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2021 Vol. 18, No. 27 Published: 2021-09-25

	7	Analysis of the situation and research hotspots of atherosclerosis projects funded by the National Natural Science Foundation of China from 2015 to 2019
		ZHANG Yunnan1,2 ZHANG Yi1,2 WANG Yifan1,2 HAN Jialun1,2 LIN Baidi1,2 YAN Jialin1,2 SHI Xiujin1 LIN Yang1,2▲
		Objective To analyze the arteriosclerosis-related projects funded by the National Natural Science Foundation of China from 2015 to 2019, to discuss current research hotspots in this field, and to provide references for subsequent research on atherosclerosis. Methods The atherosclerosis-related projects approved from 2015 to 2019 were counted, and the project year, type, and subject distribution were analyzed, while CiteSpace software for keyword visualization analysis was applied to explore the current funding hotspots of the National Natural Science Foundation of China in the field of atherosclerosis. Results In the past five years, the total number of atherosclerosis-related projects has been 662 items, and the number of projects each year has been relatively stable. Among them, the medical science department has 612 items (92.4%), which account for the highest proportion, and the establishment of the project showed the phenomenon of multi-disciplinary collaboration. The regional distribution of funded projects was uneven, and the projects were concentrated in Beijing, Shanghai, Guangdong and other regions. Keyword co-occurrence results showed that macrophages, inflammation, and endothelial cells were the top three keywords with frequency. Keyword clustering results showed that endothelial cells, macrophages, and microRNA were the top three research clusters. Conclusion The National Natural Science Foundation of China is an important national support for basic research. Researchers should grasp research hotspots, multi-disciplinary collaboration, and multi-technology joint application to promote deeper exploration of atherosclerosis research.
		2021 Vol. 18 (27): 7-11,16 [Abstract] ( 178 ) HTML (1 KB) PDF (1451 KB) ( 113 )

	12	Relationship between long noncoding RNA TUBA4B and prognosis of patients with type Ⅱ endometrial carcinoma
		GUO Yanjuan ZHAO Nannan ZHOU Jianli DONG Jianxin YUAN Jinling GAO Jie
		Objective To explore the relationship between long noncoding RNA (lncRNA) TUBA4B and prognosis of patients with type Ⅱ endometrial carcinoma (EC). Methods A total of 123 patients with type Ⅱ EC treated in the North China University of Science and Technology Affiliated Hospital from March 2013 to July 2017 were selected as the study subjects. Data on EC differentiation, International Federation of Gynecology and Obste-trics staging (FIGO staging) and treatment of patients were collected. The patients with type Ⅱ EC were divided into survival group (82 cases) and death group (41 cases) according to the three-year prognosis. The level of lncRNA TUBA4B in EC tissues was detected by real-time quantitative PCR. Receiver operator characteristic curve was used to evaluate the diagnostic value of lncRNA TUBA4B for the prognosis of EC. The patients were divided into high TUBA4B group (TUBA4B > 0.70, 93 cases) and low TUBA4B group (TUBA4B≤0.70, 30 cases) according to the optimal cut-off point of prognosis of type Ⅱ EC patients diagnosed. The survival of high TUBA4B group and low TUBA4B group were analyzed, and the risk factors for prognosis of EC were analyzed by Cox regression. The relationship between lncRNA TUBA4B and the prognosis of EC was analyzed by restrictive cubic spline fitting Cox regression. Results The three-year survival rate of type Ⅱ EC patients was 66.67%. The level of lncRNA TUBA4B in survival group was higher than that in death group, and the difference was statistically significant (P ＜ 0.05). The area under the receiver operating characteristic curve, sensitivity and specificity of LncRNA TUBA4B for the prognosis of type Ⅱ EC patients were 0.836, 63.41% and 95.12%, respectively. The median survival time of the high TUBA4B group was higher than that of the low TUBA4B group, and the difference was statistically significant (P ＜ 0.05). Cox multivariate analysis showed that high FIGO stage and complex treatment were independent risk factors for prognosis of type Ⅱ EC (HR = 3.466, 1.751, P ＜ 0.05). High degree of differentiation and high level of lncRNA TUBA4B were independent protective factors for prognosis of type Ⅱ EC (P ＜ 0.05). The results of restrictive cubic spline fitting Cox regression analysis showed that lncRNA TUBA4B was correlated with the prognosis of type Ⅱ EC (P < 0.05), and the relationship was nonlinear (HR = 0.516, 0.073, P ＜ 0.05). Concluson The level of LncRNA TUBA4B is associated with the prognosis of type Ⅱ EC, and a high level of LncRNA TUBA4B indicates a low risk of poor prognosis.
		2021 Vol. 18 (27): 12-16 [Abstract] ( 169 ) HTML (1 KB) PDF (777 KB) ( 87 )

	17	Effects of jiájǐ point electroacupuncture on spontaneous pain behavior and hyperalgesia in central pain model rats after experimental spinal cord injury
		ZUO Wei1 MU Jingping2 XU Mingjun1▲
		Objective To observe the effects of jiájǐ point electroacupuncture on spontaneous pain behavior and hyperalgesia in central pain model rats after experimental spinal cord injury (SCI). Methods Thirty SPF male SD rats (56 days of age, weight 230-240 g) were divided into blank control group, SCI group and jiájǐ point group by random number table method, with ten rats in each group. In the SCI group and the jiájǐ point group, Allen’s percussion method was used to establish the experimental SCI central pain model at the L1 segment of the spinal cord, and the blank control group was not operated to create the model. The jiájǐ point group was treated with direct acupuncture at T8-T12 jiájǐ point for 30 min, once a day, for 14 days, while the blank control group and the SCI group were only fixed (30 min). The spontaneous pain behavior of rats was observed during treatment. After 14 days of treatment, Spinal cord motor evoked potential (scMEP) was recorded by unipolar transcortical electrical stimulation. Somatosensory evoked potential (SEP) in L1 was recorded by stimulation. Mechanical pain threshold was determined by von Frey hair method. The hot plate method was used to determine the hyperalgesia. Basso Beattie Bresnahan (BBB) score and oblique plate test were used to evaluate the treatment effect. Results The incidence of spontaneous screaming, scratching, licking, biting and autophagy in the jiájǐ point group was lower than that in the SCI group, and the difference was statistically significant (P ＜ 0.05). Compared with the SCI group, N1 and N2 peaks of early components of scMEP in the jiájǐ point group were increased, and the latency of SEP, P and N waves were shortened, the pain response threshold of the lower trunk of the injured plane to non-invasive mechanical light pressure and light touch and 50% forepaw lifting in the jiájǐ point group were increased, the Paw withdrawal latency of the jiájǐ point group was increased, the paw withdrawal latencies were prolonged, the incidence of hyperalgesia was decreased, the BBB score was increased, and the inclination of inclined plate was increased, with statistical significance (P ＜ 0.05). Conclusion Electroacupuncture at jiájǐ point can improve the pain threshold, dredge the meridians of “governor channel injury” and improve the spontaneous pain and hyperalgesia, which is conducive to the recovery of nerve conduction and motor function.
		2021 Vol. 18 (27): 17-20 [Abstract] ( 133 ) HTML (1 KB) PDF (726 KB) ( 112 )

