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2022 Vol. 19, No. 16
Published: 2022-06-05
 
 
5 Effects of stromal cell-derived factor-1α overexpression on migration of mesenchymal stem cells under extreme hypoxia
WANG Hui1 XU Liangliang2 SUN Daming2 MENG Yi2 ZHANG Chenglong1 XU Haijia1 NING Yu3 LI Zhanghua1
Objective To investigate the effects of stromal cell-derived factor-1α (SDF-1α) overexpression on migration of mesenchymal stem cells (MSCs) under extreme hypoxia. Methods MSCs derived from two normal male Japanese white rabbits (two weeks of age, body weight [250±30] g) were divided into blank group (no intervention), AMD3100 group (added CXC subfamily receptor 4 [CXCR4] specific inhibitor AMD3100), SDF-1α adenovirus (Ad-SDF-1α) group (Ad-SDF-1α transfected), and Ad-SDF-1α+AMD3100 group (Ad-SDF-1α transfected and added AMD3100). The four groups were cultured under extreme hypoxia (1%) for 48 h, and the changes of migration ability were detected by Transwell experiment. The mRNA and protein expressions of HIF-1α, vascular endothelial growth factor (VEGF), and CXCR4 were detected by real-time quantitative PCR and Western blot. Results MSCs adhered to the wall in spindle and polygonal shape, and showed clonal growth. Uniform and bright green fluorescence could be observed after transfection with Ad-SDF-1α. The optical density (OD) value of AMD3100 group was lower than that of blank group, OD value of Ad-SDF-1α group was higher than that of blank group, OD value of Ad-SDF-1α+AMD3100 group was higher than that of AMD3100 group and lower than that of Ad-SDF-1α group, the differences were statistically significant (P ＜ 0.05). The mRNA expressions of VEGF and CXCR4 in AMD3100 group were lower than those in blank group, while the mRNA expressions of HIF-1α, VEGF, and CXCR4 in Ad-SDF-1α group were higher than those in blank group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The mRNA expressions of VEGF and CXCR4 in Ad-SDF-1α+AMD3100 group were higher than those in AMD3100 group, while the mRNA expressions of HIF-1α, VEGF, and CXCR4 were lower than those in Ad-SDF-1α group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The protein expressions of HIF-1α, VEGF, and CXCR4 in AMD3100 group were lower than those in blank group, while the protein expressions of HIF-1α, VEGF, and CXCR4 in Ad-SDF-1α group were higher than those in blank group, the protein expressions of HIF-1α, VEGF, and CXCR4 in Ad-SDF-1α+AMD3100 group were higher than those in AMD3100 group and lower than those in Ad-SDF-1α group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion SDF-1α overexpression can still promote MSCs migration under extreme hypoxia, and reverse the inhibitory effect of AMD3100 to some extent.
2022 Vol. 19 (16): 5-10 [Abstract] ( 54 ) HTML (1 KB)  PDF (1380 KB)  ( 66 )
11 Study on prescription medication rules of modern Chinese materia medica compound in treating chronic migraine based on data mining
LIU Zhen1 DU Shan2 GU Jinghui3 LI Weidong4 LIU Yan5▲
Objective To explore the prescription medication rules of modern Chinese materia medica compound in treating chronic migraine by using modern information technology. Methods Literatures on Chinese materia medica compound therapy for chronic migraine were retrieved from VIP Information Chinese Science and Technology Journal database, Chinese National Knowledge Infrastructure, and Wanfang Medical Network database from January 2013 to December 2020, and the literatures meeting the inclusion and exclusion criteria were preprocessed. Excel 2019 was used to conduct statistical analysis on the frequency of use, efficacy categories, and nature and flavour and channel tropism of Chinese materia medica in the database. SPSS Modeler 18.0 and SPSS Statistics 20 were used for association rule analysis and cluster analysis respectively. Results A total of 236 literatures meeting the standard were screened, involving 255 groups of prescriptions, 165 Chinese materia medica were recorded, and 36 Chinese materia medica with high frequency (frequency ≥27 times) were screened, such as Chuanxiong Rhizoma, Glycyrrhizae Radix Et Rhizoma, Paeoniae Radix Alba, Gastrodiae Rhizoma, etc. According to the statistics of high-frequency Chinese materia medica, drug classification were mainly drugs for promoting blood circulation for removing blood stasis, suppressing hyperactive liver for calming endogenous wind, and invigorating qi and blood; drug properties were mainly warm drugs; drug tastes were mainly pungent drugs; channels tropism were mainly liver and spleen channels. The association rule analysis and cluster analysis of high frequency Chinese materia medica formed 23 couplet medicines combinations and five cluster combinations respectively. Conclusion Chronic migraine drugs are mainly drugs for promoting blood circulation for removing blood stasis, suppressing hyperactive liver for calming endogenous wind, and invigorating qi and blood, most of the selection of warm nature, taste pungent, return to the liver and spleen channel drugs.
2022 Vol. 19 (16): 11-15 [Abstract] ( 28 ) HTML (1 KB)  PDF (1470 KB)  ( 25 )
16 Analysis of the rules of medication of spleen and stomach diseases in Weisheng Baojian
YANG Yuying1 WANG Fangyuan1 DOU Xiaoxin1 SHI Haoyang1 ZHAO Shuang1 MENG Jingyan2
Objective To analyze the formulae and the rules of medication used in the treatment of spleen and stomach diseases in the Weisheng Baojian, the representative work of Luo Tianyi, a medical practitioner of the Yi Shui school, with the aid of the traditional Chinese medicine inheritance computing platform V3.0 software. Methods Data mining was carried out for prescriptions for the treatment of spleen and stomach diseases in Weisheng Baojian by using the traditional Chinese medicine inheritance computing platform V3.0 software, and data analysis was conducted on the four nature, five flavours, channel tropism, medication frequency, association rules, cluster analysis for the drugs in the prescription. Results A total of 98 prescriptions were included. The top five Chinese materia medica in frequency were Glycyrrhizae Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, Aucklandiae Radix, Zingiberis Rhizoma, and Citri Reticulatae Pericarpium. The drug properties mostly belongs to warm, cold, plain. The drug taste was mainly pungent, bitter, and sweet, and the most drugs enter the spleen, stomach, and lung channels. Tonifying deficiency, regulating qi, and warming interior were the most commonly used Chinese materia medica. Twenty-eight groups of common combinations were obtained by association rule analysis, and four associated prescriptions were obtained by unsupervised cluster analysis. Conclusion The characteristics of Luo Tianyi’s treatment of spleen and stomach diseases are as follows: sweet and warm tonifying spleen while pay attention to regulating qi; flexible combination of pungent, bitter, sweet, and warm medicine; based on eliminating and reinforcing together for strengthening the stomach; eliminating downward stagnation to strengthen the spleen and stomach.
2022 Vol. 19 (16): 16-20 [Abstract] ( 31 ) HTML (1 KB)  PDF (1571 KB)  ( 44 )
21 Research on the characteristics of pulse diagnosis information in people with qi deficiency based on principal component analysis and LS / Lasso regression
FAN Xiqian1 AN Erxia1 SONG Shibo2 WANG Xingya1 LIU Luo1 LIU Jia2 WANG Nanyue2
Objective To analyze the characteristics of pulse diagnosis information of people with qi deficiency constitution in Shaanxi Province. Methods From March 2019 to April 2020, the traditional Chinese medicine constitution questionnaire information and the information of cun, guan, and chi pulse diagnosis were collected from the medical examiners of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine and students of Shaanxi University of Chinese Medicine. The constitution was classified according to the information of the traditional Chinese medicine constitution questionnaire, and the qi deficiency constitution group and the peaceful constitution group were screened out. The pulse diagnosis information of the two groups was extracted through preprocessing and characteristic parameters based on harmonic fitting, and a total of 193 characteristic parameters were obtained. Principal component analysis based on unsupervised learning and LS regression, Lasso regression, and other analysis methods based on supervised learning were used for classification and judgment, and a judgment model of pulse diagnosis information for people with qi deficiency was established, and the time domain and frequency domain characteristic parameters of pulse diagnosis information for people with qi deficiency constitution were mined. Results After screening for data integrity and pulse diagnosis signal quality, a total of 119 subjects were selected for modeling, including 61 people with qi deficiency and 58 people with peaceful constitution group. The discriminant accuracy rates of the constructed models were 76%, 72%, and 65%, respectively; the pulse number, right cun s, right foot s, right cun s2, and right foot s2 in the qi deficiency group were higher than those in the Pinghe quality group, and the energy of the Zuoguan was lower than that in the peaceful constitution group, and the differences were statistically significant (P ＜ 0.05). Conclusion The physiological differences between qi deficiency constitution and peaceful constitution are reflected in the time-frequency domain parameters of radial artery pulse diagnosis information. Through the pulse diagnosis information data model, the people of two groups can be more accurately classified and identified, which provides an objective basis for the identification of qi deficiency to a certain extent.
