensively analyze problems, improve clinical thinking skills, improve learning interest and increase knowledge, improve the effect and enhance efficiency of learning, and the accuracy of mastering basic concepts and theories in the observation group was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of knowledge application in the observation group was higher than that in the control group in deepening impression, understanding knowledge, helping memory, knowledge application, knowledge extension, independent thinking, and thinking expansion, and the differences were statistically significant (P ＜ 0.05). Conclusion The implementation of CBL combined with PBL education in the actual teaching of thoracic surgery can achieve better results, with better assessment results, better self-learning performance of medical students, obvious advantages in teaching effect, and good use of knowledge.
		2022 Vol. 19 (25): 76-80 [Abstract] ( 17 ) HTML (1 KB) PDF (700 KB) ( 32 )

	81	Application effect of the mixed teaching mode of small private online course + flipped classroom in the teaching of ultrasonic diagnostics in colleges and universities of traditional Chinese medicine
		SHI Guangyu ZHANG Xuesong QU Bing CHE Yanling ZHAO Fangyuan
		DOI: 10.20047/j.issn1673-7210.2022.25.18
		Objective To explore the application effect of the mixed teaching mode of “small private online course + flipped classroom” in the teaching of ultrasonic diagnostics in colleges and universities of traditional Chinese medicine. Methods A total of 50 undergraduate students of 2018 clinical medicine of traditional Chinese and western medicine (Russian Federation) of Heilongjiang University of Chinese Medice were selectded, according to their student number for entering school, they were divided into control group and experimental group, the single number student were the control group (25 students), and the double number student were the experimental group (25 students). The control group carried out traditional teaching, and the experimental group carried out mixed teaching of “small private online course+flipped classroom”. The teaching effects of the two groups were compared by issuing questionnaires and final theoretical examination results. Results The experimental group was higher than the control group in terms of improving the learning efficiency of learning this course, stimulating interest in learning this course, improving clinical problem-solving and problem-analyzing ability, strengthening language expression ability, and improving the ability to memorize knowledge points, and the differences were statistically significant. Significance (P ＜ 0.05). The theoretical scores of head, chest, abdomen, pelvis, blood vessels and total score in the experimental group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The mixed teaching mode of “small private online course+flipped classroom” can improve the boring single teaching mode of ultrasonic diagnostics, stimulate students’ interest in learning and strengthen students’ autonomous learning ability.
		2022 Vol. 19 (25): 81-84 [Abstract] ( 17 ) HTML (1 KB) PDF (572 KB) ( 58 )

	85	Visualization analysis of research hotspots and trends of biomarkers for idiopathic pulmonary fibrosis based on CiteSpace
		XU Lili1 LI Zhihui1 YU Ningxia1 YANG Shuguang2 LIN Qingqing1 YU Xueqing2
		DOI: 10.20047/j.issn1673-7210.2022.25.19
		Objective To summarize the research hotspots and trends of biomarkers in idiopathic pulmonary fibrosis (IPF) based on CiteSpace software. Methods Literatures on IPF biomarkers in CNKI and Web of Science from January 2001 to August 2021 was retrieved, with authors, institutions, and keywords as nodes, and CiteSpace 5.7.R2 software was used for visual analysis. Results A total of 507 literatures were included. The number of published literatures at home and abroad was on the rise. There were few and relatively scattered authors and institutions in this field in China. There were many foreign authors and institutions with close cooperation. The research hotspots at home and abroad included gene polymorphisms, proteins, diagnostic, and prognostic biomarkers. The research trends included diagnostic and prognostic biomarkers. Conclusion Domestic authors or institutions should strengthen academic exchanges and cooperation, further study the hot spots and trends in this field, and provide reference for the clinical diagnosis and treatment of IPF.
		2022 Vol. 19 (25): 85-89 [Abstract] ( 25 ) HTML (1 KB) PDF (3111 KB) ( 41 )

	90	Meta-analysis of IL-6-572 gene polymorphism and susceptibility to hepatitis B virus infection in East Asian population
		ZHANG Yalong1* XU Honghai2* CHENG Jun1 GAO Yufeng1
		DOI: 10.20047/j.issn1673-7210.2022.25.20
		Objective To systematically evaluate the association between IL-6-572C/G gene polymorphism and susceptibility to hepatitis B virus (HBV) infection in East Asian population. Methods PubMed, Web of Science, CNKI, Wanfang Data, and VIP were searched for case-control studies on the relationship between IL-6-572C/G (rs1800796C＞G) gene polymorphism and HBV infection in East Asian population. The retrieval time was from the inception to October 2021, and Stata S12.0 software was used for meta-analysis. Results Finally, ten literatures were included, including 3 532 hepatitis B virus infected patients and 4 020 controls. The results of meta-analysis showed that carrying G allele and GG+GC, GG, GC genotypes were protective factors for HBV infection in East Asian population (G vs C[OR = 0.80, 95%CI: 0.74-0.87, P ＜ 0.001]；GG+GC vs CC[OR = 0.77, 95%CI: 0.70-0.85, P ＜ 0.001]；GG vs CG+CC[OR = 0.72, 95%CI: 0.59-0.87, P = 0.001]；GC vs CC[OR = 0.79, 95%CI: 0.72-0.87, P ＜ 0.001]；GG vs CC[OR = 0.66, 95%CI: 0.54-0.80, P ＜ 0.001]). Conclusion The altered IL-6-572 gene polymorphism (C＞G) may reduce the risk of HBV infection in East Asian population.
		2022 Vol. 19 (25): 90-93,102 [Abstract] ( 17 ) HTML (1 KB) PDF (2964 KB) ( 25 )

