基于数据挖掘的国医大师张大宁治疗慢性肾脏病用药规律分析

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Abstract Objective To analyze and summarize the medication rule of master of national physician Zhang Daning in the treatment of chronic kidney disease based on data mining. Methods Medical records of Professor Zhang Daning’s diagnosis and treatment of chronic kidney disease from January 2020 to December 2020 were selected from the medical records database of famous doctors’ studio of Zhang Daning of Guangdong Provincial Hospital of Chinese Medicine. Descriptive analysis and cluster analysis were performed for high-frequency drugs in medical cases (frequency≥20%). The association rules analysis were conducted with Apriori algorithm. Results A total of 143 medical cases, 143 prescriptions, and 138 single Chinese herbs were included. The top five Chinese herbs were Astragali Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Chuanxiong Rhizoma, Smilacis Glabrae Rhizoma, and Dendrobii Caulis. The top five high-frequency herbs in frequency were promoting blood circulation and removing stasis, tonifying deficiency, unblocking fu-organs to remove turbidity, removing dampness, and astringent herbs. Herbs were distinguished by four nature of drugs, 12 herbs were warm and slightly warm, 9 herbs were flat, 5 herbs were cold and slightly cold. Herbs were distinguished by five flavors, 16 herbs were sweet, 14 herbs were bitter, and 9 herbs were pungent. Herbs were distinguished by channel tropism, 20 herbs belonged to spleen channel, 13 herbs belonged to liver channel, 12 herbs belonged to kidney channel. High-frequency drugs were divided into 7 clusters by cluster analysis. After the analysis of association rules, 33 related rules were obtained. Conclusion Professor Zhang Daning’s treatment of chronic kidney disease focuses on tonifying deficiency, promoting blood circulation and removing stasis, and unblocking fu-organs to remove turbidity. The self-made prescription Yinchen Shixiao Powder is the basic prescription, which could provide reference for traditional Chinese medicine treatment of chronic kidney disease.

Key words： Chronic kidney disease Cluster analysis Association rule analysis Medication rule

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	LI Hucai LIN Junjie HE Zhiren WANG Lixin

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LI Hucai LIN Junjie HE Zhiren WANG Lixin. Analysis of medication rule of master of national physician Zhang Daning in the treatment of chronic kidney disease based on data mining[J]. 中国医药导报, 2022, 19(14): 133-137.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I14/133

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