	21	Study of sodium butyrate combined with fibroblast growth factor 2 on differentiation of bone marrow mesenchymal stem cells into cardiomyocytes
		ZHAO Yaru LIU Yang LYU Yang WANG Wenhua WANG Haoyu WANG Qiaomin WANG Haiping
		Objective To investigate the feasibility of inducing the differentiation of bone marrow mesenchymal stem cells (BMMSC) into cardiomyocytes by sodium butyrate and fibroblast growth factor 2 (FGF-2) in vitro. Methods BMMSC were isolated and purified by whole bone marrow adherent method and identified by flow cytometry. Normal complete medium (control group), 1 mmol/L sodium butyrate medium (sodium butyrate group), 1 ng/ml FGF-2 medium (FGF-2 group), 1 mmol/L sodium butyrate and 1 ng/ml FGF-2 medium (combined group) were added to induce culture. Total RNA was extracted from four groups at 1, 2 and 4 weeks after induction. Myocardial specific transcription factors were detected by quantitative reverse transcriptase-mediated PCR (qRT-PCR). Immunocytochemistry and Western blot were used to detect the expression of myocardial specific proteins induced by BMMSC after four weeks. Results After 48 h of culture, the primary cells showed oblate and adherent growth, and some cells had short fusiform changes. BMMSC cultured for one week were further extended and showed spindle shape, polygon shape and irregular shape. BMMSC cultured for four weeks showed obvious directional arrangement between adjacent cells, and some cells even formed whirlpool-like structures. Flow cytometry results showed that the isolated cells were purified BMMSC. The results of qRT-PCR showed that the expression of myocardium specific gene GATA-4 was the highest after two weeks of culture, and the expression in the combined group was significantly higher than that in the other groups (P ＜ 0.05). The results of Western blot and immunocytochemistry showed that after four weeks of BMMSC culture, the heart-specific protein level in combined group was higher than those in the other groups (P ＜ 0.05). Conclusion Sodium butyrate and FGF-2 induced the differentiation of BMMSC into cardiomyoid cells, and the combined induction is better than the single induction.
		2021 Vol. 18 (27): 21-25 [Abstract] ( 150 ) HTML (1 KB) PDF (998 KB) ( 83 )

	26	Research on anti-inflammatory and immune effects of quercetin and its partial mechanism
		SI Lijun WANG Xue WANG Linlin HUANG Hua
		Objective To investigate the anti-inflammatory and immune effects of quercetin and its partial mechanism. Methods Different concentrations of quercetin were used to intervene RAW 264.7 cells to observe the effects of quercetin on the viability of RAW 264.7 cells. Quercetin with no influence on the viability of RAW 264.7 cells was selected for further study. Untreated RAW 264.7 cells were used as blank group, and the inflammatory cell model was established by stimulating RAW 264.7 cells with 1 μg/ml lipopolysaccharide (LPS). The cells were divided into model group, quercetin 0.98, 1.95, 3.90, and 7.80 μg/ml dose groups. Cell viability, reactive oxygen species (ROS), and monocyte chemoattractant protein 1 (MCP1) levels were observed. The cyclooxygenase (COX)-1 and COX-2 inhibitor screening kit was used to detect the inhibition of quercetin on COX-1 and COX-2. In addition, 20 SPF BALB/C male mice (6-8 weeks old, 18-22 g body weight) were selected to prepare splenic lymphocyte suspension, and different concentrations of quercetin were used to interfere with the splenic lymphocytes of mice, and the effects of quercetin on cell proliferation were observed. Mice spleen lymphocytes were respectively treated with LPS (10 μg/ml) or concanavalin A (Con A) (8 μg/ml) were divided into LPS group, Con A group, and quercetin 0.98, 1.95, 3.90, 7.80 μg/ml groups. The effects of different concentrations of quercetin on the proliferation of spleen lymphocytes, T cells induced by Con A and B cells induced by LPS, and the levels of tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6) and interferon γ (INF-γ) in T cells were observed. Results When quercetin ＜ 7.8 μg/ml, there was no significant difference in the activity of RAW 264.7 cells compared with untreated cells (P ＞ 0.05). The levels of ROS and MCP1 in quercetin 0.98, 1.95, 3.90, and 7.80 μg/ml groups were lower than those in model group, and the difference was highly statistically significant (P ＜ 0.01). The IC50 of quercetin to COX-1, COX-2 were 12.73 and 0.44 μg/ml, respectively, and the IC50 ratio of COX-2 to COX-1 was 0.034. The proliferation of spleen lymphocytes of mice with quercetin concentration of 0.98, 1.95, 3.90, and 7.80 μg/ml were higher than those without quercetin, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). T cells in quercetin 1.95, 3.90, and 7.80 μg/ml dose groups were lower than those in Con A group, and B cells in quercetin 3.90 and 7.80 μg/ml dose groups were lower than those in LPS group, with statistical significance (P ＜ 0.05). The levels of TNF-α in quercetin 1.95, 3.90, and 7.80 μg/ml groups were lower than those in Con A group, the leves of IL-6 and INF-γ in quercetin dose groups were lower than those in Con A group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion Quercetin is a selective COX-2 inhibitor with good anti-inflammatory activity, which can promote the proliferation of splenic lymphocytes in mice, inhibit the proliferation of T and B cells and the secretion of cytokines.
		2021 Vol. 18 (27): 26-29,34 [Abstract] ( 129 ) HTML (1 KB) PDF (1111 KB) ( 417 )