2022 Vol. 19 (16): 21-25 [Abstract] ( 25 ) HTML (1 KB)  PDF (1486 KB)  ( 63 )
26 Study on the effects of D-Cycloserine combined with Rifampicin and Isoniazid on drug-resistant Mycobacterium tuberculosis in vitro
CHEN Shengjie1 LI Xi1 LI Chao2▲
Objective To evaluate the effect of D-Cycloserine (DCS) combined with Rifampicin and Isoniazid on drug-resistant Mycobacterium tuberculosis in vitro. Methods The minimum inhibitory concentration (MIC) of 38 clinical isolates against DCS, Rifampicin and Isoniazid were determined by microporous plate Alamar Blue method, the combined effect of DSC and Rifampicin and Isoniazid in vitro was detected by checkerboard dilution method, and the combined effect was determined by fractional inhibitory concentration index (FICI). Results Seven strains (18.4%) displayed synergistic effect in DCS combination with Rifampicin, and combined MIC of 24 strains (63.2%) reduced several concentration gradients. After combined DSC with Isoniazid, 5 strains (13.2%) showed synergistic effect, and the combined MIC of 22 strains (57.9%) reduced several concentration gradients. No antagonistic effect was observed with either combination drug regimen. MIC50 and MIC90 decreased after DSC combined with Rifampicin and Isoniazid. Conclusion DSC combined with Rifampicin and Isoniazid can reduce the resistance of clinical drug-resistant strains to varying degrees. DCS combined with therapy is beneficial to the treatment of drug-resistant tuberculosis patients.
2022 Vol. 19 (16): 26-29,37 [Abstract] ( 32 ) HTML (1 KB)  PDF (1000 KB)  ( 36 )
30 Analysis and clinical significance of gut microbiota in colorectal adenoma
XU Jun1 CHEN Bingxin1 ZHU Yongliang2 XI Qinhua1 YAN Su1
Objective To analyze the characteristics of gut microbiota in colorectal adenoma (CRA) and to build a model to screen early colorectal lesions. Methods A total of 96 patients with CRA who underwent colonoscopy in the First Affiliated Hospital of Soochow University from January 2017 to July 2018 were enrolled as CRA group, and 59 healthy subjects with normal colonoscopy during the same period were enrolled as control group. All subjects underwent faecal occult blood test (FOBT) and serum carcinoembryonic antigen (CEA) detection. The gut microbiota composition of two groups was compared by 16S rRNA sequencing, and the weighted dysbiosis index (WDI) model was constructed based on the different strains of two groups, and the efficacy of the model, FOBT, and CEA in the diagnosis of CRA was analyzed. Results Compared with control group, the abundance of Klebsiella Pneumoniae, Parabacteroides Merdae, and Fusobacterium were increased in CRA group; while the abundance of Actinobacteria, Lachnospiraceae, Blautia, Bifidobacterium, Roseburia, Streptococcus, Pseudobutyrivibrio, and Fusobacterium Ulcerans were decreased. The sensitivity of FOBT in the diagnosis of CRA was 15.63%, specificity was 91.53%, the false positive rate was 8.47%, the false negalive rate was 84.38%; the sensitivity of CEA in the diagnosis of CRA was 71.88%, specificity was 52.54%, the area under the curve (AUC) was 0.614; the sensitivity of WDI in the diagnosis of CRA was 83.33%, specificity was 71.19%, AUC was 0.795. Conclusion The composition of gut microbiota of CRA showes characteristic changes. The sensitivity of WDI model is better than that of FOBT and serum CEA, which may be a potential marker for early screening of colorectal tumors.
2022 Vol. 19 (16): 30-33 [Abstract] ( 24 ) HTML (1 KB)  PDF (1153 KB)  ( 195 )
34 Study progress on the mechanism of Vitamin K on type 2 diabetes mellitus
GUO Anran LIU XiuXiang
Type 2 diabetes mellitus is one of the major chronic diseases of global concern. Its pathogenesis has not yet been fully elucidated. It is a worldwide public health problem threatening human health. Vitamin K is a kind of naphthoquinone derivative with phylloquinone biological activity. It is a biologically active compound necessary to maintain optimal body function. It can participate in the carboxylation process of Vitamin K dependent proteins, it plays a positive role in prerenting and treating atherosclerosis, reducing the release of inflammatory factors, and improving insulin sensitivity have a positive effect. This review focuses on the possible mechanism of Vitamin K in regulating insulin sensitivity and blood sugar status, adding new adjuvant treatments to better control the progress of diabetes.
2022 Vol. 19 (16): 34-37 [Abstract] ( 103 ) HTML (1 KB)  PDF (498 KB)  ( 43 )
38 Research progress on the function and role of CLCA1 in diseases
WAN Shengjun KE Changbin
Calcium-activated chloride channel regulator 1 (CLCA1) is a secretory autocatalytic lysate protein, a member of the CLCA family, that activates calcium-dependent chloride currents in mammalian cells and has zinc metalloproteinase properties. Through its metalloproteinase and anion channel activation, CLCA1 plays an important role in the pathogenesis of mucus hypersecretion-related diseases of the respiratory and digestive systems, such as bronchial asthma and ulcerative colitis. At the same time, it is involved in the occurrence and development of malignant tumors due to the conduction regulation of chloridion and other anions in epithelial cells. In this review, the molecular structure, related properties and the relationship between CLCA1 and related diseases are reviewed.
2022 Vol. 19 (16): 38-41,45 [Abstract] ( 33 ) HTML (1 KB)  PDF (655 KB)  ( 154 )
42 Research progress of traditional Chinese medicine on prevention and treatment of normal high blood pressure
ZHANG Shuo DUAN Jinlong WANG Qingqing LI Caiying YAO Kuiwu
Normal high blood pressure is a high risk predictor of hypertensive patients, early intervention is of great significance. The prevention and treatment of normal high blood pressure with traditional Chinese medicine fully embodies the advantages and characteristics of “ preventive treatment of disease” in traditional Chinese medicine. This paper summarizes the research progress of traditional Chinese medicine in the prevention and treatment of normal high blood pressure from the aspects of Chinese medicine prescription, with medicine generation of tea, acupuncture, moxibustion, auricular point pressing with bean, acupoint application, catgut implantation at acupoint, foot bath, and so on, which provides an important basis for better reducing the risk of patients with normal high blood pressure.
2022 Vol. 19 (16): 42-45 [Abstract] ( 27 ) HTML (1 KB)  PDF (578 KB)  ( 88 )
46 Application and prospect of virtual reality in stroke rehabilitation #br#
CHEN Xueting YAO Liqing LI Wangxiang LI Zhengchao MAO Ruitao▲
Stroke is the first cause of death in China, and the incidence is increasing year by year, 75% of stroke patients are left with different degrees of dysfunction. Virtual reality (VR) is an emerging rehabilitation technology with great potential, which has the advantages of low cost, high immersive, high participation, interest, and safety compared with traditional rehabilitation method. Recent studies have focused on the application of VR technology in motor and cognitive function after stroke and confirmed the mutual influence between the two, but the mechanism has not been clarified. VR technology is expected to be applied to study the mechanism between motor and cognitive function, and higher motor cognition after stroke. This article reviews application progress of VR technology in stroke rehabilitation in recent years, providing a reference for popularizing and deepening the application of VR technology in the field of rehabilitation medicine.
2022 Vol. 19 (16): 46-49,57 [Abstract] ( 70 ) HTML (1 KB)  PDF (649 KB)  ( 68 )
50 Research progress on the effect of Exendin-4 on islet β cells and related mechanisms
LIU Chen
Exendin-4 is a short incretin polypeptide, belonging to a long-acting agonist of glucagon-like peptide-1 (GLP-1) receptor. In recent years, it has been found that Exendin-4 can act on islet β cells in various ways and play a role in the treatment of diabetes. On the one hand, Exendin-4 regulates insulin secretion by specifically binding to GLP-1 receptors on islet β cells. On the other hand, Exendin-4 can also promote the proliferation of islet β cells, regulate autophagy and inhibit apoptosis, and protect islet function. This paper reviews the recent studies on the effects of Exendin-4 on islet β cells and related molecular mechanisms, in order to promote the further application of Exendin-4 in the treatment of diabetes mellitus.
2022 Vol. 19 (16): 50-52,66 [Abstract] ( 24 ) HTML (1 KB)  PDF (492 KB)  ( 37 )
53 Research progress on the protective effect of silent information regulator 1 in postoperative cognitive dysfunction
QIN Xiaoyu1 WANG Chunai2
Postoperative cognitive dysfunction is particularly common after anesthesia, which has a serious impact on the quality of life and postoperative rehabilitation of patients, increasing the postoperative morbidity and mortality, and increasing the length of hospital stay and economic expenditure of patients. Silencing information regulator 1 (SIRT1) plays a crucial role in the pathogenesis of postoperative cognitive dysfunction, and plays a key protective role in neuroinflammatory response, oxidative stress, mitochondrial energy metabolism, endoplasmic reticulum stress, neuronal apoptosis, autophagy, and regulating nerve cell-related factors or proteins. In this paper, SIRT1 will be taken as the core to focus on the mechanism of its protective effect on cognitive impairment caused by anesthesia surgery, in order to provide some help for future scientific research in this field.
