血清TGFBI蛋白、促胃液素-17及幽门螺杆菌- IgG水平对早期胃癌患者内镜黏膜下剥离术后复发的预测价值

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Abstract Objective To investigate the predictive value of serum TGFBI protein, gastrin-17 (G-17), and Helicobacter pylori-IgG (HP-IgG) levels in patients with early gastric cancer after endoscopic submucosal dissection (ESD). Methods A total of 255 patients with early gastric cancer who received ESD treatment in Shaanxi Province 3201 Hospital (hereinafter referred to as “our hospital”) from February 2016 to February 2019 were selected, and they were divided into recurrence group (20 cases) and non-recurrence group (235 cases) according to wether recurrence. Clinical data and preoperative levels of TGFBI protein, G-17, and HP-IgG were collected and compared between the two groups to analyze the influencing factors of recurrence in early gastric cancer patients undergoing ESD. The predictive value of each index and combined detection for recurrence of early gastric cancer after ESD was analyzed by the receiver operation characteristic curve. Results The proportion of submucosal infiltration depth and the preoperative serum levels of TGFBI protein, G-17, and HP-IgG in the recurrence group were higher than those in the non-recurrence group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that preoperative high levels of serum TGFBI protein, G-17, HP-IgG, and submucosal infiltration depth were independent risk factors for recurrence after ESD in early stage gastric cancer patients (OR ＞ 1, P ＜ 0.05). Preoperative combined detection of serum TGFBI protein, G-17, and HP-IgG showed a greater area under the curve in predicting recurrence after ESD in patients with early gastric cancer than that of TGFBI protein, G-17, and HP-IgG alone (P ＜ 0.05). Conclusion The combined detection of serum levels of TGFBI, G-17, and HP-IgG before ESD have high predictive value for recurrence of early gastric cancer after ESD, and it is worthy for clinical investigation.

Key words： Early gastric cancer Endoscopic submucosal dissection TGFBI protein Gastrin-17 Helicobacter pylori-IgG

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	PAN Chunsheng1 FAN Zhigang2

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PAN Chunsheng1 FAN Zhigang2. Predictive value of serum TGFBI protein, gastrin-17, and Helicobacter pylori-IgG levels for recurrence after endoscopic submucosal dissection in patients with early gastric cancer[J]. 中国医药导报, 2022, 19(14): 109-112.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I14/109

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