	30	Finite element analysis of biomechanical changes of tibiofemoral joint under different knee flexion after anterior cruciate ligament reconstruction combined with partial medial meniscectomy
		ZHANG Xiaohui1 WANG Jun2 LIAO Bagen1
		Objective To construct finite element models of different knee flexion angles after anterior cruciate ligament reconstruction combined with partial medial meniscectomy, and to analyze the biomechanical characteristics of tibiofemoral joint. Methods A male patient who underwent anterior cruciate ligament reconstruction combined with partial medial meniscectomy in the Department of Sports Medicine, Guangzhou Sport University was selected to construct the finite element model of the knee joint. After load verification, the maximum stress of tibiofemoral articular cartilage and meniscus displacement were used as indicators to analyze the stress characteristics of tibiofemoral joint at different knee bending angles. Results The total number of elements in the knee joint finite element model was 582 044 and the total number of nodes was 391 670. The stress characteristics of tibiofemoral joint under different bending angles were simulated. The results showed that the stress of femoral condyle cartilage was concentrated in the middle, the stress of tibial plateau cartilage was mainly concentrated in the middle and posterior, and the stress of medial meniscus was concentrated in the residual end after resection when bending knee was 0°. At 30° and 60°, the stress of femoral condyle cartilage was concentrated in the posterior part. At 30°, the stress of tibial plateau cartilage mainly concentrated in the anterolateral part, and at 60°, the stress concentrated in the middle part. The stress of the medial meniscus is concentrated in the front at 30° and in the middle at 60°. The maximum stress of medial femoral condylar cartilage and tibial cartilage was 60°, 0°, and 30° respectively. The maximum stress of lateral femoral condylar cartilage, tibial plateau cartilage and medial meniscus was 60°, 30°, and 0° respectively. The maximum stress of the lateral meniscus was 30°, 60°, and 0° respectively. The maximum stress of medial tibial plateau and femoral condylar cartilage at different knee bending angles was greater than the lateral one, the maximum stress of medial meniscus was less than the lateral one at 0° and 30°, and greater than the lateral one at 60°. The results showed that the deformation displacement of the medial meniscus was smaller than that of the lateral meniscus at all angles. Conclusion The stress in the tibiofemural joint is the greatest when the knee is bent at 60°. The maximum stress in the cartilage of the medial tibial plateau and femoral condyle is greater than that of the lateral side at all angles of the knee bending, and the displacement of the medial meniscus is less than that of the lateral side.
		2021 Vol. 18 (27): 30-34 [Abstract] ( 98 ) HTML (1 KB) PDF (1242 KB) ( 102 )

	35	Effects of Yunzhi Wuweizi Extract on liver injury induced by Sulfasalazine in mice
		YU Haitao1 WANG Qunying1 MIAO Qing2 DONG Wenzhu1
		Objective To study the effects of Yunzhi Wuweizi Extract on liver injury induced by Sulfasalazine in mice. Methods Sixty 6-week-old male ICR mice weighing 18-22 g were randomly divided into six groups by numbering method. Control group, model group, Ursodeoxycholic acid group and Yunzhi Wuweizi Extract low, medium, and high dosage groups, with 10 mice in each group. Model group, Ursodeoxycholic acid group and Yunzhi Wuweizi Extract low, medium, and high dose groups were intragastric with Sulfasalazine solution (1000 mg/kg, suspended in 0.5% sodium carboxymethyl cellulose [CMC-Na]) every day to prepare drug liver injury model. Ursodeoxycholic acid group and Yunzhi Wuweizi Extract low, medium, and highdose groups were given ursodeoxycholic acid (10 mg/kg) and Yunzhi Wuweizi Extract solution (50, 100, 300 mg/kg) by intragastric administration 2 h after Sulfadiazine administration, respectively. Model group and control group were given isopyknic 0.5% CMC-Na solution. The intervention lasted for 14 days. On the 15th day, after blood was collected from eyeballs, the serum of each group was separated and determined for glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), and alkaline phosphatase (ALP). The liver tissues of each group were stained with hematoxylin-eosin (HE) to observe the pathological changes of the liver. Results The levels of GPT, GOT, and ALP in model group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). The levels of GPT, GOT, and ALP of Yunzhi Wuweizi Extract in low, medium, and high dose groups were lower than those in model group, and those in Yunzhi Wuweizi Extract medium and high dose groups were lower than those in Yunzhi Wuweizi Extract low dose group, with statistical significance (P ＜ 0.05 or P ＜ 0.01). HE staining results showed that hepatic cell swelling, cell membrane detachment and rupture in model group, and liver injury was significantly improved in Ursodeoxycholic acid group and Yunzhi Wuweizi Extract low, medium, and high dose groups. Conclusion Yunzhi Wuweizi Extract has protective effect on liver injury induced by sulfasalazine in mice.
		2021 Vol. 18 (27): 35-38 [Abstract] ( 79 ) HTML (1 KB) PDF (853 KB) ( 230 )

	39	Research progress in pharmacogenomics of anesthesia and perioperative period management in enhanced recovery after surgery
		MA Lina1,2 GUO Haiyun2 MA Yumei1,2 NIE Huang2▲
		Individualized management of standardized clinical pathways is one of the goals of enhanced recovery after surgery, and drug gene polymorphism is an important genetic factor that causes individual differences in drug response. This review discusses the pharmacogenomics of drugs commonly used during anesthesia and perioperative period. Focusing on analgesics, introduces the gene polymorphism and clinical application of opioid analgesics and non-steroidal anti-inflammatory drugs, and also involves the common drugs involved in anesthesia and perioperative period management such as intravenous anesthesia drugs, inhalation anesthesia drugs, neuromuscular blockers, and antiemetic drugs. The effectiveness and feasibility of using pharmacogenomics to guide individual medicine are demonstrated, and the future research direction is discussed.
		2021 Vol. 18 (27): 39-42 [Abstract] ( 151 ) HTML (1 KB) PDF (583 KB) ( 35 )

