中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2022 Vol. 19, No. 8
Published: 2022-03-15
 
 
5 Protective effect of Shuxuetong Injection on acute pulmonary embolism rats and its effect on cell apoptosis#br#
ZHANG Shengbi1 LIU Yanling2 XU Liying3
Objective To study the protective effect of Shuxuetong Injection on acute pulmonary embolism (APE) and its effect on cell apoptosis. Methods Seventy-five SPF male SD rats aged seven weeks and weighing (250±20) g were divided into sham operation group, model group, Shuxuetong low-dose, medium-dose and high-dose groups according to random number table method, with 15 rats in each group. Except for the sham operation group, the APE model was prepared by autologous thrombosis transfusion, and the sham operation group was injected with the same amount of normal saline. Two hours before modeling, Shuxuetong dose groups were subcutaneously injected with 0.25, 0.5 and 1 ml/kg Shuxuetong Injection, and sham operation group and model group were subcutaneously injected with Dimethyl sulfoxide. The rats were anesthetized four hours after operation, the mean pulmonary artery pressure (mPAP) and right ventricular pressure (RVP) were detected, blood gas analysis, lung wet-dry ratio, oxidative stress, and pathological indicators of lung were detected, cell apoptosis was detected by TUNEL staining, and protein expression levels of Bcl-2, Bax, and Caspase-3 were detected by Western blot. Results Compared with sham operation group, the levels of mPAP and RVP in model group were increased (P ＜ 0.01). Compared with model group, mPAP level in Shuxuetong medium-dose and high-dose groups was decreased, while RVP level in Shuxuetong high-dose group was decreased (P ＜ 0.05). Compared with Shuxuetong low-dose group, the mPAP level in Shuxuetong medium-dose and high-dose groups was decreased (P ＜ 0.05). Compared with sham operation group, arterial partial pressure of oxygen (PaO2) in model group was decreased (P ＜ 0.01); compared with model group, the level of PaO2 in Shuxuetong high-dose group was increased (P ＜ 0.01). There was no significant difference in arterial blood partial pressure of carbon dioxide among all groups (P > 0.05). The lung tissue of the model group was seriously injured, while the lung tissue of Shuxuetong high-dose, medium-dose and low-dose groups showed some improvement, and the improvement was more obvious in Shuxuetong high-dose group. Compared with sham operation group, lung wet-dry ratio in model group was increased (P ＜ 0.01). Compared with model group and Shuxuetong low-dose group, the lung wet-dry weight ratio in Shuxuetong high-dose group was decreased (P ＜ 0.05). Compared with sham operation group, the activity levels of superoxide dismutase (SOD) and glutathione (GSH) in model group were decreased, while the activity level of myeloperoxidase (MPO) was increased (P ＜ 0.01). Compared with model group, SOD activity level of Shuxuetong medium-dose and high-dose groups was increased, MPO activity level was decreased, GSH activity level of Shuxuetong high-dose group was increased (P ＜ 0.05 or P ＜ 0.01). Compared with Shuxuetong low-dose and medium-dose groups, MPO activity in Shuxuetong high-dose group was decreased (P ＜ 0.01), and compared with Shuxuetong low-dose group, GSH activity in Shuxuetong high-dose group was increased (P ＜ 0.05). There were a lot of apoptosis in model group, the apoptosis of Shuxuetong low-dose group was alleviated, and the apoptosis of Shuxuetong medium-dose and high-dose groups was improved significantly. Compared with sham operation group, the expression levels of Bax and Caspase-3 protein in the lung tissues of model group were increased, while the expression level of Bcl-2 protein was decreased (P ＜ 0.01). Compared with model group, Bax protein expression level in the lung tissues of Shuxuetong medium-dose and high-dose groups was decreased, Bcl-2 protein expression level was increased, and Caspase-3 protein expression level in the lung tissues of Shuxuetong high-dose group was decreased (P ＜ 0.05). Compared with Shuxuetong low-dose group , the Bax and Caspase-3 protein expression levels in Shuxuetong high-dose group were decreased, while the Bcl-2 protein expression level was increased (P ＜ 0.05 or P ＜ 0.01). Compared with Shuxuetong medium-dose group, the expression level of Bax protein in the lung tissue of Shuxuetong high-dose group was decreased (P ＜ 0.05). Conclusion Shuxuetong Injection can effectively improve pulmonary embolism injury and inhibit apoptosis in rats.
2022 Vol. 19 (8): 5-10 [Abstract] ( 62 ) HTML (1 KB)  PDF (1897 KB)  ( 54 )
11 Relationship between HPV infection and expressions of TLR4， NF-κB protein in breast cancer and its clinical significance#br#
SHI Zhe1* REN Shan2* YANG Li1 DAI Wenbin1
Objective To investigate the relationship between human papilloma virus (HPV) infection and expressions of Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) protein in breast cancer and its clinical significance. Methods A total of 50 cases of invasive cancer breast samples from January 2018 to December 2019 in Department of Breast Surgery, Liuzhou People’s Hospital, Guangxi Zhuang Autonomous Region were classified as cancer group, 30 cases of ductal atypical ductal hyperplasia (ADH) breast samples were classified as ADH group, and 30 cases of normal breast tissue were classified as normal group. Immunohistochemical staining was used to detect the positive expression of HPV16/18E6, TLR4, and NF-κB protein in three groups; the correlation between HPV16/18E6, TLR4, and NF-κB protein in cancer group and ADH group were analyzed; the relationship between positive expression of HPV16/18E6, TLR4, and NF-κB protein and clinicopathological features in cancer group were compared. Results The positive expression rate of HPV16/18E6, TLR4, and NF-κB protein among three groups were highly significantly different (P < 0.01). The positive expression rate of HPV16/18E6 in cancer group was higher than that in ADH group and normal group (P < 0.017); the positive expression rate of TLR4 and NF-κB protein cancer group was higher than that in ADH group and normal group, and ADH group was higher than normal group (P < 0.017). In cancer group and ADH group, HPV16/18E6 were positively correlated with TLR4 and NF-κB protein (P < 0.01), and TLR4 was positively correlated with NF-κB protein (P < 0.01). The positive expression rate  of HPV16/18E6, TLR4, and NF-κB protein were correlated with histological grade, tumor diameter, lymph node metastasis, and clinicopathological stage (P < 0.05). Conclusion High-risk HPV infection plays an important role in the development and progression of breast cancer in conjunction with TLR4 and NF-κB inflammatory factors.
2022 Vol. 19 (8): 11-15 [Abstract] ( 89 ) HTML (1 KB)  PDF (1047 KB)  ( 142 )
16 Exploration of the material basis and molecular mechanism of Rhizoma Polygonati in the treatment of non-small cell lung cancer based on network pharmacology and molecular docking#br#
YANG Jiani1 ZHU Xingmei1 YUAN Panpan2 GUO Kaili2 XUE Miao2 LIU Jiping1 WANG Chuan1 WANG Bin1
Objective To explore the material basis and molecular mechanism of Rhizoma Polygonati in the treatment of non-small cell lung cancer (NSCLC) based on network pharmacology and molecular docking. Methods The active components and effect targets of Rhizoma Polygonati were searched in traditional Chinese medicine systems pharmacology database and analysis platform, the targets of NSCLC were searched in Online Mendelian Inheritance in Man, Human Genome Annotation database, and Therapeutic Target database, the component-disease common targets were integrated. DAVID database was used for gene ontology and kyoto encyclopedia of genes and genomes pathway enrichment analysis, the network of “component-target-pathway” was constructed by Cytoscape 3.6.1 software, and the network was analyzed by network analyzer plug-in. AutoDock 4.2 was used for molecular docking, CCK8 method and flow cytometry were used for studying the anti-proliferation and apoptosis induced effects of flavone of Rhizoma Polygonati on A549 cells in vitro. Results 8 components in Rhizoma Polygonati exerted anti-NSCLC effects through 43 targets; these mainly included cancer, apoptosis, hypoxia inducible factor-1, tumor necrosis factor and other signaling pathways; 3’-methoxydaidzein, baicalein, liquiritigenin, and 5,4’-dihydroxyflavone played major roles corresponding to 7 targets; the IC50 of 3’-methox- ydaidzein, baicalein, and liquiritigenin acted on A549 cells for 48 h were 6.88×10, 7.99, 4.34×10 μg/ml respectively; high dose baicalein could induce apoptosis of A549 cells in a concentration-dependent manner. Conclusion Flavonoids in Rhizoma Polygonati could suppress proliferation and induce apoptosis to play the role of anti-NSCLC.
2022 Vol. 19 (8): 16-20 [Abstract] ( 88 ) HTML (1 KB)  PDF (1710 KB)  ( 231 )
21 Visual analysis of literatures related to animal model of femur head necrosis in the past 30 years based on CiteSpace#br#
ZENG Xiangrong1 LI Taixian2 CHEN Weiheng3
Objective To explore the research situation of animal model of femoral head necrosis, and to summarize the research hotspots. Methods “femoral head necrosis” and “experimental animal models” were used as the subject words in the CNKI database, the search period was from January 1992 to December 2020, visual analysis of literatures was carried out with CiteSpace, which were analyzed from the number of published articles by years, author cooperation network, number of published articles by authors, institutional cooperation network, and keyword co-occurrence network. Results 790 related literatures were finally included, the number of annual published articles in 2009 was the most (69 articles); in terms of the author cooperation network and the number of published articles by authors, three cooperative teams had been formed, with Tong Peijian, Fan Meng, and Wang Kunzheng as the cores, respectively, among them, Tong Peijian’s team had published the most articles (19 articles); institutional cooperation network had mainly concentrated in Chengdu, Shanghai, and Tianjin, the cooperation relationship was in the same region; keyword co-occurrence network showed that steroid-induced femoral head necrosis was the current research hotspot. Conclusion Research on animal models of femoral head necrosis has gradually matured, research hotspots tend to be steroid-induced femoral head necrosis, but the cooperation among research institutions in different regions should be strengthened.
