东亚人群中IL-6-572基因多态性与乙型肝炎病毒感染易感性的meta分析

doi:10.20047/j.issn1673-7210.2022.25.20

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Abstract Objective To systematically evaluate the association between IL-6-572C/G gene polymorphism and susceptibility to hepatitis B virus (HBV) infection in East Asian population. Methods PubMed, Web of Science, CNKI, Wanfang Data, and VIP were searched for case-control studies on the relationship between IL-6-572C/G (rs1800796C＞G) gene polymorphism and HBV infection in East Asian population. The retrieval time was from the inception to October 2021, and Stata S12.0 software was used for meta-analysis. Results Finally, ten literatures were included, including 3 532 hepatitis B virus infected patients and 4 020 controls. The results of meta-analysis showed that carrying G allele and GG+GC, GG, GC genotypes were protective factors for HBV infection in East Asian population (G vs C[OR = 0.80, 95%CI: 0.74-0.87, P ＜ 0.001]；GG+GC vs CC[OR = 0.77, 95%CI: 0.70-0.85, P ＜ 0.001]；GG vs CG+CC[OR = 0.72, 95%CI: 0.59-0.87, P = 0.001]；GC vs CC[OR = 0.79, 95%CI: 0.72-0.87, P ＜ 0.001]；GG vs CC[OR = 0.66, 95%CI: 0.54-0.80, P ＜ 0.001]). Conclusion The altered IL-6-572 gene polymorphism (C＞G) may reduce the risk of HBV infection in East Asian population.

Key words： IL-6-572 gene Hepatitis B virus East Asian population Meta-analysis

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	ZHANG Yalong1* XU Honghai2* CHENG Jun1 GAO Yufeng1

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ZHANG Yalong1* XU Honghai2* CHENG Jun1 GAO Yufeng1. Meta-analysis of IL-6-572 gene polymorphism and susceptibility to hepatitis B virus infection in East Asian population[J]. 中国医药导报, 2022, 19(25): 90-93,102.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.25.20 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I25/90

[1] Khanizadeh S，Hasanvand B，Nikoo HR，et al. Association between miRNA-146a rs2910164（G/C）polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance in an Iranian population [J]. J Med Virol，2019，91（6）：1063-1068.
[2] Alawad AS，Auh S，Suarez D，et al. Durability of Spontaneous and Treatment-Related Loss of Hepatitis B s Antigen [J]. Clin Gastroenterol Hepatol，2020，18（3）：700-709.
[3] Wang C，Tzeng IS，Su WC，et al. The association of vitamin D with hepatitis B virus replication：Bystander rather than offender [J]. J Formos Med Assoc，2020，119（11）：1634-1641.
[4] Georges JL，Loukaci V，Poirier O，et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction：the ECTIM study [J]. J Mol Med（Berl），2001，79（5/6）：300-305.
[5] Park JS，Son JH，Park CS，et al. Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes [J]. Yonsei Med J，2019，60（1）：1-9.
[6] Handelman GJ，Handelman SK. Single-Nucleotide Polymorphisms in CD36 are Associated With Macular Pigment Among Children [J]. J Nutr，2021，151（9）：2507-2508.
[7] 陈立，陈治新，潘晨，等.白细胞介素-6基因多态性与慢性HBV感染的相关性[J].中西医结合肝病杂志，2006， 16（2）：82-86.
[8] Li M，Zhou Y，Xu Y，et al. Genetic Association of Interleukin-6 Polymorphism（rs1800796）with Chronic Hepatitis B Virus Infection in Chinese Han Population [J]. Viral Immunol，2021，34（4）：267-272.
[9] 刘承铭，庞军，胡文钰，等.中国人群MTHFR C677基因多态性与冠心病发病相关性的meta分析[J].中国医药导报，2021，18（32）：78-82.
[10] Behnaz R，Zahurin M，Yamunah DA，et al. Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population [J]. Biomedical Reports，2018，3（9）：213-220.
[11] 朱秀云，汪文斐，吴伟刚，等.IL-6基因单核苷酸多态性与中国汉族人群乙型肝炎易感性的相关性研究[J].中华实验和临床病毒学杂志，2017，31（5）：397-400.
[12] 张亚龙.云南傣族和汉族人群IL-6-572C/G和IFNAR1-168G/C基因多态性与HBV感染相关性的研究[D].昆明：昆明理工大学，2016.
[13] Zhang G，Wang W，Li S，et al. IL6 gene allele-specific C/EBPα-binding activity affects the development of HBV infection through modulation of Th17/Tregbalance [J]. Genes Immun，2015，16（8）：528-532.
[14] Lu Y，Peng J，Wang C，et al. IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection [J]. Clin Lab，2014，60（11）：1903-1907.
[15] Tang S，Liu Z，Zhang Y，et al. Rather than Rs1800796 polymorphism，expression of interleukin-6 is associated with disease progression of chronic HBV infection in a Chinese Han population [J]. Dis Markers，2013，35（6）：799-805.
[16] 戴悦，刘晓琳，柴庆波，等.中国部分汉族人群中IL-6基因启动子-572G/C多态性与HBV感染易感性的关系[J].世界华人消化杂志，2009，17（15）：1522-1526.
[17] 邢培祥，邹明瑾，邢全台，等.前炎性细胞因子基因多态性与乙型肝炎病毒感染的关系[J].山东大学学报（医学版），2007，45（12）：1229-1233.
[18] Park BL，Lee HS，Kim YJ，et al. Association between interleukin 6 promoter variants and chronic hepatitis B progression [J]. Exp Mol Med，2003，35（2）：76-82.
[19] Moudi B，Heidari Z，Mahmoudzadeh-Sagheb H. CCR5，MCP-1 and VDR gene polymorphisms are associated with the susceptibility to HBV infection [J]. Indian J Clin Biochem，2019，34（4）：407-417.
[20] Nyarko E，Obirikorang C，Owiredu WKBA，et al. NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population [J]. Virol J，2020，17（1）：91.
[21] Al-Anazi MR，Nazir N，Abdo AA，et al. Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection [J]. Saudi J Biol Sci，2019，26（2）：270-280.
[22] Tsai TY，Huang MT，Sung PS，et al. SIGLEC-3（CD33）serves as an immune checkpoint receptor for HBV infection [J]. J Clin Invest，2021，131（11）：e141965.
[23] Vergori A，Rossetti B，Vicenti I，et al. Analysis of genetic and viral determina-nts of HBsAg levels in patients with chronic HBV infection [J]. Infez Med，2020，28（4）：576-586.
[24] Koukoulioti E，Fischer J，Schott E，et al. Association of HLA-DPA1 and HLA-DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians [J]. Liver Int，2019，39（4）：646-654.
[25] Wang X，Yan Z，Ye Q. Interleukin-6 gene polymorphisms and susceptibility to liver diseases：A meta-analysis [J]. Medicine（Baltimore），2019，98（50）：e18408.