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2022 Vol. 19, No. 14 Published: 2022-05-15

	5	Bibliometric analysis of the research of liver cancer stem cell based on CiteSpace and VOSviewer#br#
		ZHANG Zhichun1 SUN Lichao2 SUN Qiuyue1 TIAN Gu3
		Objective To explore the research hotspots and research trends in the field of liver cancer stem cells (LCSCs) in the past 10 years through the bibliometric analysis of LCSCs. Methods The annual distribution of articles published, countries, institutions, authors, journals, cited situation, and keywords of articles published from 2011 to 2020 were performed visual analysis through CiteSpace and VOSviewer based on the Web of Science core database. Results From 2011 to 2020, the number of LCSCs-related articles published was 1000, and the number of LCSCs-related articles published showed an overall increasing trend. The top five countries in the number of published articles were China, United States, Japan, South Korea, and Italy. The top five research institutions in the number of published articles were Second Military Medical University, Sun Yat-sen University, Fudan University, University of Hong Kong, and Shanghai Jiao Tong University. The top five authors in the number of published articles were Stephanie Ma, Taro Yamashita, Jia Fan, Hongyang Wang, and Shuichi Kaneko. The top five publications in the number of published articles were Oncotarget, Hepatology, Cancer Letters, PLoS One, and Scientific Reports. In the cited literatures, Taro, etc. 2009 published “EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features” was cited the most frequently; studies on dry markers identified by LCSCs, studies on transcription factors, long non-coding RNA, microRNAs, oncogenes, signaling pathways that regulate LCSCs and other sides were the research hotspots in the field of LCSCs; LCSCs stem research-targeted LCSCs therapy research-LCSCs biological mechanism research was the research trend of LCSCs, the research on inhibitors targeting LCSCs was the focus of LCSCs research. Conclusion The research of genes and signal pathways regulating LCSCs is a research hotspot in the field of LCSCs, and the research of drugs targeted LCSCs is a key research direction in the field of LCSCs.
		2022 Vol. 19 (14): 5-9,18 [Abstract] ( 58 ) HTML (1 KB) PDF (1869 KB) ( 98 )

	10	Analysis on the selection rules of acupuncture points for improving endometrial receptivity in recent ten years based on data mining#br#
		WANG Yanhui1 ZHOU Yan1 WEI Aiwu2
		Objective To analyze the selection rules of acupuncture points for improving endometrial receptivity in recent ten years by data mining technology. Methods Relevant literatures on acupuncture improving endometrial receptivity in CNKI, Wangfang Data, VIP, CBM, PubMed from January 2011 to September 2021 were searched. The acupoint database was established. Descriptive analysis, association rule analysis, and cluster analysis were used by software. Results A total of 82 literatures were included, 82 acupoint prescriptions were obtained, involving 55 acupoints. The most frequently used acupoints were guānyuán, sānyīnjiāo, and zǐgōng. Acupoints were mostly focused on conception channel and distributed in the abdomen and lower limbs. Crossing points were mostly used in specific acupoints. The results of association rule analysis show that “guānyuán-zǐgōng” and “guānyuán- sānyīnjiāo” have the highest support, three clusters were obtained by cluster analysis. Conclusion Acupuncture can improve the receptivity of endometrium mainly by combining far-far points, specimen points, and points based on syndrome differentiation, special points, especially crossing points, should be emphasized.
		2022 Vol. 19 (14): 10-13 [Abstract] ( 52 ) HTML (1 KB) PDF (1093 KB) ( 100 )

	14	Analysis of hotspots and frontiers of traditional Chinese medicine treatment of liver cirrhosis based on CiteSpace#br# #br#
		ZHANG Yingxue SUN Fengxia LI Xiaoling GUO Yufei
		Objective To make a visual analysis of the literatures related to the treatment of liver cirrhosis with traditional Chinese medicine by CiteSpace software, and to explore the research status and hotspots in this field. Methods The literatures related to the traditional Chinese medicine treatment of liver cirrhosis collected in CKNI from January 2011 to December 2020 were searched, and the cooperation network of authors and institutions, keywords co-occurrence, clustering, and emergent words were analyzed by CiteSpace 5.6.R5. Results A total of 2550 literatures were included. Generally speaking, the annual number of articles published developed steadily. The author cooperation network represented by Wang Tianfang, Xue Xiaolin,Wu Xiuyan, Li Xin, Li Yonggang was large, etc. and the main research institutions were concentrated in traditional Chinese medicine universities and affiliated hospitals, forming multi-cooperation centers. The high-frequency key words included liver cirrhosis, ascites of liver cirrhosis, traditional Chinese medicine, liver cirrhosis in hepatitis B, integration of traditional and western medicine treatment, etc. The research hotspots on the treatment of liver cirrhosis by traditional Chinese medicine gradually transitions to data mining, meta-analysis, traditional Chinese medicine nursing, acupoint application, traditional Chinese medicine umbilical application, traditional Chinese medicine constitution, intestinal flora, etc. Conclusion More attention has been paid to the treatment of liver cirrhosis with traditional Chinese medicine, and the cooperation between different teams needs to be strengthened. The research methods of traditional Chinese medicine in the treatment of liver cirrhosis are more diversified and the treatment methods are more and more comprehensive.
		2022 Vol. 19 (14): 14-18 [Abstract] ( 82 ) HTML (1 KB) PDF (2131 KB) ( 111 )

	19	Expression and clinical significance of TRIM59 and PPM1B in nasopharyngeal carcinoma tissues#br#
		LIU Xu ZHOU Qiang PU Gaoxiang LIU Xiaomei
		Objective To study the expression and clinical significance of tripartite motif-containing 59 (TRIM59) and protein phosphatase 1B (PPM1B) in nasopharyngeal carcinoma (NPC) tissues. Methods A total of 97 NPC patients diagnosed and treated in Suining Central Hospital of Sichuan Province from February 2014 to February 2018 were collected, the expressions of TRIM59 and PPM1B in cancer tissues and adjacent tissues of NPC patients were detected by immunohistochemistry, and the relationship between them and clinical features were analyzed. The effects of TRIM59 and PPM1B on the prognosis of NPC patients were used to Kaplan-Meier survival curve. Results Compared with adjacent tissues, the positive rate of TRIM59 expression in cancer tissues was higher（P < 0.05), while the positive rate of PPM1B expression was lower(P < 0.05). The expression of TRIM59 and PPM1B was negatively correlated (r = -0.524, P ＜ 0.01). The positive expression rate of TRIM59 and the negative expression rate of PPM1B in NPC patients with stage Ⅲ-Ⅳ, lymph node metastasis were higher than those in NPC patients with stage Ⅰ-Ⅱ, without lymph node metastasis (P < 0.05). The 3-year survival rate of TRIM59 positive expression was lower than that of TRIM59 negative expression (P < 0.05); the 3-year survival rate of PPM1B positive expression was higher than that of PPM1B positive expression (P < 0.05). Conclusion The expression of TRIM59 in NPC is up-regulated, while the expression of PPM1B is down-regulated. Both expressions are related to tumor TNM staging and lymph node metastasis, and have certain clinical significance in prognosis evaluation of nasopharyngeal carcinoma.
		2022 Vol. 19 (14): 19-22 [Abstract] ( 51 ) HTML (1 KB) PDF (959 KB) ( 78 )

	23	Knowledge graph analysis of chronic disease health management research in recent ten years
		LU Dandan GUO Xiaolan WANG Pingli YAO Jie LIU Fang
		Objective To summarize the research status of chronic disease health management in China in recent ten years by using knowledge graph, and analyze the relevant hot spots and trends, providing reference for future research. Methods Literatures related to chronic disease health management published by China National Knowledge Infrastructure, Wanfang and VIP databases from January 1, 2010 to September 30, 2021 were searched, and CiteSpace software was used to analyze the authors, institutions and keywords of literatures. Results A total of 7021 articles were included, and the number of articles published gradually increased in the past decade. The highest number of articles published was 882 papers (12.56%) in 2019. There were many related researchers and institutions, but there were not many high-yielding authors. There were 14 authors whose publications were ≥10 papers. There were 22 research institutions with publications were≥3 papers. High blood pressure was the most studied disease, with older adults being the primary study subjects, research hotspots such as the combination of physical and medical treatment had emerged since 2019. Conclusion Research on chronic health management has not yet formed a strong and productive author collaboration network. In the future, all institutions should strengthen cooperation, actively explore effective management methods of chronic diseases, and promote the rapid development of chronic disease health management research.
		2022 Vol. 19 (14): 23-27,47 [Abstract] ( 50 ) HTML (1 KB) PDF (3039 KB) ( 50 )

	28	Analysis of failure factors of vaginal delivery in women with re-pregnancy with scar uterus
		LI Yi JIN Xinglin JIANG Yufen
		Objective To analyze the failure factors of vaginal delivery in women with re-pregnancy with scar uterus. Methods The clinical data of 246 pregnant women with a history of cesarean scar uterus who gave birth in Huaibei Maternal and Child Health Hospital of Anhui Province from December 2018 to April 2021 were retrospectively analyzed. The results of trial production through vaginal delivery were counted and divided into a successful trial production group (198 cases) and a trial production failure group (48 cases). The clinical data of puerperae of the two groups were compared, the influencing factors of the failure of vaginal delivery in women with re-pregnancy with scar uterus were explored, and the predictive value of the failure of trial of vaginal delivery in women with re-pregnancy with scar uterus was evaluated. Results In this study, the failure rate of vaginal delivery in women with re-pregnancy with scar uterus was 19.51%. Body mass index (BMI) before labor and the proportions of pregnancy complications in the failed trial production group were higher than those in the successful trial production group, and the differences were statistically significant (P ＜ 0.05). The thickness of the lower uterine segment myometrium and the Bishop score of the cervix before labor in the failed trial production group were lower than those in the successful trial production group, and the differences were statistically significant (P ＜ 0.05). The results of logistic regression analysis showed that BMI before labor, thickness of lower uterine segment myometrium, and Bishop score of cervix before labor were the related factors affecting the failure of vaginal delivery in women with re-pregnancy with scar uterus (OR = 3.688, 2.878, 3.983, P ＜ 0.05). ROC curve analysis showed that the best cut-off points of pre-partum BMI, lower uterine segment myometrial thickness and Bishop score of the cervix before labur for predicting the failure of vaginal delivery in women with re-pregnancy with scar uterus were 27.85 kg/m2, 2.21 mm, and 6.92 points, respectively; whie the AUCs were 0.619, 0.733, and 0.777, respectively. Conclusion Pre-labor BMI, lower uterine segment myometrial thickness and pre-labor cervix Bishop score can be used as important reference indicators for predicting the failure of vaginal delivery in these patients.
		2022 Vol. 19 (14): 28-31 [Abstract] ( 81 ) HTML (1 KB) PDF (670 KB) ( 36 )