	43	Application of three-dimensional finite element model in the developmental dysplasia of the hip complicated by femoral head necrosis
		SONG Zhigang
		Developmental dysplasia of the hip can lead to hip dysfunction and even osteonecrosis of the femoral head, traditional imaging examination can not predict and reflect the condition comprehensively and timely. The three-dimensional finite element model, using image data combined with finite element mechanics, can simulate the stress condition of the proximal femur in different scenes and build model so as to provide a scientific solution for the treatment. The modeling experiment of developmental dislocation of the hip shows that establishing abduction angle is 80°, femoral head on the surface stress increases obviously, acetabulum stress than bone tissue to yield maximum intensity of stress directly affects internal vascular blood flow of the femoral head, the femoral head is prone to necrosis and collapse, the abduction angle should not exceed 80° during treatment. Establishment of prediction model of osteonecrosis of the femoral head reveals when the angle limite central is over 25°, there would be stress concentration points at the edge of the acetabulum, cartilage compression, leading to osteonecrosis of the femoral head. Therefore, the correctional treatment should be based on the restoration of the angle limite central to radiological “normal” range. According to the clinical classification of patients in the “severe, moderate, mild” situation, the best correction angle limite central should follow the law from small to large, which can get a satisfactory therapeutic effect.
		2021 Vol. 18 (27): 43-46 [Abstract] ( 115 ) HTML (1 KB) PDF (550 KB) ( 215 )

	47	Research progress in the weak-promoting treatment of prolonged disorders of consciousness in patients with severe traumatic brain injury
		HE Chao WU Haitao
		Prolonged disorders of consciousness after severe head trauma is a common neurosurgery critical illness. The embarrassing situation of patients “can’t wake up and die”, brings a heavy burden to family and society. At present, the main treatment methods for wake-promoting chronic consciousness disorder after severe head trauma include drugs, hyperbaric oxygen, acupuncture, sensory stimulation, non-invasive nerve regulation, and surgery. This article reviews the current research status of different wake-promoting treatment methods, aiming to provide references for related clinical and scientific research.
		2021 Vol. 18 (27): 47-50 [Abstract] ( 72 ) HTML (1 KB) PDF (551 KB) ( 368 )

	51	Research progress on the relationship between glycemic variability and prognosis of patients undergoing percutaneous coronary intervention
		XU Di1 TIAN Jinping 1，2 LIU Yunyue1 WANG Mi1 WANG Jie1
		Although percutaneous coronary intervention (PCI) is becoming more and more mature, the problem of blood glucose fluctuation associated with PCI is becoming more and more prominent. Blood glucose fluctuations, or glycemic variability, are unstable states between peaks and valleys in blood glucose values, including short-term and long-term glycemic variability. Glycemic variability is the result of the interaction of multiple factors, which is easy to accelerate the process of coronary artery disease in patients treated by PCI, resulting in stent restenosis. It is also an independent predictor of poor prognosis in patients treated with PCI, which can lead to an increased incidence of cardiovascular adverse events and mortality. In this paper, the relevant influencing factors of glycemic variability in patients treated with PCI, the relationship between glycemic variability and patient prognosis, and blood glucose management were reviewed in order to provide theoretical reference for future research in this area.
		2021 Vol. 18 (27): 51-54 [Abstract] ( 84 ) HTML (1 KB) PDF (592 KB) ( 42 )

	55	Research progress in magnetic resonance imaging of pediatric obsessive-compulsive disorder related brain regions
		ZHANG Hui GUO Suqin
		Obsessive-compulsive disorder (OCD) usually occurs in childhood / adolescence, and its pathogenesis is still unclear. However, with the development of neural imaging, magnetic resonance imaging has been widely used in the study of OCD, and has played an important role in exploring the mechanism of pediatric OCD. Existing studies have suggested that pediatric OCD have abnormalities in the brain regions. The structural abnormalities are mainly located in the frontal lobe, thalamus, temporal lobe, etc., and the functional abnormalities are mainly in the attention network, executive network, etc., indicating that the disease may be related to neurodevelopmental abnormalities. Therefore, this paper reviews the research progress of magnetic resonance imaging in children and adolescents with OCD, providing evidence for the pathogenesis of pediatric OCD.
		2021 Vol. 18 (27): 55-58 [Abstract] ( 113 ) HTML (1 KB) PDF (541 KB) ( 106 )

	59	Association research on depression and anxiety state of medical students in colleges and universities based on generalized additive model
		FENG Gong1 WU Xiaohui2 CHEN Min2 WANG Ke2 YAN Qinqin1▲
		Objective To clarify the relationship between the depression and anxiety state of medical students in colleges and universities, and to increase the pertinence and effectiveness of psychological interventions. Methods From May to September 2020, a questionnaire survey was conducted among students in a university in Shaanxi Province to analyze the independent influencing factors of anxiety. On this basis, the generalized additive model was used to analyze the non-linear relationship between the self-rating depression scale (SDS) score and anxiety state. Results A total of 1000 questionnaires were distributed in this survey, a total of 979 valid questionnaires were returned, and the effective response rate was 97.9%. The major, gender, mother’s educational level, physical condition, study burden, sleep time, number of good friends, and the proportion of depression state among college students with different psychological conditions showed statistically significant differences (P ＜ 0.05). Gender (OR = 0.649), physical condition (OR = 1.395), study burden (OR = 1.762), number of friends (OR = 0.673), depression status (OR = 8.276) were independent influencing factors of anxiety status (P ＜ 0.05). After adjusting for confounding factors, when the SDS scores ＜40 points, the risk of anxiety would increase by 21% for every additional unit (point) of SDS. When SDS scores ＞40 points, for every additional unit (point) of SDS, the risk of anxiety would increase by 10%. Conclusion For medical students in colleges and universities, men, the worse their physical condition, the heavier the burden of study, the fewer the number of good friends, and the heavier the degree of depression, will aggravate the anxiety state. And there is a threshold effect relationship between SDS score and anxiety state, which provides a basis for taking corresponding effective anxiety prevention intervention measures for colleges and universities to cope with the psychological crisis of medical students.
		2021 Vol. 18 (27): 59-62 [Abstract] ( 152 ) HTML (1 KB) PDF (480 KB) ( 165 )

	63	Singlecenter survey and analysis of self-transcendence in peritoneal dialysis patients
		CHEN Guowei HUANG Yanlin WANG Han
		Objective To investigate the status and influencing factors of self-transcendence in patients with peritoneal dialysis (PD). Methods Using convenience sampling method, a total of 162 PD patients who visited the peritoneal dialysis clinic of the First Affiliated Hospital of Guangxi Medical University from June to October 2020 were selected as the survey subjects. General information questionnaire, self-transcendence scale, self-esteem scale, social support rating scale were used to conduct questionnaire surveys. Results The self-transcendence score of peritoneal dialysis patients was (38.49±7.56) points, which was at a low level. Univariate analysis showed that there were statistically significant differences in the self-transcendence scores of peritoneal dialysis patients with different education levels, work status, and comorbidities (P ＜ 0.01). The self-transcendence score was positively correlated with the self-esteem score (r = 0.470, P ＜ 0.001), and the self-transcendence score was positively correlated with the total score of social support and the scores of all dimensions (r = 0.480, 0.482, 0.353, 0.409, P ＜ 0.001). Five variables including education level, work status, comorbidities, self-esteem, and social support entered the regression model (F = 24.26, P ＜ 0.001), which could explain 43.2% of the total variation of PD patients’ self-transcendence score. Conclusion Patients with peritoneal dialysis have low self-transcendence scores and should be given personalized care to improve their self-transcendence level.
		2021 Vol. 18 (27): 63-66 [Abstract] ( 131 ) HTML (1 KB) PDF (420 KB) ( 95 )

	67	Application effect of field intravenous infusion monitoring device in infusion management of special ward
		XU Man1 YANG Yingchun2 YE Ling2 YU Yan3 LI Ping1▲
		Objective To explore the application effect of self-developed field intravenous infusion monitoring device in infusion management. Methods A total of 214 infusion patients admitted to the Department of Digestive of a Grade A general hospital in Beijing from November 2020 to January 2021 were selected as research objects. According to the random number table method, they were divided into the control group and the experimental group, with 107 cases in each group. The control group used the traditional human infusion monitoring mode, and the experimental group used the intravenous infusion monitoring device. The call rate of the liquid change ringing, the rate of liquid dripping, the rate of blood return in the infusion tube, and the average time taken to change a single bottle of liquid in the two groups were compared. Results The call rate of liquid change ringing, the rate of liquid dripping, and the rate of blood return in the infusion tube in the experimental group were lower than those of the control group, and the differences were statistically significant (P < 0.05). The average time taken to change a single bottle of liquid in the experimental group was shorter than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The intravenous infusion monitoring device has a significant application effect in clinical nurse infusion management, can improve the safety of patients and nurses work efficiency, worthy of clinical promotion and application.
		2021 Vol. 18 (27): 67-70,74 [Abstract] ( 73 ) HTML (1 KB) PDF (722 KB) ( 268 )

	71	Effect of Xiaoma Zhitong Granules in of diabetic peripheral neuropathy patients with syndrome of deficiency of both qi and yin complicated by stasis
		HU Wenxiao1 TANG Yu2 ZHOU Yuehong3
		Objective To study the clinical effect of Xiaoma Zhitong Granules in the treatment of diabetic peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis. Methods A total of 80 diabetic peripheral neuropathy patients with syndrome of deficiency of both qi and yin complicated by stasis treated in the Second Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine from June 2017 to June 2018 were selected. According to random number table method, they were divided into control group (Lipoic Acid Capsules) and treatment group (Xiaoma Zhitong Granules), with 40 cases in each group. After 12 weeks of treatment, the efficacy of the two groups was compared. The changes of motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve, serum superoxide dismutase (SOD) were compared between the two groups before and after treatment. Results The total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve were faster than before treatment, SOD level was higher than before treatment, the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve in the treatment group were faster than those in the control group, and the SOD level was higher than that in the control group, with statistical significance (P ＜ 0.05). Conclusion Xiaoma Zhitong Granules can significantly improve the clinical symptoms and nerve conduction velocity of diabetic peripheral neuropathy patients with syndrome of deficiency of both qi and yin complicated by stasis, and increase the level of SOD.
		2021 Vol. 18 (27): 71-74 [Abstract] ( 113 ) HTML (1 KB) PDF (392 KB) ( 123 )

	75	Meta-analysis of the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion
		XIE Jiahao1 GUO Haiwei1 WANG Yufeng2 CHEN Bolai2 FU Miaoling3 YANG Qingqi4
		Objective To systematically evaluate the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion. Methods Randomized controlled trial from PubMed, Embase, Medline, Cochrane Library, CNKI, CBM, VIP, Wanfang and other self-built databases up to December 2020 were searched using the keywords “trantranic acid” and “lumbar fusion”. The experimental group was intravenous Tranexamic Acid, and the control group was intravenous normal saline. Total blood loss, intraoperative blood loss, postoperative drainage, blood transfusion rate and incidence of deep venous thrombosis events were compared between the two groups. Meta-analysis was performed using RevMan 5.3 software. Results A total of six literatures were included, including 557 patients. Meta-analysis results showed that total blood loss (MD = -280.88, 95%CI: -309.18, -252.59, P ＜ 0.000 01), intraoperative blood loss (MD = -73.34, 95%CI: -128.52, -18.15, P = 0.009), postoperative drainage volume (MD = -150.29, 95%CI: -211.48, -89.10, P ＜ 0.000 01), transfusion rate (OR = 0.32, 95%CI: 0.19, 0.52, P ＜ 0.000 01) in the experimental group were lower than the control group. There was no significant difference in the incidence of deep vein thrombosis events between the two groups (P ＞ 0.05). Conclusion Intravenous Tranexamic Acid is effective and safe in short-segment posterior lumbar interbody fusion, but it needs more high-quality randomized controlled trial to confirm.
		2021 Vol. 18 (27): 75-79 [Abstract] ( 140 ) HTML (1 KB) PDF (1589 KB) ( 236 )

	80	Analysis of influential factors of knee osteoarthritis in middle-aged and old people
		WANG Shengyu LIN Yuan TAO Shuqing
		Objective To analyze the risk factors of primary knee osteoarthritis in middle-aged and elderly population. Methods A case-control study was conducted with reference to the diagnostic criteria of knee osteoarthritis in the Guidelines for the Diagnosis and Treatment of Osteoarthritis (2007 edition) formulated by the Orthopaedic Society of Chinese Medical Association. Seventy-six patients with knee osteoarthritis who were admitted to the Department of Joint Surgery of the Second Affiliated Hospital of Harbin Medical University from January 2016 to January 2017 and 71 patients in the control group were selected as the research objects. The relevant influencing factors were screened by binary logistic regression analysis. Including single factor analysis, multi-factor stepwise screening and so on. Results Logistic regression analysis showed that age (OR = 1.074, 95%CI: 1.034-1.115, P < 0.001), use of aluminum cooking utensils (OR = 7.132, 95%CI: 1.508-33.718, P = 0.013) and stainless steel cooking utensils (OR = 2.163, 95%CI: 1.010-4.631, P = 0.047) were risk factors for knee osteoarthritis. Conclusion The incidence of knee osteoarthritis is affected by age and the use of aluminum and stainless steel cooking utensils. Therefore, according to the above influencing factors, corresponding intervention measures can be taken to prevent the occurrence of knee osteoarthritis.
		2021 Vol. 18 (27): 80-83 [Abstract] ( 128 ) HTML (1 KB) PDF (540 KB) ( 238 )

	84	Effect of limited contact dynamic compression plate internal fixation and bone grafting combined with Qili San in the treatment of aseptic nonunion after traumatic fracture of extremities
		LI Guode1 YANG Yuanmin2 ZENG Ping3▲
		Objective To compare the clinical effect and safety of locking compression plate internal fixation and bone grafting combined with Qili San in patients with aseptic nonunion after the operation of limbs trauma fracture. Methods A total of 98 patients with postoperative aseptic bone nonunion from limb trauma fractures treated in Department of Orthopedics, Hezhou Hospital of Traditional Chinese Medicine from January 2015 to June 2019 were collected as the research objects. According to random number table method, they were divided into experimental group and control group, with 49 cases in each group. Both groups received Qili San, the experimental group received limited contact dynamic compression plate internal fixation and bone grafting, while the control group received locked compression plate internal fixation and bone grafting. Incision length, operative time, mean intraoperative blood loss, fracture healing time, X-ray callus score, incidence of postoperative complications, insulin-like growth factor, and basic fibroblast growth factor were compared between the two groups. Results The incision length in the experimental group was shorter than that in the control group, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in operative time, average intraoperative blood loss, fracture healing time, and X-ray callus score between the two groups (P ＞ 0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P ＞ 0.05). After surgical treatment, insulin-like growth factor and basic fibroblast growth factor were significantly increased in both groups compared with before surgical treatment, the difference was statistically significant (P ＜ 0.05), but there was no significant difference between groups (P ＞ 0.05). Conclusion The length of incision in patients with aseptic nonunion after operation of limbs trauma fracture is shorter than that of locking pressure plate. Both methods can achieve better therapeutic effect and safety, but the limited contact dynamic pressure plate fixation is more minimally invasive.
		2021 Vol. 18 (27): 84-87 [Abstract] ( 66 ) HTML (1 KB) PDF (503 KB) ( 56 )

	88	Clinical effect of Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium in the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid antibody syndrome
		MA Fei1 LUO Songping2 GAO Jie2 LIU Yulei1 HE Shan3 NING Yan1▲
		Objective To observe the clinical efficacy and safety of Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium in the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome. Methods The clinical data of 138 patients with kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome admitted to Affiliated Shenzhen Maternity ＆ Child Healthcare Hospital, Southern Medical University from March 2017 to December 2019 were selected. According to the treatment method, they were divided into observation group (Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium treatment) and control group (Low Molecular Weight Heparin Calcium treatment), with 69 cases in each group. The course of treatment was seven weeks. Pregnancy outcome, clinical efficacy, improvement of traditional Chinese medicine symptom, negative conversion rate of antiphospholipid antibody, coagulation-fibrinolysis indexes and the occurrence of adverse reactions were recorded and compared between two groups. Results The success rate of abortion in the first and third trimester in observation group were higher than those in control group, and the differences were statistically significant (P < 0.05). After treatment, the traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). The total negative conversion rate of antiphospholipid antibody in observation group was higher than that in control group, and the difference was statistically significant (P < 0.05). After treatment, plasma prothrombin time and activated partial thrombin time in two groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P < 0.05); the levels of fibrinogen and D-dimer were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). The total incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P < 0.05). Conclusion Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium has a significant effect on the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome, which can improve the success rate of abortion and clinical efficacy, reduce the traditional Chinese medicine syndrome score, increase the negative conversion rate of antiphospholipid antibody, and improve the indexes of coagulation-fibrinolysis.
		2021 Vol. 18 (27): 88-92,109 [Abstract] ( 148 ) HTML (1 KB) PDF (846 KB) ( 242 )

	93	Diagnostic value of macrophage migration inhibitory factor, human leukocyte DR antigen expression in peripheral blood for autoimmune premature ovarian failure
		WANG Qun1 LUO Mingyan2
		Objective To investigate the value of peripheral blood macrophage migration inhibitory factor (MIF) and human leukocyte antigen DR (HLA-DR) in the diagnosis of autoimmune premature ovarian failure (APOF). Methods A total of 124 patients with POF admitted to Chengdu Xindu District Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from June 2018 to June 2020 were selected. According to the APOF diagnostic criteria, the patients were divided into APOF group (45 cases) and NAPOF group (79 cases), and 60 healthy women who underwent physical examination in the Department of Obstetrics and Gynecology of our hospital during the same period were selected as control group. The expression of MIF, HLA-DR+CD3+, HLA-DR+CD19+, anti ovarian antibodies (AOAb), anti-zona pellucida antibodies (AZpAb), and antinuclear antibody (ANA) in peripheral blood were detected. The relationship between the above indicators and the incidence of APOF and the diagnostic value of APOF were analyzed. Results The positive proportion of AOAb, AZpAb, ANA and MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in APOF group were higher than those in NAPOF group and control group (P < 0.05); and MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in NAPOF group were higher than those in control group (P < 0.05). MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in APOF patients with autoimmune disease, positive AOAb, positive AzpAb, and positive ANA were higher than those patients with no autoimmune disease, negative AOAb, negative AZpAb and negative ANA (P < 0.05). Autoimmune diseases, high MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels were risk factors for APOF (OR > 1, P < 0.05). The areas under the curve of MIF, HLA-DR+CD3+, HLA-DR+CD19+, and combined MIF and HLA-DR+CD3+, HLA-DR+CD19+ were 0.717, 0.736, 0.705, 0.934, respectively. Conclusion MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in peripheral blood of APOF patients are increased, and the high levels of MIF, HLA-DR+CD3+, and HLA-DR+CD19+ are closely related to the pathogenesis of APOF, which can provide a reference for the diagnosis of APOF.
		2021 Vol. 18 (27): 93-97 [Abstract] ( 77 ) HTML (1 KB) PDF (625 KB) ( 109 )

	98	Application effect of COOK cervical dilatation balloon combined with artificial rupture of membranes in full-term programed delivery
		ZHANG Nan LIU Yu LI Xiaoyan
		Objective To explore the application effect of COOK cervical dilatation balloon combined with artificial rupture of membranes in full-term programed delivery. Methods From January 2017 to December 2019, 732 full-term pregnant women in Anhui Maternal and Child Health Hospital who needed to programed delivery were selected for this study. According to the random number table method, they were divided into COOK cervical dilation balloon combined with artificial rupture group (group A) and COOK cervical dilation balloon group (group B). According to inclusion and exclusion criteria, there were 347 cases in group A and 357 cases in group B. The effective rate of induced labor, labor rate and delivery outcome of two groups were compared. Results There were no significant differences in the total effective rate and labor rate between two groups (P > 0.05). The natural delivery rate and 24 h delivery rate of group A were higher than those of group B (P < 0.05). The labor time, the first stage of labor and the total stage of labor of pregnant with natural delivery in group A were shorter than those of group B (P < 0.05). The incidence of amniotic fluid pollution was lower than that of group B (P < 0.05); while there were no significant differences in the incidence of fetal distress, oligohydramnios, chorioamnionitis, neonatal asphyxia, and postpartum hemorrhage between two groups (P > 0.05). Conclusion COOK cervical dilatation balloon combined with artificial rupture of membranes can shorten the labor time and total labor time, improve 24 h delivery rate and natural delivery rate, and optimize the programed delivery process.
		2021 Vol. 18 (27): 98-101 [Abstract] ( 71 ) HTML (1 KB) PDF (592 KB) ( 91 )

	102	Clinical effect of Compound Sea Buckthorn Seed Oil Suppository combined with Nifuratel Tablets in the treatment of senile bacterial vaginitis
		ZHANG Lu1 DING Ding2 CHEN Bin3 ZHOU Qi1
		Objective To explore the effect of Compound Sea Buckthorn Seed Oil Suppository combined with Nifurtel Tablets in the treatment of senile bacterial vaginitis. Methods A total of 300 cases of senile bacterial vaginitis admitted to Beijing Obstetrics and Gynecology Hospital, Capital Medical University from March 2019 to March 2020 were included. They were divided into the study group and the control group according to the random number table method, with 150 cases in each group. The control group was treated with Nifuratel Tablets, and the study group was treated with Compound Sea Buckthorn Seed Oil Suppository on the basis of control group, both groups were treated for two weeks and the clinical efficacy of the two groups were observed. The improvement time of clinical symptoms, changes in vaginal environment, levels of inflammatory factors (interleukin-13 [IL-13], IL-6, tumor necrosis factor-α [TNF-α]) in vaginal lavage fluid and the occurrence of adverse reactions during treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group (P < 0.05). The improvement time of leucorrhea, pruritus vulvae, pain, vaginal wall congestion, and edema in the study group were shorter than those in the control group (P < 0.05). After two weeks of treatment, the improvement of vaginal pH value and vaginal microflora density in the study group was better than those in the control group (P < 0.05). After two weeks of treatment, the levels of IL-13, IL-6, and TNF-α in vaginal lavage fluid of the two groups were lower than those before treatment, and the study group was lower than that the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Compound Sea Buckthorn Seed Oil Suppository combined with Nifuratel Tablets can improve the vaginal microecological environment of senile patients with bacterial vaginitis, reduce the vaginitis reaction, and have a good effect in the treatment of senile bacterial vaginitis.
		2021 Vol. 18 (27): 102-105 [Abstract] ( 88 ) HTML (1 KB) PDF (587 KB) ( 108 )

	106	Simultaneous determination of three active components in Wuchong Huayu Tongluo Capsules by high performance liquid chromatography
		RONG Juanjuan QI Jun HAN Xiaoke XU Bin CHEN Juan WANG Quan
		Objective To establish high performance liquid chromatography method for the simultaneous determination of ferulic acid，salvianolic acid B and tanshinone ⅡA in Wuchong Huayu Tongluo Capsules. Methods The analysis was performed on Agilent ZORBAX SB-C18 column (4.6 mm×250 mm, 5 μm); mobile phase was acetonitrile-0.1% phosphoric acid with gradient elution; flow rate was 1.0 ml/min; the detection wavelength were 286 nm (detected ferulic acid and salvianolic acid B) and 270 nm (detected tanshinone Ⅱ A); column temperature was 20℃. Results Ferulic acid, salvianolic acid B and tanshinone ⅡA showed good linear relationships within the ranges of 0.528-5.280 μg/ml (R2 = 0.9999), 10.953-109.530 μg/ml (R2 = 0.9996) and 0.326-3.260 μg/ml (R2 = 0.9994), whose average recovery rate were 98.51%, 99.51% and 102.32%, with the RSD of 1.29%, 1.25% and 1.41%, respectively. Conclusion The method is stable and reliable, and can be used for the simultaneous determination of three components in Wuchong Huayu Tongluo Capsules.
		2021 Vol. 18 (27): 106-109 [Abstract] ( 147 ) HTML (1 KB) PDF (446 KB) ( 115 )

	110	Clinical effect of Saifurun combined with vitamin B6 in the treatment of patients with hand-foot syndrome caused by Osimertinib
		GUO Lianying1 LI Jiuqiang2 WANG Jumei1
		Objective To explore the clinical effect of Saifurun combined with vitamin B6 in the treatment of patients with hand-foot syndrome (HFS) caused by Osimertinib. Methods A total of 114 patients with HFS due to oral Osimertinib admitted to Handan Central Hospital of Hebei Province from January 2017 to June 2019 were selected and divided into control group and observation group according to random number table method, with 57 patients in each group. The control group was given vitamin B6 orally, 100 mg/time, three times per day. Based on the control group, the observation group was applied with Saifurun on hands and feet, two to three drops per time, four times per day. During the treatment period, both groups still received oral Osimertinib Mesylate, 80 mg/time, once a day. After six months of treatment, the HFS grading and the improvement rate of quality of life were observed in the two groups, and the quantitative symptom score changes before and after treatment were compared between the two groups. Results After six months of treatment, the HFS grading of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After six months of treatment, the quantitative symptom scores of erythema edema and desiccated skin in both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P ＜ 0.05). The improvement rate of quality of life in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Saifurun combined with vitamin B6, it can improve the symptoms of HFS caused by Osimertinib and improve the quality of life of patients.
		2021 Vol. 18 (27): 110-112,124 [Abstract] ( 88 ) HTML (1 KB) PDF (905 KB) ( 65 )