2022 Vol. 19 (8): 21-24,29 [Abstract] ( 195 ) HTML (1 KB)  PDF (2198 KB)  ( 189 )
25 Mediation effect of negative cognitive emotion regulation between maladaptive perfectionism and subthreshold depression in medical college students#br#
SUI Kaixin ZHANG Yichunzi ZHAO Chenjie XIAO Yun KONG Junhui
Objective To explore the mediation role of negative cognitive emotion regulation between non-adaptive perfectionism and subthreshold depression in medical college students, and to provide evidence for intervention in subthreshold depression. Methods A cluster sampling method was adopted to select 1016 college students from four medical schools in Beijing from May to July 2019. The Chinese version of the frost multidimensional perfectionism scale (CFMPS), the Chinese version of the cognitive emotion regulation questionnaire (CERQ-C) and the center for epidemiological studies depression scale (CES-D) were used to investigate. Correlation analysis, Hayes’ PROCESS 3.5 program and Bootstrap method were used to test the mediating effect and significance. Results A total of 1200 questionnaires were actually distributed, a total of 1016 valid questionnaires were recovered, and the effective recovery rate was 84.67%. The subthreshold depression score of medical college students was (19.98±8.88) points; the perfectionism score was (83.38±14.51) points; the negative cognitive emotion regulation score was (45.16±8.86) points. There were statistically significant differences in the scores of adaptive perfectionism among students of different genders (P ＜ 0.05); comparing the scores of perfectionism, non-adaptive perfectionism, and negative cognitive emotion regulation among medical college students at different training levels, and the differences were statistically significant (P ＜ 0.05). There was positive correlation between nonadaptive perfectionism and subthreshold depression in medical students (r = 0.669, P ＜ 0.01); there was negative correlation between adaptive perfectionism and subthreshold depression (r = -0.298, P ＜ 0.01); negative cognitive emotion regulation was positively correlated with subthreshold depression (r = 0.689, P ＜ 0.01). Negative cognitive emotion regulation had mediating effect between maladaptive perfectionism and subthreshold depression, with an effect size of 0.20 (Boot CI: 0.17, 0.23). Conclusion Negative cognitive emotion regulation mediates the relationship between maladaptive perfectionism and subthreshold depression in medical school students. Therefore, schools should intervene by focusing on non-adaptive perfectionist personality and improving negative cognitive emotion regulation to improve students’ subthreshold depression.
2022 Vol. 19 (8): 25-29 [Abstract] ( 81 ) HTML (1 KB)  PDF (792 KB)  ( 208 )
30 Regularity and mechanism study of Chinese medicine to treat DPN based on data mining and network pharmacology#br#
XING Qichang CHEN Jia LIU Zheng LI Wei LIU Xiang
Objective To explore the rule of traditional Chinese medicine for the treatment of diabetic peripheral neuropathy (DPN), to discover the core drug pair and analyze the corresponding targets and pathways with the help of network pharmacology. Methods Literature on the treatment of DPN with traditional Chinese medicine prescriptions from January 2009 to September 2020 was retrieved and collected from China National Knowledge Infrastructure. The traditional Chinese medicine inheritance assistance system software (V3.0) was used to analyze the medication rules, and the core drug pairs were obtained based on association rule analysis. The chemical composition, action target and disease target of the core drug were obtained by traditional Chinese medicine system pharmacology database and analysis platform, DrugBank, TTD, and DisGeNET database. GO and KEGG analysis of the action target of the drug on DPN was performed by DAVID database. Finally, molecular docking technology was used to verify the docking between core chemical components and key targets. Results In terms of data mining, 204 Chinese medicines were used in 437 Chinese medicine prescriptions for DPN. The most commonly used were traditional Chinese medicines such as tonifying deficiency, promoting blood circulation and removing blood stasis, the core drug pairs were obtained based on association rule analysis, among which astragalus milkvetch root-Chinese angelica had the highest support. In the part of network pharmacology, 104 compounds in milkvetch root-Chinese angelica act on 218 targets, and 33 targets related to DPN disease. KEGG enrichment analysis showed that the mechanism of action of the drug on the treatment of DPN mainly involved the interaction of neuroactive ligands and receptors 140 biological processes such as stimulation response, 18 cellular components such as cell membrane, and 25 molecular functions such as protein binding were obtained by GO analysis. The molecular docking verification drug had a good affinity for the core chemical components and the key targets of DPN. Conclusion The treatment of traditional Chinese medicine on DPN is based on replenishing qi and nourishing yin, promoting blood circulation for removing blood stasis, warming yang for dispelling cold. The compatibility of milkvetch root-Chinese angelica can intervene the course of DPN through multi-component, multi-target and multi-action pathways.
2022 Vol. 19 (8): 30-34 [Abstract] ( 166 ) HTML (1 KB)  PDF (2833 KB)  ( 125 )
35 Application progress of nutritional support in patients with radiotherapy for malignant tumors#br#
WANG Qinglan PAN Cen▲ DENG Yangqing
Patients with radiotherapy for malignant tumors have metabolic disorders of organism, radiation side effects, and psychological conditions due to their own diseases, vulnerable to malnutrition, which affect the therapeutic effect, quality of life, and overall survival situation. Compliant and reasonable tumor nutritional treatment can greatly improve the survival treatment and treatment sensitivity of cancer patients. The nutritional risk screening scale 2002 should be routinely used for patients with tumor radiotherapy to conduct nutritional risk screening, evaluating and monitoring nutritional status before, during, and after radiotherapy. This paper further used the patient-generated subjective global assessment scale for patients at nutritional risk, and classification criteria for acute radiation injury in the radiation therapy oncology group during radiotherapy to determine the next intervention strategy. Tumor patients should adopt the principle of five-step treatment according to the degree of malnutrition. The strengthening of clinical nursing work also has great significance and influence on improving patients’ satisfaction with treatment outcome and quality of life, satisfaction, and so on. This article reviews the application progress in the application of nutritional support therapy in patients with malignant tumors undergoing radiotherapy, in order to promote the more standardized implementation of nutritional support in patients with tumor radiotherapy.
2022 Vol. 19 (8): 35-38,47 [Abstract] ( 120 ) HTML (1 KB)  PDF (655 KB)  ( 214 )
39 Research progress of postpartum self-management in women with gestational diabetes mellitus#br#
HU Rong GUO Honghua LI Tong ZHANG Caihong
With the decline of the diagnostic threshold of gestational diabetes mellitus (GDM) and the opening of the national two-child and three-child policy, the prevalence of GDM in my country has continued to rise, and it has also become a major health problem that threatens women’s health. Relevant studies have confirmed that GDM women have a significantly higher risk of developing type 2 diabetes (T2DM) in the future than normal women, and long-term postpartum self-management is an effective strategy to prevent and delay T2DM. Therefore, by reviewing the content, influencing factors, research status, and intervention measures of postpartum self-management in women with GDM, this paper aims to provide a reference for clinical formulation of postpartum self-management intervention programs, thereby improving postpartum outcomes.
2022 Vol. 19 (8): 39-42 [Abstract] ( 157 ) HTML (1 KB)  PDF (560 KB)  ( 132 )
43 Analysis of status quo and influencing factors of self-perceived burden in patients with lower extremity deep vein thrombosis#br#
XIAO Mian1 JIA Rufu1 YIN Guimei2 WANG Yafei2
Objective To investigate the level of self-perceived burden (SPB) in patients with lower extremity deep vein thrombosis (DVT) and to explore the influencing factors. Methods A total of 280 patients with lower extremity DVT who were hospitalized in Cangzhou Central Hospital, Hospital of Integrated Traditional Chinese and Western Medicine, and People’s Hospital of Vascular Surgery in Hebei Province from September 2020 to April 2021 were selected as the research subjects. General information questionnaire, self-perceived burden scale (SPBS), perceived social support scale, and venous insufficiency quality of life / symptom questionnaire were used to investigate. Results The SPB score of lower extremity DVT patients was (28.83±7.43) points.  There were statistically significant differences in the SPBS total scores of lower extremity DVT patients with different age, marital status, work situation, payment method, per capita monthly income of family, caregivers and their health status, time in bed, and chronic diseases (P ＜ 0.05). The results of Pearson correlation analysis showed that except physiological functions the SPBS score and each dimension score of patients with lower extremity DVT were negatively correlated with PSSS and venous insufficiency symptoms (P < 0.05 or P ＜ 0.01). The results of multiple linear regression analysis showed that work status, payment method, health status of caregivers, time in bed, combined chronic diseases, venous insufficiency quality of life / symptoms, and perception of social support were the influencing factors of SPB in patients with lower extremity DVT (P ＜ 0.05). A total of 43% of the total variance in variance was explained. Conclusion SPB in patients with lower extremity DVT is in the mild to moderate level. Clinical medical staff should formulate targeted nursing strategies to reduce the burden of self-perceived patients, thereby reducing the impact of psychological factors on the disease.
