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| Effect of folic acid on ischemic stroke complicated with H-type hypertension |
| ZHAO Wenjun1 HAO Weihua1 LIN Wenjing1 SHI Yinhua2 LI Qing1 ZHAO Huiying1 ZHANG Jianping1 |
1.Department of Geriatrics, Shijiazhuang People’s Hospital, Hebei Province, Shijiazhuang 050000, China;
2.Department of Cardiac Surgery, Shijiazhuang People’s Hospital, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To investigate the effect of folic acid on ischemic stroke patients with H-type hypertension. Methods A total of 200 patients with ischemic stroke complicated with H-type hypertension admitted to Shijiazhuang People’s Hospital from December 2018 to December 2019 were selected, and they were divided into treatment group and routine group according to random number method, with 100 cases in each group. The routine group was given anti-platelet drugs, statins, anti-hypertensive drugs, improving cerebral circulation, and other basic treatments, and the treatment group was given folic acid orally on the basis of the routine group. The course of treatment in both groups was six months. The levels of homocysteine (Hcy), matrix metalloproteinase-9 (MMP-9), and Montreal cognitive assessment (MoCA) scale score were compared between the two groups before and after treatment. The correlation between MoCA score and Hcy, MMP-9 level was analyzed. Results After treatment, the levels of Hcy and MMP-9 in the treatment group were lower than those before treatment, and those in the treatment group were lower than those in the routine group, the differences were statistically significant (P ＜ 0.05). After treatment, the MoCA scores of both groups were higher than those of before treatment, and the MoCA score of the treatment group was higher than that of the routine group, the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that Hcy and MMP-9 levels were negatively correlated with MoCA score (r ＜ 0, P ＜ 0.05). Conclusion Folic acid treatment can reduce Hcy and MMP-9 levels and improve MoCA score in patients with ischemic stroke complicated with H-type hypertension, which is worthy of further clinical promotion.
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