Exendin-4对胰岛β细胞的作用及相关机制的研究进展

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Abstract Exendin-4 is a short incretin polypeptide, belonging to a long-acting agonist of glucagon-like peptide-1 (GLP-1) receptor. In recent years, it has been found that Exendin-4 can act on islet β cells in various ways and play a role in the treatment of diabetes. On the one hand, Exendin-4 regulates insulin secretion by specifically binding to GLP-1 receptors on islet β cells. On the other hand, Exendin-4 can also promote the proliferation of islet β cells, regulate autophagy and inhibit apoptosis, and protect islet function. This paper reviews the recent studies on the effects of Exendin-4 on islet β cells and related molecular mechanisms, in order to promote the further application of Exendin-4 in the treatment of diabetes mellitus.

Key words： Exendin-4 Glucagon-like peptide-1 Diabetes mellitus Islet &beta cell

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	LIU Chen

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LIU Chen. Research progress on the effect of Exendin-4 on islet β cells and related mechanisms[J]. 中国医药导报, 2022, 19(16): 50-52,66.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I16/50

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