2022 Vol. 19 (8): 43-47 [Abstract] ( 196 ) HTML (1 KB)  PDF (710 KB)  ( 108 )
48 Analysis of the status quo and influencing factors of depression in the elderly#br#
WAN Qiurong HUANG Yalian MAO Xiaoyu TANG Ping
Objective To understand the status quo and influencing factors of depression in the elderly. Methods The 2018 China Health and Retirement Longitudinal Survey (CHARLS) data was used, demographic variables such as gender, age, marital status, education level were selected, and the level of observations on the simplified epidemiological survey center depression scale was used. After excluding samples with missing values, a total of 1581 samples were included for research. Results The survey results showed that 34.9% of the elderly had depressive symptoms. There were statistically significant differences in the scores of depression level among the elderly with different residence, marital status, self-assessed health status, brain intelligence, deafness and disability (P ＜ 0.05). The logistic regression results showed that residence, marital status, whether drinking in the past year, and self-assessed health status were the influencing factors of depression in the elderly (P ＜ 0.05). Among them, compared with the elderly in rural areas, the probability of depressive symptoms in the elderly in urban areas was reduced by 0.34 times (OR = 0.66, P ＜ 0.05); compared with the elderly in unmarried and separated status, the probability of depressive symptoms in the elderly in married was reduced by 0.37 times (OR = 0.66, P ＜ 0.05); compared with the elderly with very good self-assessed health status, the probability of depressive symptoms in the elderly with very poor self-assessed health status increased by 1.73 times (OR = 2.73, P ＜ 0.05). Conclusion A variety of factors jointly affect the depressive symptoms of the elderly, and comprehensive intervention methods should be used to intervene in the depressive symptoms of the elderly.
2022 Vol. 19 (8): 48-51,63 [Abstract] ( 209 ) HTML (1 KB)  PDF (584 KB)  ( 191 )
52 Correlation analysis between death anxiety and mental health screening scale of Chinese college students in higher vocational nursing students#br#
YANG Shilai HUANG Chunying JI Xiaofeng HU Shaofen XIN Huiming
Objective To understand the current situation of death anxiety among nursing students in higher vocational colleges, and to analyze the predictive value of the Chinese college students mental health scale (CCSMHS). Methods A total of 1553 nursing students of Quanzhou Medical College were sampled by convenience from March to June 2020, and a cross-sectional survey was conducted using CCSMHS and death anxiety scale. Receiver operating characteristic (ROC) curve was drawn to evaluate the value of mental health status in predicting death anxiety of higher vocational nursing students. Results The score of death anxiety of higher vocational nursing students was (43.72±14.40) points. There were statistically significant differences in death anxiety among higher vocational nursing students of different genders, only-child or not (P ＜ 0.05). Logistic regression results showed that employment pressure, sensitivity, hallucinations, and delusions were the risk factors for high death anxiety in higher vocational nursing students (OR ＞ 1, P ＜ 0.05), while suicidal intent and self-injury behavior were protective factors for high death anxiety (OR ＜ 1, P ＜ 0.05). Employment stress, sensitivity, hallucinations and delusions had predictive value for high death anxiety, and the area under the ROC curve of employment stress was the largest, which was 0.615. Conclusion Higher vocational nursing students are more serious in high death anxiety. Students with high scores on employment pressure, sensitivity, and hallucinations and delusions are more likely to have high death anxiety. At the same time, focus on the evaluation of death anxiety by students with high scores on suicide intention and self-injury behavior.
2022 Vol. 19 (8): 52-55 [Abstract] ( 123 ) HTML (1 KB)  PDF (781 KB)  ( 158 )
56 Analysis on the influencing factors of employee satisfaction in a maternal and child healthcare hospital in Shenzhen#br#
LIN Yihao1 YANG Xiuqiao2 LIN Hong2 XU Xiaoyi2 JIN Shuyan3 WANG Hao1 WEN Ping2
Objective To analyze the current situation of employee job satisfaction and the influencing factors in a tertiary-level A women’s and children’s hospital in Shenzhen (hereinafter referred to as “FY hospital”), and to provide a basis for the improvement of the hospital’s human resources management and decision-making. Methods A questionnaire was designed based on the Minnesota job satisfaction scale, and a random sampling method was used to conduct a questionnaire survey among 200 employees of FY hospital from June to August 2020. A multiple linear regression model was used to analyze the effect of job category on job satisfaction. Results A total of 180 valid questionnaires were recovered in this survey, with a recovery rate of 90.0%. The overall satisfaction of employees in FY hospital was (3.53±0.43) points, and the employee satisfaction score of “salary and welfare” in each dimension was the lowest (2.78±0.68) points. There were statistically significant differences in the overall satisfaction scores of employees with different genders, job categories, professional titles, and political affiliations (P ＜ 0.05). Comparing the satisfaction scores of clinicians, nursing staff, medical technicians, administration, and other departments in the three dimensions of “work pressure”, “doctor-patient conflict”, and “shift scheduling system”, the differences were statistically significant (P ＜ 0.05). After adjusting for age, gender, professional title and political outlook, clinicians and nurses had lower satisfaction scores in overall job satisfaction, job stress and doctor-patient relationship (P ＜ 0.05 or P < 0.01). In addition, the satisfaction score of clinicians in the scheduling system was also lower than that of medical technicians, administrative staff and other departments (P ＜ 0.05). Conclusion Staff satisfaction with remuneration and benefits is low, and the job satisfaction of clinicians and nurses is lower than that of medical technicians, administration and other departments. Hospitals should take measures to improve the job satisfaction of clinical front-line medical staff.
2022 Vol. 19 (8): 56-59 [Abstract] ( 168 ) HTML (1 KB)  PDF (582 KB)  ( 212 )
60 Analysis of anemia in elderly patients with chronic heart failure and its influencing factors#br#
CHENG Changsheng1 CAI Wenjuan1 CAO Huiling2
Objective To investigate the anemia and its influencing factors in elderly patients with chronic heart failure. Methods A total of 1275 elderly patients with chronic heart failure diagnosed and treated in Jiangsu Province Hospital of Traditional Chinese Medicine from March to September 2018 were selected and divided into non-anemia group (946 cases) and anemia group (329 cases) according to hemoglobin ＜120 g/L (male) or <110 g/L (female). The general data and clinical data of the two groups were compared to analyze the influencing factors of anemia in elderly patients with chronic heart failure. Results A total of 329 (25.8%) elderly patients with chronic heart failure complicated with anemia, including 167 cases of mild anemia, 98 cases of moderate anemia, 64 cases of severe anemia. The causes of anemia were iron deficiency anemia in 241 cases, renal anemia in 34 cases, megaloblastic anemia in 27 cases, and anemia of other causes in 27 cases. Age, course of heart failure, proportion of New York Heart Association (NYHA) grade Ⅲ to Ⅳ, proportion of complicated chronic kidney disease, average number of hospitalization, and length of hospitalization for heart failure within one year in anemia group were higher than those in non-anemia group, the differences were statistically significant (P ＜ 0.05). The results of multivariate analysis showed that education level, albumin level, heart failure course, and NYHA grade were the influencing factors of anemia in elderly patients with chronic heart failure (P ＜ 0.05). Conclusion Anemia in elderly patients with chronic heart failure may be related to their educational level, albumin level, heart failure course, and NYHA grade.
2022 Vol. 19 (8): 60-63 [Abstract] ( 196 ) HTML (1 KB)  PDF (499 KB)  ( 61 )
64 Meta-analysis and trial sequential analysis of the effects of SGLT2 inhibitors on cardiovascular adverse events in type 2 diabetes mellitus patients with cardiovascular disease#br#
ZHOU Xinrong1 LI Yan1 ZHU Jiajun1 WANG Ning2▲
Objective To evaluate the effects of sodium-glucose linked transporter 2 (SGLT2) inhibitors on cardiovascular adverse events in type 2 diabetes mellitus patients with cardiovascular disease. Methods PubMed, Cochrane Library, Google Scholar, Wanfang Data, CNKI, and Chinese Biomedical Database were searched for randomized controlled trial (RCT) on the effects of SGLT2 inhibitors on cardiovascular adverse events in type 2 diabetes mellitus patients with cardiovascular disease. The retrieval period is from the inception to April 2021. Meta-analysis, sequential analysis, and evidence quality evaluation were performed by RevMan, TSA, and GRADE pro, respectively. Results Six RCTs were included, with a total of 30 534 patients. Meta-analysis showed that cardiovascular mortality rate (RR = 0.84, 95%CI: 0.72-0.99, P = 0.03), hospitalization rate for heart failure (RR = 0.67, 95%CI: 0.60-0.73, P ＜ 0.000 01), and all-cause mortality (RR = 0.85, 95%CI: 0.78-0.92, P ＜ 0.0001) were lower than those in placebo group. GRADE evidence quality evaluation results showed that the quality GRADE of meta-analysis results was “high”. The sequential analysis results showed that the meta-analysis results were relatively positive and did not need to be proved by more experiments. Conclusion SGLT2 inhibitors plays a good cardioprotective role in type 2 diabetes mellitus patients with cardiovascular disease.
2022 Vol. 19 (8): 64-68 [Abstract] ( 192 ) HTML (1 KB)  PDF (2134 KB)  ( 75 )
69 Characteristics of the video nystagmography in patients with cerebellar ataxia#br#
CHEN Fang HU Ningning YANG Dongju LIU Jing LIU Aihua FAN Chunqiu▲
Objective To clarify the characteristics of the video nystagmography in patients with cerebellar ataxia, and to provide evidence for early diagnosis of cerebellar ataxia and differentiation of vestibular central and peripheral lesions of eye movement abnormalities. Methods A total of 20 patients with cerebellar ataxia treated in Department of Neurology, Xuanwu Hospital Capital Medical University from October 2019 to May 2020 were collected. The performance characteristics of the video nystagmography including spontaneous nystagmus, visual nystagmus, stationary tracking test, saccades test, gaze test, position test and double temperature test were analyzed, and the performance characteristics of each project were summarized. Results Spontaneous nystagmus test: 7 cases (35%) had various types of nystagmus and saccade; visual nystagmus: asymmetric slow phase velocity was found in 3 cases (15%), and abnormal gain was found in 19 cases (95%); stationary tracing test: 18 cases (90%) showed type Ⅲ and type Ⅳ curves, and 10 cases (50%) showed abnormal gain; gaze test: 10 cases (50%) had abnormal eye movement; saccade test: peak velocity decreased in 13 cases (65%), accuracy abnormal in 12 cases (60%), and latency abnormal in 1 case (5%); static position test: 15 cases (75%) showed abnormal eye movement; vestibular double temperature test: 1 case (5%) showed hypersemicircular canal function. Conclusion The abnormal gain and smooth tracing curve of optic nystagmus indicate abnormal vestibular center, which is one of the basis for early diagnosis of cerebellar ataxia.