	94	Effect of BCG polysaccha-ride nucleic acid combined with photodynamic therapy and its influence on immune function of patients with condyloma acuminatum of femal external genitalia
		LIU Wenhong DA Surong MA Lifei▲
		DOI: 10.20047/j.issn1673-7210.2022.25.21
		Objective To investigate the effect of BCG polysaccha-ride nucleic acid combined with photodynamic therapy and its influence on immune function of patients with condyloma acuminatum of female external genitalia. Methods A total of 84 patients with condyloma acuminatum of organ external genitalia treated in the Fourth People’s Hospital of Huaian City, Jiangsu Province from January to December 2020 were selected as the research objects and divided into the control group (42 cases) and the study group (42 cases) according to the parity method. The control group was treated with photodynamic therapy, and the study group was treated with BCG polysaccha-ride nucleic acid on this basis. The treatment time in both groups was six months. The clinical efficacy of the two groups was compared. The levels of serum tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), CD3+, CD4+, and CD8+ T cells were compared between the two groups before and after treatment. The occurrence of adverse reactions in the two groups was recorded. The recurrence rate was compared between the two groups after one year follow-up. Results The efficacy of the study group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum TGF-β1 and CD3+, CD4+ T cells in the two groups were higher than those before treatment, and the study group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the levels of serum TNF-α and CD8+ T cells in the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). After one year of follow-up, one case in the study group and two cases in the control group were lost to follow-up. The overall follow-up rate was 96.43%. The recurrence rate in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion BCG polysaccha-ride nucleic acid combined with photodynamic therapy in the treatment of fpatients with condyloma acuminatum of female external genitalia is effective, which can reduce the body’s inflammatory response, improve immune function, safe and reliable, and the prognosis is good.
		2022 Vol. 19 (25): 94-97 [Abstract] ( 20 ) HTML (1 KB) PDF (611 KB) ( 60 )

	98	Effect of goal-directed fluid therapy on brain protection in elderly patients with old cerebral infarction undergoing beach chair position operation
		LU Xiaoxing1 WANG Kai1 ZHOU Meiyan1 WANG Liuyi2 WANG Liwei1
		DOI: 10.20047/j.issn1673-7210.2022.25.22
		Objective To evaluate the effect of goal-directed fluid therapy (GDFT) on brain protection in elderly patients with old cerebral infarction undergoing beach chair position（BCP） operation. Methods From September 2020 to September 2021, a total of 152 elderly patients with old cerebral infarction who underwent shoulder arthroscopic operation under BCP in Xuzhou Central Hospital of Jiangsu Province were selected. According to the random number table method, they were divided into control group (group C) and GDFT group (group G), with 76 cases in each group. Group C was given routine fluid therapy; group G was given GDFT. Mean arterial pressure (MAP) and regional cerebral oxygen saturation (rScO2) between two groups were compared before anesthesia induction (T0), after tracheal intubation (T1), in BCP immediately (T2), in BCP for 30 min (T3), and back to supine position (T4); the content of serum S100β protein between two groups were compared before operation and one day after operation; operation time, intraoperative fluid volume, urine volume, use of vasoactive drugs, and incidence of postoperative cognitive dysfunction (POCD) were compared between two groups. Results Compared with T0, MAP decreased at T1-T4 in both groups, and the difference was highly statistically significant (P < 0.01); in group C, rScO2 increased at T1 and T4, and decreased at T2, and the differences were highly statistically significant (P < 0.01); rScO2 in group G increased at T1-T4, and the differences were statistically significant (P < 0.05 or P < 0.01); there were significant differences in MAP and rScO2 between two groups at T2-T4, and the differences were statistically significant (P < 0.05 or P < 0.01); rScO2 in group G was higher than that of group C, and the difference was statistically significant (P < 0.05). Compared with pre-operation, the serum S100β protein content of two groups was increased at 1 day after operation, and the difference was highly statistically significant (P < 0.01). One day after operation, the serum S100β protein content in group G was lower than that in group C, and the difference was highly statistically significant (P < 0.01). There was no significant difference in operation time between two groups (P > 0.05). Compared with group C, the amount of crystal fluid, total infusion volume, urine volume, and utilization rate of vasoactive drugs during operation in group G were decreased, while the amount of colloidal fluid was increased, and the differences were highly statistically significant (P < 0.01). The incidence of POCD in group G was lower than that in group C, and the difference was statistically significant (P < 0.05). Conclusion For elderly patients with old cerebral infarction undergoing BCP surgery, GDFT can effectively improve intraoperative cerebral hypoxia and reduce the occurrence of postoperative neurological complications, and play a certain role in brain protection.
		2022 Vol. 19 (25): 98-102 [Abstract] ( 12 ) HTML (1 KB) PDF (664 KB) ( 66 )

	103	Professor Bai Yanping’s experience in the treatment of acne by the Tiao Zhong Zhou Method
		LUO Sha1 BAI Yanping2 YANG Haoyu3 DONG Xiaowan1 WANG Aijuan1 LIU Jiayi1
		Acne is a chronic inflammatory skin disease of the pilosebaceous glands. By sorting out and analyzing the relevant traditional Chinese medicine theories and summarizing the typical medical records, this paper elaborates on Professor Bai Yanping’s theory in differentiation and treatment of acne by the Tiao Zhong Zhou Method. Professor Bai Yanping advocates using the Tiao Zhong Zhou Method in the treatment of acne, should distinguish yin and yang，cold and heat, deficiency and excess, and treatment based on syndrome differentiation. According to different pathogenesis such as exuberance of dampness due to spleen deficiency, dampness-heat stagnating in spleen, intermingled cold and heat, and yangming fu-viscera excess, Professor Bai Yanping respectively use the tiao zhong method of invigorating spleen for eliminating dampness, tiao zhong method of clearing heat and promoting diuresis, tiao zhong method of acrid dispersing and bitter descending, he zhong method of clearing the organs to treat acne. The treatment effect is obvious.
		2022 Vol. 19 (25): 103-105,110 [Abstract] ( 13 ) HTML (1 KB) PDF (608 KB) ( 40 )

	106	Network meta-analysis on constipation in patients with heart failure treated by different traditional Chinese medicine external treatment
		ZHENG Chaonan1 JIA Mengnan1 WANG Jianru2 LI Bin3 ZHU Mingjun2
		Objective To analyze the effect of traditional Chinese medicine external treatment on constipation in patients with heart failure by network meta-analysis. Methods The randomized controlled trials on constipation in patients with heart failure treated by traditional Chinese medicine external treatment from the databases of CNKI, Wangfang, VIP, SinoMed, EMbase, Cochrane Library, PubMed databases, the retrieval time was from inception to October 2021, the data were analyzed by Stata. Results A total of 21 randomized controlled trials were included, covering nine traditional Chinese medicine external treatment methods. In terms of clinical efficacy, abdominal massage (OR = 8.8, 95%CI [3.2, 24.2], P ＜ 0.05), point massage combined with traditional Chinese medicine sticking (OR = 4.0, 95%CI [1.7, 9.2], P ＜ 0.05), abdominal massage combined with foot bath (OR = 4.0, 95%CI [1.6, 9.6], P ＜ 0.05), auricular application pressure (OR = 3.9, 95%CI [1.7, 9.0], P ＜ 0.05}, traditional Chinese medicine sticking (OR = 4.4, 95%CI [2.6, 7.5], P ＜ 0.05), abdominal massage combined with point massage (OR = 21.8, 95%CI [5.6, 85.5], P ＜ 0.05), moxa-wool moxibustion (OR = 0.1, 95%CI [0, 1.0], P ＜ 0.05) were better than conventional treatment; traditional Chinese medicine sticking (OR = 0.2, 95%CI [0.1, 0.9], P < 0.05), auricular application pressure (OR = 0.2, 95%CI [0, 0.9], P < 0.05), abdominal massage combined with foot bath (OR = 0.2, 95%CI [0, 0.9], P < 0.05), point massage combined with traditional Chinese medicine sticking (OR = 0.2, 95%CI [0, 0.9], P < 0.05) and point massage (OR = 0.1, 95%CI [0, 0.3], P < 0.05) were better than abdominal massage combined with point massage. Point massage (OR = 0.2, 95%CI [0.1, 0.6], P < 0.05) was better than abdominal massage. Point massage(OR = 0.3, 95%CI [0.2, 0.8], P < 0.05) was better than traditional Chinese medicine sticking. In terms of traditional Chinese medicine syndrome score, traditional Chinese medicine sticking (OR = 0, 95%CI [0, 0.2], P < 0.05) and auricular application pressure combined with traditional Chinese medicine sticking (OR = 0, 95%CI [0, 0.2], P < 0.05) were better than conventional treatment. Conclusion Traditional Chinese medicine external treatment has different effects on improving the clinical symptoms of constipation and reducing the score of traditional Chinese medicine syndromes, but this conclusion needs further research to verify.
		2022 Vol. 19 (25): 106-110 [Abstract] ( 15 ) HTML (1 KB) PDF (2143 KB) ( 44 )

	111	Discussion on the significance of protecting traditional knowledge of Chinese medicine to solve the pain of “not transmitted” of traditional Chinese medicine
		AN Hong1 LIU Qian2 WANG Liuqing1 QIN Peijie1 SHI Xueqin1 ZHANG Fengxia1 LIU Jianfeng1
		DOI: 10.20047/j.issn1673-7210.2022.25.25
		The inheritance characteristic of traditional Chinese medicine is “secret but not transmitted”, which affects the integrity and innovation of traditional Chinese medicine, and this problem needs to be solved from the system level. this paper analyzes the reasons why traditional Chinese medicine is “secret but not transmitted”, and points out that the protection of traditional knowledge of Chinese medicine is an effective system to solve the “not transmitted” problem of traditional Chinese medicine. The establishment of a collection network is helpful to clarify the background of traditional knowledge of Chinese medicine and prevent the loss of medical techniques. Through the specialized intellectual property right confirmation, the rights of holders of traditional knowledge of Chinese medicine can be protected; through the cooperative mechanism of development and promotion, the conservative inheritance mode of traditional Chinese medicine can be reformed. All measures should be taken to improve the service capacity of traditional Chinese medicine and meet people’s growing health needs.
		2022 Vol. 19 (25): 111-114,123 [Abstract] ( 19 ) HTML (1 KB) PDF (728 KB) ( 33 )

	115	Professor Li Liyun’s treatment of infertility with polycystic ovary syndrome based on the theory of “making up deficiency and reducing superfluity”
		ZHANG Sijun1 GENG Hongling2 TAN Yawen1 DU Shuntang1 XU Min2
		DOI: 10.20047/j.issn1673-7210.2022.25.26
		Professor Li Liyun is a famous traditional Chinese medicine in Guangdong Province, with rich experience in the treatment of infertility with polycystic ovary syndrome. The idea of “making up deficiency and reducing superfluity” originates from the “the law of nature is to make up for the deficiency rather than the excess” of Tao Te Ching. Based on the overall view and the concept of “harmony of man with nature” of traditional Chinese medicine, Professor Li Liyun thinks that the theory of “making up deficiency and reducing superfluity” is also applicable to the traditional Chinese medicine differentiation and treatment of human diseases. There are many pathogenic factors of infertility with polycystic ovary syndrome, and the overall pathogenesis can be summarized as “deficiency” and “excess” acting on the body. “deficiency” mainly lies in kidney and spleen deficiency, while “excess” mainly lies in qi depression, phlegm dampness and static blood. In the treatment, it is necessary to strengthen healthy qi and repaire the deficiency and replenish the deficiency of the spleen and kidney and other viscera, restrain the deficiency caused by the deficiency of the viscera, and remove the superfluity of stagnation of qi, phlegm-dampness and blood stasis to fill the deficiency of the viscera caused by excess evil, and integrate the “making up deficiency and reducing superfluity”, harmonize yin, yang, qi and blood, to provide new ideas for the diagnosis and treatment of infertility with polycystic ovary syndrome.
		2022 Vol. 19 (25): 115-118,128 [Abstract] ( 15 ) HTML (1 KB) PDF (803 KB) ( 35 )