2022 Vol. 19 (16): 53-56 [Abstract] ( 65 ) HTML (1 KB)  PDF (636 KB)  ( 167 )
58 Research progress on the application of vascular endothelial growth factor in the diagnosis and treatment of endometriosis
PANG Qiaoyan1 SHAO Yuwei1 YOU Chen1 LI Canmei1 ZHANG Yaping2
Endometriosis is a vascular-dependent disease, and vascular endothelial growth factor (VEGF) is the main angiogenic factor, because of its strongest effect and highest specificity, it is a key factof in the early occurrence of endometriosis and progress. In clinical diagnosis and treatment, VEGF can be used as a marker to assist in the diagnosis of endometriosis, and the staging of endometriosis can be judged based on its expression level. VEGF/VEGF receptor is a crucial target of angiogenesis, and VEGF-targeted drugs and related traditional Chinese medicine are expected to become a new direction in the treatment of endometriosis.
2022 Vol. 19 (16): 58-61 [Abstract] ( 33 ) HTML (1 KB)  PDF (598 KB)  ( 22 )
62 Application of “mind mapping combined with inventory” teaching method in clinical practice teaching of fascial space infection of maxillofacial region
LI Zhiye ZHANG Junrui KONG Liang LU Bin NIU Qiang LI Haiqiang CONG Bingfeng LI Yunpeng
Objective To evaluate the application effect of “mind mapping combined with inventory” teaching method in clinical practice teaching of fascial space infection of maxillofacial region. Methods From July 2020 to October 2021, 40 undergraduate students majoring in stomatology practiced in the Ward of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University were selected. They were assigned to experimental group and control group by random number table method, 20 students in each group. The experimental group adopted the “mind mapping combined with inventory” teaching method for clinical practice teaching, while the control group adopted the “traditional guidance” mode for clinical practice teaching. The internship effect of two groups were compared by the questionnaire and exam. Results In this study, 40 questionnaires were actually sent out, and a total of 40 questionnaires were recovered with effective recovery of 100%. The self-evaluation scores of the experimental group in “the clinical practice has obviously consolidated my relevant theoretical knowledge”, “the clinical practice has significantly improved my doctor-patient communication ability”, “after the clinical practice, I have completely mastered the diagnosis and treatment process of fascial space infection of maxillofacial region” were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). In the experimental group, the self-evaluation score of “I think the teaching method of ‘mind mapping combined with inventory’ is very important in clinical practice of fascial space infection of maxillofacial region” was (4.6±0.6) points. The test results of the experimental group were higher than the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The teaching method of “mind mapping combined with inventory” can obviously improve the clinical teaching effect of maxillofacial space infection, which is worthy of further promotion in teaching.
2022 Vol. 19 (16): 62-66 [Abstract] ( 61 ) HTML (1 KB)  PDF (1396 KB)  ( 43 )
67 Application effect of 3D printing model assisted CBL and PBL teaching mode in the teaching of spinal deformity
ZHAO Xiong1 ZHANG Feng2 WANG Xinli1 MENG Bing1
Objective To explore the application effect of 3D printing model assisted case based learning (CBL) and problem based learning (PBL) in the teaching of spinal deformity. Methods A total of 60 five-year undergraduate students majoring in clinical medicine from grade 2016 who were practicing in the First Affiliated Hospital of Air Force Military Medical University from August 2020 to April 2021 were selected and divided into observation group and control group by random number table method, with 30 students in each group. The observation group used 3D printing model to assisted CBL and PBL teaching mode, while the control group used CBL and PBL teaching mode to teach. At the end of the semester, the learning interest, comprehension ability, content mastery, and satisfaction of the two groups were scored and compared. At the same time, the assessment scores of the two groups were recorded and compared. Results The learning interest, comprehension ability, content mastery, and satisfaction scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The scores of theoretical knowledge and clinical skills of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The 3D printing model assisted CBL and PBL teaching mode can improve students’ learning interest, enable students to better understand and master the anatomical characteristics, deformity progression mechanism, and surgical correction scheme of spinal deformity, which is worthy of popularization and application.
2022 Vol. 19 (16): 67-70,79 [Abstract] ( 33 ) HTML (1 KB)  PDF (777 KB)  ( 112 )
71 Exploration and practice on the cultivation of the “dual thinking” ability of students majoring in traditional Chinese medicine based on undergraduate tutorial system
LIU Yuan1 XIE Hailong1 YANG Lin2 LIU Yan1 KUANG Haixue1 YANG Bingyou1
Traditional Chinese medicine is China’s unique health resources and cultural heritage, and plays an important role in safeguarding people’s lives and health. As a rational, practical and comprehensive subject, chinese materia medica especially needs the active and effective guidance of tutors in the learning process of students. Based on the background proposed by pharmaceutical tutor, combined with the implementation of undergraduate tutorial system of chinese materia medica in Heilongjiang University of Chinese Medicine, this paper analyzes the effective strategies of interactive education, thought guidance, scientific research training, and thinking training to promote ability improvement. It is proved that the implementation of the tutorial system can effectively promote the improvement of students’ comprehensive quality, scientific research thinking ability, clear career planning and the improvement of the guidance ability of full-time teachers, indicating that the tutorial system can effectively help the “dual thinking” ability training of undergraduates majoring in Chinese materia medica and provide reference for the teaching reform of relevant colleges and majors.
2022 Vol. 19 (16): 71-74 [Abstract] ( 57 ) HTML (1 KB)  PDF (626 KB)  ( 43 )
75 General situation of health management education in foreign universities and its enlightenment to China
LUO Guihua REN Jiarui LI Wenqing BAI Simin GUO Kun OUYANG Jing
The implementation of Healthy China 2030 Plan is in urgent need of a large number of health service workers. In 2015, the Ministry of Education added the undergraduate major of “health service and management” under the first-level discipline of management. Up to now, there are 124 colleges and universities offering this major. However, there are still some problems in this major, such as short construction time, little accumulation, and lack of experience. Therefore, colleges and universities actively explore and innovate the training mode of health management talents, and cultivate applied talents to meet the development needs of the big health industry under the guidance of healthy China plan. This paper introduces the general situation of health management education in the United States and Japan, and sorts out the problems and challenges of health management education in China from the aspects of curriculum system, subject orientation, academic education system, and teacher team construction, trying to provide reference and thinking for the development of health management education in colleges and universities in China.
2022 Vol. 19 (16): 75-79 [Abstract] ( 33 ) HTML (1 KB)  PDF (752 KB)  ( 197 )
80 Construction and practice research on case-based teaching of specialty courses in pharmaceutical engineering in local colleges and universities under the background of new engineering
YIN Deming1 SHAN Yuxin2
Facing the background of Industry 4.0 era and new engineering in higher education, this paper studies the construction and practice of case-based teaching in local colleges and universities of pharmaceutical engineering specialty application-oriented courses. Using the Feynman constructivism learning method, the abstract theoretical knowledge of traditional Chinese medicine pharmaceutical process is reconstructed in the form of a box to reconstruct the operational framework knowledge, and a pharmaceutical case process teaching system supported by the Internet, information and digital technology is established. To construct a teaching model of “classroom case teaching-intelligent scene teaching in factories and schools-validating experimental process teaching-comprehensive process experimental training and operation teaching-self-designed pharmaceutical workshop process-multi-dimensional resource integration to improve case teaching gender degree”. Emphasis is placed on the progressive process of case process selection, process analysis, technical operation and engineering thinking from easy to difficult, from simple to comprehensive. It can cultivate “high-quality technical talents with strong adaptability, strong sense of innovation and entrepreneurship, and the core literacy and innovative values of new engineering engineers.
2022 Vol. 19 (16): 80-83,87 [Abstract] ( 21 ) HTML (1 KB)  PDF (811 KB)  ( 127 )
84 Design and practice of the experimental teaching of Chinese medicine major by project-based learning from the perspective of “curriculum politics”
ZHANG Yanli1 ZHAI Chunmei1 TIAN Yuan1 WU Lihong1 LIU Peng1 MENG Yonghai2
In order to improve the advanced, innovative, and challenging degree of experimental teaching of traditional Chinese pharmacy, this study took project-based learning as the main method, designed, and implemented the project-based experimental teaching reform of “Shuanghuanglian and other pharmaceutical preparations pharmaceutical research” in the perspective of “curriculum politics”. A comprehensive questionnaire survey is conducted on Grade 2017 and 2018 students of Heilongjiang University of Traditional Chinese Medicine (92 students) to implement teaching reform. The results shows that the positive parity results are more than 70%, the horizontal evaluation results are less than 20%, and the negative evaluation results are less than 5%. This teaching design can realize the experiment skill, innovation ability, and cultural thinking of traditional Chinese medicine and other comprehensive ability training to significantly expand the academic thinking of students, improve the ability of students find and solve problems, stimulating the enthusiasm of explore scientific problems and self learning, to enhance the cultural identity of Chinese medicine, and realize the unity of knowledge and ability training.