2022 Vol. 19 (8): 69-71,76 [Abstract] ( 38 ) HTML (1 KB)  PDF (520 KB)  ( 150 )
72 Clinical effect of warming acupuncture combined with imitating bioelectric stimulation in the treatment with diminished ovarian reserve patients of kidney deficiency and blood stasis syndrome #br#
HU Jing1 YUAN Yuning2 CHENG Si1
Objective To observe the clinical effect of warming acupuncture combined with imitating bioelectric stimulation in the treatment with diminished ovarian reserve (DOR) patients of kidney deficiency and blood stasis syndrome. Methods A total of 60 patients with DOR from Huangshi Maternal and Child Health Care Hospital, Hubei Province from January to June 2021, they were divided into combination group and western medicine group, according to the random number table method, with 30 cases in each group. The combination group was treated with warming acupuncture combined with imitating bioelectric stimulation, and western medicine group was treated with Estradiol Valerate Tablet/Cycloproterone Estradiol Tablets, both groups were treated for three courses. The curative effect of traditional Chinese medicine syndrome was compared, traditional Chinese medicine clinical syndrome scores, follicle stimulating hormone (FSH), FSH/luteinizing hormone (LH), peak systolic velocity (PSV), resistance index (RI), pulse index (PI), ovarian volume (OV), anti-mullerian hormone (AMH), and antral follicle count (AFC) before and after treatment were compared. Results The curative effect of traditional Chinese medicine syndrome in combined group was better than that in western medicine group, and the difference was statistically significant (P < 0.05). Before treatment, there were no significant differences in traditional Chinese medicine syndrome scores between two groups (P > 0.05); after treatment, the traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and combined group was lower than western medicine group, and the differences were statistically significant (P < 0.05). Before treatment, there were no significant differences in FSH, FSH/LH, AMH, AFC, OV, PSV, RI, and PI between two groups (P > 0.05). After treatment, AMH in combination group was higher than that before treatment, and combination group was higher than western medicine group, and the differences were statistically significant (P < 0.05); after treatment, AFC and OV in two groups were higher than those before treatment, and the differences were statistically significant (P < 0.05); but there were no statistical significance in AFC and OV between two groups (P > 0.05); after treatment, PSV in both groups were higher than those before treatment, and combination group was higher than western medicine group, and the differences were statistically significant (P < 0.05); after treatment, FSH, FSH/LH, RI, and PI in two groups were lower than those before treatment, and the differences were statistically significant (P < 0.05); but there were no statistical significance in FSH, FSH/LH, RI, and PI in two groups (P > 0.05). Conclusion Warming acupuncture combined with imitating bioelectric stimulation can effectively relieve the clinical symptoms of DOR patients with kidney deficiency and blood stasis syndrome, increase ovarian blood perfusion, increase the ovarian volume, regulate sex hormone levels, improve AMH and AFC, and then improve the ovarian reserve capacity.
2022 Vol. 19 (8): 72-76 [Abstract] ( 154 ) HTML (1 KB)  PDF (725 KB)  ( 280 )
77 Relationship between uterine artery blood flow parameters and embryo abortion#br#
GAO Hui SHAN Ke MAO Ruimin▲
Objective To explore and analyze the relationship between uterine artery blood flow parameters and embryo abortion. Methods A retrospective analysis was performed on the clinical data of 138 pregnant women of 6-12 weeks of pregnancy admitted to Liaocheng Hospital of Traditional Chinese Medicine, Shandong Province from May 2018 to May 2021. They were divided into normal group (121 cases) and abortion group (17 cases) according to different developmental conditions. At the same time, the abortion group was divided into empty gestational sac group (7 cases) and embryo and no fetal heart group (10 cases). The uterine artery blood flow parameters were compared between normal group and abortion group at different gestational ages and different embryo types. Results Compared with the 6th week of pregnancy, the values of peak systolic / diastolic flow rate (S/D), resistance index (RI), and pulsatility index (PI) in the 9th and 12th weeks of pregnancy in normal group and abortion group were decreased, and the differences were statistically significant (P < 0.05); compared with the 9th week of pregnancy, the values of S/D, RI, and PI in the 12th week of pregnancy were decreased in normal group and abortion group, and the differences were statistically significant (P < 0.05). Compared with normal group, the values of S/D, RI, and PI in the 9th and the 12th weeks of abortion group were decreased, and the differences were statistically significant (P < 0.05). The gestational age of abortion group was negatively correlated with S/D, PI, and RI values (r = -0.978, -0.971, -0.990, P < 0.05). There were no significant differences in S/D and PI values at admission among three groups (P > 0.05). RI values at admission were significantly different among three groups (P < 0.05); compared with normal group, RI value at admission of embryo and no fetal heart group was lower, and the difference was statistically significant (P < 0.05). Conclusion Using vaginal color Doppler ultrasound to monitor uterine artery blood flow parameters has a high application value in embryo monitoring.
2022 Vol. 19 (8): 77-80 [Abstract] ( 43 ) HTML (1 KB)  PDF (1413 KB)  ( 23 )
81 Observation of short-term and long-term effects of basic intermittent exotropia correction surgery in children with different age groups#br#
WANG Fei GAO Sumin ZHANG Yuan WANG Wenqi▲
Objective To explore the short-term and long-term effects of basic intermittent exotropia correction surgery in children with different age groups. Methods A total of 115 children with intermittent exotropia correction surgery in one eye who were admitted to the Affiliated Huaian No.1 Hospital of Nanjing Medical University from February 2017 to January 2020 were selected as research subjects. According to children age, they were divided into low-age group (52 cases) and advanced-age group (63 cases). Both groups were treated with intermittent exotropia correction surgery. The strabismus degree, fusion function, and child-intermittent rxotropia questionnaire scores(Child-IXTQ) were compared between two groups before operation and three months after operation; three months after operation, the short-term clinical effects of two groups were compared; one year after operation, the long-term clinical efficacy of two groups were compared. Results Before operation, there were no statistically significant differences in strabismus degree, fusion function, and Child-IXTQ scores between two groups (P > 0.05). Three months after operation, strabismus degree in two groups were lower than those before operation, and low-age group was lower than advanced-age group (P ＜ 0.05); the Child-IXTQ score and fusion function of two groups were higher than those before operation, and low-age group was higher than advanced-age group (P ＜ 0.05). Three months after operation, the difference in the short-term efficacy between two groups were statistically significant (P ＜ 0.05). One year after operation, There was no statistically significant difference in long-term efficacy between two groups (P > 0.05). Conclusion the short-term clinical efficacy of intermittent exotropia in younger children is better than that in older children, but different age groups have little influence on the long-term effect of intermittent exotropia correction surgery.
2022 Vol. 19 (8): 81-84 [Abstract] ( 202 ) HTML (1 KB)  PDF (493 KB)  ( 31 )
85 Relationship between 25-OH-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in children with neonatal pneumonia#br#
GAN Yiwen1 CHENG Rui2▲ QI Rong3
Objective To analyze the relationship between 25-hydroxyvitamin (OH)-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in children with neonatal pneumonia (NP). Methods A total of 100 cases of NP children treated in the Affiliated Jiangning Hospital of Nanjing Medical University from February to June 2021 were selected, all children were treated with Ambroxol Hydrochloride, at three days of treatment, the therapeutic effect of children was evaluated, and they were divided into effective group and ineffective group. 25-OH-D level in cord blood of children at birth and the serum indexes (procalcitonin [PCT], C-reactive protein [CRP]) before treatment were detected, the relationship between 25-OH-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in NP children were analyzed. Results The effective rate of Ambroxol Hydrochloride treatment was 86.00%. Serum PCT and CRP level in ineffective group were higher than those in effective group, and 25-OH-D level in cord blood was lower than those in effective group (P < 0.05). The expression levels of serum PCT, CRP, and 25-OH-D in cord blood were the influencing factors of the ineffective treatment of Ambroxol Hydrochloride in NP childre (P < 0.05). When the cut-off value was 80.655 nmol/L, cord blood 25-OH-D predicted that the AUC of Ambroxol Hydrochloride treatment in NP children was 0.810 (95%CI: 0.725-0.895). Conclusion Cord blood 25-OH-D level can predict the risk of failure to ambroxol treatment in NP children.
2022 Vol. 19 (8): 85-88 [Abstract] ( 87 ) HTML (1 KB)  PDF (744 KB)  ( 17 )
89 Clinical observation of the effect of Jianpi Yangxue Decoction combined with chemotherapy of gastric cancer#br#
LI Chengyin1 XU Yifang1 ZHAO Jingling2 GONG Hongwei1 JU Mengying3 YANG Jie3 ZHU Lu3
Objective To explore the efficacy and safety evaluation of Jianpi Yangxue Decoction combined with Capecitabine and Oxaliplatin (CAPOX) chemotherapy for patients with gastric cancer. Methods A total of 120 gastric cancer patients admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as the research subjects, and they were divided by lottery into observation group (Jianpi Yangxue Decoction + CAPOX chemotherapy regimen) and control group (CAPOX chemotherapy regimen), with 60 patients in each group. After two sessions, traditional Chinses medicine syndrome score, the Eastern Cooperative Oncology Group (ECOG) score, tumor markers (carcinoembryonic antigen [CEA] and carbohydrate antigen 19-9 [CA19-9]) levels, and the occurrence of adverse reaction of chemotherapy (Ⅱ-Ⅳ degrees of bone marrow supression [white blood cells, platelets, hemoglobin], liver and kidney function, gastrointestinal reaction, and peripheral nerve toxicity) were compared in two groups. Results There were six cases of detachment in the observation group and five cases in the control group, and 109 cases were included in the study. After treatment, traditional Chinses medicine syndrome score, CEA, and CA19-9 levels in both groups were lower than those before the treatment, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). ECOG score of observation group before and after treatment had no statistical significance (P ＞ 0.05). After treatment, the ECOG score of the control group was higher than that before the treatment, and observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The incidences of hemoglobin Ⅱ-Ⅳ degrees of bone marrow supression, gastrointestinal reaction, and peripheral neurotoxicity in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion After the addition of Jianpi Yangxue Decoction to gastric cancer patients receiving chemotherapy, it can improve the traditional Chinses medicine symptoms, quality of life, and the expression of tumor markers, reduce the adverse reactions caused by chemotherapy, and play a synergistic and toxic role.
