妊娠合并噬血细胞综合征1例并文献复习

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Abstract Pregnancy with hemophagocytic lymphohistiocytosis (HLH) is a rare disease seriously endangering maternal and infant health in obstetrics, and the specific pathogenesis is still unclear. In this report, the patient had liver function change as the initial symptom, and was accompanied by high fever of unknown reason from the third day after admission, and her condition became worse. It was suggested to terminate pregnancy by surgery. After postoperative symptomatic treatment, such as infection prevention, liver protection, bile acid reduction, and fever reduction, the liver function improved significantly, but the patient still suffered from recurrent high fever. After multidisciplinary consultation, laboratory examination, and bone marrow biopsy, the patient was confirmed to be pregnant with HLH. After symptomatic treatment such as antiviral therapy and immunotherapy, the patient had a good prognosis, and no abnormality was found in follow-up. In this paper, the clinical characteristics, pathogenesis, diagnostic criteria, treatment methods, and prognosis of pregnancy with HLH were introduced by reporting the diagnosis and treatment of the patient and reviewing relevant literatures, so as to improve clinicians’ understanding of the disease, broaden the diagnosis and treatment ideas, and reduce missed diagnosis and misdiagnosis.

Key words： Pregnancy Hemophagocytic lymphohistiocytosis EB virus Treatment

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	LU Xiaoshan XIN Jiachun LI Li WANG Hailin

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LU Xiaoshan XIN Jiachun LI Li WANG Hailin. A case of pregnancy with hemophagocytic lymphohistiocytosis and literature review[J]. 中国医药导报, 2022, 19(14): 184-187.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I14/184

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