	32	Research progress of traditional Chinese medicine intervention in colorectal cancer based on Wnt/β-catenin signaling pathway
		YANG Binbin1 CUI Ning1 ZHANG Yanan2 ZHAO Wenxiao3 WANG Shijun2
		Colorectal cancer is an important public health problem all over the world, Wnt classical signaling pathway participates in the occurrence and development of colorectal cancer by affecting life activities such as cell growth, proliferation, and differentiation. Its abnormal activation can lead to the proliferation, invasion and metastasis of tumor cells, β-catenin has become an important target for the treatment of colorectal cancer. Traditional Chinese medicine believes that colorectal cancer belongs to the category of “intestinal qin”, “intestinal addiction”, “accumulation”. The treatment is mainly to strengthen the spleen and soft and firm, clear away heat and dampness, regulate qi and activate blood circulation. It has achieved good effect in the prevention and treatment of colorectal cancer. Many studies have found that traditional Chinese medicine monomer or compound play an anti-tumor role by inhibiting the activation of Wnt pathway. This paper reviews the relevant research results of traditional Chinese medicine in the treatment of colorectal cancer through targeted intervention of Wnt/β-catenin signaling pathway, in order to promote the research on the clinical anticancer mechanism of traditional Chinese medicine, and make more rational use of traditional Chinese medicine in clinic.
		2022 Vol. 19 (14): 32-35 [Abstract] ( 113 ) HTML (1 KB) PDF (530 KB) ( 564 )

	36	Research progress of acupuncture in the treatment of myocardial ischemia reperfusion injury
		TANG Qiang1 WANG Yanxia2 LI Yuting2 YIN Xia2 MA Xiyuan2 LI Hongyu1
		Myocardial ischemia reperfusion injury (MIRI) is a type of myocardial injury in patients with ischemic heart disease after coronary intervention or thrombolytic therapy, which aggravates further and presents more severe clinical symptoms than before reperfusion. Studies have shown that acupuncture and moxibustion of traditional Chinese medicine can protect damaged myocardial cells through multiple channels, multiple ways, and multiple targets to reduce myocardial reperfusion injury, with precise effect and practical value. Acupuncture is involved in regulating apoptosis, oxidative stress, calcium overload, inflammatory response, and mitochondrial structural dysfunction. Treatment prescription is associated with the etiology of MIRI and the mechanism of acupuncture. Moxibustion mainly stimulates the corresponding acupoints through its warming and tonifying effect to protect the heart. This paper analyzes the mechanism and treatment plan of traditional Chinese medicine acupuncture and moxibustion in treating MIRI, hoping to provide theoretical basis for clinical treatment of MIRI.
		2022 Vol. 19 (14): 36-39 [Abstract] ( 115 ) HTML (1 KB) PDF (590 KB) ( 142 )

	40	Systematic review of the progress of tumor heat diagnosis
		PENG Jianqiao Matthew1 HE Jian2▲ GUO Zhihua3▲
		Through consulting the latest literatures on tumor heat diagnosis, the ideas and methods of tumor heat diagnosis are summarized, sorted out and summarized. The diagnosis of tumor can be realized by infrared thermal imaging, microwave radiation temperature measurement, ultrasonic temperature measurement, magnetic resonance thermal imaging, and other industrial technologies. Through the historical review of the development process of heat diagnosis, this paper clarified the internal law of tumor heat diagnosis, thoroughly understood the principles and methods of heat diagnosis in the past, and provided reference for future innovative ideas.
		2022 Vol. 19 (14): 40-42 [Abstract] ( 45 ) HTML (1 KB) PDF (706 KB) ( 32 )

	43	Analysis of the mental health status and its influencing factors of senior three students in a middle school in the plateau area#br# #br#
		LIU Shuangjuan1 Zetaduoji2 JIANG Yingjiu3 Pubusuolang2 Deqinglacuo2 LIAO Juan4 YAN Junjun5 YANG Deyu1
		Objective To analyze the mental health status and its influencing factors of senior high school students in a middle school in Chamdo in the plateau area, and to provide a theoretical basis for improving the mental health education mechanism of high school students in the plateau area. Methods From January to March 2021, cluster sampling was used to investigate the senior three students of a middle school in Qamdo City using the patient health questionnaire-9 （PHQ-9） and general anxiety disorder-7 （GAD-7） scales. Results A total of 835 questionnaires were distributed in this survey, of which 814 were valid, and the recovery rate of valid questionnaires was 97.5%. The median overall score for PHQ-9 was 3.00 (1.00, 7.00) points, while the median overall score for GAD-7 was 2.00 (0.00, 6.00) points. The detection rate of depression was 39.3% (320/814), and the detection rate of anxiety was 34.5% (281/814). There were statistically significant differences in the scores of depression and anxiety among senior three students in different ethnic groups, living conditions, history of mental illness, daily browsing time on mobile phones and computers, times of playing video games per week, and times of weekly exercise (P ＜ 0.05). There were statistically significant differences in the depression scores of students with different history of chronic diseases (P ＜ 0.05). The history of mental illness, living conditions, the number of times of playing video games per week, and the number of times of weekly exercise were all independent influencing factors of depression or anxiety (P ＜ 0.05). Conclusion There are different degrees of depression or anxiety among senior high school students in a middle school in Qamdo City in the plateau area. The occurrence of depression or anxiety is related to the students’ mental illness history and living habits and other factors.
		2022 Vol. 19 (14): 43-47 [Abstract] ( 51 ) HTML (1 KB) PDF (607 KB) ( 176 )

	48	Exploration of the current situation and influencing factors of drug safety in patients with diabetes based on the “5 moments” of drug safety
		CHEN Na1 LI Zhen2 YUAN Ping3 QIN Yuelan4 LIU Tongbi2
		Objective Based on the “5 moments” of drug safety, to understand the current situation and influencing factors of medication safety in patients with diabetes. Methods From June to September 2021, a convenience sampling method was used to select 185 diabetic patients from the Department of Endocrinology of Hunan Provincial People’s Hospital as the survey subjects. The self-designed general information questionnaire and medication safety “5 moments” questionnaire were used to investigated. Results The total score of medication safety in diabetic patients was (64.76±10.65) point. There were statistically significant differences in the medication safety scores of diabetic patients with different educational levels, occupation, monthly income, medical insurance type, medical burden, long-term residence, regular monitoring of blood sugar, and emphasis on diabetes drug treatment (P ＜ 0.05). Multiple linear regression showed that educational level, occupation, medical burden, and emphasis on diabetes medication were the influencing factors of medication safety in diabetic patients (P ＜ 0.05). The above variables explained 44.7% of the total variation of medication safety in diabetic patients. Conclusion Based on the “5 moments” of medication safety, the medication safety level of diabetic patients is relatively low, which may be affected by various factors, and medical staff can carry out targeted medication guidance accordingly.
		2022 Vol. 19 (14): 48-51,64 [Abstract] ( 57 ) HTML (1 KB) PDF (629 KB) ( 31 )

	52	Investigation on the current situation of colonoscopy
		HUANG Qing1* ZHOU Jin2* WANG Ruigang1 WEI Zhengjie1 WANG Xu2 JIANG Xuan1
		Objective To study the current situation of colonoscopy. Methods From October 2019 to February 2020, the questionnaire was filled out through the Internet. This study screened five representative provinces and municipalities (Beijing, Shaanxi Province, Shanxi Province, Guangdong Province, and Liaoning Province) with different regions and economic levels in the country. In these five regions, 41 hospitals with different levels and regular endoscopy rooms were selected for questionnaire survey. The content includes the experience of colonoscopy operation, the evaluation of the operation performance of colonoscopy equipment and the related physical fatigue. A total of 328 valid questionnaires were collected for investigation. Results Study subjects were more prone to injuries and increased overall fatigue in the hands, waist, and legs. The parts with obvious fatigue or damage were the most frequent in the base of the thumb of the left hand (71 people, 21.6%), the first joint of the thumb (61 people, 18.6%), and the tip of the thumb (53 people, 16.2%), waist (51 people, 15.6%), and left shoulder (42 people, 12.8%). 42.1%-61.6% of colonoscopy operators were dissatisfied with the design of the colonoscope handle, gas and water buttons, and locking switches. A total of 238 people (72.6%) believed that the colonoscope handle needed to be improved, and 186 people (56.7%) supported the development of the colonoscope handle intelligent assist system. Conclusion Colonoscopy operation will cause obvious physical fatigue and discomfort of limbs and joints. It is necessary to improve the colonoscopy handle through the intelligent system.
		2022 Vol. 19 (14): 52-55 [Abstract] ( 52 ) HTML (1 KB) PDF (552 KB) ( 42 )