2022 Vol. 19 (8): 89-92 [Abstract] ( 182 ) HTML (1 KB)  PDF (618 KB)  ( 25 )
93 Relationship between the expression of NM23 and E-cadherin and the efficacy of neoadjuvant chemotherapy in breast cancer#br#
YANG Lei1 YANG Hongwei1 CHEN Maoshan1 MU Dewu1 CHENG Xiaoming2
Objective To investigate the relationship between the expression of NM23 and E-cadherin and the efficacy of neoadjuvant chemotherapy (NCT) in breast cancer. Methods The clinical data of 87 patients with invasive breast cancer who received NCT were collected from Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University from October 2014 to October 2017. According to the effect of NCT, they were divided into effective group (63 cases) and ineffective group (24 cases). The expression of NM23 and E-cadherin in NCT precancerous tissues of 87 patients with invasive breast cancer was detected by immunohistochemical method, and the relationship between the expression of NM23 and E-cadherin and the effect of NCT was analyzed. Results The proportion of NM23 positive, TNM stage Ⅲ, and human epidermal growth factor receptor-2 positive in ineffective group were lower than those in effective group, and the proportion of E-cadherin positive was higher than that in effective group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that positive E-cadherin expression was an independent risk factor for NCT inefficacy in breast cancer (OR ＞ 1, P ＜ 0.05), while positive NM23 expression and TNM stage Ⅲ were protective factors (OR ＜ 1, P ＜ 0.05). Conclusion The expression levels of NM23 and E-cadherin in breast cancer tissues are significantly correlated with the effect of NCT in breast cancer, which has certain reference value for evaluating the effect of breast cancer patients after NCT.
2022 Vol. 19 (8): 93-96 [Abstract] ( 116 ) HTML (1 KB)  PDF (500 KB)  ( 28 )
97 Influencing factors of the efficacy of hyperfractionated intensity-modulated radiotherapy for advanced non-small cell lung cancer#br#
HUAN Jiale WANG Xiao ZHANG Wenwen PAN Dejian▲
Objective To investigate the influencing factors of hyperfractionated intensity-modulated radiotherapy for advanced non-small cell lung cancer (NSCLC). Methods A total of 127 patients with advanced NSCLC who received three months of hyperfractionated intensity-modulated radiotherapy in the 904th Hospital of People’s Liberation Army from January 2017 to February 2020 were selected as subjects. According to the response evaluation criteria in solid tumors (version 1.1), patients were divided into disease progression (PD) group (29 cases) and non-PD group (98 cases). The clinical data of the two groups and the levels of serum tumor abnormal protein (TAP), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) before radiotherapy were compared, and the factors influencing the efficacy of large fractionated intensity-modulated radiotherapy in patients with advanced NSCLC were analyzed. Results Age ＞ 65 years old, proportion of TNM stage Ⅳ, and serum TAP level before radiotherapy in PD group were higher than those in non-PD group, CEA and CA19-9 levels were lower than those in non-PD group, the differences were statistically significant (P < 0.05). The results of multivariate analysis showed that age, TNM stage, and serum TAP, CEA, CA19-9 levels before radiotherapy were all influencing factors for the efficacy of hyperfractionated intensity-modulated radiotherapy in advanced NSCLC patients (P ＜ 0.05). Conclusion Age, TNM stage, and serum TAP, CEA, CA19-9 levels before radiotherapy are related to the efficacy of hyperfractionated intensity-modulated radiotherapy in advanced NSCLC patients.
2022 Vol. 19 (8): 97-99,108 [Abstract] ( 93 ) HTML (1 KB)  PDF (561 KB)  ( 178 )
100 Comparison of the effect of laparoscopic surgery and open surgery in the treatment of cervical cancer patients#br#
CHEN Jijia WU Yumei HE Yue SUN Xuesong
Objective To study the effect of different surgical methods on the intraoperative and postoperative autonomous behavior of patients with cervical cancer. Methods A total of 180 patients with cervical cancer who underwent extensive hysterectomy in the Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2018 to February 2021 were selected. The patients were divided into two groups according to their wishes, the control group received open surgery (138 cases), and the observation group received laparoscopic surgery (42 cases). The intraoperative indexes, postoperative autonomous behavior recovery, self-rating depression scale (SDS) and self-rating anxiety scale (SAS) scores, and complications were compared between the two groups. Results The intraoperative blood loss and the incidence of intraoperative organ adhesion in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the length of hospital stay, the time of first defecation after surgery, the time of first getting out of bed after surgery, and the time of drainage after surgery between the two groups (P ＞ 0.05). The first defecation time in the observation group was shorter than that in the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the SDS and SAS scores of the two groups were lower than those before treatment, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The overall effect of laparoscopic surgery for cervical cancer is better than that of open surgery, which can improve patients’ anxiety and depression and reduce the incidence of complications.
2022 Vol. 19 (8): 100-102,112 [Abstract] ( 124 ) HTML (1 KB)  PDF (658 KB)  ( 76 )
104 Effect of oral vestibular approach laparoscopic thyroid surgery in the treatment of benign thyroid tumors#br#
LIN Jianhua1 WU Qianfu1▲ WEN Jibin1 LI Lanxin2
Objective To investigate the efficacy and safety of oral vestibular approach endoscopic thyroid surgery in the treatment of benign thyroid tumors. Methods From July 2020 to May 2021, 120 cases diagnosed as benign thyroid tumors and indicated for endoscopic thyroid surgery in Guiping People’s Hospital, Guangxi Zhuang Autonomous Region were selected as the research objects. According to the random number table method, they were divided into observation group and control group, with 60 cases in each group. The observation group received oral vestibular approach laparoscopic thyroid surgery, and control group received transfrontal approach laparoscopic thyroid surgery. The operation time, surgical blood loss, total wound discharge, postoperative pain time, complication rate, patients’ incision satisfaction, postoperative neck movement comfort, and social adaptability were compared between two groups. Results The operation time and postoperative pain time in observation group were shorter than those in control group, the surgical blood loss and total wound discharge were less than those in control group, and the complication rate was lower than that in control group (P < 0.05). The incision satisfaction in observation group was higher than that in control group (P < 0.05). The incidence of postoperative pillow discomfort, maladjustment of auxiliary tools, pain and discomfort, high temperature, and other neck discomfort in observation group were lower than those in control group (P < 0.05). Before surgery, there was no significant difference in social adaptability scores between two groups (P > 0.05); after surgery, the social adaptability scores in both groups were higher than those before surgery, and observation group was higher than control group (P < 0.05). Conclusion Compared with transfrontal approach laparoscopic thyroid surgery, oral vestibular approach laparoscopic thyroid surgery for benign thyroid tumors can achieve better perioperative indicators, with higher postoperative neck activity comfort, higher incision satisfaction, and stronger postoperative social adaptability.
2022 Vol. 19 (8): 104-108 [Abstract] ( 151 ) HTML (1 KB)  PDF (706 KB)  ( 43 )
109 Efficacy and security of breast conserving surgery in the treatment of early triple negative breast cancer patients#br#
WANG Xiaodong CHEN Dapeng PENG Yongqiang
Objective To investigatethe clinical efficacy and security of breast conserving surgery in the treatment of early triple negative breast cancer (TNBC) patients. Methods A total of 110 early TNBC patients admitted to Bozhou People’s Hospital, Anhui Province from January 2018 to February 2021 were selected as study objects. According to the random number table method, they were divided into control group and observation group, with 55 cases in each group. The control group was treated with modified radical mastectomy, and observation group was treated with breast conserving surgery. The amount of intraoperative blood loss, operation time, postoperative drainage time, and the incidence of postoperative complications were compared between two groups, local recurrence and distant metastasis were observed during postoperative follow-up for three months, and the quality of life scores before and after operation were compared. Results The amount of intraoperative blood loss of observation group was lower than that of control group, and operation time and postoperative drainage time were shorter than those of control group, and the differences were statistically significant (P < 0.05). The total incidence of complications in observation group was lower than that in control group, and the difference was statistically significant (P < 0.05). There were no significant differences in local recurrence rate and distant metastasis rate between two groups (P > 0.05). Before operation, there were no significant differences in quality of life scores between two groups (P > 0.05); after operation, the quality of life scores of two groups were higher than those before operation, and observation group was higher than control group, and the differences were statistically significant (P < 0.05). Conclusion Breast conserving surgery for early TNBC patients has significant effect, rapid recovery and high safety, which is worthy of clinical application.