2022 Vol. 19 (16): 84-87 [Abstract] ( 29 ) HTML (1 KB)  PDF (1005 KB)  ( 52 )
88 Bibliometric and visualization analysis of research on pathogenesis of myelodysplastic syndromes
XU Hao TAO Yuchen HU Kexin XUE Tingting WANG Yanlu LIANG Chenhui DONG Xiaojie LU Jiahui
Objective To explore the current status and development trend of the pathogenesis of myelodysplastic syndromes (MDS). Methods Using Web of Science core collection as data source, combined with the visualization function of CiteSpace software, the literature information (journals, authors, institutions, countries, keywords, and highly cited literatures) on the pathogenesis of MDS from January 2011 to December 2020 were analyzed. Results A total of 941 articles were included. The journal with the most publications was Blood, and the author with the most publications was Jaroslaw P. Maciejewski from the cleveland clinic in the United States. The university of Texas MD Anderson Cancer Center was the institution with the most published literature. A total of 13 keyword clusters and 14 emergent keywords were found. Keywords with higher frequency include acute myeloid leukemia, hematopoietic stem cells, somatic mutations, and gene expression, etc. Conclusion The research field of MDS pathogenesis has made great progress. The main research directions include clonal hematopoiesis, somatic gene mutation, bone marrow microenvironment, and immune abnormalities. The development of various new drugs for pathogenesis will become the future research trend.
2022 Vol. 19 (16): 88-92 [Abstract] ( 20 ) HTML (1 KB)  PDF (2678 KB)  ( 24 )
93 Correlation analysis of intestinal flora with serum inflammatory factors and clinical symptoms in patients with depression
Hasichaolu LI Xin LU Hong LI Ke
Objective To explore the correlation analysis of intestinal flora with serum inflammatory factors and clinical symptoms in patients with depression. Methods A total of 154 patients with first-episode depression treated in the First Hospital of Shanxi Medical University from July 2020 to December 2020 were selected as the study group, and 154 healthy subjects were randomly selected as the control group according to the ratio of 1∶1. The intestinal flora of the two groups was measured by 16S ribosomal RNA (16S rRNA), and the levels of serum tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 were measured by enzyme-linked immunosorbent assay, and the level of IL-6 was evaluated by Hamilton depression scale (HAMD-17). The level of inflammatory factors and the expression of intestinal flora were observed between the two groups. Results The TNF-α, IL-1β, and IL-6 in the study group were higher than that in the control group (P ＜ 0.05). A total of 154 patients in the study group were divided into mild (67 cases), moderate (51 cases) and severe (36 cases) according to HAMD-17. The levels of TNF-α, IL-1β, and IL-6 in patients with severe depression were significantly higher than those in patients with mild and moderate depression, the levels of TNF-α, IL-1β, and IL-6 in patients with moderate depression were significantly higher than those in patients with mild depression (P ＜ 0.05). Shannon index in the study group was significantly higher than that in the control group (P ＜ 0.05). The abundance of Firmicutes in the study group was lower than that in the control group (P ＜ 0.05), and the abundance of Bacteroidetes, Proteus, and Dendrobacteria in the study group were higher than those in the control group (P ＜ 0.05); the abundance of Bacteroides, Prevotella, Another Mycobacterium, Faecalis and Koalas in the study group were lower than those in the control group (P ＜ 0.05), and the abundance of Spirillum, Parabacterium, Brautherella and Macromonas in the study group were higher than those in the control group (P ＜ 0.05). There were negative correlation between Bacteroides (r = -0.418, -0.375, -0.464, -0.382), Faecalis (r = -0.492, -0.528, -0.367, -0.412), Koalas (r = -0.382, -0.403, -0.396, -0.349) and TNF-α, IL-1β, IL-6 and depression degree(P ＜ 0.05). Conclusion Intestinal flora is related to inflammatory factors and the severity of depression. Further discussion on the relationship between intestinal flora and inflammation and depression can provide new ideas for the prevention and treatment.
2022 Vol. 19 (16): 93-97 [Abstract] ( 92 ) HTML (1 KB)  PDF (656 KB)  ( 113 )
98 Clinical value of salivary cortisol and secretory immunoglobulin A levels in cognitive function of elderly patients with burning mouth syndrome
TONG Xi PU Lili LYU Chenyi LI Guomin WANG Pengcheng
Objective To investigate the effects of salivary cortisol (Cor) and secretory immunoglobulin A (SIgA) levels on cognitive function in elderly patients with burning mouth syndrome (BMS). Methods A total of 103 elderly patients with BMS admitted to Jinhua Municipal Central Hospital, Zhejiang Province (hereinafter referred to as “our hospital”) from February 2019 to April 2021 were selected as the study group, and 54 healthy elderly people in our hospital during the same period were selected as the control group. The levels of salivary Cor, SIgA, and cognitive function of the two groups were determined. The study group was divided into cognitive impairment group (26 cases) and normal cognitive function group (77 cases) according to the existence of cognitive impairment. The clinical data of the two groups were compared to analyze the influencing factors of cognitive impairment in BMS patients and the predictive value of related indicators. Results Salivary Cor level in the study group was higher than that in the control group, salivary SIgA level, mini mental status examination, and Montreal cognitive assessment scale scores were lower than those in the control group (P ＜ 0.05). The scores of Hamilton depression (HAMD) scale, the levels of Th2 cells in peripheral blood, and salivary Cor in cognitive impairment group were higher than those in normal cognitive function group, while the levels of Th1 cells in peripheral blood and salivary SIgA were lower than those in normal cognitive function group (P ＜ 0.05). Multivariate analysis showed that HAMD score and salivary Cor, SIgA levels were independent influencing factors of cognitive impairment in BMS patients (P ＜ 0.05). The area under the receiver operating characteristic curve of Cor and SIgA combined diagnosis of cognitive dysfunction in elderly patients with BMS was higher than those of Cor and SIgA alone (P ＜ 0.05). Conclusion The levels of salivary Cor and SlgA of BMS patients are related to neurological function. The combination of the two has certain efficacy in predicting cognitive function of BMS patients, which is worthy of further clinical research.
2022 Vol. 19 (16): 98-101 [Abstract] ( 30 ) HTML (1 KB)  PDF (797 KB)  ( 91 )
102 Effect of folic acid on ischemic stroke complicated with H-type hypertension
ZHAO Wenjun1 HAO Weihua1 LIN Wenjing1 SHI Yinhua2 LI Qing1 ZHAO Huiying1 ZHANG Jianping1
Objective To investigate the effect of folic acid on ischemic stroke patients with H-type hypertension. Methods A total of 200 patients with ischemic stroke complicated with H-type hypertension admitted to Shijiazhuang People’s Hospital from December 2018 to December 2019 were selected, and they were divided into treatment group and routine group according to random number method, with 100 cases in each group. The routine group was given anti-platelet drugs, statins, anti-hypertensive drugs, improving cerebral circulation, and other basic treatments, and the treatment group was given folic acid orally on the basis of the routine group. The course of treatment in both groups was six months. The levels of homocysteine (Hcy), matrix metalloproteinase-9 (MMP-9), and Montreal cognitive assessment (MoCA) scale score were compared between the two groups before and after treatment. The correlation between MoCA score and Hcy, MMP-9 level was analyzed. Results After treatment, the levels of Hcy and MMP-9 in the treatment group were lower than those before treatment, and those in the treatment group were lower than those in the routine group, the differences were statistically significant (P ＜ 0.05). After treatment, the MoCA scores of both groups were higher than those of before treatment, and the MoCA score of the treatment group was higher than that of the routine group, the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that Hcy and MMP-9 levels were negatively correlated with MoCA score (r ＜ 0, P ＜ 0.05). Conclusion Folic acid treatment can reduce Hcy and MMP-9 levels and improve MoCA score in patients with ischemic stroke complicated with H-type hypertension, which is worthy of further clinical promotion.
2022 Vol. 19 (16): 102-104,108 [Abstract] ( 61 ) HTML (1 KB)  PDF (561 KB)  ( 18 )
105 Effect of Deanxit combined with aerobic exercise on sleep quality of patients with depression during consolidation treatment
WU Yechen1 ZHANG Zheng1 CHEN Qianqian1 WANG Jiawei2 FAN Lijun1 ZHU Yinglun1 HE Yeting1 ZHAO Yingyu1
Objective To investigate the effect of Deanxit combined with aerobic exercise on sleep quality in patients in the comsolidation treatment period of depression. Methods A total of 82 patients with unipolar depressive disorder who were admitted to Qinhuangdao Jiulongshan Hospital, Hebei Province from September 2019 to December 2020 were selected. After eight weeks of standardized treatment, their depressive symptoms achieved clinical relief. They were divided into observation group (41 cases) and control group (41 cases) according to the random number table method. The control group was treated with Deanxit, and the observation group was treated with Deanxit combined with aerobic exercise. The sleep quality, psychologit status, and quality of life before and after treatment were compared between the two groups. Results Before treatment, there was no significant difference in the scores of pittsburgh sleep quality index (PSQI) between the two groups (P ＞ 0.05); after treatment, the PSQI scores of the two groups decreased compared with before treatment, and the observation group was lower than the control group (P ＜ 0.05). Before treatment, there was no significant difference in the scores of hamilton anxiety scale (HAMA) and hamilton depression scale (HAMD) in the two groups (P ＞ 0.05); after treatment, HAMA and HAMD scores in the two groups were lower compared with before treatment, and those in the control group were lower than those in the observation group (P ＜ 0.05). After treatment, the scores of role function, physical function, social function, emotional function, and cognitive function in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Deanxit combined with aerobic exercise can improve the sleep quality and psychological status of patients in the consolidation treatment of depression, which is worthy of clinical promotion
2022 Vol. 19 (16): 105-108 [Abstract] ( 68 ) HTML (1 KB)  PDF (569 KB)  ( 29 )
109 Clinical and immunopathological analysis of patients with tumor-associated membranous nephropathy #br#
DONG He１ FENG Zhe2▲
Objective To investigate the differences of clinical and pathological features in patients with tumor-associated membranous nephropathy, so as to guide clinical practice. Methods A retrospective analysis of 102 patients with membranous nephropathy was performed in the Department of Nephrology, People’s Liberation Army General Hospital from January 2017 to December 2018. According to the etiology, they were divided into idiopathic group (91 cases) and tumor group (11 cases), followed up for 24 months. The general clinical data of the two groups were compared, including age, gender, smoking, hypertension, hematuria, and serous cavity effusion, etc.; laboratory tests: 24-hour urine protein quantification, serum albumin, serum creatinine, serum complement C3, C4, serum anti-phospholipase A2 receptor (PLA2R) antibody, etc. renal pathology including membranous nephropathy stage, renal interstitial inflammatory cell infiltration grade, renal tubular atrophy, immunofluorescence IgG1, and IgG4 deposition were recorded. Results The age of the tumor group was higher than that of the idiopathic group, and the difference was statistically significant (P ＜ 0.05). The degree of renal tubular atrophy in the tumor group was higher than that in the idiopathic group, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in the positive rate of IgG4 deposition and the positive rate of anti-PLA2R antibody between the two groups (P ＞ 0.05). Conclusion The positive rate of IgG4 subtype and whether the anti-PLA2R antibody is positive still need to be cautious in distinguishing membranous nephropathy from tumors. In patients with membranous nephropathy with relatively less severe renal tubular damage, potential tumors should be carefully excluded.
2022 Vol. 19 (16): 109-112 [Abstract] ( 24 ) HTML (1 KB)  PDF (469 KB)  ( 37 )
113 Effect of Dexmedetomidine combined with Atropine on perioperative period of pediatric strabismus correction surgery
WU Hao SU Xiaohu DAI Lingyun TIAN Yufeng
Objective To investigate the effect of Dexmedetomidine combined with Atropine on perioperative period of pediatric strabismus correction surgery. Methods A total of 120 children with strabismus correction surgery under general anesthesia were enrolled in Suqian First People’s Hospital Affiliated to Nanjing Medical University from August 2018 to August 2021. According to the random number table method, they were divided into group A, B, C, and D, with 30 cases in each group. Group A was given normal saline 2 ml after conventional anesthesia induction; group B was given Dexmedetomidine 1 μg/kg nasal drops after admission to the operating room, routine anesthesia induction, and maintenance; group C received Atropine 0.01 mg/kg intravenously after conventional anesthesia induction; group D was given Dexmedetomidine 1 μg/kg nasal drip after admission to the operating room, and Atropine 0.01 mg/kg intravenous after induction of anesthesia. The incidence of postoperative nausea and vomiting, abdominal pain, ocular and cardiac reflexes, and the changes of gastroenteroencephalogram (main frequency, average frequency, and average amplitude) were observed. Results There were statistically significant differences in the incidence of nausea and vomiting, abdominal pain, and ocardial reflex among four groups (P < 0.05); the incidence of nausea and vomiting and abdominal pain in group D was lower than that in group A (P < 0.008). During operation, the main frequency, average frequency, and average amplitude of four groups were higher than those before operation (P < 0.05); the main frequency, average frequency, and average amplitude of groups C and D were lower than those of groups A and B (P < 0.05). Conclusion Dexmedetomidine nasal drop and Atropine intravenous can effectively improve the occurrence of adverse reactions related to strabismus correction surgery, which can be used safely and effectively in pediatric strabismus correction surgey.
2022 Vol. 19 (16): 113-116 [Abstract] ( 24 ) HTML (1 KB)  PDF (532 KB)  ( 53 )
117 Experience of Professor Lin Qian in treating perioperative patients with acute myocardial infarction
LI Yuxuan1 YAN Rongkun1 LI Peng1 LI Dong1 CUI Xiaoyun1 LU Jinjin1 LIU Jialin2 LIN Qian3 LI Yan1
This article summarizes Professor Lin Qian’s experience in treating patients with acute myocardial infarction in the perioperative period using a combination of whose and local syndrome differentiation of qi and blood theory. Professor Lin Qian believes that blood stasis due to qi deficiency, stagnation, and blood heat, and stasis and heat are the main pathogenic mechanisms for the recurrence of major adverse cardiovascular events and the development of in-stent restenosis in patients with acute myocardial infarction in the perioperative period. Professor Lin Qian inherited Professor Liao Jiazhen’s academic ideas of whole and local syndrome differentiation, and proposed the “qi and blood theory” of holistic identification combined with “trauma repair theory” of localized treatment. Professor Lin Qian applied the method of benefiting qi, invigorating blood, and cooling blood locally to generate muscle in perioperative patients with acute myocardial infarction. This approach has good clinical outcomes, can improve patient discomfort, reduces the occurrence of major adverse cardiovascular events, can reduce the probability of in-stent restenosis, and improves the quality of life of patients in the perioperative period of acute myocardial infarction.
2022 Vol. 19 (16): 117-121,126 [Abstract] ( 58 ) HTML (1 KB)  PDF (907 KB)  ( 17 )
122 Investigation on the booklist quoted of Biographies of Chinese Doctors of All Dynasties
CHEN Shaohua MA Qin ZHAO Kezhuo ZHANG Lijun DING Kan
Objective To discuss the types, era, geographical distribution, and quoted in the literatures collected from traditional Chinese medicine character reference books. Methods Through the method of bibliography, Biographies of Chinese Doctors of All Dynasties was used as the research object, the booklist quoted data table was established, counted, and screened, and the frequency distribution table was made. Results A total of 3376 kinds of literatures were collected in the Biographies of Chinese Doctors of All Dynasties, mainly involving medical scholar, local chronicle, catalogue, novelists, and other collection types. There were 2196 kinds of specific citation the era of literatures, 1130 kinds of literature era that were still doubtful, and 50 kinds of foreign literatures. It was represented by doctors and catalogues types, the era of cited literature could be roughly divided into Tang and before Tang dynasty, Song, Jin, and Yuan dynasties, Ming and Qing dynasties, modern times, and contemporary times. There were 985 kinds of literatures of local chronicle type, of which 5 kinds were unknown, and the rest 980 kinds were distributed in 24 provinces such as Sichuan, Jiangsu, and Zhejiang; 175 kinds of literatures were cited from more than 50 kinds of literatures, mainly catalogues, medical scholar, local chronicles, and likeness book types. Among the cited literatures, there were 55 literatures with unclear types, and the remaining 120 literatures were mostly cited from medical scholar, other collections, novelists, and catalogues types. Conclusion Biographies of Chinese Doctors of All Dynasties is indeed the most abundant reference book for the data collection of biographies of currently medical. In addition to realizing the various arranging methods of the cited bibliography of the book, this study can also provide convenience and methodological reference for searching medical historical materials.
2022 Vol. 19 (16): 122-126 [Abstract] ( 25 ) HTML (1 KB)  PDF (669 KB)  ( 102 )
127 Clinical effect of Liangxue Tuibi Decoction on patients of psoriasis vulgaris with syndrome of blood heat
GONG Ke1 GUO Jianhui1 GUO Wen1 DU Kaiqing1 SHEN Yana2
Objective To observe the clinical effect of Liangxue Tuibi Decoction on patients of psoriasis vulgaris with syndrome of blood heat. Methods A total of 80 patients of psoriasis vulgaris with syndrome of blood heat were treated in the Department of Dermatology, Cangzhou Hospital of Integrated traditional Chinese and Western Medicine Affiliated to Hebei University of Chinese Medicine from November 2020 to August 2021 were selected as the research object. They were divided into treatment group and control group by random number table method, 40 cases in each group. The control group was given Xiaoyin Granules, the observation group was given Liangxue Tuibi Decoction. After 8 weeks of treatment, the clinical effect was compared between the two groups, the changes in the psoriasis area and severity index (PASI) score, traditional Chinese medicine syndrome score, dermatology life quality index (DLQI) score, serum squmaous cell carcinoma antigen (SCCA) level and vascular endothelial growth factor (VEGF) level and the incidence of adverse reactions before and after treatment were observed. Results The clinical effect of the treatment group was better than that of the control group (P ＜ 0.05). After treatment, PASI scores in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, the traditional Chinese medicine syndrome scores of both groups were lower than those before treatment , and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, DLQI scores in both groups were lower than those before treatment, but there was no significant difference in DLQI scores between the two groups (P ＞ 0.05). After treatment, the levels of serum SCCA and VEGF in both groups were lower than those before treatment, and those in treatment group were lower than those in control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.2632, P = 0.6079). Conclusion Liangxue Tuibi Decoction can effectively improve the skin lesions and symptoms of psoriasis vulgaris patients with syndrome of blood heat, with obvious clinical effect and few adverse reactions, which is worthy of clinical application.
2022 Vol. 19 (16): 127-130,146 [Abstract] ( 57 ) HTML (1 KB)  PDF (716 KB)  ( 27 )
131 Analysis of prescription composition rules for treating limb lymphedema based on data mining
LIU Zheng1 LIANG Jiawei2 WANG Hongjie3 LIU Gouyan3 WANG Yingrui2
Objective To conclude and summarizc the medication rules of traditional Chinese medicine prescriptions in the treatment of limb lymphedema Based on TCMISS V2.5 system software. Methods The literatures of clinical studies on CNKI, Wanfang, VIP, and Chinese biomedical literature databases from January 1989 to December 2019 were searched for the oral prescription for the treatment of limb lymphedema, the retrieved prescriptions were screened and arranged, the TCMISS V2.5 system software was applied for data mining to explore the medication rule. Results A total of 160 prescriptions and 198 kinds of drugs were included, for 2233 times. There were 36 drugs with frequency ≥10%, including Astragali Radix, Poria, Atractylodis Macrocephalae Rhizoma, etc. The four nature of drugs were mainly warm and flat; the five flavours were mainly sweet and bitter; the main channel tropism were liver and spleen channels. The degree of confidence was set to 0.7, and rule analysis was selected to obtain 24 rules. The network visualization relationship between three drug combinations was obtained. A total of 26 drug core combinations were obtained, corresponding to 13 new formula combinations. Conclusion By using the TCMISS system, it is concluded that three new formula combinations of common syndromes, namely, qi deficiency and damp obstruction, dampness-heat amassment, and phlegm and blood stasis intermingled syndromes, are suitable for limb lymphedema, it is consistent with the prescription composition rules of staging treatment of limb lymphedema in clinical practice, that is, the formula law of benefiting qi and warming yang for diuresis in the early stage, clearing heat, removing toxicity, and promoting diuresis in the progressive stage, and promoting blood circulation and dispersing swelling in the late stage.
2022 Vol. 19 (16): 131-134 [Abstract] ( 27 ) HTML (1 KB)  PDF (1104 KB)  ( 18 )
135 Effect of electroacupuncture at Zusanli and Shangjuxu on postoperative ileus and its influence on inflammation response
YU Min1 YANG Xianyu2 CHEN Panmin2 ZHENG Huihua2 LI Qun1
Objective To observe the effect of electroacupuncture at Zusanli and Shangjuxu on postoperative ileus after abdominal surgery and its influence on inflammation. Methods A total of 50 patients with postoperative ileus after abdominal surgery admitted to Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2020 to July 2021 were selected, and the patients were divided into control group (conventional postoperative treatments, 25 cases) and electroacupuncture group (electroacupuncture at Zusanli and Shangjuxu combined with conventional postoperative treatments, 25 cases) by the random number table method. Both groups were treated for seven days. The clinical efficacy and the recovery situation of gastrointestinal function (bowel sound recovery time, first exhaust and defecation time, and eating time) were compared between the two groups, and the levels of serum inflammatory factors (tumor necrosis factor-α, interleukin-6, and C reaction protein) were compared on one day before operation, one day and seven days after operation, and the adverse reaction was observed. Results There was no significant difference in clinical efficacy between the two groups (P ＞ 0.05). Bowel sound recovery time, first exhaust time, defecation time, and eating time in electroacupuncture group were significantly shorter than those in the control group, the differences were statistically significant (P ＜ 0.05). The overall analysis showed that there were statistically significant differences between groups, time points, and interactions (P ＜ 0.05). Intra-group comparison: serum tumor necrosis factor-α, interleukin-6, and C reaction protein levels at seven days after operation were lower than those before operation and one day after operation, the differences were statistically significant (P ＜ 0.05); comparison among groups: the levels of serum tumor necrosis factor-α, interleukin-6, and C reaction protein in the electroacupuncture group were lower than those in the control group at seven days after operation, the differences were statistically significant (P ＜ 0.05). There were no adverse reactions in the two groups during treatment. Conclusion Electroacupuncture at Zusanli and Shangjuxu can effectively promote the recovery of gastrointestinal function in patients with postoperative ileus, reduce the inflammation reaction, and have good safety.
2022 Vol. 19 (16): 135-138,160 [Abstract] ( 23 ) HTML (1 KB)  PDF (730 KB)  ( 41 )
139 Effect of functional recovery after total knee arthroplasty with Chinese herb Tazi Decoction
LI Yan1 WANG Xianghong2 LIU Xingxing1 ZHAO Chuanwei1 DI Dongxue1 ZHANG Hongmei1
Objective To observe the effect of Chinese herb Tazi Decoction on functional recovery after total knee arthroplasty (TKA). Methods From December 2020 to July 2021, 90 patients in Wangjing Hospital of China Academy of Chinese Medical Sciences who were undergoing TKA were selected as the study subjects. Two weeks after stitches removal, the patients were divided into control group and experimental group by random number table method, with 45 cases in each group. The control group was given Voltaren, and the experimental group was given Chinese herb Tazi Decoction. After two weeks of intervention, visual analogue scale (VAS) score, lower limb circumference difference value, Kendall percentage of quadriceps femoris muscle, range of motion (ROM), and knee score of American Hospital for Special Surgery (HSS) were compared between the two groups. Results After intervention, VAS score of two groups were lower than those before intervention, and that in the experimental group was lower than that in the control group, HSS score of two groups were higher than those before intervention, and that in the experimental group was higher than that in the control group (P ＜ 0.05). After intervention, two groups of lower limb swelling degree were lower than those before intervention, and that in the experimental group was lower than that in the control group. Both groups of active quadriceps muscle and ROM were higher than those before intervention, and those in the experimental group were higher than those in the control group (P ＜ 0.05). There were no adverse reactions in experimental group and control group during administration. Conclusion Chinese herb Tazi Decoction can significantly relieve the pain and swelling of limbs of patients after TKA, improve joint function, and promote the rehabilitation of TKA.
2022 Vol. 19 (16): 139-142 [Abstract] ( 31 ) HTML (1 KB)  PDF (580 KB)  ( 45 )
143 Effect of Chinese herb acupoint application combined with warm moxibustion on end-stage liver disease
ZHANG Kun1 HAN Qian1 XIA Mengtian1 WANG Zhihua1 ZHENG Yanhua1 ZHAO Lina2▲
Objective To analyze the intervention effect of Chinese herb acupoint application and warm moxibustion on end-stage liver disease. Methods A total of 150 patients with end-stage liver disease admitted to Shijiazhuang Fifth Hospital of Hebei Province from January 2019 to December 2020 were enrolled as the research subjects. According to the random number table method, there were divided into two groups, with 75 cases in each group. The control group was intervened with Chinese herb acupoint application, and the observation group was intervened with warm moxibustion intervention on the basis of the control group. After two courses of treatment, the intervention effect, symptoms and signs, liver function level, and safety were compared between the two groups. Results The clinical effect of observation group was better than that of the control group (P ＜ 0.05). After intervention, the abdominal circumference and maximum depth of ascites dark area in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group, 24 h urine volume in both groups were higher than those before intervention, and that in the observation group was more than that in the control group (P ＜ 0.05). After intervention, alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group (P ＜ 0.05). No serious adverse reactions occurred in the two groups during the intervention, and no obvious abnormalities were found in the examination results. Conclusion The intervention of Chinese herb acupoint application and warm moxibustion has a significant effect on end-stage liver disease, which can help to improve the symptoms and liver function level of patients, and has a high safety.
2022 Vol. 19 (16): 143-146 [Abstract] ( 29 ) HTML (1 KB)  PDF (591 KB)  ( 85 )
147 Clinical effect of wrist-ankle acupuncture combined with needle-embedding therapy on patients with pain in lower extremities and waist
XIANG Shaoqian HU Xiaolei
Objective To explore the therapeutic effect of wrist-ankle acupuncture and needle-embedding therapy in the treatment of patients with pain in lower extremities and waist. Methods A total of 66 patients with lower extremities and waist pain who were hospitalized in the Department of Orthopedics, Wenzhou Hospital of Traditional Chinese Medicine, Zhejiang Province from June 2019 to May 2020 were selected as the research subjects. They were divided into control group and observation group by random number table method. The control group (33 cases) was received needle-embedding therapy intervention, the observation group (33 cases) was received wrist-ankle acupuncture combined with needle-embedding therapy, the intervention time of both groups was 20 d. Pain control, mood improvement, clinical efficacy, and adverse reactions were observed in both groups. Results After intervention, numerical rating scale, pain rating index, and present pain intensity scores of two groups were lower than those before intervention, and those in the observation group were lower than those in the control group (P ＜ 0.05). After intervention, Hamilton depression scale and Hamilton anxiety scale scores in the two groups were lower than those before intervention, and those in the observation group were lower than those in the control group (P ＜ 0.05). The clinical effect of observation group was better than that of control group (P ＜ 0.05). After intervention, there was no significant difference in adverse reactions between the two groups (P ＞ 0.05). Conclusion In the pain treatment of patients with pain in lower extremities and waist, wrist-ankle acupuncture and needle-embedding therapy are performed at the same time, can obtain the higher efficiency, and the security is good.
2022 Vol. 19 (16): 147-150 [Abstract] ( 57 ) HTML (1 KB)  PDF (611 KB)  ( 193 )
151 Application value of ACR thyroid imaging reporting and data system in diagnosising of thyroid nodules
FENG Lingyan XIAO Baojun
Objective To explore the application value of American College of Radiology (ACR) thyroid imaging reporting and data system (TI-RADS) in diagnosising of thyroid nodules. Methods A total of 110 patients with thyroid nodules (118 nodules) who received ultrasound examination and obtained pathological results in the Department of Ultrasound, Daxing Teaching Hospital of Capital Medical University from January to December 2019 were selected as the research objects. Two-dimensional ultrasonographic characteristics of 118 nodules were observed, according to ACR TI-RADS classification criteria, the ACR TI-RADS classification was counted and the receiver operating characteristic (ROC) curve was drawn to observe its diagnostic value for nodules ≥1 cm and < 1 cm. Results Of the 118 nodules, 73 were benign and 45 were malignant. All (100%) of 45 malignant nodules were solid; 43 nodules showed low echo or very low echo, and only 2 nodules showed isechoic; 31 (68.9%) nodules showed aspect ratio > 1; 30 nodules had irregular margins, and 3 nodules had extrinsic thyroid invasion; 22 nodules with punctal calcification and 3 nodules with extensive calcification. Among 118 thyroid nodules, 26 nodules were TI-RADS 2; 7 nodules was TI-RADS 3; 32 nodules was TI-RADS 4; 53 nodules was TI-RADS 5. The critical value of ACR TI-RADS for benign and malignant nodules ≥1 cm was 6.5 points, the area under the curve was 0.935, and the sensitivity and specificity were 88.9% and 87.0%; The critical value of ACR TI-RADS classification for benign and malignant nodules < 1 cm was 6.5 points, the area under the curve was 0.725, and the sensitivity and specificity were 92.6% and 40.7%. Conclusion ACR TI-RADS classification has high accuracy in benign and malignant diagnosis of ≥1 cm thyroid nodule, and medium accuracy in diagnosis of < 1 cm thyroid nodule, which should be referred to in clinical decision making.
2022 Vol. 19 (16): 151-154 [Abstract] ( 25 ) HTML (1 KB)  PDF (1026 KB)  ( 33 )
156 Comparative study on mathematical models of ultrasonic two-dimensional grayscale image identification of benign and malignant thyroid nodules
SUI Xin1 XIE Peng2 LIU Zongjie1 ZHAO Ying1 CHEN Simei1 ZHAO Bingxin1 LIU Jia1 ZHANG Yi3▲
Objective To establish and compare various mathematical models of ultrasonic two-dimensional grayscale image of benign and malignant thyroid nodules. Methods A total of 504 patients diagnosed with thyroid nodule in the Third Hospital of Hebei Medical University from June 2015 to June 2021 were collected. A total of 546 thyroid nodule samples were cut for pathological examination, including 415 benign nodules and 131 malignant nodules. According to the gray value of two-dimensional ultrasonic image of thyroid nodule, the significant characteristics of differentiating benign and malignant thyroid nodules were found; a variety of classifiers were established by mathematical model, and the best mathematical classification model was found by comparing the accuracy and coverage of different classifiers. Results Using significant features of benign and malignant nodules build Fisher classification, regression classification, Bayesian classification, and Libsvm classification. Libsvm classification of benign and malignant thyroid nodules has the best accuracy and coverage, and the accuracy of benign thyroid nodules was 93.8%, coverage was 78.9%; and  the accuracy of malignant thyroid nodules was  81.8%, coverage was 94.7%. Conclusion Libsvm classifier can quickly and accurately determine the benign and malignant thyroid nodules, and further promote the clinical diagnosis and treatment of thyroid nodules. 
2022 Vol. 19 (16): 156-160 [Abstract] ( 22 ) HTML (1 KB)  PDF (1290 KB)  ( 121 )
161 Effects of Buspirone in the treatment of negative symptoms of schizophrenia and its influence on cognitive function
SONG Gaofeng ZHANG Chengzhen JI Xiangli
Objective To explore the effect of Buspirone on the treatment of negative symptoms of schizophrenia and its influence on cognitive function. Methods A total of 82 patients with negative symptoms of schizophrenia admitted to the Suzhou City Second People’s Hospital from February 2020 to February 2021 were selected. They were divided into control group and study group according to the random number table method. The control group was treated with low-dose Amisulpride, and the study group was treated with low-dose Amisulpride combined with Buspirone. Two groups of patients’ positive and negative symptom scale (PANSS) score, extrapyramidal side effects scale (RSESE) score, clinical efficacy, cognitive function (MMSE) score, serum prolactin (PRL), testosterone (T) levels, and adverse reactions were compared. Results After treatment, PANSS scores in both groups were lower than those before treatment, and the study group was lower than the control group (P ＜ 0.05); RSESE scores of the two groups were higher than before treatment, and the study group was higher than the control group (P ＜ 0.05); the clinical efficacy of the study group was better than that of the control group (P ＜ 0.05); MMSE scores of the two groups were higher than those before treatment, and the study group was higher than the control group (P ＜ 0.05); serum PRL and T levels in both groups were higher than those before treatment (P ＜ 0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Buspirone can improve clinical symptoms and cognitive function in patients with negative symptoms of schizophrenia, and is safe and reliable.
2022 Vol. 19 (16): 161-164 [Abstract] ( 23 ) HTML (1 KB)  PDF (524 KB)  ( 164 )
165 Effects of different positive psychological interventions on improving depression in cancer survivors：net meta-analysis
YE Jinchan1 ZHU Wei2 KONG Weilei3 MA Jing1 SU Jianping1

Objective To explore the effect of nine kinds of positive psychological intervention on improving depression in cancer survivors. Methods Randomized controlled trials (RCTs) of positive psychological intervention to improve depression were collected from PubMed, Web of Science, CNKI and Wanfang database during January 2000 to May 2021. After two reviewers independently screened the literature, extracted the data and evaluated the risk of bias in the included studies, a net meta-analysis was performed using Stata 14.2. Results A total of 28 RCTs were included, the results of mesh meta-analysis showed that: compared with the control group, gratitude intervention (MD = -1.25, 95%CI [-3.08, -0.58], P < 0.001) had the best effect on depression in cancer survivors, followed by acceptance and commitment therapy [MD = -2.19, 95%CI (-4.24, -0.15), P = 0.002], mindfulness based cognitive therapy [MD = -2.13, 95%CI (-3.19, -0.57), P = 0.021], positive psychological therapy [MD = -1.24, 95%CI (-4.24, -1.76), P = 0.022], life review [MD = -1.77, 95%CI (-3.09, -0.44), P = 0.019], mindfulness based stress reduction [MD = -1.87, 95%CI (-3.26, -0.48), P = 0.026], reminiscence therapy [MD = -0.42, 95%CI (-1.09, -0.25), P = 0.047) compared with the control group, hope therapy [MD = -1.09, 95%CI (-4.84, 2.66), P = 0.215], meaning making intervention [MD = -0.00, 95%CI (-3.64, 2.44), P = 0.608] and there was no significant difference compared with the control group; the order of surface under the cumulative ranking for different interventions were gratitude intervention (73.3%) ＞ acceptance and commitment therapy (66.8%) ＞ life review (62.4%) ＞ mindfulness based cognitive therapy (59.6%) ＞ positive psychological therapy (53.7%) ＞ mindfulness based stress reduction (52.0%) ＞ hope therapy (46.1%) ＞ meaning making intervention (37.7%) ＞ reminiscence therapy (33.6%) ＞ routine psychological nursing (14.8%). Gratitude intervention was the best in improving depression in cancer survivors in the short term. Conclusion The evidence suggests that gratitude intervention, mindfulness based stress reduction, cognitive therapy with mindfulness, acceptance commitment therapy and positive psychotherapy may be the best therapy to improve the depression of cancer survivors, which has the value of promotion. Meaning therapy, life review, recall therapy and hope therapy may be more suitable for palliative care patients. Appropriatepsychological intervention should be selected according to the patient’s condition.
2022 Vol. 19 (16): 165-169 [Abstract] ( 36 ) HTML (1 KB)  PDF (1132 KB)  ( 61 )
170 Effect of mind mapping health education on rehabilitation training of patients after thoracoscopic pulmonary nodule resection
CHENG Dongping1 WU Xuehua2
Objective To explore the effects of mind mapping health education on rehabilitation self-efficacy and pulmonary function recovery of patients undergoing thoracoscopic pulmonary nodule resection. Methods A total of 95 patients with thoracoscopic pulmonary nodule resection treated in the Department of Thoracic Surgery of Huangshan People’s Hospital from March 2019 to June 2021 were selected as the study subjects, according to medical records, 48 cases were randomly divided into observation group and 47 cases were randomly divided into control group. The control group was given routine lung rehabilitation training health education, and the observation group was combined with mind mapping health education. One month after operation, the rehabilitation self-efficacy, pulmonary function and complications were compared between the two groups. Results One month after surgery, the scores of information acquisition and application, symptom self-management, rehabilitation training and skill training, coping with treatment side effects, daily life management, emotion management, and rehabilitation self-efficacy total score in the two groups were higher than those in the same group before operation, and the information acquisition and application, symptom self-management, rehabilitation training and skill training, treatment side effects, and rehabilitation self-efficacy scores of observation group were higher than the control group, the differences were statistically significant (P ＜ 0.05). Vital capacity, forced expiratory volume in the first second, forced vital capacity, and maximum chase air volume in the two groups were lower than those before operation, and observation group were higher than control group, and the differences were statistically significant (P < 0.05). The complication rate in the observation group was 6.25%, lower than 21.28% in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Mind mapping health education is helpful to improve the level of rehabilitation self-efficacy of patients undergoing thoracoscopic pulmonary nodule resection, promote the recovery of postoperative pulmonary function and reduce the incidence of complications.
2022 Vol. 19 (16): 170-174 [Abstract] ( 64 ) HTML (1 KB)  PDF (1396 KB)  ( 32 )
175 Clinical study of children with Kawasaki disease using a nursing program based on thromboelastogram
DUAN Suxian SU Meiyan FENG Dongling ZHANG Yingqian▲
Objective To explore the improvement effect of nursing program based on thromboelastogram on children with Kawasaki disease. Methods A total of 57 children with Kawasaki disease treated in Hebei Children’s Hospital (hereinafter referred to as “our hospital”) from January to December 2018 were selected as the control group, and routine care was taken. A total of 57 children with Kawasaki disease admitted to our hospital from January to December 2019 were selected as the observation group, and on the basis of the control group, combined with thromboelastogram to guide nursing. The length of stay, hospitalization cost, parents’ nursing satisfaction and incidence of adverse reactions were compared and analyzed between the two groups. Results The length of stay and hospitalization cost in the observation group were lower than those in the control group, and nursing satisfaction was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P ＞ 0.05). There were no significant differences in platelet inhibition rates of adenosine diphosphate and arachidonic acid pathways between the two groups (P ＞ 0.05). Conclusion The application of the nursing program based on thrombus elastic diagram in the clinical treatment of children with Kawasaki disease can effectively improve the nursing satisfaction of the children’s family members and reduce the family medical burden of children, which is worth promoting in the clinical care.
2022 Vol. 19 (16): 175-178 [Abstract] ( 57 ) HTML (1 KB)  PDF (700 KB)  ( 77 )
179 Qualitative meta-integration of dying patients’ and their families’ perceptions of dying with dignity
FU Dou1 OUYANG Yanqiong1 ZHANG Lili2 ZHANG Qing1 HU Quan1 LIU Xiaoqian1 LI Mengjuan1
Objective To integrate the results of qualitative research on the concept of death of dignity in patients and their families. Methods Chinese databases including CNKI, Wanfang, VIP, and CBM Database, while English databases included PubMed, EMbase, CochraneLibrary, CINAHL, Web of Science, and PsycINFO were searched, qualitative studies on end-of-life patients’ and their families’ perceptions of death with dignity were searched from database construction to April 2021. The literatures were evaluated using JBI evidence-based health care center quality evaluation criteria, and the results were integrated using an aggregative integration method. Results Five results were extracted: self-realization, no burden, value embodiment, multi-care and spiritual strength. Conclusion Maintaining the dignity of patients at the end of life is the core of improving the quality of death, dignified death needs to fully respect personal will, cultural sensitivity and family-oriented intervention methods on the basis of symptom control and comfort care.
2022 Vol. 19 (16): 179-182 [Abstract] ( 25 ) HTML (1 KB)  PDF (1391 KB)  ( 216 )
183 Application effect of rapid rehabilitation surgical nursing in patients with hypertensive cerebral hemorrhage treated by minimally invasive intracranial hematoma puncture and drainage
JIANG Xia ZHOU Lifeng DUAN Lina ZENG Xiaolu
Objective To explore the intervention effect of fast rehabilitation surgical nursing after minimally invasive surgery in patients with hypertensive cerebral hemorrhage. Methods A total of 110 patients with hypertensive cerebral hemorrhage treated by minimally invasive intracranial hematoma puncture and drainage who were admitted to the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine from January 2020 to June 2021 were divided into observation group (55 cases) and control group (55 cases) by random number table method. The control group received routine nursing, while the observation group received rapid rehabilitation surgical nursing. The self-care ability, clinical efficacy, nursing satisfaction rate, complication rate, daily activity ability, and disturbance of consciousness were compared between the two groups. Results After the intervention, the scores of self-concept, self-care responsibility, self-care function, and health knowledge in the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After intervention, the total efficacy rate of the nursing observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The nursing satisfaction rate in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The scores of the modified Barthel index and Glasgow coma scale in the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Rapid rehabilitation surgical nursing is applied to patients with hypertensive cerebral hemorrhage treated by minimally invasive intracranial hematoma puncture and drainage, which is worthy of clinical promotion.
2022 Vol. 19 (16): 183-186 [Abstract] ( 27 ) HTML (1 KB)  PDF (621 KB)  ( 108 )
187 Effect of diet management guidance combined with isometric resistance exercise in patients with gestational diabetes mellitus
QIAO Juan WANG Yonghong ZENG Xiaochun CHEN Chengxing YAO Yahui▲
Objective To explore the effect of dietary management guidance combined with isometric resistance exercise in patients with gestational diabetes mellitus (GDM). Methods A total of 100 patients with GDM who were treated in Chenzhou First People’s Hospital from July 2019 to July 2021 were selected. The experiment was blinded and they were divided into control group (50 cases) and observation group (50 cases) according to lottery. The control group received routine intervention + diet management guidance, while the observation group received routine intervention + diet management guidance + isometric resistance exercise training. Before the intervention and two months after the intervention, blood glucose indexes, pregnancy outcomes, and neonatal outcomes were compared between the two groups. Results Two months after the intervention, the glycosylated hemoglobin, fasting blood glucose, and 2 h postprandial blood glucose in the two groups were lower than those before the intervention, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The incidence of adverse neonatal outcomes in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Diet management guidance combined with isometric resistance exercise for GDM patients can effectively control blood sugar, improve pregnancy outcomes and neonatal outcomes.
2022 Vol. 19 (16): 187-190 [Abstract] ( 36 ) HTML (1 KB)  PDF (538 KB)  ( 95 )
191 Evaluation of the effect of applying the theory of Ziwu Liuzhu theory applied to wax in nursing patients with cold-damp lumbar disc herniation
LIANG Xue ZHANG Hongyan ZHANG Aojun
Objective To explore the nursing effect of Ziwu Liuzhu theory applied to wax in cold-damp lumbar disc herniation (LDH). Methods A total of 200 patients with cold-damp LDH who were treated in the Department of Acupuncture and Moxibustion, Bozhou Hospital of Traditional Chinese Medicine from January 2019 to June 2021 were selected, and the patients were divided into control group (100 cases) and experimental group (100 cases) by random number table method. The control group was given routine nursing measures, while the experimental group was given Meridian Liuzhu wax therapy on the basis of the control group, once a day, 10 d as a course of treatment, a total of one courses of treatment. Results After nursing, the scores of flexion-extension activity, lateral flexion activity, and rotation activity in the two groups were higher than those before nursing, while those of the treatment group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After nursing, the physiological function, health status, pain intensity, self-care ability, and social function of the two groups were higher than those before nursing, while except for pain intensity, the quality of life scores in the treatment group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of the theory of Ziwu Liuzhu to wax therapy in nursing patients with cold-damp LDH can effectively improve the pain intensity of the body and improve the quality of life, which is of great significance for patients to promote recovery and ensure the curative effect.
2022 Vol. 19 (16): 191-193,封三 [Abstract] ( 24 ) HTML (1 KB)  PDF (630 KB)  ( 38 )
194 Application of intentional relaxation training in patients with patient-controlled intravenous analgesia pump after thoracoscopic lobectomy
NI Qiong FENG Xiaolan▲
Objective To investigate the application value of intentional relaxation training in patients with patient-controlled intravenous analgesia (PCIA) after thoracoscopic lobectomy. Methods According to the random number table method, a total of 100 patients with PCIA after thoracoscopic lobectomy who were admitted to Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from February 2020 to March 2021 were divided into two groups, with 50 cases in each group. The control group received routine nursing, while the observation group received routine nursing plus intentional relaxation training. The sedation (Ramsay score) and analgesia (visual analog scale [VAS] score) were compared between the two groups at 12, 24, and 48 h after operation. The anxiety level (self-rating anxiety scale [SAS] score) was evaluated before and 48 h after operation in the two groups, while nursing satisfaction was compared between the two groups 48 h after operation. Results There were statistically significant differences in VAS, Ramsay score time, between groups, and interaction between the two groups (P ＜ 0.05). Among them, within the group comparison, the VAS and Ramasy scores of the two groups at 24 and 48 h after operation were lower than those at 12 h after operation, and the scores 48 h after operation were lower than those at 24 h after operation, and the differences were statistically significant (P ＜ 0.05); compared between groups, the VAS and Ramasy scores of the observation group at 24 and 48 h after operation were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The SAS score at 48 h after operation in the two groups was lower than that at two hours before operation, while the observation group was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The total nursing satisfaction of the observation group was higher than that of the control group at 48 h after operation, and the difference was statistically significant (P ＜ 0.05). Conclusion Intentional relaxation training can enhance the sedative and analgesic effect of PCIA patients after thoracoscopic lobectomy, improve patients’ nursing satisfaction, and improve anxiety.
2022 Vol. 19 (16): 194-封三 [Abstract] ( 28 ) HTML (1 KB)  PDF (570 KB)  ( 24 )
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