	56	Relationship between serum liver enzyme level and atrial fibrillation in patients with coronary heart disease
		ZHAO Xia1 LI Yong2
		Objective To investigate the relationship between serum liver enzyme level and atrial fibrillation (AF) in patients with coronary heart disease(CHD). Methods A total of 1520 patients diagnosed with CHD from January 2018 to January 2020 were collected from the Department of Cardiovascular Medicine, Changzhou Wujin People’s Hospital, Jiangsu Province. The baseline data, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ glutamyl transpeptidase (GGT), personal history, and past history of AF and non-AF patients at admission were compared. Multi-factor logistic regression analysis was carried out to explore the independent risk factors for AF in CHD patients, and the receiver operating characteristic (ROC) curve was drawn. Results There were 152 patients with AF on admission, and the incidence of AF was 10%. The comparison of the clinical data of AF and non-AF patients showed that, in GGT, age, history of hypertension, and history of acute coronary syndrome (ACS), the differences were highly significant (P ＜ 0.01); there were statistical significances in AST and ALT (P ＜ 0.05). Multiple logistic regression analysis showed that, GGT [OR = 1.018, 95%CI (1.013-1.024)], age [OR = 1.030, 95%CI (1.012-1.048)], history of hypertension [OR = 2.667, 95%CI (1.671-4.257)], and ACS history [OR = 2.960, 95%CI (1.896-4.622)] were independent risk factors for AF (P ＜ 0.01). ROC curve was drawn and it was found that the area under the curve of GGT was 0.693 in predicting the occurrence of AF. Conclusion In CHD patients, liver enzyme level is associated with the occurrence of AF, especially the elevation of GGT is independently associated with the presence of AF, and GGT may be a circulating marker of AF risk.
		2022 Vol. 19 (14): 56-59 [Abstract] ( 84 ) HTML (1 KB) PDF (561 KB) ( 24 )

	60	Clinical effect of Maiguan Fukang Capsules in the adjuvant treatment of acute cerebral infarction
		HE Daosheng ZHOU Hui LI Liangyong HUO Xingxing MA Kuijun▲
		Objective To investigate the clinical effect of Maiguan Fukang Capsules in the adjuvant treatment of acute cerebral infarction. Methods A total of 60 patients with acute cerebral infarction admitted to the Department of Encephalopathy, Bozhou Hospital of Traditional Chinese Medicine in Anhui Province from March 2019 to November 2020 were selected. By pre-creating randomized even and odd sequences, they were divided into control group and treatment group, with 30 patients in each group. The control group was treated with Aspirin Enteric-coated Tablets, Atorvastatin Calcium Tablets and Butylphthalide Soft Capsules, and the treatment group was treated with Maiguan Fukang Capsules on the basis of the control group. The course of treatment was two weeks. The changes of clinical response rate, traditional Chinese medicine syndrome score, National Institute of Health stroke scale (NIHSS) score, activity of daily living (Barthel index), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), angiotensin-1 (Ang-1), and homocysteine (Hcy) levels were compared between two groups before and after treatment. Adverse events during treatment were recorded in both groups. Results The clinical efficacy of the treatment group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant differences in traditional Chinese medicine syndrome score, NIHSS score, Barthel index, hs-CRP, IL-6, Ang-1, and Hcy levels between the two groups (P ＞ 0.05). After treatment, traditional Chinese medicine syndrome score, NIHSS score, hs-CRP, IL-6, Ang-1, and Hcy levels in the two groups were significantly lower than before treatment, and Barthel index was significantly higher than before treatment, and traditional Chinese medicine syndrome score, NIHSS score, hs-CRP, IL-6, Ang-1, and Hcy levels in the treatment group were lower than those in the control group, the Barthel index was significantly higher than that of the control group, and the differences were highly statistically significant (P ＜ 0.01). There were no serious adverse reactions in both groups. Conclusion Maiguan Fukang Capsules has definite curative effect in the treatment of acute cerebral infarction and is worthy of clinical promotion.
		2022 Vol. 19 (14): 60-64 [Abstract] ( 147 ) HTML (1 KB) PDF (659 KB) ( 40 )

	65	Expression and clinical significance of miR-29 and PARK2 in serum of patients with Parkinson’s disease
		SHI Jian YUAN Xiaoqin LUO Qian ZHANG Yun
		Objective To explore the expression and clinical significance of micro RNA-29 (miR-29) and human Parkinson’s disease protein 2 (PARK2) in the serum of patients with Parkinson’s disease (PD). Methods A total of 85 patients with primary PD admitted to Mianyang Central Hospital, Sichuan Province from March 2014 to May 2020 were selected as the PD group, and 90 cases underwent healthy during physical examination in this hospital were selected as the control group. The expression level of serum miR-29 and PARK2 were detected; the diagnostic value of serum miR-29 and PARK2 expression levels for PD was evaluated by using area under curve (AUC) of receiver operating characteristic; logistic regression analysis was used to analyze the influencing factors. Results There were no significant differences in gender, age, BMI, and the proportion of hypertension between the two groups (P ＞ 0.05). The level of serum miR-29 in PD group was higher than that in control group, and the level of PARK2 in PD group was lower than that in control group (P ＜ 0.05). The high expression of miR-29 and low expression of PARK2 in serum were independent risk factors for PD (OR ＞ 1, P ＜ 0.05). ROC results showed that the AUC of combined detection of PD was higher than that of miR-29 and PARK2 alone (Z = 8.317, P ＜ 0.001; Z = 6.124, P ＜ 0.001). Conclusion The expression level of miR-29 in the serum of PD patients is increased, and the expression level of PARK2 in the serum of PD patients is decreased, both of which can be used as potential biological indicators for the early diagnosis of PD.
		2022 Vol. 19 (14): 65-68 [Abstract] ( 46 ) HTML (1 KB) PDF (650 KB) ( 26 )

	69	Effect of Tongxinluo Capsules on cerebral infarction patients with the syndrome of qi deficiency and blood stasis
		DONG Yanhua ZHU Lianying
		Objective To explore the clinical effect of Tongxinluo Capsules on cerebral infarction patients with the syndrome of qi deficiency and blood stasis. Methods A total of 80 cerebral infarction patients with the syndrome of qi deficiency and blood stasis from June 2019 to May 2020 in the People’s Hospital of Huaiyin, Shandong Province were selected as the research objects, and they were randomly divided into control group (40 cases) and research group (40 cases). The control group received conventional Western medicine treatment, and the research group received Tongxinluo Capsules on the basis of the control group. After 28 d of treatment, limb motor function, walking ability, nerve damage situation, and self-care ability of two groups were evaluated. Results There were two cases of detachment, all male patients in the study group. After treatment, Fugl-Meyer motor scale scores of upper and lower limbs in the two groups were higher than those before treatment, and those in the study group were higher than those in the control group (P ＜ 0.05). After treatment, the scores of walking ability in the two groups were lower than those before treatment, and that in the study group was lower than that in the control group (P ＜ 0.05). After treatment, the scores of National Institutes of health stroke scale in the two groups were lower than those before treatment, and that in the study group was lower than that in the control group (P ＜ 0.05). After treatment, the scores of daily living activities in the two groups were higher than those before treatment, and that in the study group was higher than that in the control group (P ＜ 0.05). Conclusion Tongxinluo Capsules can improve the limb motor function and self-care ability of cerebral infarction patients with the syndrome of qi deficiency and blood stasis, promote the recovery of patients’ cerebral nerve function, help to improve the clinical treatment effect, and is worthy of clinical application.
		2022 Vol. 19 (14): 69-72 [Abstract] ( 43 ) HTML (1 KB) PDF (566 KB) ( 20 )

	73	Analysis on influencing factors of cognitive dysfunction in convalescent patients with cerebral infarction
		ZHANG Chenhua1 ZHANG Chong2 ZHANG Jiafang1 LI Xiaojing1 XIAO Xia3 LYU Chenran4 WU Yiping5
		Objective To analyze the influencing factors of cognitive dysfunction (CD) in convalescent patients with cerebral infarction (CI). Methods The clinical data of 100 convalescence patients with CI admitted to Handan First Hospital in Hebei Province from January 2018 to June 2019 were retrospectively analyzed, they were divided into groups according to their CD status (assessed according to Montreal cognitive assessment scale), the patient’s medical records were consulted, the patient’s relevant baseline information was recorded, and possible influencing factors were included. Logistic regression analysis was conducted to find out the influencing factors leading to the occurrence of CD in convalescent patients with cerebral infarction. Results The proportion of patients with diabetes mellitus, hyperlipidemia, and hypoalbuminemia in the occurrence group were higher than those in the non-occurrence group, and the levels of CysC and Hcy were higher than those in the non-occurrence group (P ＜ 0.05); there was no significant difference in other relevant baseline data between the two groups (P ＞ 0.05). Through logistic regression analysis, the results showed that the increase of the proportion of diabetes mellitus, hyperlipidemia, and hypoalbuminemia and the levels of CysC and Hcy were the influencing factors for the occurrence of CD in convalescent patients with CI (OR ＞ 1, P ＜ 0.05). Conclusion The occurrence of CD in convalescent patients with CI may be affected by diabetes mellitus, hyperlipidemia, hypoalbuminemia, increased CysC level, and increased Hcy level.
		2022 Vol. 19 (14): 73-76 [Abstract] ( 72 ) HTML (1 KB) PDF (578 KB) ( 18 )

	77	Comparative analysis of before and after five years of very low gestational age preterm infants
		LI Min1 XU Wenying2 DING Sufang2 ZHANG Li2 WANG Yumei2 PAN Zhaojun2 CAI Shizhong1
		Objective To compare and analyze the change of demographic characteristics, disease spectrum, clinical outcomes, and growth outcomes of preterm infants with gestational age＜32 weeks very low gestational age preterm (VLGA) in 2015 and 2020. Methods A total of 174 VLGA preterm infants hospitalized from January 1 to December 31, 2015 and 157 from January 1 to December 31, 2020 were selected from Neonatal Medical Center, Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical College. The clinical outcome was analyzed; the demographic information, disease spectrum, and treatment of VLGA preterm infants who met discharge criteria were analyzed. Results There were statistically significant differences in the clinical outcomes of preterm infants born in different years (P < 0.05). A total of 135 VLGA preterm infants were discharged from hospital in 2015, and 125 in 2020. The gestational age and birth weight of preterm infants born in 2020 were lower than those in 2015; cesarean section rate, discharge gestational age, and discharge weight were higher than those in 2015, and hospitalization days were longer than that in 2015 (P < 0.05). The incidence of neonatal respiratory distress syndrome, septicemia, moderate and severe intraventricular hemorrhage, bronchopulmonary dysplasia, and patent ductus arteriosus in 2020 was higher than that in 2015 (P < 0.05). There was no significant difference in the growth outcomes of preterm infants born who met discharge criteria in different years (P > 0.05). Conclusion Focusing on VLGA preterm infants with lower birth mass, younger birth gestational age, and combined more critical complications results in better clinical outcomes and growth outcomes.
		2022 Vol. 19 (14): 77-80 [Abstract] ( 76 ) HTML (1 KB) PDF (556 KB) ( 35 )