2022 Vol. 19 (8): 109-112 [Abstract] ( 186 ) HTML (1 KB)  PDF (518 KB)  ( 34 )
113 Study on the cognitive impairment in first-opisode depression elderly patient with diabetes mellitus and sleep disorders and its influencing factors#br#
LIU Shuwei1 YANG Shuqian2▲
Objective To explore the cognitive impairment of first-episode depression elderly patients with diabetic mellitus and sleep disorders and its influencing factors. Methods From May 2019 to April 2021, 166 first-episode elderly patient with diabetes mellitus and sleep disorders and 90 healthy volunteers were enrolled in the Third People’s Hospital of Huaian, Jiangsu Province, and they were divided into study group and health group, respectively. The repeatable battery for the assessment of neuropsychological status scores were compared between the two groups. The detection rate of cognitive dysfunction in 166 patients was analyzed and divided into cognitive dysfunction group and non-cognitive dysfunction group according to whether cognitive dysfunction occurred. The clinical data of the cognitive dysfunction group and the non-cognitive dysfunction group were compared. Logistic regression analysis of risk factors affecting cognitive function in first-episode elderly depression patients with diabetes mellitus and sleep disorders. Results The duration of diabetes mellitus and (Hamilton depression scle-17, HAMD-17) score of the study group were higher than those of the healthy group (P ＜ 0.05). The study group had lower immediate memory, speech function, attention, visual span, delayed memory and total score than the healthy group (P ＜ 0.05). The detection rate of cognitive dysfunction in 166 patients was 28.92%. The proportion of sleep disorders, carotid artery stenosis, diabetes course and HAMD-17 score in the cognitive dysfunction group were higher than those in the non-cognitive dysfunction group (P ＜ 0.05). Logistic regression analysis showed that sleep disorders, carotid artery stenosis, long diabetes course and high HAMD-17 score were all risk factors affecting cognitive function in elderly patients with first-episode diabetic depression (OR = 3.955, 3.483, 2.832, 2.793, P ＜ 0.05). Conclusion The detection rate of cognitive dysfunction in first-episode elderly depression patient with diabetic mellitus and sleep disorders is higher. Sleep disorders, carotid artery stenosis, the course of diabetes, and the HAMD-17 score are all risk factors affecting the cognitive function of elderly patients with diabetic first-episode depression. In order to reduce the incidence of cognitive dysfunction, it is necessary to control the influence of each of the above factors on elderly patients with first-onset depression in diabetes in clinical practice.
2022 Vol. 19 (8): 113-116 [Abstract] ( 183 ) HTML (1 KB)  PDF (505 KB)  ( 51 )
117 Effect of Cefoperazone / Sulbactam combined with bedside bronchoscopy lavage in the treatment of aspiration pneumonia after stroke#br#
HAO Xingliang1 JI Yanrong1 ZHANG Jian1 WANG Naizhi1 LI Shuang1 WANG Yingying2
Objective To investigate the effect of Cefoperazone/Sulbactam combined with bedside bronchoscopy lavage in the treatment of aspiration pneumonia after stroke. Methods A total of 98 patients with secondary aspiration pneumonia after stroke admitted to Shengli Oilfield Central Hospital of Shandong Province from June 2019 to June 2020 were selected. According to the diagnosis and treatment process, the patients were divided into Cefoperazone / Sulbactam treatment group (group A, 48 cases) and Cefoperazone and Sulbactam combined with bedside bronchoscopy treatment group (group B, 50 cases). Group A was given Cefoperazone / Sulbactam to fight infection on the basis of routine treatment. Group B was given bedside portable bronchoscopy and lavage on the basic of routine treatment and Cefoperazone/Sulbactam anti-infection treatment. Blood gas analysis indexes, white blood cell (WBC) count, procalcitonin (PCT), chest film and clearance rate of pathogenic bacteria were compared between the two groups before and after seven days of treatment. The temperature recovery time, antibiotic application time, hospital stay time and treatment effect were compared between the two groups after seven days of treatment. Results After after seven days of treatment, the arterial partial pressure of oxygen (PaO2) level in the two groups was increased compared with that before treatment, and the arterial partial pressure of carbon dioxide (PaCO2), WBC, and PCT levels were decreased compared with before treatment (P ＜ 0.05). The levels of PaO2 in group B were higher than those in group A, while the levels of PaCO2, WBC, and PCT were lower than those in group A (P ＜ 0.05). The results of chest radiography in group B were better than that in group A (P ＜ 0.05). The clearance rate of pathogenic bacteria in group B was higher than that in group A (P ＜ 0.05). Body temperature recovery time, antibiotic application time, and hospital stay time in group B were shorter than those in group A (P ＜ 0.05). After after seven days of treatment, the total effective rate of group B was higher than that of group A (P ＜ 0.05). Conclusion Cefoperazone / Sulbactam combined with bedside bronchoscopy lavage is beneficial to clearing airway secretions, improving clinical symptoms, and improving the isolation and removal of pathogenic bacteria, which is worthy of promotion in inhalation pneumonia.
2022 Vol. 19 (8): 117-120,125 [Abstract] ( 115 ) HTML (1 KB)  PDF (688 KB)  ( 48 )
121 Application effect of modified central venous catheter in drainage after single-port thoracoscopic sublobar resection#br#
YAO Yi XIE Xiaoyang LI Ji YANG Yanhui WANG Yi▲
Objective To compare the effect of modified central venous catheter and conventional silicone drainage tube for closed thoracic drainage after single-port thoracoscopic sublobar resection. Methods A total of 104 patients with single-port thoracoscopic sublobar resection enrolled in the First People’s Hospital of Neijiang from January 2015 to December 2020 were selected and according to different drainage tube indwelling methods, they were divided into observation group (56 cases) and control group (48 cases). The clinical efficacy, total drainage volume, drainage tube indwelling time, the average number of painkiller use, hospitalization days, hospitalization expenses, incision scar formation, incision satisfaction, and postoperative complications were compared between the two groups. Visual analogue scale (VAS) was used and scored at 12, 24, 48 h and extubation. Results The total postoperative drainage flow of the observation group was less than that of the control group, the indwelling time of chest catheter and the hospitalization days were shorter than that of the control group, the average number of painkiller use was less than that of the control group, and the hospitalization expenses was lower than that of the control group, with statistically significance (P ＜ 0.05). The incision scar formation rate in the observation group was lower than that in the control group, and the incision satisfaction was higher than that in the control group, with statistically significance (P ＜ 0.05). There were statistically significant differences in VAS score at 12, 24, 48 h and at the time of extubation between the two groups, time, and interaction (P ＜ 0.05). Further pairwise comparison: VAS score at 48 h after surgery was lower than 24 and 12 h after surgery, VAS score at 24 h after surgery was lower than 12 h after surgery, VAS score at extubation was higher than 48 h after surgery, with statistically significance (P ＜ 0.05). Comparison between groups: VAS scores of the observation group were lower than those of the control group at 12, 24, 48 h after surgery and at extubation, with statistically significance (P ＜ 0.05). There was no significant difference in the total number of postoperative complications between the two groups (P ＞ 0.05). Conclusion After single-port thoracoscopic sublobectomy, the use of modified central venous catheter for closed thoracic drainage can achieve the clinical effect of conventional closed thoracic drainage tube and has more advantages.
2022 Vol. 19 (8): 121-125 [Abstract] ( 61 ) HTML (1 KB)  PDF (706 KB)  ( 112 )
126 Professor Sun Liyun’s experience in the treatment of acne of tuberous cyst type with syndrome of phlegm and stasis obstructing the internal by Neixiao Lianqiao Pills#br#
XU Yichuan1,2 SUN Liyun2
Professor Sun Liyun believes that the key to the pathogenesis of acne of tuberous cyst type is phlegm and stasis obstructing the internal. aeipathia causes the formation of phlegm turbidity and blood stasis, blocking the veins and channels, treatment should be based on resolving phlegm and resolving stasis, cooperates with the methods of clearing heat, regulating qi, draining pus, softening hardness, etc, adding and subtracting with the symptoms, and the prescription should be changed from Neixiao Lianqiao Pills, thus gaining curative effect in clinical practice. This article discusses etiological factors and pathogenesis, traditional Chinese medicine treatment principle, syndrome differentiation and treatment with acne, summarizes Professor Sun Liyun’s academic thoughts in the treatment of acne with the addition and subtraction of Neixiao Lianqiao Pills, enriches the clinical treatment ideas of acne.
2022 Vol. 19 (8): 126-129 [Abstract] ( 108 ) HTML (1 KB)  PDF (697 KB)  ( 32 )
130 Analysis of characteristics of Jiangsu medical school in Ming and Qing dynasties#br#
WU Chengyan1 ZHANG Lei2 WU Chengyu2 REN Weiming2 FAN Chongfeng1 LIN Yibing1
Through comprehensive understanding and research of Jiangsu medical school, this paper focuses on analyzing the characteristics of Wumen medical school, Menghe medical school, and Shanyang medical school, which are famous for their regional schools in Jiangsu during the Ming and Qing dynasties, it summarizes and elaborates the characteristics of Wumen medical school, including the establishment of treatise on febrile, multiple medical families, multiple imperial doctors and official doctors, and multiple medical books; Menghe medical school is famous for its value of classic and extensive clinical practice, gentle and flexible drug use, and its diversification of medical teaching; Shanyang medical school is characterized by the study of treatise on febrile to further improve the theory and the wide spread of medical works among the people; Longsha medical school makes good use of the theory of five evolutive phases and six climatic factors, attaches importance to the application of the classical prescription in the Treatise on Febrile Diseases, which makes it famous in the medical field. It demonstrates the achievements and charm of Jiangsu medical school in Ming and Qing dynasties. In order to better inherit, excavate, and promote the medical schools of academic thought and experience to provide some ideas and reference.
