抑郁症患者肠道菌群与血清炎症因子和临床症状的相关性分析

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Abstract Objective To explore the correlation analysis of intestinal flora with serum inflammatory factors and clinical symptoms in patients with depression. Methods A total of 154 patients with first-episode depression treated in the First Hospital of Shanxi Medical University from July 2020 to December 2020 were selected as the study group, and 154 healthy subjects were randomly selected as the control group according to the ratio of 1∶1. The intestinal flora of the two groups was measured by 16S ribosomal RNA (16S rRNA), and the levels of serum tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 were measured by enzyme-linked immunosorbent assay, and the level of IL-6 was evaluated by Hamilton depression scale (HAMD-17). The level of inflammatory factors and the expression of intestinal flora were observed between the two groups. Results The TNF-α, IL-1β, and IL-6 in the study group were higher than that in the control group (P ＜ 0.05). A total of 154 patients in the study group were divided into mild (67 cases), moderate (51 cases) and severe (36 cases) according to HAMD-17. The levels of TNF-α, IL-1β, and IL-6 in patients with severe depression were significantly higher than those in patients with mild and moderate depression, the levels of TNF-α, IL-1β, and IL-6 in patients with moderate depression were significantly higher than those in patients with mild depression (P ＜ 0.05). Shannon index in the study group was significantly higher than that in the control group (P ＜ 0.05). The abundance of Firmicutes in the study group was lower than that in the control group (P ＜ 0.05), and the abundance of Bacteroidetes, Proteus, and Dendrobacteria in the study group were higher than those in the control group (P ＜ 0.05); the abundance of Bacteroides, Prevotella, Another Mycobacterium, Faecalis and Koalas in the study group were lower than those in the control group (P ＜ 0.05), and the abundance of Spirillum, Parabacterium, Brautherella and Macromonas in the study group were higher than those in the control group (P ＜ 0.05). There were negative correlation between Bacteroides (r = -0.418, -0.375, -0.464, -0.382), Faecalis (r = -0.492, -0.528, -0.367, -0.412), Koalas (r = -0.382, -0.403, -0.396, -0.349) and TNF-α, IL-1β, IL-6 and depression degree(P ＜ 0.05). Conclusion Intestinal flora is related to inflammatory factors and the severity of depression. Further discussion on the relationship between intestinal flora and inflammation and depression can provide new ideas for the prevention and treatment.

Key words： Depression Intestinal flora Inflammatory factors Degree of depression

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	Hasichaolu LI Xin LU Hong LI Ke

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Hasichaolu LI Xin LU Hong LI Ke. Correlation analysis of intestinal flora with serum inflammatory factors and clinical symptoms in patients with depression[J]. 中国医药导报, 2022, 19(16): 93-97.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I16/93

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