	119	Clinical effect of nape cluster acupuncture in the treatment of swallowing dysfunction after stroke
		YAO Shan1 GUO Pengfei1 XU Dehui2 SUN Jie1
		DOI: 10.20047/j.issn1673-7210.2022.25.27
		Objective To explore the clinical effect of nape cluster acupuncture in the treatment of swallowing dysfunction after stroke. Methods One hundred and twenty-four patients with swallowing dysfunction after stroke treated in Xuzhou Central Hospital from September 2019 to September 2021 were selected, and they were divided into control group and observation group by random number table method, with 62 cases in each group. The control group was treated with routine rehabilitation treatment, and the observation group was treated with nape cluster acupuncture on the basis of the control group. Both groups took four weeks as a course of treatment and continued for three courses of treatment. The clinical efficacy, swallowing function score, brain hemodynamic indexes, brain injury markers level and adverse reactions were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P < 0.05). After treatment, the scores of Kubota water swallowing test, video fluoroscopic swallowing study and eating assessment tool-10 score in the two groups were lower than those before treatment, and the scores in the observation group were lower than those in the control group (P < 0.05). After treatment, maximum peak velocity (MPV) and average velocity (VM) in the two groups were faster than those before treatment, resistance index (RI) in the two groups was lower than before treatment, and MPV and VM in the observation group were faster than those in the control group, RI in the observation group was lower than that in the control group (P < 0.05). After treatment, the levels of serum amyloid A, myelin basic protein and phospholipid transfer protein factor in the two groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Nape cluster acupuncture is effective in the treatment of swallowing dysfunction after stroke. It can improve the swallowing function, cerebral blood flow microcirculation state, reduce the level of brain injury markers, and has good safety.
		2022 Vol. 19 (25): 119-123 [Abstract] ( 15 ) HTML (1 KB) PDF (726 KB) ( 29 )

	124	Application effect of yijinjing exercise in patients with lumbar disc herniation during remission period
		LI Yang WANG Wenyi SI Mengran JI Qing CAI Junhao WANG Guimao
		Objective To evaluate application effect of yijinjing exercise in patients with lumbar disc herniation during remission period. Methods Seventy-two patients with lumbar disc herniation treated in Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine from May to December 2019 were selected and they were divided into control group and treatment group according to the random number table method, with 36 cases in each group. The control group was treated with massage manipulation, each time for 30 minutes, three times a week, for four weeks, a total of 12 times. On the basis of the control group, the treatment group was treated with yijinjing exercise, five times a week, each time for about 15 minutes, for four weeks. The scores of visual analogue scale (VAS) score, pain rating index (PRI), SF-36 scale and Oswestry dysfunction index (ODI) scale score were compared between the two groups before and after treatment. Results After treatment, the VAS and PRI scores of the two groups were lower than those before treatment, and the scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the scores of physical function, physiological function, physical pain, overall health, energy, social function, emotional function and mental health in the two groups were higher than those before treatment, and the scores in the treatment group were higher than those in the control group (P < 0.05). The overall analysis found that there was a statistically significant difference in the scoring time points of ODI scale (P < 0.05); Further comparison between the two groups showed that the ODI scale scores of the two groups after two and four weeks of treatment were lower than those before treatment (P < 0.05). Conclusion Yijinjing exercise can improve the function, relieve the degree of pain and improve the quality of life of patients with lumbar disc herniation in remission, which is worthy of clinical application and promotion.
		2022 Vol. 19 (25): 124-128 [Abstract] ( 13 ) HTML (1 KB) PDF (756 KB) ( 518 )

	129	Professor Song Aiyin’s experience in treating recurrent laryngeal nerve paralysis after lung cancer surgery based on syndrome differentiation
		KONG Youqian1 SONG Aiying2▲
		DOI: 10.20047/j.issn1673-7210.2022.25.29
		Recurrent laryngeal nerve paralysis is a common complication after lung cancer surgery. The pathogenesis is complex and its condition is difficult to heal, which seriously affects the quality of life of patients. Professor Song Aiying is a famous traditional Chinese medicine in Heilongjiang Province. She has rich clinical experience in the diagnosis and treatment of recurrent laryngeal nerve paralysis after lung cancer surgery. According to Professor Song Aiying, the disease pathogenesis is incised wound, laryngeal pulse damage, which leads to qi deficiency and blood stasis, and loss of maintenance for laryngeal orifices. Therefore, the treatment method of supplementing qi and dispersing blood stasis, reinforcement and elimination in combination is put forward. The self-made Tongluo Kaiyin Decoction has good clinical effect. The author followed Professor Song Aiying, summarizes her clinical diagnosis and treatment ideas, summarizes and shares Professor Song Aiying’s traditional Chinese medicine syndrome differentiation ideas and treatment experience of recurrent laryngeal nerve paralysis after lung cancer surgery, and analyzes two experimental cases.
		2022 Vol. 19 (25): 129-132,140 [Abstract] ( 19 ) HTML (1 KB) PDF (764 KB) ( 72 )

	133	Meta analysis of Guizhi Fuling Pills combined with Gestrinone in the treatment of adenomyosis
		TANG Lei1 WANG Guohua2 PANG Ying3 LIU Yuxin1
		DOI: 10.20047/j.issn1673-7210.2022.25.30
		Objective To systematically evaluate the clinical efficacy of Guizhi Fuling Pills combined with Gestrinone in the treatment of adenomyosis. Methods All randomized controlled trials about Guizhi Fuling Pills combined with Gestrinone in the treatment of adenomyosis were collected by computer search supplemented by manual search of CNKI, Wanfang, VIP, PubMed, Cochrane Library, Web of Science, and SinoMed. The search date was from inception to November 2021. Two researchers independently screened the literature, and performed meta analysis and bias statistical analysis through Review Manager 5.3 and Stata 12.0 software. Results A total of 489 patients were included in five literatures. The results of meta analysis showed that the total effective rate of the experimental group was higher than that of the control group (RR = 0.18, 95%CI: 0.08-0.28, P = 0.000 3), the levels of carbohydrate antigen 125 (MD = -14.81, 95%CI: -17.41 to -12.21, P < 0.000 01), visual analogue scale score (SMD = -2.91, 95%CI: -3.22 to -2.59, P < 0.000 01) and pictorial blood loss assessment chart score (MD = -39.32, 95%CI: -41.55 to -37.08, P < 0.000 01) in the experimental group were lower than those in the control group. Conclusion Guizhi Fuling Pills combined with Gestrinone is reliable in the treatment of adenomyosis, but more high-quality randomized controlled trials are needed to provide clinical evidence.
		2022 Vol. 19 (25): 133-136,145 [Abstract] ( 19 ) HTML (1 KB) PDF (2071 KB) ( 66 )

	137	Diagnostic value of quantitative parameters of intravoxel incoherent motion imaging combined with ultrasound scoring method for antenatal placenta previa with placenta accreta
		ZHOU Xiaodong YU Wenxia ZHANG Qin SONG Wei MIAO Dandan▲
		DOI: 10.20047/j.issn1673-7210.2022.25.31
		Objective To explore the diagnostic value of quantitative parameters of intravoxel incoherent motion imaging combined with ultrasound scoring method for antenatal placenta previa with placenta accreta. Methods A total of 84 patients with antenatal placenta previa admitted to Nantong Maternity and Child Health Hospital of Jiangsu Province from March 2017 to September 2021 were selected as the research subjects. All subjects received antenatal ultrasound and MRI at 35-38 weeks of gestation. The quantitative parameters of intravoxel incoherent motion imaging and ultrasound score were analyzed, the results of postpartum pathology or surgery were taken as the gold standard, and the patients were divided into implantation group and non-implantation group according to whether they had placenta accreta. The quantitative parameters of intravoxel incoherent motion imaging and ultrasound scores, and pregnancy outcomes between the two groups were compared, receiver operating characteristic curve was used to evaluate the diagnostic efficacy of quantitative parameters of intravoxel incoherent motion imaging within voxel and ultrasound scores in the diagnosis of prenatal placenta previa with placenta accreta. Results Among the 84 patients with placenta previa, 31 patients(36.47%) had placenta accreta. The proportions of postpartum hemorrhage and Apgar score ≤ 7 at one minute after birth in implantation group were higher than those in non-implantation group (P < 0.05). The ultrasound score of implantation group was higher than that of non-implantation group, and hepatic arerial fracture (f value) was lower than that of non-implantation group (P < 0.05). The diagnostic sensitivity of single and combined f value and ultrasound score in the diagnosis of prenatal placenta previa with placental implantation were 77.42%, 80.65%, and 87.09% respectively, the specificity were 71.70%, 71.70%, and 75.47% respectively. Conclusion Quantitative parameters of intravoxel incoherent motion imaging and ultrasound scores have high clinical diagnostic efficacy for antenatal placenta previa with placenta accreta.
		2022 Vol. 19 (25): 137-140 [Abstract] ( 16 ) HTML (1 KB) PDF (658 KB) ( 20 )

	141	Construction and application of clinical laboratory management platform based on mobile internet technology
		XIAO Mingyuxin1 PAN Gangxi1 CHEN Xianhua1 CHEN Xiang1 LI Xia2 SUN Yifan1
		DOI: 10.20047/j.issn1673-7210.2022.25.32
		The development of the internet and mobile terminals has made the intelligent development of laboratory management possible. The platform builds a clinical laboratory management platform based on mobile internet technology through computer-side BS-based web pages and third-party public service platforms based on WeChat mini-programs and official accounts, making laboratory management more intelligent and precise, and achieving “anytime”, “anywhere” to remember what I remember, to help the intelligent development of laboratory management.
		2022 Vol. 19 (25): 141-145 [Abstract] ( 25 ) HTML (1 KB) PDF (2205 KB) ( 182 )

	146	Exploration on the construction and management of emergency medical team in public hospitals for emergency public health events
		ZHANG Xiaoyan1 WANG Binbin2▲
		DOI: 10.20047/j.issn1673-7210.2022.25.33
		Public hospitals are the frontline and main force in responding to emergency public health events. This paper analyzes the current situation of emergency medical team construction in public hospitals, and proposes to build a public hospital emergency medical team management model from the aspects of unified management structure, planning science job placement, strengthing the training of medical staff, improving the incentive, and guarantee system of emergency medical team, etc., and explore to establish an action plan of emergency medical teams covering the entire cycle of emergency public health events including symptom period, outbreak period, extension period, recovery period, etc., this paper expects to strengthen the construction of emergency medical teams in public hospitals and improve the emergency response capabilities of public hospitals, this paper hopes to strengthen the construction of emergency medical teams in public hospitals and improve the emergency response capabilities of public hospitals through the above measures.
		2022 Vol. 19 (25): 146-148,157 [Abstract] ( 19 ) HTML (1 KB) PDF (1089 KB) ( 70 )

	150	Construction of performance appraisal of hospital functional departments system based on balanced score card
		LIANG Yan YANG Guowang
		DOI: 10.20047/j.issn1673-7210.2022.25.34
		Based on the balanced score card theory, this paper analyzes the problems and causes of the performance appraisal of the functional departments of Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, transforms the strategic objectives of the hospital into the appraisal indicators that meet the performance management needs of the functional departments, and constructs the appraisal system framework including four dimensions of finance, service object, internal business process, and learning and growth, to provide innovative ideas and scientific reference for other medical institutions to carry out performance appraisal of functional departments.
		2022 Vol. 19 (25): 150-153 [Abstract] ( 16 ) HTML (1 KB) PDF (816 KB) ( 46 )

	154	The occurrence of medical safety adverse events in acquired immune deficiency syndrome ward and preventive measures
		HE Caiyu YAN Dingyan ZHU Yuzhu
		DOI: 10.20047/j.issn1673-7210.2022.25.35
		Objective To study the occurrence of medical safety adverse events in acquired immune deficiency syndrome ward and preventive measures. Methods A total of 81 medical safety adverse events in acquired immune deficiency syndrome ward of Xixi Hospital of Hangzhou from January 2018 to April 2021 were retrospectively analyzed. The categories and severity of medical safety adverse events in acquired immune deficiency syndrome ward were analyzed, and the causes and preventive measures of adverse events were studied. Results Among 81 medical safety adverse events, 74 cases (91.36%) had adverse events of medical safety, and 7 medical staff (8.64%) had adverse events of occupational exposure. Among the adverse events, 27 cases (33.33%) had safety hazards, 25 cases (30.86%) had accidental extubation, 13 cases (16.05%) had pressure injury, and 9 cases (11.11%) had administration errors. Judging from the classification of event levels, there were 58 cases (38.75%) of grade Ⅳ events, 14 cases (55.00%) of grade Ⅲ events, and 9 cases (6.25%) of grade Ⅱ events. Among the 27 cases of safety hazards, 18 patients fell and 9 patients fell out of bed; 19 patients occurred during daytime and 8 patients occurred at night. Among the 25 cases of accidental extubation incidents, 20 patients occurred at night and 5 patients occurred during daytime; 16 patients occurred 1-3 days after catheterization, 7 patients occurred 4-7 days after catheterization, and 2 patients occurred 7 days after catheterization. Among the 13 cases of pressure injury, 10 patients were stage Ⅰ pressure injury and 3 patients were stage Ⅱ pressure injury; 10 patients were complicated by infectious pneumonia, and 3 patients were complicated by renal impairment. In the 9 cases of drug administration errors, the nurses did not check the number and type of drugs administered one by one in strict accordance with the drug administration process. Among the 7 cases of occupational exposure incidents, 5 cases were mucosal exposure and 2 cases were needle stick injuries; judging from the identity of the parties involved in the incident, the 7 parties were all in-hospital nurses; and they were all within three years of practice. Conclusion All kinds of medical safety adverse events are easy to occur in acquired immune deficiency syndrome ward. In clinical practice, more comprehensive nursing care and more strict quality control management should be adopted for patients in special wards to avoid all kinds of adverse events.
		2022 Vol. 19 (25): 154-157 [Abstract] ( 12 ) HTML (1 KB) PDF (535 KB) ( 27 )

	158	Feasibility and effectiveness of staged standardized psychological support in improving the psychological state of patients with head and neck tumors radiotherapy
		LIN Juan1 ZHANG Qing2 HU Yunxia3 ZHANG Yuanyuan1 TONG Yusuo1 FENG Wanting4 DENG Xue1▲
		DOI: 10.20047/j.issn1673-7210.2022.25.36
		[Abstract] Objective To explore the effect of staged standardized psychological support on the psychological state of patients undergoing radiotherapy for head and neck tumors. Methods From February 2019 to June 2021, a total of 94 patients with head and neck tumor radiotherapy admitted to Huaian First Hospital Affiliated to Nanjing Medical University were selected as the research subjects, and they were divided into two groups according to the subjective wishes of their families. The control group received routine nursing care, while the observation group received standardized psychological support in stages. The psychological states of the two groups were observed at the time of entry (T0), 14 days (T1), 28 days (T2), and 56 days (T3) of the intervention, and the self-management ability and quality of life were compared between the two groups at T0 and T3. Results The overall analysis showed that there were statistically significant differences in the mini-mental adjustment to canccer scale (Mini-MAC-29) score between the two groups, time comparison, and interaction comparison (P ＜ 0.05). Further pairwise comparisons and intra-group comparisons: the scores of each dimension of the Mini-MAC-29 at T1, T2, and T3 in the two groups were lower than those at T0 in the same group, while the scores in each dimension of the scale at T2 and T3 were lower than those of the same group at T1, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: the scores of Mini-MAC-29 in each dimension at T0, T1, and T2 between the two groups showed no significant difference (P ＞ 0.05). The scores of each dimension at T3 in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). At T3, the scores of the health promotion strategy questionnaire in the two groups were higher than those at T0 in the same group, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). At T3, the scores of Chinese head and neck tumors patients’ quality of life scale were higher than those at T0 in the same group, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Staged standardized psychological support for patients undergoing radiotherapy for head and neck tumors can improve their psychological state, self-management ability and quality of life.
		2022 Vol. 19 (25): 158-162 [Abstract] ( 15 ) HTML (1 KB) PDF (1225 KB) ( 111 )

	163	Application effect of operating room nursing based on compound thermal insulation intervention of cesarean delivery women
		YUAN Huijuan BAO Yiyong PAN Xinlan
		DOI: 10.20047/j.issn1673-7210.2022.25.37
		Objective To explore the application effect of operating room nursing based on compound insulation intervention in temperature control of cesarean delivery. Methods A total of 105 cases of women undergoing cesarean section in Xuancheng Central Hospital, Anhui Province from June 2019 to May 2021 were selected as the research subjects, and they were divided into control group 52 cases and experimental group 53 cases by random number table method. Routine thermal insulation intervention was used in the control group and compound thermal insulation intervention was used in the experimental group. Temperature change, incidence of hypothermia and chills, and thermal comfort score were compared between the two groups during childbirth and obstetrics. The changes of coagulation indexes before and after operation were compared between the two groups. Results Tympanic membrane temperature was different at different time and group, and there was an interaction between time and group (P ＜ 0.05). Comparison within the group showed that the temperature of maternal tympanic membrane in the control group was lower than that in the same group to the operating room (T0) at the time of skin incision (T2), fetal delivery (T3), fetal delivery 10 min (T4), fetal delivery 20 min (T5), fetal delivery 30 min (T6), and the end of operation (T7) (P ＜ 0.05). At T4 - T7, the temperature of maternal tympanic membrane in test group was lower than that at T0 (P ＜ 0.05). At (T1), T2 - T7, the temperature of the tympanic membrane in experimental group were higher than that in control group (P ＜ 0.05). The rates of hypothermia and chills in the experimental group were lower than those in the control group (P ＜ 0.05). Postpartum thermal comfort score of experimental group was lower than that of control group (P ＜ 0.05). The values of prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT) in the control group were higher than those before operation (P ＜ 0.05), while fibrinogen (FIB) was lower than that before operation (P ＜ 0.05). The values of PT, APTT, and TT in experimental group were lower than those in control group (P ＜ 0.05), and FIB value was higher than that in control group (P ＜ 0.05). Conclusion Operating room nursing based on compound insulation intervention can help maintain the relative stability of maternal body temperature, reduce the incidence of hypothermia and chills, enhance maternal thermal comfort, and also have a certain protective effect on coagulation function.
		2022 Vol. 19 (25): 163-167 [Abstract] ( 15 ) HTML (1 KB) PDF (724 KB) ( 30 )

	168	Influence of “admission-discharge-family follow-up” one-stop health education on compliance of anticoagulation therapy after catheter radio-frequency ablation for patients with atrial fibrillation
		XU Hanli LIU Dan ZHOU Yuqin▲
		DOI: 10.20047/j.issn1673-7210.2022.25.38
		Objective To explore influence of “admission-discharge-family follow-up” one-stop health education on compliance of anticoagulation therapy after catheter radiofrequency ablation for patients with atrial fibrillation. Methods A total of 120 patients with atrial fibrillation admitted to the No.904 Hospital of Chinese People’s Liberation Army Joint Logistics Support Force from May 2018 to May 2021 were selected. All patients were treated with anticoagulant drugs after radiofrequency catheter ablation, they were divided into control group and experimental group by random number table, with 60 cases in each group. The control group was given routine health education, while the experimental group was given one-stop health education of “admission-discharge-family follow-up”. The medication compliance, awareness rate of medication knowledge, and quality of life of the two groups were compared before and after six months of education. Results After six months of education, the medication compliance of experimental group was higher than that of control group (P ＜ 0.05); the awareness rate of medication in both groups were higher than those before education, and the experimental group was higher than the control group (P ＜ 0.05). The quality of life scores of the two groups were higher than those of the control group, and the experimental group was higher than that of the control group (P ＜ 0.05). Conclusion One-stop health education of “admission-discharge-family follow-up” can improve patients’ knowledge of medication for diseases, enhance their compliance with medication, promote rapid recovery of diseases and improve their quality of life.
		2022 Vol. 19 (25): 168-171 [Abstract] ( 11 ) HTML (1 KB) PDF (681 KB) ( 40 )

	172	Effects of Baduanjin Phase Ⅰ cardiac rehabilitation exercise on cardiopulmonary function and sleep quality in patients with acute myocardial infarction after percutaneous coronary intervention
		CAI Yu1 ZHENG Hongyun1 ZHOU Yuanyuan1 YANG Chao2 WANG Ying3 YIN Jing4▲
		DOI: 10.20047/j.issn1673-7210.2022.25.39
		[Abstract] Objective To investigate the effect of Baduanjin Phase Ⅰ cardiac rehabilitation exercise on the cardiopulmonary function and sleep quality of patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods Ninety patients with acute myocardial infarction after PCI who were admitted to the Suzhou Science and Technology City Hospital Affiliated to Nanjing Medical University and Wuhan Asian Heart Hospital from June 2020 to May 2021 were selected as the research objects. According to the random number table method, they were divided into control group and experimental group, with 45 cases in each group. The control group was guided by routine exercises after the operation, and the experimental group was used Baduanjin stage Ⅰ cardiac rehabilitation exercises on the basis of the control group. Both groups continued to intervene for two weeks. The maximum metabolic equivalent (METmax), maximum oxygen uptake (VO2max), 6-minute walking distance (6MWT), and Pittsburgh sleep quality index (PSQI) score were compared between two groups before and after the intervention. Complications of two groups were compared. Results After intervention, the METmax, VO2max, 6MWT of the two groups were higher than before intervention, and the experimental group were higher than the control group (P ＜ 0.05); the PSQI scores of the two groups were lower than before intervention , and the PSQI score of the experimental group was lower than that of the control group (P ＜ 0.05). Conclusion Baduanjin Phase Ⅰ cardiac rehabilitation exercise can improve cardiopulmonary function, sleep quality and exercise tolerance in patients with acute myocardial infarction after PCI.
		2022 Vol. 19 (25): 172-175 [Abstract] ( 18 ) HTML (1 KB) PDF (679 KB) ( 98 )

	176	Application effect of descending ladder thinking in post-hospital emergency nursing of craniocerebral injury patients combined with cervical spine injury
		LI Chunjuan GU Jie CHEN Tingting
		DOI: 10.20047/j.issn1673-7210.2022.25.40
		Objective To explore the application effect of descending ladder thinking in post-hospital emergency nursing of craniocerebral injury patients combined with cervical spine injury. Methods From April 2019 to April 2021, 80 patients with craniocerebral injury combined with cervical spine injury in Yancheng First People’s Hospital of Jiangsu Province were selected as the research objects, according to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group received routine nursing, while the observation group received descending ladder thinking intervention nursing. The time of emergency treatment after hospital, warning time, time of venous access establishment, incidence of complications, and Glasgow coma index score were compared between the two groups. Results After intervention, the early warning time, emergency treatment time, venous channel establishment time, and triage evaluation time in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05); the total incidence of complications in observation group was lower than that in control group, and the difference was statistically significant (P ＜ 0.05). The communication, vision, speech, hearing, motor, and arousal scores of the two groups were higher than those before intervention, and the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion For patients with craniocerebral injury and cervical spine injury, emergency nursing with ladder descending thinking after hospital can improve the application time of each emergency treatment, improve complications, reduce Glasgow coma index, and improve prognosis, which is worthy of clinical promotion and adoption.
		2022 Vol. 19 (25): 176-179 [Abstract] ( 14 ) HTML (1 KB) PDF (708 KB) ( 18 )

	180	Influence of volunteer participation model on psychological status and quality of life of patients with lung cancer targeted therapy
		ZHANG Minglan CHEN Meiting QIU Shu
		DOI: 10.20047/j.issn1673-7210.2022.25.41
		Objective To explore the effect of volunteer participation model application on the psychological status and quality of life of patients with lung cancer targeted therapy. Methods A total of 80 patients with lung cancer who were diagnosed and treated in the Department of Oncology, Anhui Anhui No.2 Provincial People’s Hospital from January 2018 to October 2021 were selected and divided into routine nursing group and volunteer participation group by random number table method. The routine nursing group (40 cases) received routine nursing during the treatment period, while the volunteer participation model was introduced into the nursing of the volunteer participation group (40 cases). The negative emotions, changes in quality of life, and nursing satisfaction were observed in the two groups. Results After the intervention, the scores of the self-rating anxiety scale and the self-rating depression scale in the two groups were lower than those before the intervention, while those of the volunteer participation group were lower than those of the routine nursing group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the scores of physical function, role function, emotional function, cognitive function, and social function in the two groups were higher than those before the intervention, while those of the volunteer participation group were higher than those of the routine nursing group, with statistically significant differences (P ＜ 0.05). The nursing satisfaction of the volunteer participation group was higher than that of the routine nursing group, and the difference was statistically significant (P ＜ 0.05). Conclusion In the nursing of patients with lung cancer targeted therapy, the intervention in the mode of volunteer participation can effectively help patients improve their psychological status, significantly promote improvement of quality of life after treatment, and improve nursing satisfaction.
		2022 Vol. 19 (25): 180-183,188 [Abstract] ( 14 ) HTML (1 KB) PDF (739 KB) ( 117 )

	184	Bibliometric study of PET-CT nursing research hotspots based on co-word analysis
		MA Ping WANG Yating LI Ruihong ZHAO Shutao▲
		DOI: 10.20047/j.issn1673-7210.2022.25.42
		Objective To conduct bibliometric research on PET-CT nursing research in recent years based on co-word analysis, clarify the research hotspots and development direction in this field, and to provide reference for relevant nursing researchers. Methods Using the title “PET” + “CT” + “Nursing” as the search formula, the relevant literature in the Chinese National Knowledge Infrastructure was searched, and the search period was from the establishment of the database to January 2022. The data was exported in RefWorks format, calculated, and analyzed by CiteSpace software, and a visual knowledge map was generated by the minimum spanning tree algorithm. The graph of the total number of documents, graph of the cited network, a graph of the co-occurrence frequency of keywords, cluster analysis graph of co-authored publications, and graph of the distribution of publishing units were drew. Results From 2003 to 2021, there were 167 related literatures; the most cited monograph PET/CT Diagnostics (2008 edition) edited by Professor Pan Zhongyun. The keywords with the highest co-occurrence frequency were “subject”, “FDG (imaging agent)”, “image quality”, and other keywords; the author with the highest number of collaborative publications was Chen Wei (the First Affiliated Hospital of Third Military Medical University). The institutions with the most publications were Zibo Wanjie Hospital, Shandong Provincial Hospital, Provincial Hospital Affiliated to Anhui Medical University, and General Hospital of Jinan Military Region of the People’s Liberation Army. Conclusion At present, the research hotspots in the field of PET-CT nursing are imaging agents, subjects, nursing cooperation, image quality, and intravenous injection, which has a certain reference value for relevant nursing researchers, in order to provide better PET-CT inspection and nursing services.
		2022 Vol. 19 (25): 184-188 [Abstract] ( 13 ) HTML (1 KB) PDF (1117 KB) ( 62 )

	189	Influence of nursing intervention based on case management model on pain status and neurophysiological level of diabetic peripheral neuropathy
		SHAO Qi ZHENG Jiandi ZHOU Yuqin CHEN Fangfang
		DOI: 10.20047/j.issn1673-7210.2022.25.43
		Objective To explore the effect of nursing intervention based on case management model on the pain status and neurophysiological level of diabetic peripheral neuropathy. Methods A total of 80 patients with diabetic peripheral neuropathy who were diagnosed and treated in Hangzhou Red Cross Hospital from June 2018 to June 2021 were selected as the research objects. According to the random number table method, they were divided into control group and research group, with 40 cases in each group. The control group received routine cognitive intervention and rehabilitation nursing, while the study group received cognitive intervention and rehabilitation nursing based on the case management model on the basis of the control group. After three months of nursing, the scores of visual analogue scale (VAS), Toronto clinical neuropathy score (TCSS), self-rating depression scale (SDS) score, and self-rating anxiety scale (SAS) score were compared between the two groups. The EMG detection indicators (median nerve, common peroneal nerve sensory conduction velocity, and motor conduction velocity) and the awareness rate of diabetes-related knowledge were evaluated in the two groups. Results The pain relief rate in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). After nursing, the scores of TCSS, SDS, and SAS in the two groups were lower than those before nursing, while those of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). After nursing, the sensory conduction and motor conduction velocities of the median nerve and common peroneal nerve in the two groups were higher than those before nursing, while those of the study group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After nursing, the awareness scores of diabetes-related knowledge in the two groups were higher than those before nursing, and the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Nursing intervention based on case management model applied to diabetic peripheral neuropathy can significantly reduce pain and improve nerve conduction function, which is worthy of application and promotion.
		2022 Vol. 19 (25): 189-192 [Abstract] ( 19 ) HTML (1 KB) PDF (714 KB) ( 25 )

	193	Effect of cardiac rehabilitation intervention in patients with acute myocardial infarction undergoing interventional therapy
		GAO Huanxiao QIN Haihong▲ YIN Jiao WU Xueqin
		DOI: 10.20047/j.issn1673-7210.2022.25.44
		Objective To explore the effect of cardiac rehabilitation nursing in patients with acute myocardial infarction (AMI). Methods A total of 110 AMI patients who underwent interventional surgery in the Department of Cardiovascular Medicine, Tangdu Hospital, Air Force Medical University from June 2018 to June 2021 were selected, they were divided into conventional group and intervention group by random number table method, with 55 cases in each group. The routine group received routine nursing, and the intervention group received cardiac rehabilitation intervention. The improvement of psychological symptoms, cardiac function, and complications were observed after two weeks of intervention. Results After the intervention, the scores of psychological symptom self-rating scale score of the two groups were lower than those before the intervention, and the scores of the intervention group were lower than those of the routine group (P ＜ 0.05); the levels of left ventricular end-diastolic volume and left ventricular end-systolic volume in the two groups were lower than those before intervention, and those in the intervention group were lower than those in the conventional group(P ＜ 0.05); the left ventricular ejection fraction in the intervention group was higher than that before intervention, and the intervention group was higher than that of the conventional group (P ＜ 0.05); the total incidence of complications in the intervention group was lower than that in the routine group (P ＜ 0.05). Conclusion Cardiac rehabilitation intervention in the nursing of AMI patients with interventional therapy can effectively improve the effect of psychological symptoms, promote better improvement of cardiac function, and effectively reduce complications.
		2022 Vol. 19 (25): 193-196 [Abstract] ( 12 ) HTML (1 KB) PDF (711 KB) ( 28 )

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