2022 Vol. 19 (8): 130-133,138 [Abstract] ( 32 ) HTML (1 KB)  PDF (808 KB)  ( 110 )
134 Professor Liu Qiquan’s experience in treating melanosis coli based on unblocking and removing stagnation#br#
ZHANG Tingting1 WANG Rui1 SUN Jianhui1 CHEN Tiange1 WANG Caiyun1 TAO Rui1 LIU Qiquan2 ZHANG Wan2
Melanosis coli is a bowel disease with non-inflammatory, benign, and reversible, and characterized by constipation and abdominal pain, the etiology is complex and varied, disease nature is deficiency and excess complex, lingering difficult to heal, and incidence is increasing year by year. Professor Liu Qiquan believes that melanosis coli is located in the large intestine, closely related to spleen, stomach, liver, lung, and kidney, and the fundamental pathogenesis is “obstructing and generating stagnation”. Based on the traditional Chinese medical theory of “unblocking and removing stagnation”, Professor Liu Qiquan proposes that unblocking and descending as the main method of treatment, and according to the viscus, the treatment methods such as harmonizing soil and removing stagnation, dredging wood and promoting stagnation, descending gold and regulating stagnation, and pacifying water and moving stagnation are used, and focuses on upbearing lifting and downbearing turbidity, transporting fluids and qi, descending upper and warming lower, pacifying yin and yang, etc, in order to restore the conduction of large intestine, and the clinical curative effect is significant.
2022 Vol. 19 (8): 134-138 [Abstract] ( 185 ) HTML (1 KB)  PDF (830 KB)  ( 29 )
139 Medical education thought of Waike Zhengzong#br#
ZHAO Yang DONG Wei YANG Tianren GUO Hongwei
Waike Zhengzong which is written by Ming Dynasty physician Chen Shigong that contains a wealth of moral and professional content and medical education thoughts. It is not only a relatively complete medical standard at that time, but also has important significance for improving personal cultivation and medical services of modern physicians. In the process of elaborating medical theory, Chen Shigong summarizes the medical ethics of doctors in the past dynasties, and creatively put forward the special articles “the five precepts of doctors” and “the ten essentials of doctors”. In the process of research, this article summarizes the medical education thoughts of Chen Shigong. He warns that doctors should know confucianism first, then study medical knowledge, medicine is benevolence; doctors use prescriptions like soldiers, and proficient medical theory is the principle of learning medicine; familiar, universal, and enjoyable for the people; go over ancient books and read new books, lifelong learning of medical students is the main task, etc. Summarizing this medical education thought is of great significance to the training of Chinese medicine talents.
2022 Vol. 19 (8): 139-142,155 [Abstract] ( 71 ) HTML (1 KB)  PDF (868 KB)  ( 46 )
143 Discussion on medication rules of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome#br#
DU Juan1 LI Ziran2 YE Yan2
Objective To explore the medication rules of Chinese medicine of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome. Methods The subject words were “acute exacerbation of chronic obstructive pulmonary disease” or “AECOPD” and “phlegm heat”. The literatures included in CNKI, Wanfang and VIP database from January 2010 to June 2021 were searched and prescription database was established. Excel 2019, SPSS Modeler 18.0, and SPSS Statistics 26.0 softwares were used to analyze frequency, efficacy, meridian tropism, related drug pairs, and clustering prescription. Results A total of 126 articles and 128 prescriptions were counted, including 178 herbs. The top five high frequency drugs were Scutellariae Radix, Armeniacae Semen Amarum, Pinelliae Rhizoma Praeparatum, Glycyrrhizae Radix et Rhizoma, Mori Cortex. It was mainly used for clearing heat and resolving phlegm, relieving cough and relieving asthma. The taste of medicine was mainly bitter, sweet and pungent, and its properties were mainly cold, warm and flat, and its meridians were mainly in lung, stomach, liver and spleen, and so on. The drug pairs with the highest correlation were Perillae Fructus and Mori Cortex. Five kinds of drugs were classified by cluster analysis. Conclusion Clearing heat and resolving phlegm, relieving cough and relieving asthma are the core treatment principles of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome. Drugs for regulating qi, removing dampness, promoting blood circulation and diarrhea are matched with the syndrome.
2022 Vol. 19 (8): 143-146,168 [Abstract] ( 140 ) HTML (1 KB)  PDF (1645 KB)  ( 29 )
147 Analysis on Professor He Liqun’s clinical prescription of diabetic nephropathy#br#
YUAN Zhongzhao ZHENG Qidan HE Liqun CHEN Gang▲
This article records Professor He Liqun’s ideas on clinical diagnosis and treatment of diabetic nephropathy. Professor He believes that the pathogenesis of this disease always belongs to difficiency in origin and excess in superficiality, and deficiency and excess are mixed. The deficiency of spleen and kidney’s qi and yin is the beginning of the disease; after a long time, the yang is damaged from the deficiency of yin; in the middle and late stage, both yin and yang of spleen and kidney are deficient; blood stasis throughout the whole process of diabetic nephropathy. The treatment should be based on the main principles of supplementing qi and nourishing yin, tonifying kidney and warming yang, dispelling wind, activating blood circulation and removing blood stasis. In the early stage, tonifying qi and yin can take care of its origin, and in the middle and late stage, the yang of spleen and kidney should be raised to help its movement. Dispelling wind, activating blood circulation and dredging kidney collaterals should run through the whole treatment process when it takes too long for the course of the disease. With constant changes, combination of disease and syndrome, consideration of both evil and positive, and treatment of both symptoms and signs, we could achieve good results.
2022 Vol. 19 (8): 147-150 [Abstract] ( 144 ) HTML (1 KB)  PDF (681 KB)  ( 37 )
151 Construction and application of precise continuation nursing program for postoperative patients with esophageal cancer based on Omaha system#br#
ZHANG Xinchun1 LIU Lijuan2 HAN Yan3 WU Xuan4 CHEN Ling5▲
Objective To explore the construction and application effect of precise continuing nursing program for postoperative patients with esophageal cancer based on Omaha system. Methods From January 2018 to June 2019, 80 patients with esophageal cancer after radical resection in the Affiliated Tumor Hospital of Xinjiang Medical University were selected, according to the random number table method, they were divided into control group and study group, with 40 cases in each group. The control group used conventional continuing care, and the study group used precise continuing nursing based on Omaha system, the nursing outcome, quality of life, and nursing satisfaction of the two groups were evaluated after three months follow-up. Results Followed up for three months, the scores of cognition, behavior, and status in environment, psychology, physiology, and health care outcomes in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The scores of functional areas of quality of life in the study group were higher than those on discharge and the control group, while the scores of symptom areas were lower than those on discharge and the control group, and the differences were statistically significant (P ＜ 0.05). Nursing satisfaction in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The precise continuous nursing program for postoperative patients with esophageal cancer based on Omaha system is comprehensive, effective, and scientific, so as to improve the patient care outcome more effectively, improve the quality of life and nursing satisfaction.
2022 Vol. 19 (8): 151-155 [Abstract] ( 115 ) HTML (1 KB)  PDF (704 KB)  ( 35 )
156 Visual analysis of domestic trigeminal neuralgia nursing research based on CiteSpace#br#
LI Wenya1 LI Chunhui2 XIAO Chun1 LIU Yajian2 PENG Xiaoling3▲
Objective To discuss the hotspots and trends of trigeminal neuralgia nursing research in our country, and provide a basis for trigeminal neuralgia nursing research. Methods The words of “trigeminal neuralgia”“nursing” were searched in CNKI, Wanfang and VIP from January 1996 to December 2020. CiteSpace 5.7R1 was used for literature visualization, and co-occurrence network analysis was carried out on the authors, institutions and keywords of the literatures. Results A total of 637 literatures were included, and the amount of publications showed an overall upward trend. The author with the largest number of publications was Chang Qing, and the cooperation between the authors is not close. Five institutions were the main research units for trigeminal neuralgia care, with little cooperation among them. The research focused on perioperative nursing and complications nursing of microvascular decompression and radiofrequency thermocoagulation. The research trend was psychological state and comprehensive nursing. Conclusion There are few researches on trigeminal neuralgia nursing in China, the quality of papers is not high, and the cooperation between institutions and authors is less. We should increase investment in scientific research in this field, increase exchanges and cooperation between institutions, and make further contributions to the research field of trigeminal neuralgia nursing in China.
2022 Vol. 19 (8): 156-160 [Abstract] ( 167 ) HTML (1 KB)  PDF (2407 KB)  ( 74 )
161 Effect of narrative therapy on uncertainty in illness and health-related behaviors of patients after radiofrequency ablation of atrial fibrillation#br#
DING Lan WANG Lin LAI Juju
Objective To explore the application effect of narrative therapy in patients with atrial fibrillation after radiofrequency ablation. Methods A total of 85 patients after radiofrequency ablation of atrial fibrillation admitted to Jiangsu Province Hospital from July 2019 to August 2020 were selected. Using the random number table method, they were divided into treatment group and control group, 43 cases in the treatment group and 42 cases in the control group. The control group was given regular health education and nursing intervention, and the treatment group was combined with narrative therapy. After six months follow-up, the two groups were compared with uncertainty in illness, health-related life and quality of life. Results After six months of follow-up, the scores of inconsistency, complexity, unpredictability, and disease uncertainty in two groups were lower than before those intervention, and those in treatment group were lower than those in control group (P ＜ 0.05); the scores of medication compliance, regular monitoring, healthy lifestyle, and health-related behavior in both groups were higher than those before intervention, and those in treatment group were higher than those in control group (P ＜ 0.05); the scores of physiological dimension, psychological dimension, sexual dimension, and quality of life of the two groups were higher than before intervention, and the treatment group was higher than the control group (P ＜ 0.05). Conclusion Narrative therapy can help relieve the uncertainty of patients after radiofrequency ablation of atrial fibrillation, promote the development of health-related behaviors, and improve the quality of life of patients.
