外泌体在重要脏器缺血再灌注损伤中的治疗作用研究进展

doi:10.20047/j.issn1673-7210.2022.25.07

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Abstract Ischemia reperfusion injury (IRI) is a multi-step chain process from potential risk factors to obvious clinical diseases. Vascular cells, blood cells, cardiomyocytes, and stem cells all participate in pathophysiology through continuous and multiple crosstalk. As a powerful carrier of cell-cell communication, exosomes has always been the focus of basic and clinical research. A large amount of evidence shows that exosomes are involved in the evolution of IRI to a large extent, but their actual therapeutical effect is still controversial. The clinical role of exosomes in cell-cell communication at different stages of disease is still poorly understood. This article reviews the latest research on the application of exosomes in IRI of important organs, and focus on the clinical application prospect of their targeted modification.

Key words： Exosomes Ischemia-reperfusion Organ injury and protection Targeted therapy

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	ZENG Kejun1 YANG Yuhui1 HU Zhe2▲

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ZENG Kejun1 YANG Yuhui1 HU Zhe2▲. Research progress on the therapeutical effect of exosomes in ischemia reperfusion injury in important organs[J]. 中国医药导报, 2022, 19(25): 33-37.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.25.07 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I25/33

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