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| Effect of Shengxian Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy |
| JIANG Cuihong1 LYU Yutong1 ZHAO Zhizheng2 |
| 1.Department of Oncology, Southern District of Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences, Beijing 102600, China; 2.Department of Oncology, Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences, Beijing 100053, China |
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Abstract Objective To investigate the effect of Shengxin Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy. Methods A total of 102 patients with oncogenic fatigue admitted to the Southern District of Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences from May 2018 to February 2022 were selected, according to the random number table method, they were divided into control group and combined group, with 51 cases in each group. The control group was given albumin Paclitaxel + Platinum, on this basis, the combined group was treated with Shengxian Decoction. The degree of cancer-related fatigue were compared between the two groups, the pulmonary function, quality of life and immune function of the two groups were compared before and after treatment, and the side effects of the two groups were observed, and the treatment compliance of the two groups was compared. Results After treatment, the improvement of cancer-related fatigue in the combined group was better than that in the control group (P ＜ 0.05). After treatment, forced expiratory volume in one second, forced vital capacity ratio and maximum peak expiratory flow rate in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P ＜ 0.05); the scores of quality of life in the two group were higher than those before treatment, and the combined group was higher than that in the control group (P ＜ 0.05). CD3+, CD4+, and CD4+/CD8+ in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P ＜ 0.05). The treatment compliance of the combined group was better than that of the control group (P ＜ 0.05). The incidence of side effects in combination group was lower than that in control group (P ＜ 0.05). Conclusion Shengxian Decoction can improve the quality of life of patients with oncogenic fatigue in lung cancer chemotherapy, improve the immune function and degree of cancer-related fatigue, and with less toxic side effects, high compliance, which is worthy of further clinical promotion.
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