2022 Vol. 19 (8): 161-164 [Abstract] ( 83 ) HTML (1 KB)  PDF (570 KB)  ( 106 )
165 Effect of collaborative nursing mode on negative emotion and pulmonary function of patients with respiratory function training of cervical spinal cord injury#br#
TONG Wei ZHUGE Hengyan ZHOU Jianmei LIU Yuyan ZHANG Leyun XU Juan▲
Objective To investigate the effect of collaborative nursing mode on negative emotion and pulmonary function of patients with respiratory function training of cervical spinal cord injury. Methods A total of 92 patients with cervical spinal cord injury admitted to the 904th Hospital of Joint Service Support Force of the Chinese People’s Liberation Army from July 2019 to June 2020 were selected. According to the random number table method, they were divided into intervention group and control group, with 46 cases in each group. The control group was given respiratory function rehabilitation training, and the intervention group was combined with collaborative nursing intervention. After two months of training, negative mood, pulmonary function, and respiratory complications were compared between the two groups. Results After training, the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the two groups were significantly lower than before training, and the SAS and SDS scores in the intervention group were significantly lower than those in the control group (P ＜ 0.05). The vital capacity (VC), forced vital capacity (FVC), maximum chase air volume (MVV) and forced expiratory volume in one second (FEV1) in the two groups were significantly higher than before training, and the VC, FVC, MVV, and FEV1 in the intervention group were significantly higher than those in the control group (P ＜ 0.05). The incidence of respiratory complications in intervention group was significantly lower than that in control group (P ＜ 0.05). Conclusion Collaborative nursing mode can relieve anxiety and depression, improve pulmonary function, and reduce respiratory complications in patients with cervical spinal cord injury.
2022 Vol. 19 (8): 165-168 [Abstract] ( 101 ) HTML (1 KB)  PDF (595 KB)  ( 96 )
169 Application effect of health education combined with Baduanjin training in patients with lumbar disc herniation#br#
LI Lei1 CHE Hengying2
Objective To observe the effect of health education combined with Baduanjin training in patients with lumbar disc herniation. Methods A total of 96 patients with lumbar disc herniation treated in Taihe Hospital of Traditional Chinese Medicine, to Anhui University of Chinese Medicine from January 2018 to January 2021 were selected as the research subjects. They were divided into routine group and intervention group by random number table method, with 48 cases in each group. The routine group received routine clinical treatment and nursing on the basis of personalized health education and guidance, the intervention group received baduanjin rehabilitation exercise intervention on the basis of the routine group. The traditional Chinese medicine symptom response rate, the modified Oswestry dysfunction index (ODI), visual analog scale (VAS), Japanese Orthopaedic Association (JOA), and self-management behavior score were compared between the two groups. Results After intervention, the effective rate of traditional Chinese medicine symptoms in the intervention group was higher than that in the conventional group, the difference was statistically significant (P ＜ 0.05); ODI and VAS scores of the two groups were lower than those before intervention, and JOA and self management behavior score scores were higher than those before intervention. After intervention, ODI and VAS scores of the intervention group were lower than those of the conventional group, and JOA scores were higher than those of the conventional group, ference was statistically significant (P ＜ 0.05). There was no significant difference in self management behavior score score between the two groups (P ＞ 0.05). Conclusion The patients with lumbar disc herniation are given health education combined with baduanjin therapy, which can significantly improve the patients’ limbs and other functions, alleviat the sense of pain, and promot the recovery of the body.
2022 Vol. 19 (8): 169-172 [Abstract] ( 190 ) HTML (1 KB)  PDF (592 KB)  ( 128 )
173 Effects of problem-oriented health education on improving self-management ability, negative emotion, and quality of life of elderly patients with coronary heart disease and angina pectoris#br#
QIU Yuedan1 LIU Juya2 WANG Chunling1
Objective To explore the effect of problem-oriented health education on improving self-management ability, negative emotion, and quality of life of elderly patients with coronary heart disease and angina pectoris. Methods A total of 100 patients with coronary heart disease and angina pectoris admitted to Liaoning Provincial People’s Hospital from January 2020 to January 2021 were selected, and divided into observation group and control group according to random number table method, with 50 cases in each group. The control group was given routine nursing intervention, and the observation group was given problem-oriented health education on this basis, self-management ability, negative emotion, angina pectoris, and quality of life were compared between the two groups after intervention, and treatment compliance was recorded. Results After intervention, the scores of management ability in both groups were higher than those before intervention, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05); the negative emotion scores of both groups were lower than those before intervention, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After intervention, the quality of life score of observation group was higher than control group, the difference was statistically significant (P ＜ 0.05). The observation group had better treatment compliance than the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Problem-oriented health education can improve self-management ability, negative emotion, and life quality of elderly patients with coronary heart disease and angina pectoris, which is worth promoting.
2022 Vol. 19 (8): 173-176 [Abstract] ( 204 ) HTML (1 KB)  PDF (574 KB)  ( 46 )
177 A case report of 31 and 32 fusion with talon cusp and literature review#br#
HAO Yifan1 SI Chao2 YAN Hongjing1 FENG Jing1 GONG Baijuan2 LI Zhimin1
Fusion teeth and  talon cusp are abnormal tooth morphological development caused by different external stimuli during tooth development. This paper reported a rare case of fusion of left mandibular permanent central incisor and mandibular permanent incisor, with a malformed lingual cusp on the lingual side of the fused tooth. Since the lesion had not caused pulp and periodontal diseases, fossa and sulcus were closed at the lingual cusp and regular review was ordered. On relevant literature review introduced the pathogenesis, clinical features of fused teeth, the key points of treatment, in order to improve the understanding of the disease diagnosis and clinical workers, early diagnosis and treatment is the key to improve the effect of fusion tooth prognosis, early detection, correct judgment combined with imaging examination fusion of tooth type, joint multidisciplinary treatment, regular review, it can effectively improve the therapeutic effect of fused teeth.
2022 Vol. 19 (8): 177-180 [Abstract] ( 28 ) HTML (1 KB)  PDF (805 KB)  ( 37 )
181 Current situation and problems of innovation and entrepreneurship education for college students of traditional Chinese medicine in the new era  #br#
MENG Jiannan1 LIU Haotian1 SI Wei2 JIA Hong tao1 YU Qinming1
At present, the form of innovation and entrepreneurship in China is developing rapidly, but there are some problems in the practice of innovation and entrepreneurship education. At the same time, the education system and concept need to be reformed and innovated, and the literacy of innovation and entrepreneurship awareness of Chinese medicine students need to be improved. The implementation of practice, the establishment of distinctive concepts, a complete faculty system and the establishment of an innovation platform can stimulate and improve the awareness of innovation and entrepreneurship of traditional Chinese medicine students, follow up the innovation construction of traditional Chinese medicine, and provide innovative practical talents for today’s society. At the same time, it will promote the excellent traditional Chinese medicine culture and promote the vigorous development of the traditional Chinese medicine industry.
2022 Vol. 19 (8): 181-184 [Abstract] ( 206 ) HTML (1 KB)  PDF (653 KB)  ( 146 )
185 Analysis of English translation on Chinese medical Qigong terms from the perspective of the theory of adaptation and selection#br#
WANG Tingting ZHANG Chunxiao SHEN Yi
Since Chinese medical Qigong has absorbed the theoretical knowledge of Taoism, Confucianism, Buddhism and others, its terms are rich in connotation, which causes the difficulty in English translation. Because of the lack of a unified translation standard of Chinese medical Qigong terms, therefore, the translation of the same term varies from one version to another. Although the translation can be simplified through common methods as literal translation and transliteration, it loses the cultural connotation and characteristics. Taking it for consideration, based on the theory of adaptation and selection, the author takes “Ba Duan Jin”, “Tiao Xi”, “Dan Tian”, and “Wu Qin Xi” as examples to analyze different translation versions from the language dimension, culture dimension, and communication dimension through the method of comparative study. And the paper stresses the importance of the cultural connotation in translation and aims to explore a new way for Chinese medicine Qigong terms translation to make contribution for its standardization.
2022 Vol. 19 (8): 185-188 [Abstract] ( 84 ) HTML (1 KB)  PDF (533 KB)  ( 32 )
189 Research on the establishment of standard system for medical devices used in human assisted reproduction technology#br#
MAO Xin HAN Qianqian▲
Based on the research on the current status of domestic and international standardization of medical devices used in human assisted reproductive technology, according to the four basic principles of establishing the standard system: clear goal, complete set, appropriate level and clear division, the construction ideas of the standard system for medical devices used in human assisted reproduction technology are put forward. It can be divided into four aspects: fundamental and general standards, product standards, methodology standards and other standards. Perfect human assisted reproductive technology is given with the advice of the medical devices standards system, standard system of each parts of the hierarchy and part of the standard in the classification need to speed up the research project, formulate and perfect, especially should attach great importance to the study of common and basic standard and formulation.
2022 Vol. 19 (8): 189-192,封三 [Abstract] ( 32 ) HTML (1 KB)  PDF (685 KB)  ( 86 )
193 Construction of clinical research system based on actor network theory#br#
HU Zhimin1,2 JIA Xiaofeng3▲
Clinical research is an important link in the chain of medical science and technology innovation. The clinical research system involves multi-disciplines and multi-institutions, which is connected with basic research and clinical application transformation. It is a collaborative innovation network system integrating medical teaching and research, medical research, and enterprise, and industry, university, and research. Based on the actor network theory, this paper analyzes the actors and structure of the clinical research system in China, and explains the dynamic mechanism of the clinical research system through the translation approaches of problem presentation, benefit enfranchisement, recruitment and mobilization. This paper provides theoretical reference for further understanding the network construction and collaborative innovation mechanism of clinical research system, and puts forward the direction for the construction and development of clinical research system in China.
2022 Vol. 19 (8): 193-封三 [Abstract] ( 88 ) HTML (1 KB)  PDF (976 KB)  ( 78 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech