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| Effect of Dexmedetomidine combined with Atropine on perioperative period of pediatric strabismus correction surgery |
| WU Hao SU Xiaohu DAI Lingyun TIAN Yufeng |
| Department of Anesthesiology, Suqian First People’s Hospital Affiliated to Nanjing Medical University, Jiangsu Province, Suqian 223800, China |
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Abstract Objective To investigate the effect of Dexmedetomidine combined with Atropine on perioperative period of pediatric strabismus correction surgery. Methods A total of 120 children with strabismus correction surgery under general anesthesia were enrolled in Suqian First People’s Hospital Affiliated to Nanjing Medical University from August 2018 to August 2021. According to the random number table method, they were divided into group A, B, C, and D, with 30 cases in each group. Group A was given normal saline 2 ml after conventional anesthesia induction; group B was given Dexmedetomidine 1 μg/kg nasal drops after admission to the operating room, routine anesthesia induction, and maintenance; group C received Atropine 0.01 mg/kg intravenously after conventional anesthesia induction; group D was given Dexmedetomidine 1 μg/kg nasal drip after admission to the operating room, and Atropine 0.01 mg/kg intravenous after induction of anesthesia. The incidence of postoperative nausea and vomiting, abdominal pain, ocular and cardiac reflexes, and the changes of gastroenteroencephalogram (main frequency, average frequency, and average amplitude) were observed. Results There were statistically significant differences in the incidence of nausea and vomiting, abdominal pain, and ocardial reflex among four groups (P < 0.05); the incidence of nausea and vomiting and abdominal pain in group D was lower than that in group A (P < 0.008). During operation, the main frequency, average frequency, and average amplitude of four groups were higher than those before operation (P < 0.05); the main frequency, average frequency, and average amplitude of groups C and D were lower than those of groups A and B (P < 0.05). Conclusion Dexmedetomidine nasal drop and Atropine intravenous can effectively improve the occurrence of adverse reactions related to strabismus correction surgery, which can be used safely and effectively in pediatric strabismus correction surgey.
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