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| Research progress of traditional Chinese medicine intervention in colorectal cancer based on Wnt/β-catenin signaling pathway |
| YANG Binbin1 CUI Ning1 ZHANG Yanan2 ZHAO Wenxiao3 WANG Shijun2 |
1.College of Health Sciences, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China;
2.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China;
3.School of Nursing, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China |
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Abstract Colorectal cancer is an important public health problem all over the world, Wnt classical signaling pathway participates in the occurrence and development of colorectal cancer by affecting life activities such as cell growth, proliferation, and differentiation. Its abnormal activation can lead to the proliferation, invasion and metastasis of tumor cells, β-catenin has become an important target for the treatment of colorectal cancer. Traditional Chinese medicine believes that colorectal cancer belongs to the category of “intestinal qin”, “intestinal addiction”, “accumulation”. The treatment is mainly to strengthen the spleen and soft and firm, clear away heat and dampness, regulate qi and activate blood circulation. It has achieved good effect in the prevention and treatment of colorectal cancer. Many studies have found that traditional Chinese medicine monomer or compound play an anti-tumor role by inhibiting the activation of Wnt pathway. This paper reviews the relevant research results of traditional Chinese medicine in the treatment of colorectal cancer through targeted intervention of Wnt/β-catenin signaling pathway, in order to promote the research on the clinical anticancer mechanism of traditional Chinese medicine, and make more rational use of traditional Chinese medicine in clinic.
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