	81	The value of serum total IgE and allergen-specific IgE detection in the clinical diagnosis of asthma in children under five years old
		PAN Wei ZHU Ying MAO Guoshun LI Guitao
		Objective To explore the value of serum total IgE and allergen-specific IgE in the clinical diagnosis of asthma in children under five years old. Methods Thirty asthmatic children under five years old who were hospitalized in Fuyang People’s Hospital of Anhui Province (hereinafter referred to as “our hospital”) from September 2019 to February 2020 were selected as the asthma group, and 30 non-asthmatic children under five years old with cough and/or wheezing symptoms during the same period in our hospital were selected as the non-asthma group. The positive rates of serum total IgE and allergen-specific IgE antibodies were compared between the two groups, and their diagnostic value in asthma in children under five years old was analyzed. Results The positive rate of serum total IgE and allergen-specific IgE antibodies in the asthmatic group was higher than that in the non-asthmatic group (P < 0.05). The area under the curve of total serum IgE and allergen-specific IgE were 0.800 and 0.817 respectively. Conclusion The detection of serum total IgE and allergen-specific IgE has a higher response value in the clinical diagnosis of asthma in children under five years old.
		2022 Vol. 19 (14): 81-83,87 [Abstract] ( 89 ) HTML (1 KB) PDF (650 KB) ( 47 )

	84	Effect comparison of Sodium Valproate Sustained Release Tablets and Levetiracetam Tablets in the treatment of children with primary epilepsy
		LU Lin MA Suqing▲ BI Jinzhu
		Objective To study the effect and adverse reactions of Sodium Valproate Sustained Release Tablets and Levetiracetam Tablets in children with primary epilepsy. Methods A total of 100 children with primary epilepsy admitted to the Second People’s Hospital of Lianyungang, Jiangsu Province from January 2020 to February 2021 were selected as the study objects. According to random number table method, they were divided into experimental group and control group, with 50 cases in each group. The control group received Sodium Valproate Sustained Release Tablets, and the experimental group received Levetiracetam Tablets. Blood drug concentration, clinical effect, electroencephalogram evaluation results, and the occurrence of adverse reactions were observed and compared between two groups after six months of treatment. Results The average blood drug concentration of control group was (69.73±30.15) μg/ml; and the average blood drug concentration of experimental group was (13.92±4.76) mg/ml. The total effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P < 0.05). The correction rate of electroencephalogram in experimental group was higher than that in control group, and the difference was statistically significant (P < 0.05). There was no statistical difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Levetiracetam Tablets monotherapy is superior to Sodium Valproate Sustained Release Tablets in the treatment of children with primary epilepsy, and has certain safety.
		2022 Vol. 19 (14): 84-87 [Abstract] ( 82 ) HTML (1 KB) PDF (523 KB) ( 37 )

	88	Isolation and analysis of circulating tumor cells in patients by a microfluidic chip device
		JIANG Jianing WANG Qi WANG Ruoyu GAO Jinqi CHEN Wenting WANG Gang
		Objective To analyze the relevance of the results of the circulating tumor cells (CTC) detection to the clini pathological features and curative effect of the patients. Methods A total of 55 patients with different cancer types of treated first from January 2017 to December 2018 in Affiliated Zhongshan Hospital of Dalian University were selected, the CTC detection device based on microfluidic chip was used to detect CTC in peripheral blood of clinical tumor patients. The correlation between CTC detection rate and age of onset, gender, degree of tumor differentiation, clinical stage of tumor, different tumor types and tumor metastasis of patients was analyzed. Kappa method was used to analyze the consistency between the number changes before and after CTC treatment and the evaluation of imaging efficacy. Results Among the 55 patients with malignant tumor, 29 cases were positive for CTC, and the detection rate was 52.73%. It was found that the detection rate was correlated with the degree of tumor differentiation, tumor stage and metastasis (P ＜ 0.05), but not correlated with the age of onset, gender and cancer type (P ＞ 0.05). Consistency analysis showed that, the changes of CTC detected in the same patients before and after treatment were consistent with the evaluation results of clinical imaging examination (P ＞ 0.05). Conclusion Peripheral blood CTC detection by microfluidic chip contributes to tumor staging, tumor differentiation evaluation, metastasis identification, and the curative efficacy evaluation.
		2022 Vol. 19 (14): 88-92 [Abstract] ( 45 ) HTML (1 KB) PDF (844 KB) ( 56 )

	93	Effect of nutritional support combined with palliative treatment on patients with advanced non-small cell lung cancer
		ZHANG Jinke1 CHU Meiqing1 LI Yan1 ZHAO Mengchen1 CHEN Feng1 CHEN Yang2▲
		Objective To investigate the effect of nutritional support combined with palliative treatment on patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 72 patients with advanced NSCLC from January 2018 to October 2020 in Ma’anshan Hospital of Traditional Chinese Medicine were divided into control group and study group by random number table method, with 36 patients in each group. The control group received conventional cancer treatment and the study group received nutritional support combined with palliative treatment for four weeks. The quality of life (EORTC QLQ-C30), karnofsky performance status (KPS), death attitude and negative emotion (depression scale [SDS] and self-rating anxiety scale [SAS]) of the two groups were measured. Results After intervention, the scores of overall health, role function, emotional function, cognitive function, and social function in the two groups were higher than those before intervention, and those of the study group were higher than the control group (P ＜ 0.05). After intervention the KPS scores of the two groups increased, and the study group was higher than the control group (P ＜ 0.05). After intervention, the scores of escape acceptance, death avoidance, and fear of death in the two groups were lower than those before intervention, and the study were lower than the control group, and the scores of approach acceptance and natural acceptance were higher than those before intervention, and the study group were higher than the control group (P ＜ 0.05). After intervention the SDS and SAS scores of the two groups were lower than those before intervention, and the study group was lower than the control group (P ＜ 0.05). Conclusion The combination of nutritional support and palliative treatment can regulate the physical and mental state of patients with advanced NSCLC, which is worth promoting.
		2022 Vol. 19 (14): 93-96,116 [Abstract] ( 48 ) HTML (1 KB) PDF (695 KB) ( 32 )

	97	Diagnostic value of FIB, D-dimer and serum CysC in bone metastasis of prostate cancer
		LI Xuanyu1 HAO Lin2 HAN Conghui1▲
		Objective To investigate the diagnostic value of Fibrinogen (FIB), D-dimer, and serum CystatinC (CysC) levels in bone metastasis of prostate cancer (PCa). Methods Clinical data of 207 patients initially diagnosed with PCa in Xuzhou Central Hospital of Jiangsu Province from June 2016 to January 2019 were retrospectively collected, and they were divided into 102 patients with bone metastasis and 105 patients without bone metastasis according to bone scanning and imaging examination. Intergroup control study, univariate, and multivariate logistic regression analysis were used to evaluate the diagnostic value of FIB, D-dimer, CysC and clinical indicators for PCa bone metastasis. Receive operating characteristic curve was used to evaluate the clinical significance of FIB, D-dimer, CysC, and their combined indexes in the diagnosis of PCa bone metastasis. Results The levels of FIB, D-dimer, and CysC in bone metastasis group were higher than those in non-metastasis group (P ＜ 0.05), and the multivariate regression analysis showed that the three factors were independent risk factors for PCa bone metastasis (OR > 1, P ＜ 0.05). The combined index level was the best, followed by single index CysC, D-dimer, and FIB, which showed good diagnostic value (AUC > 0.5, P ＜ 0.05). Conclusion FIB, D-dimer, and CysC are closely related to bone metastasis of PCa, and can be used in conjunction with clinical T stage and Gleason score to evaluate bone metastasis of PCa, which has high clinical value.
		2022 Vol. 19 (14): 97-100,120 [Abstract] ( 82 ) HTML (1 KB) PDF (731 KB) ( 25 )

	101	Efficacy of Tongguanteng Injection combined with GC regimen in the treatment of advanced NSCLC and its influence on peripheral blood T lymphocyte subsets
		XIU Junqing1 LI Liang2 LIU Rui3
		[Abstract] Objective To investigate the efficacy of Tongguanteng Injection combined with GC regimen in the treatment of advanced non-small cell lung cancer (NSCLC) and its influence on peripheral blood T lymphocyte subsets. Methods Seventy patients with NSCLC treated in the Department of Oncology, Guang’anmen Hospital Southern District, China Academy of Traditional Chinese Medicine from March 2020 to March 2021 were selected and they were divided into control group and study group according to the random number table method, with 35 patients in each group. The control group was treated with GC alone, and the study group was treated with GC + Tongtengteng Injection. The adverse reactions of the two groups were recorded, the short-term efficacy was evaluated, and the changes of T lymphocyte subsets and quality of life were observed. Results The short-term efficacy of the study group was better than the control group, and the objective remission rate was higher than the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in disease control rate between the two groups (P ＞ 0.05). After two cycles of treatment, the proportion of CD3+, CD4+ and CD4+/CD8+ in both groups increased, and those in the study group were higher than the control group, and the proportion of CD8+ was decreased, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After two cycles of treatment, KPS score of both groups increased and the study group was higher than the control group, the differences were statistically significant (P ＜ 0.05). Compared with the control group, the incidence of grade Ⅲ-Ⅳ nausea and vomiting and grade Ⅲ-Ⅳ leukopenia was significantly decreased in the study group, while the incidence of grade Ⅰ-Ⅱ leukopenia was increased, and the differences were statistically significant (P ＜ 0.05). Conclusion Tongguanteng Injection and combined GC regimen in the treatment of advanced NSCLC can achieve better short-term efficacy, improve the distribution of T lymphatic subgroups, promote the recovery of immune function, reduce the side effects of chemotherapy, and improve the quality of life of patients, which is worthy of clinical reference.
		2022 Vol. 19 (14): 101-104 [Abstract] ( 43 ) HTML (1 KB) PDF (555 KB) ( 27 )

	105	Application effect of video assisted thoracoscopy combined with three incisions of neck in patients with esophageal cancer
		QIAN Hairong YIN Dongming MAO Kai
		Objective To investigate the application effect of video assisted thoracoscopy combined with three incisions of neck in the treatment of esophageal cancer. Methods A total of 124 patients diagnosed with esophageal cancer in Rugao Hospital Affiliated to Nantong University from April 2015 to July 2017 were selected as the study subjects. The patients were divided into observation group and control group by random number table method, with 62 cases in each group. The control group was treated with traditional open surgery, and the observation group was treated with video assisted thoracoscopy combined with three incisions of neck. Surgery related indexes were compared between the two groups. The changes in cellular immune function (T cells and cell subsets [CD4+, CD8+, CD4+/CD8+], natural killer [NK] cells, C-reactive protein [CRP]) and lung function (percentage of forced expiratory volume in one second in the expected value [FEV1%], percentage of forced expiratory volume in the expected value [FEV%], percentage of forced vital capacity in the expected value [FVC%], percentage of vital capacity in the expected value in the expected value [VC%], and percentage of maximal voluntary ventilation in the expected value [MVV%]) were compared between the two groups before and after treatment. The incidence of complications and postoperative quality of life scores were compared between the two groups. Results The surgery time, indplacement time of thoracic drainage tube, postoperative hospital stay, and incision length in the observation group were shorter than those in the control group, and the intraoperative blood loss was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the number of dissected lymph nodes between the two groups (P ＞ 0.05). After treatment, the levels of CD4+, CD8+, CD4+/CD8+, NK cells, CRP, MVV%, VC%, FVC%, FEV%, and FEV1% in both groups were lower than those before treatment, and the levels of CD4+, CD8+, CD4+/CD8+, NK cells, MVV%, VC%, FVC%, FEV%, and FEV1% in the observation group were higher than those in the control group, while CRP was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). The total incidence of complications and postoperative quality of life score in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Video assisted thoracoscopy combines with three incisions of neck in the treatment of esophageal cancer has good clinical efficacy, value of clinical further promotion.
		2022 Vol. 19 (14): 105-108 [Abstract] ( 75 ) HTML (1 KB) PDF (552 KB) ( 33 )

	109	Predictive value of serum TGFBI protein, gastrin-17, and Helicobacter pylori-IgG levels for recurrence after endoscopic submucosal dissection in patients with early gastric cancer
		PAN Chunsheng1 FAN Zhigang2
		Objective To investigate the predictive value of serum TGFBI protein, gastrin-17 (G-17), and Helicobacter pylori-IgG (HP-IgG) levels in patients with early gastric cancer after endoscopic submucosal dissection (ESD). Methods A total of 255 patients with early gastric cancer who received ESD treatment in Shaanxi Province 3201 Hospital (hereinafter referred to as “our hospital”) from February 2016 to February 2019 were selected, and they were divided into recurrence group (20 cases) and non-recurrence group (235 cases) according to wether recurrence. Clinical data and preoperative levels of TGFBI protein, G-17, and HP-IgG were collected and compared between the two groups to analyze the influencing factors of recurrence in early gastric cancer patients undergoing ESD. The predictive value of each index and combined detection for recurrence of early gastric cancer after ESD was analyzed by the receiver operation characteristic curve. Results The proportion of submucosal infiltration depth and the preoperative serum levels of TGFBI protein, G-17, and HP-IgG in the recurrence group were higher than those in the non-recurrence group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that preoperative high levels of serum TGFBI protein, G-17, HP-IgG, and submucosal infiltration depth were independent risk factors for recurrence after ESD in early stage gastric cancer patients (OR ＞ 1, P ＜ 0.05). Preoperative combined detection of serum TGFBI protein, G-17, and HP-IgG showed a greater area under the curve in predicting recurrence after ESD in patients with early gastric cancer than that of TGFBI protein, G-17, and HP-IgG alone (P ＜ 0.05). Conclusion The combined detection of serum levels of TGFBI, G-17, and HP-IgG before ESD have high predictive value for recurrence of early gastric cancer after ESD, and it is worthy for clinical investigation.
		2022 Vol. 19 (14): 109-112 [Abstract] ( 89 ) HTML (1 KB) PDF (596 KB) ( 118 )

	113	Clinical effect of radiotherapy combined with Gefitinib in the comprehensive treatment of elderly advanced non-small cell lung cancer
		LIU Xi1 XU Chao2 DAI Meiyun1
		Objective To explore the efficacy of radiotherapy combined with Gefitinib in the comprehensive treatment of elderly advanced non-small cell lung cancer (NSCLC). Methods A total of 82 elderly patients with advanced NSCLC admitted to Rugao Hospital Affiliated to Nantong University from November 2016 to December 2019 were selected and divided into control group (three-dimensional conformal radiotherapy, 41 cases) and observation group (three-dimensional conformal radiotherapy and Gefitinib, 41 cases) according to random number table method. After three months of continuous treatment, the short-term efficacy and the differences of tumor markers before and after treatment were compared between the two groups. The incidence of adverse reactions in the two groups was recorded. The two groups were followed up for one year, and the prognosis was compared by survival analysis. Results The short-term efficacy of observation group was better than control group, and the difference was statistically significant (P ＜ 0.05). The levels of serum cancer antigen 12-5, cancer antigen 15-3, and carcinoembryonic antigen in two groups were lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). The survival of observation group was better than control group, the difference was statistically significant (P ＜ 0.05). Conclusion Radiotherapy combined with Gefitinib can improve the short-term efficacy and 1-year survival situation of elderly patients with advanced NSCLC, and reduce the level of tumor markers, which is worthy of clinical promotion.
		2022 Vol. 19 (14): 113-116 [Abstract] ( 117 ) HTML (1 KB) PDF (573 KB) ( 30 )

	117	Analysis of serum vascular endothelial growth factor and squamous cell carcinoma antigen expression levels and their correlation with pathological parameters in patients with endometrial carcinoma
		SUN Yanhong YANG Chunling WU Wei
		Objective To investigate the serum levels of vascular endothelial growth factor (VEGF) and squamous cell carcinoma antigen (SCCAg) in patients with endometrial cancer and their correlation with pathological parameters. Methods Eighty cases of endometrial carcinoma treated in the Department of Obstetrics and Gynecology of Huangshan People’s Hospital of Anhui Province (hereinafter referred to as “our hospital”) from January 2017 to March 2021 were selected as the observation group, and 75 healthy women in the outpatient department of our hospital during the same period were selected as the control group. The levels of VEGF and SCCAg were compared between the two groups, and the differences of serum VEGF and SCCAg in patients with endometrial cancer with different characteristics were compared. Pearson correlation coefficient was used to analyze the correlation between VEGF and SCCAg expression levels and pathological parameters. Results The levels of VEGF and SCCAg in the observation group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in VEGF and SCCAg expression levels in patients with different degrees of differentiation, TNM stage, and situation of lymph node metastasis (P ＜ 0.05). Correlation analysis showed that serum VEGF and SCCAg levels were negatively correlated with the differentiation degree of endometrial carcinoma (r ＜ 0, P ＜ 0.05), and positively correlated with TNM stage and lymph node metastasis (r ＞ 0, P ＜ 0.05). Conclusion In patients with endometrial cancer, serum VEGF and SCCAg are significantly overexpressed, and their levels can provide important reference for the diagnosis and treatment of endometrial cancer.
		2022 Vol. 19 (14): 117-120 [Abstract] ( 79 ) HTML (1 KB) PDF (513 KB) ( 28 )

	121	Prevalence of sarcopenia in acute ischemic stroke using different diagnostic criteria#br#
		CHEN Rui1 LIAO Ruotong1 LUO Wanghui2 LIANG Hao3 XIAO Hui4 GUO Jianwen3 WEI Lin4
		Objective To compare the prevalence of acute ischemic stroke sarcopenia under different diagnostic criteria, and to explore the consistency and diagnostic efficacy of each diagnostic criteria. Methods A total of 117 patients of acute ischemic stroke in the encephalopathy department of Guangdong Provincial Hospital of Traditional Chinese Medicine from July 2020 to May 2021 were selected. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia (AWGS), the European Working Group on Sarcopenia in the elderly (EWGSOP), the International Working Group on Sarcopenia (IWGS), and the Foundation for the National Institutes of Health (FNIH), respectively. The general data of the patients were collected, grip strength, skeletal muscle mass of limbs were measured, and body mass index (BMI) was calculated. Concordance, sensitivity and specificity between diagnostic criteria were calculated. Results The prevalence of acute ischemic stroke sarcopenia under AWGS, EWGSOP, IWGS, and FNIH criteria were 40.2%, 33.3%, 44.4%, and 8.5%, respectively. With AWGS as the standard, the consistency rate with EWGSOP was 93.16% (Kappa = 0.97, P < 0.01), the sensitivity was 100.0%, and the specificity was 89.7%; the concordance rate with IWGS was 95.72% (Kappa = 0.99, P < 0.01), the sensitivity was 90.4%, and the specificity was 100.0%; the concordance rate with FNIH was 64.96% (Kappa = 0.06, P < 0.01), the sensitivity was 80.0%, and the specificity was 63.6%. Conclusion IWGS has the highest detection rate of sarcopenia in acute ischemic stroke, and the detection rate of FNIH is significantly lower than the other three diagnostic criteria; AWGS, EWGSOP, and IWGS have good consistency in the diagnosis of acute ischemic stroke sarcopenia, AWGS criteria have better sensitivity and specificity, and FNIH criteria have poor consistency with the other three diagnostic criteria.
		2022 Vol. 19 (14): 121-124,129 [Abstract] ( 65 ) HTML (1 KB) PDF (855 KB) ( 28 )

	125	Serum IL-6 and sTWEAK levels in patients with neuropsychiatric systemic lupus erythematosus and their clinical significance
		PANG Jie ZHANG Zongfang LI Yanxia TAO Ran YANG Wenwen XU Huaheng
		Objective To investigate the levels of serum interleukin (IL)-6 and soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) in patients with neuropsychiatric systemic lupus erythematosus (NPSLE) and their clinical significance. Methods A total of 165 patients with systemic lupus erythematosus admitted to Cangzhou Central Hospital in Hebei Province from February 2017 to September 2021 were selected and divided into NPSLE group (68 cases) and non-NPSLE group (97 cases) according to the occurrence of NPSLE. In addition, according to the systemic lupus erythematosus disease activity index (SLEDAI) score, the patients in the NPSLE group were divided into mild group (23 cases), moderate group (26 cases), and severe group (19 cases). Serum levels of IL-6 and sTWEAK were detected, and the related factors of NPSLE and the value of IL-6 and sTWEAK in the diagnosis of NPSLE were analyzed. Results The age of onset in the NPSLE group was lower than that in the non-NPSLE group, the disease duration was longer than that in the non-NPSLE group, and the SLEDAI score was higher than that in the non-NPSLE group, with statistically significant differences (P ＜ 0.05). The serum levels of IL-6 and sTWEAK in the NPSLE group were higher than those in the non-NPSLE group, and the differences were statistically significant (P ＜ 0.05). There were significant differences in serum IL-6 and sTWEAK levels in NPSLE patients with different SLEDAI scores (P ＜ 0.05). Among them, those of the severe group were higher than those of the moderate group and the mild group, while those of the moderate group were higher than those of the mild group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that SLEDAI score (OR = 1.872, 95%CI: 1.533-2.286, P ＜ 0.001), IL-6 (OR = 1.370, 95%CI: 1.113-1.687, P = 0.002), sTWEAK (OR = 1.508, 95%CI: 1.185-1.920, P < 0.001) were risk factors for NPSLE. The areas under the curve of IL-6 and sTWEAK in the diagnosis of NPSLE were 0.698 and 0.692, and the area under the curve of combined IL-6 and sTWEAK in the diagnosis of NPSLE was 0.854, which was higher than that of IL-6 and sTWEAK alone (P ＜ 0.05). Conclusion Serum levels of IL-6 and sTWEAK are increased in NPSLE patients, and are related to the occurrence and disease activity of NPSLE, which can be used as auxiliary biological indicators for the diagnosis of NPSLE.
		2022 Vol. 19 (14): 125-129 [Abstract] ( 78 ) HTML (1 KB) PDF (730 KB) ( 35 )

	130	Clinical effect of endoscopic treatment of esophageal foreign body incarceration caused by food clumps
		XU Xiaoli YAN Bichun
		Objective To study the clinical effect of digestive endoscopy in the treatment of esophageal foreign body incarceration caused by food clumps. Methods A retrospective analysis was performed on the patients who visited the hospital due to food mass incarceration in the esophagus from January 2018 to June 2021 in the People’s Hospital of Bozhou. Patients were given preoperative routine examination and endoscopic intervention. The foreign body types, comorbidities, anesthesia rate, hospitalization rate, and complication rate of all patients were counted. Results A total of 62 eligible patients were retrospectively analyzed. Among them, 17 cases of food clumps were incarcerated in the upper esophagus, 25 cases in the middle, and 20 cases in the lower esophagus. The incarcerated food clumps were 41 cases of animal meat, eight cases of steamed bread, six cases of fruits and vegetables, four cases of gluten, and three cases of other cases. Endoscopy revealed 28 cases with esophageal lesions, including 19 cases of esophageal cancer, five cases of benign esophageal stricture, two cases of reflux esophagitis, one case of hiatal hernia, and one case of eosinophilic esophagitis. Among the 62 patients, 17 cases were given intravenous anesthesia, and 13 cases were admitted to hospital for further examination and treatment. All patients were relieved of incarceration under endoscopic treatment. A total of eight cases were found to have mucosal erosions, four cases of mucosal ulcers, and three cases of mild mucosal oozing. No serious complications occurred. Conclusion Endoscopic treatment of esophageal food clumps incarcerated by a foreign body has a high success rate, strong safety and reliability, and a low incidence of serious adverse events.
		2022 Vol. 19 (14): 130-132,137 [Abstract] ( 113 ) HTML (1 KB) PDF (577 KB) ( 32 )

	133	Analysis of medication rule of master of national physician Zhang Daning in the treatment of chronic kidney disease based on data mining
		LI Hucai LIN Junjie HE Zhiren WANG Lixin
		Objective To analyze and summarize the medication rule of master of national physician Zhang Daning in the treatment of chronic kidney disease based on data mining. Methods Medical records of Professor Zhang Daning’s diagnosis and treatment of chronic kidney disease from January 2020 to December 2020 were selected from the medical records database of famous doctors’ studio of Zhang Daning of Guangdong Provincial Hospital of Chinese Medicine. Descriptive analysis and cluster analysis were performed for high-frequency drugs in medical cases (frequency≥20%). The association rules analysis were conducted with Apriori algorithm. Results A total of 143 medical cases, 143 prescriptions, and 138 single Chinese herbs were included. The top five Chinese herbs were Astragali Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Chuanxiong Rhizoma, Smilacis Glabrae Rhizoma, and Dendrobii Caulis. The top five high-frequency herbs in frequency were promoting blood circulation and removing stasis, tonifying deficiency, unblocking fu-organs to remove turbidity, removing dampness, and astringent herbs. Herbs were distinguished by four nature of drugs, 12 herbs were warm and slightly warm, 9 herbs were flat, 5 herbs were cold and slightly cold. Herbs were distinguished by five flavors, 16 herbs were sweet, 14 herbs were bitter, and 9 herbs were pungent. Herbs were distinguished by channel tropism, 20 herbs belonged to spleen channel, 13 herbs belonged to liver channel, 12 herbs belonged to kidney channel. High-frequency drugs were divided into 7 clusters by cluster analysis. After the analysis of association rules, 33 related rules were obtained. Conclusion Professor Zhang Daning’s treatment of chronic kidney disease focuses on tonifying deficiency, promoting blood circulation and removing stasis, and unblocking fu-organs to remove turbidity. The self-made prescription Yinchen Shixiao Powder is the basic prescription, which could provide reference for traditional Chinese medicine treatment of chronic kidney disease.
		2022 Vol. 19 (14): 133-137 [Abstract] ( 46 ) HTML (1 KB) PDF (1060 KB) ( 29 )

	138	Exploration on the medication rule of Professor Zhang Farong in the treatment of chronic renal failure based on data mining
		LI Meijia1 ZHANG Farong2 HU Furu3 JI Yan4
		Objective To explore Professor Zhang Farong’s medication rule in the treatment of chronic renal failure by using data mining method, and to provide reference for the treatment of traditional Chinese medicine of chronic renal failure. Methods The case information of 160 patients with chronic renal failure treated by Professor Zhang Farong in Shandong Hospital of Traditional Chinese Medicine from June 2019 to June 2021 was collected. Excel, IBM SPSS Modeler 25.0, and Cytoscape were used to perform frequency statistics, cluster analysis, and complex network analysis on the case information. Results A total of 334 prescriptions were involved, 159 drugs were included. The top three in frequency of four nature of drugs were flat, warm, and cold drugs. The top three drugs in the frequency of five flavors were sweet, bitter, and pungent. The top three meridian frequency were liver, spleen, and kidney meridians. The top four drug pairs with the highest support: Astragali Radix-Odonopsis Radix; Dioscoreae Rhizoma-Euryales Semen; Astragali Radix-Odonopsis Radix, Eucommiae Cortex; Snow In June-Rhei Radix Et Rhizoma. Two drug combinations were obtained by drug cluster analysis. Conclusion In the treatment of chronic renal failure, Professor Zhang Farong takes tonifying spleen and kidney, nourishing liver and kidney, removing blood stasis and removing turbidity as the main treatment methods, takes into account deficiency and excess, the effect is very good.
		2022 Vol. 19 (14): 138-141 [Abstract] ( 42 ) HTML (1 KB) PDF (1083 KB) ( 37 )

	142	Professor Jin Zhe’s experience in treating perimenopausal disorders
		HUANG Fangting HUANG Haitao HUANG Wenling XIANG Lizhu ZHOU Lan
		Professor Jin Zhe’s understanding of the etiology and pathogenesis of perimenopausal disorders is mainly as follows: kidney deficiency is the main cause, but there are many pathogenesis; qi movement counterflow and confusion, qi and blood disharmony; essence and blood depletion, more deficient and more stasis; deficiency-fire flaming up, malnutrition due to heart spirit. Treatment to tonify spleen and stomach, tonify liver and kidney, regulate qi and blood, disperse stasis, clear empty heat, calm nerves for the method, and add or subtract drugs according to the complication. Professor Jin Zhe pays special attention to the role of nourishing acquired in the treatment of perimenopausal disorders, and pays attention to regulate qi and blood, and flexibly uses drugs to add and subtract to treat perimenopausal disorders differentiation, with remarkable results.
		2022 Vol. 19 (14): 142-145 [Abstract] ( 91 ) HTML (1 KB) PDF (650 KB) ( 48 )

	146	Clinical effect of Qingre Jiedu Prescription adjunctive therapyc to refractory mycoplasma pneumoniae pneumonia with syndrome of phlegm and heat blocking the lung#br#
		YANG Huirong ZHANG Yingqian HUANG Kunling ZHAO Ziwei NIU Bo WANG Le LU Sukun LIU Jianhua▲
		Objective To explore the clinical effect of Qingre Jiedu Prescription adjunctive therapyc to refractory mycoplasma pneumoniae pneumonia (RMPP) with syndrome of phlegm and heat blocking the lung. Methods A total of 60 children diagnosed with RMPP in the Department of Pneumology, Children’s Hospital of Hebei Province from November 2019 to February 2021 were selected and they were divided into control group and treatment group according to random number table method, with 30 children in each group. The control group was treated with Azithromycin, Glucocorticoid and flexible tracheoscopic intervention, and the treatment group was additionally treated with Qingrejiedu Prescription for seven days. Fever reduction, cough relief and pulmonary breath sound recovery time were recorded in the two groups, and white blood cell (WBC), C-reactive protein (CRP), lactate dehydrogenase (LDH) levels in blood and the changes of MP-RNA in bronchoalveolar lavage fluid (BALF) before and after treatment were detected. Results The fever reduction, cough relief and pulmonary breath sound recovery time in the treatment group was shorter than those in the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant differences in WBC, CRP, and LDH between the two groups (P ＞ 0.05). After treatment, WBC, CRP, and LDH in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the number of patients with low bacterial count and sterility in both groups was higher than before treatment, and the number of patients in treatment group was higher than that in control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Qingre Jiedu Prescription has a significant therapeutic effect on RMPP in children, which can reduce the inflammatory index and the amount of MP-RNA bacteria in BALF.
		2022 Vol. 19 (14): 146-149 [Abstract] ( 72 ) HTML (1 KB) PDF (624 KB) ( 72 )

	150	Application of Shengjiang Powder in children with acute suppurative tonsillitis based on ascending and descending theory
		GUO Jianbo SONG Lina LUAN Junqi CHEN Hong ZHANG Wei
		Acute suppurative tonsillitis in children belongs to the category of “tonsillitis” in traditional Chinese medicine. In clinical practice, clearing heat and removing toxicity, relieving throat disorder and detumescence are the therapeutic principles. The theory of ascending and descending is based on regulating the ascending and descending tendency of viscera-qi and the development of disease tendency, and it is also an important principle for the combination and compatibility of Chinese Materia Medica, and is affected by the drug odor, channel tropism, weight of texture, processing methods and medicinal parts and other factors. Shengjiang Powder is originally designed for warm disease, that’s what it’s called “when there is heat in both interior and superficies, and sanjiao, at the same time, the syndrome and treatment can not be described, this prescription can be used”. Now this prescription has been widely used in the diagnosis and treatment of children with acute suppurative tonsillitis. The author starting from the key pathogenesis of acute suppurative tonsillitis in traditional Chinese medicine, according to the medicinal properties theory of the compatibility of Bombyx Batryticatus with Cicadae Periostracum, Curcumae Longae Rhizoma with Rhei Radix Et Rhizoma and chinese rice wine with honey in Shengjiang Powder, so as to improve the clarity and reduce turbidity, tongli sanjiao and regulate qi to balance qi. The purpose of this paper is to explore the theoretical basis for the treatment of acute suppurative tonsillitis in children with the theory of ascending and descending, to add or subtract according to the symptoms, to treat based on syndrome differentiation, and a medical record attached, to combine the medicinal properties theory with clinical practice in pediatrics, to broaden the theoretical study of Shengjiang Powder, it also provides a new idea and a new method for the treatment of acute suppurative tonsillitis in children.
		2022 Vol. 19 (14): 150-153 [Abstract] ( 40 ) HTML (1 KB) PDF (618 KB) ( 97 )

	154	Excavation the medication rule of famous old Chinese medicine practitioners in the treatment of perimenopausal insomnia based on the traditional Chinese medicine inheritance assistance system #br#
		WANG Yanying1 MA Kun2▲ FEI Fei3▲
		Objective To study the prescription medication rule of famous old Chinese medicine practitioners in the treatment of perimenopausal insomnia by using traditional Chinese medicine inheritance assistance system (V2.5) software. Methods To study the medical prescription related to perimenopausal insomnia symptoms in three medical records The Classic Medical Records of Great Chinese Medicine· Symptoms· Perimenopausal Diseases, Syndrome Before and After Menopause, Analysis of Cases of Famous Doctors in Gynecology. Through the traditional Chinese medicine inheritance assistance system (V2.5) software, the frequency of medicines, the nature and flavour and channel tropism of medicines and the regularity of prescriptions used by famous old Chinese medicine practitioners in the treatment of perimenopausal insomnia were analyzed and studied. Results A total of 118 prescriptions involving 212 traditional Chinese medicines were screened out. The statistics on the frequency of medicines showed that there were 13 medicines with frequency greater than or equal to 29 times. The statistics of nature and flavour and channel tropism showed that cold medicine accounted for the largest proportion of traditional Chinese medicine, mainly in the liver, heart, and kidney meridians. The most frequently used Os Draconis and Concha Ostreae drug pairs were extracted. Four new candidates for the treatment of perimenopausal insomnia were extracted. Conclusion Famous old Chinese medicine treatment of insomnia, liver, heart, kidney meridian drugs for the most, nourishing yin and clearing heat mainly, while using Os Draconis and Concha Ostreae drug pairs. The new formula combination suggests that in the treatment of perimenopausal insomnia, attention should be paid to the conditioning of viscera and liver, and by calming liver yang, clearing liver heat, resolving liver depression to achieve the effect of tranquilizing.
		2022 Vol. 19 (14): 154-157 [Abstract] ( 43 ) HTML (1 KB) PDF (702 KB) ( 26 )

	158	Clinical effect of head-spine electroacupuncture combined with Huatan Tongfu Decoction on finger spasm after stroke#br#
		SONG Conglin YANG Jinshan XING Xiaodong
		Objective To investigate the clinical effect of head-spine electroacupuncture combined with Huatan Tongfu Decoction on finger spasm after stroke. Methods A total of 180 patients with finger spasm after stroke treated in Department of General, Harbin Traditional Chinese Medicine Hospital from January 2020 to January 2021 were selected and they were divided into three groups according to random number table method, with 60 patients in each group. The electroacupuncture group was treated with head-spine electroacupuncture, the decoction group was treated with Huatan Tongfu Decoction, and the combined group was treated with head-spine electroacupuncture combined with Huatan Tongfu Decoction. The improvement of hand symptoms, dyskinesia and clinical effect were observed after 30 days of treatment. Results After treatment, the scores of finger spasm and hand nerve function defect in three groups were lower than before, and those in the combined group were lower than those in electroacupuncture group and decoction group, the differences were statistically significant (P ＜ 0.05); after treatment, the score of hand function in the three groups was all higher than before, and that in the combined group was higher than in the electroacupuncture group and decoction group, the differences were statistically significant (P ＜ 0.05). After treatment, the motor coordination ability score, sensory function score and total score in the three groups were higher than those before treatment, and those in the combined group were higher than those in electroacupuncture group and decoction group, the differences were statistically significant (P ＜ 0.05). After treatment, the clinical effect of combined group was better than electroacupuncture group and decoction group, and the difference was statistically significant (P ＜ 0.05). Conclusion In the clinical treatment of finger spasm after stroke, simultaneous treatment with head-spine electroacupuncture combined with Huatan Tongfu Decoction can effectively improve the total clinical effect.
		2022 Vol. 19 (14): 158-161 [Abstract] ( 79 ) HTML (1 KB) PDF (588 KB) ( 94 )

	162	Implementation status and countermeasures of the of zero-markup drug policy#br#
		WANG Qin1 ZHANG Jianwei2
		With the continuous reform of the medical and health system, “zero-markup drug” has become an important measure to change the “drug supported medical” in public hospitals, and has achieved remarkable results, meanwhile, it has a great impact on the balance of revenue and expenses of public hospitals, the quality and technical level of medical services, and so on. This paper further reveals the implementation status, significance and problems existing in the operation of “zero-markup drug” in public hospitals, and puts forward countermeasures from the perspectives of government and public hospitals respectively, hoping to provide suggestions and references for government departments to further formulate and promote relevant medical reform policies, to perfect the new mechanism of public hospitals, and to ensure the effective implementation of the “zero-markup drug” policy, so as to achieve better social and economic benefits.
		2022 Vol. 19 (14): 162-165,170 [Abstract] ( 45 ) HTML (1 KB) PDF (781 KB) ( 145 )

	166	Application of electric inflatable position pad in laparoscopic radical resection of rectal cancer
		HUANG Peipei1 CHEN Yaxing1 JIANG Yun1 HU Jia1 NIU Shoujun1 QIAN Fei2 ZHU Qin1 NI Qingfeng2
		Objective To investigate the application of electric inflatable body position pad in laparoscopic radical resection of rectal cancer. Methods A total of 72 patients with rectal cancer underwent laparoscopic radical resection from May 2019 to July 2020 in Affiliated Hospital of Nantong University were selected. According to the random number table method, 36 patients were divided into control group, conventional transverse occipital exposure of the anal orea was used. In the observation group, 36 patients were fully exposed to the anal surgical field by self-made electric inflatable pad. The placement of the position pad and the observation of the finishing time, postoperative skin compression of patients in the sacral tail, postoperative comfort, satisfaction of doctors, visiting nurses, and patient satisfaction were compared between the two groups. Results The positioning time, observation and finishing time, and total positioning time of the observation group were shorter than those of the control group, the differences were statistically significant (P ＜ 0.05). The skin of the sacral tail was intact in both groups, and the local hyperemia, redness and induration of the sacral tail in the observation group was significantly better than that in the control group, the differences were statistical significance (P ＜ 0.05). At 24 h and three days after surgery, the visual analog scale (VAS) score of the observation group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05); there was no significant difference in VAS scores between the two groups on the 7th postoperative day (P ＞ 0.05). After surgery, the satisfaction of the three parties of doctors, nurses, and patients to the two groups of position pad was compared, the observation group was higher the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The application of inflatable position pad in laparoscopic rectal cancer surgery can not only avoid postoperative lumbosacral pain and improve postoperative comfort of patients, but also reduce the time of position placement and repeated arrangement, protect the sacral tail skin of patients, and effectively improve the satisfaction of doctors, nurses, and patients.
		2022 Vol. 19 (14): 166-170 [Abstract] ( 45 ) HTML (1 KB) PDF (933 KB) ( 46 )

	171	Application study of Braden scale and Scott triggers scale in ICU elderly patients undergoing hip arthroplasty with pressure injury
		LI Yang1 QI Jinfang1 DONG Zhenghui2▲ LI Zhengang1
		Objective To explore the predictive value of Braden scale and Scott triggers scale in the risk assessment of pressure injury in elderly patients undergoing hip arthroplasty in ICU. Methods A total of 220 elderly patients admitted to ICU after hip replacement the Sixth Affiliated Hospital of Xinjiang Medical University from November 2020 to May 2021 were selected as the study subjects. Taking the occurrence of post-operative stress injury as the gold standard, the risk of stress injury was assessed by the Braden Scale and Scott Triggers Scale and the predictive value was compared. Results A total of 27 cases(12.27%) of 220 patients developed stress injury, all of which were stage Ⅰ. When the area under ROC curve of Braden scale was 0.735, the total score was 14.5, and the Jorden index was 0.373, the predictive value was the best. The prediction value was best when the area under the ROC curve of the Scott Triggers scale was 0.934, the total score was 5.5 and the Youlden index was 0.678. The Hosmer-Lemeshow goodness-of-fit test showed that (χ2=3.709, P = 0.295) of the Braden scale, and the (χ2=1.141, P = 0.565) of the Scott triggers scale. Conclusion Both the Braden scale and the Scott triggers scale can assess the risk of pressure injury in elderly patients undergoing hip arthroplasty in the ICU. The predictive value of the Scott triggers scale is better than that of the Braden scale, and the items are concise and objective, and the time is shorter.
		2022 Vol. 19 (14): 171-174,179 [Abstract] ( 44 ) HTML (1 KB) PDF (726 KB) ( 62 )

	175	Application of mind mapping combined with progressive exercise in postoperative patients with lumbar disc herniation
		XIAO Ying HU Jiahong
		Objective To explore the application effect of mind map combined with progressive exercise in patients with lumbar disc herniation after operation. Methods A total of 84 patients with lumbar disc herniation treated in the Department of Orthopedics of Xuancheng People’s Hospital from January 2019 to June 2021 were selected as the study subjects, and were randomly divided into observation group (43 cases) and control group (41 cases) by random number table method. The control group implemented progressive exercise, and the observation group added mind map for health education. After three months, the knowledge mastery, Japanese orthopaedic association scale (JOA) score, readiness for hospital discharge scale (RHDS) score were compared. Results Three months after discharge, the scores of knowledge questionnaire in both groups were higher than those at admission, and observation group was higher than control group, the differences were statistically significant（P ＜ 0.05）. Comparison of JOA score time, intergroup and interaction between the two groups, the difference were statistically significant (P ＜ 0.05); further pairwise comparison, intra-group comparison: three months after discharge, the JOA score of the two groups was higher than that before discharge and at admission; the JOA score before discharge was higher than that at admission, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: Before admission, there was no significant difference in JOA score between the two groups (P > 0.05); before and three months after discharge, JOA score in the observation group was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). The observation group’s own situation, disease knowledge, available social support and total score were higher than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Mind mapping combined with progressive exercise can improve the intervention effect of patients with lumbar disc herniation.
		2022 Vol. 19 (14): 175-179 [Abstract] ( 152 ) HTML (1 KB) PDF (1118 KB) ( 29 )

	180	Application of intervention model based on behavior change theory in postoperative nursing of patients with endometrial cancer
		WANG Yanli1 JIN Weina2 ZHAO Minhui3▲
		Objective To explore the application effect of intervention model based on behavior change theory in postoperative nursing of patients with endometrial cancer. Methods A total of 100 postoperative patients with endometrial cancer treated in the First Maternal and Infant Health Hospital Affiliated to Tongji University from January 2018 to December 2020 were selected, according to random number table method, they were divided into observation group and control group, with 50 cases in each group. The control group received routine intervention after operation, and the observation group received behavior change intervention after operation. Both groups were intervened for one month. General self-efficacy scale (GSES), adult health self-management ability self-rating scale (AHSMSRS), and the incidence of total complications during the intervention were compared between the two groups before and one month after intervention. Results After one month of intervention, the GSES and AHSMSRS scores of both groups were higher than those before intervention, and the scores of the observation group were higher than those of the control group, the differences were statistically significant (P ＜ 0.05). There was no statistical significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion The intervention model based on behavior change theory can improve the sense of self-efficacy and strengthen the ability of self-management in postoperative patients with endometrial cancer.
		2022 Vol. 19 (14): 180-183 [Abstract] ( 80 ) HTML (1 KB) PDF (574 KB) ( 59 )

	184	A case of pregnancy with hemophagocytic lymphohistiocytosis and literature review
		LU Xiaoshan XIN Jiachun LI Li WANG Hailin
		Pregnancy with hemophagocytic lymphohistiocytosis (HLH) is a rare disease seriously endangering maternal and infant health in obstetrics, and the specific pathogenesis is still unclear. In this report, the patient had liver function change as the initial symptom, and was accompanied by high fever of unknown reason from the third day after admission, and her condition became worse. It was suggested to terminate pregnancy by surgery. After postoperative symptomatic treatment, such as infection prevention, liver protection, bile acid reduction, and fever reduction, the liver function improved significantly, but the patient still suffered from recurrent high fever. After multidisciplinary consultation, laboratory examination, and bone marrow biopsy, the patient was confirmed to be pregnant with HLH. After symptomatic treatment such as antiviral therapy and immunotherapy, the patient had a good prognosis, and no abnormality was found in follow-up. In this paper, the clinical characteristics, pathogenesis, diagnostic criteria, treatment methods, and prognosis of pregnancy with HLH were introduced by reporting the diagnosis and treatment of the patient and reviewing relevant literatures, so as to improve clinicians’ understanding of the disease, broaden the diagnosis and treatment ideas, and reduce missed diagnosis and misdiagnosis.
		2022 Vol. 19 (14): 184-187 [Abstract] ( 45 ) HTML (1 KB) PDF (501 KB) ( 26 )

	188	Discussion on the construction and practice of a new type of education carrier of industry
		ZHOU Shuanglin XU Xiaojun XIA Miaofen
		Based on the transformation and upgrading of the health industry, especially the rapid development and change of the demand for talents and technical services, taking the construction of the “IVD industry innovation class” as an example, from the perspective of a community of shared destiny for the coordinated development of “discipline-professional-industrial chain”, based on the six-in-one concept of “government-industry-university-research transformation”, it integrates all resources and creates various functions, as an effective support for education and services, the carrier and platform of the company have innovated and established the operating system mechanism of this new carrier of integrated education and education according to the inherent requirements of “discipline-professional-industrial chain”. The practice results are good, which is helpful to realize the goal of deepening the integration of industry and education and collaborative education.
		2022 Vol. 19 (14): 188-191,196 [Abstract] ( 54 ) HTML (1 KB) PDF (748 KB) ( 153 )

	192	Analysis of the current situation and influencing factors of knowledge, attitude, and practice of prehabilitation among medical staff in department of thoracic surgery
		CHEN Ailian TANG Wenfeng XU Lian YANG Xiaoyi ZHANG Cheng WU Qingchen
		Objective To investigate the current situation of the knowledge, attitude, and practice (KAP) of prehabilitation medical staffs in department of thoracic surgery and its influencing factors, and to provide reference for clinical practice. Methods From November to December 2020, 394 medical staffs working in department of thoracic surgery of 38 general hospitals in Chongqing were selected as the research objects. The current situation of KAP level about prehabilitation was evaluated by using the self-designed KAP questionnaire. The single factor and multi-factor analysis were used to analyze the influencing factors of KAP level about prehabilitation of medical staffs working in department of thoracic surgery. Results The total score of KAP of medical staff in department of thoracic surgery was (63.87±9.16) points, the knowledge score was (26.20±4.84) points, the attitude score was (22.28±2.52) points, and the practice score was (15.39±4.51) points. Knowledge and attitude, knowledge and behavior, attitude and behavior were positively correlated (P < 0.01). The results of univariate analysis showed that there was significant difference in the score of knowledge, attitude and practice of pre-habilitation among thoracic medical staff of different age, education background, working years, position, hospital level and department whether to implement enhanced recovery after surgery of medical staff in department of thoracic surgery (P < 0.05). Multivariate regression analysis showed that working years (X3), hospital levels (X5), and whether the department had implemented enhanced recovery after surgery (X6) were influencing factors of medical staff in department of thoracic surgery (P ＜ 0.05). The linear regression equation was obtained: Y = 93.269-4.270 X3-3.290X5-7.123X6, F ＝ 42.902, R2 ＝ 0.420, adjusted R2 ＝ 0.410. Conclusion Medical staffs working in department of thoracic surgery have a positive attitude towards prehabilitation, but their knowledge and practice need to be improved. Working years, hospital levels, and whether their departments had implemented enhanced recovery after surgery were influencing factors of KAP level, the education and training of pre-habilitation should be strengthened for junior medical staff and primary hospitals, and accelerate the implementation of enhanced recovery after surgery in departments, so as to and promote the clinical practice of pregailitation.
		2022 Vol. 19 (14): 192-196 [Abstract] ( 57 ) HTML (1 KB) PDF (616 KB) ( 200 )

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