	113	Professor Sun Antao’s experience in the diagnosis and treatment of aplastic anemia with the idea of “strengthening vital qi to eliminate pathogenic factor, removing blood stasis for promoting tissue regeneration”
		LI Rui1 SUN Antao2 TANG Xudong3
		Aplastic anemia is a kind of pancytopenia disease with anemia, infection and bleeding as the main clinical manifestations. It is a common hematopoietic debilitating disease in blood diseases. Immunosuppressive therapy has a certain therapeutic effect on it, but the treatment cycle is longer, the side effects are larger, and after the withdrawal of the drug, there will often be a significant drop in blood manifestation, blood manifestation is difficult to return to normal, patients have to endure the side effects continue to take. Professor Sun Antao believes that in the basic treatment of tonifying the kidney and strengthening the spleen with traditional Chinese medicine and androgens, the method of activating blood and resolving stasis can promote the bone marrow to rebuild the hematopoietic microenvironment and restore hematopoietic function, which can effectively alleviate the side effects of immunosuppressive drugs and improve the quality of life of patients. In this paper, professor Sun Antao’s treatment of aplastic anemia has broken through the traditional Chinese medicine treatment of tonifying the kidney and strengthening the spleen. Professor Sun Antao focuses on the treatment of aplastic anemia patients with disease course of more than half a year from the perspective of removing blood stasis for promoting tissue regeneration method, and provides typical cases of effective clinical treatment, with obvious effect and small side effects, which is worthy of reference and application.
		2021 Vol. 18 (27): 113-116 [Abstract] ( 205 ) HTML (1 KB) PDF (768 KB) ( 98 )

	117	Professor Jin Shi’s experience in treating arthralgia syndrome with rattan drugs
		CHEN Quan1 SUN Lixia1 ZHOU Nan2 YANG Haoran1 LIU Lina1
		Impediment is due to wind, cold, dampness, heat and other evil qi blocking channel-collateral, resulting in limb bones, joints, muscles and other areas of pain, heavy, sour, numbness, or joint flexion and extension adverse, stiffness, swelling, deformation, and so on as the main disease. The disease is lingering and difficult to heal, long-term oral Western medicine treatment is easy to lead to a variety of adverse reactions, is a clinical syndrome of knotty. Professor Jin Shi believes that impediment can be divided into wind, cold, dampness, and heat pathogen partial victory. On the basis of treatment based on syndrome differentiation, impediment disease can be treated by different nature, flavour, channel tropism and function characteristics of rattan drugs. Kadsura pepper stem and common clubmoss herb can be used to treat migratory impediment, suberect spatholobus stem and piper wallichii can be used to treat painful impediment, orientvine vine and dutchmanspipe vine can be used to treat fixed arthralgia, honeysuckle stem, Chinese starjasmine stem, and Tripterygium wilfordii can be used to treat heat impediment, and the clinical effect is significant. In this paper, professor Jin Shi’s experience is summarized and discussed, and a medical case is attached for evidence, so as to enrich the clinical diagnosis and treatment ideas of impediment.
		2021 Vol. 18 (27): 117-120 [Abstract] ( 173 ) HTML (1 KB) PDF (757 KB) ( 209 )

	121	Discussion on metastasis of colorectal cancer from Shaoyang theory
		ZHAN Xiangyang JIN Jingyun LI Qi LIU Hui
		By systematically combing the theory of “Shaoyang” in traditional Chinese medicine, it is found that the theory of “Shaoyang” is closely related to the metastasis of colorectal cancer. Physiologically, shaoyang is the pivot of the body, communicating the inside and outside of the body, maintaining the movement of qi, regulating the flow of fluid, blood and emotions. If shaoyang is unfavorable, it will lead to poor communication inside and outside the human body, form the turbid phlegm and blood stasis, disturb qi’s rise and fall, cause emotional disorder and spiritual failure. “Shaoyang” theory can affect the metastasis of colorectal cancer in the following aspects: first, the cancer toxin such as turbid phlegm and blood stasis will be endogenous if Shaoyang qi is not favorable; second, the cancer toxin will be transferred if qi mechanism is not working properly; third, if the Shaoyang cardinal mechanism is unfavorable, the body will be blocked inside and outside, the cancer toxin has no place to be released, emotional disorder and the supernatural power will leak out, then healthy qi deficiency can’t prevent cancer. Further connecting the theory of “Shaoyang” with the modern research progress, it can be found that abnormal autophagy，intestinal flora disorder, tumor angiogenesis and immune disorder may be the biological basis of intestinal cancer metastasis caused by unfavorable Shaoyang. It is helpful to prevent and treat the metastasis of colorectal cancer in consideration of “Shaoyang”.
		2021 Vol. 18 (27): 121-124 [Abstract] ( 69 ) HTML (1 KB) PDF (760 KB) ( 142 )

	125	Application survey of hand diagnosis in coronary heart disease
		LIU Meihan YANG Jian LI Xiaoning ZHU Tingyu SHI Xueqin ZHAO Shupei ZHANG Limei▲ LIU Jianfeng▲
		Hand diagnosis is one of the unique diagnostic methods of traditional Chinese medicine. At present, there is still a lack of scientific data reports on the diagnosis rate of coronary heart disease by hand diagnosis. Based on the national key research and development program, this paper summarizes the experience of many hand diagnosis methods for coronary heart disease represented by Liu Jianfeng’s qi color form hand diagnosis, summarizes the important characteristics of different hand diagnosis methods for heart diseases such as hand color, shape, palm print, fingerprint and nail, summarizes the advantages of hand diagnosis in the diagnosis of coronary heart disease and heart diseases, and puts forward the author’s experience in the application of hand diagnosis and the prospect of scientific research on hand diagnosis, so as to clarify the thinking of further clinical research on the diagnosis of coronary heart disease by qi color form hand diagnosis.
		2021 Vol. 18 (27): 125-128 [Abstract] ( 112 ) HTML (1 KB) PDF (819 KB) ( 46 )

	129	Meta analysis on effectiveness and safety of traditional Chinese medicine in adjuvant treatment of posterior circulation ischemic vertigo
		MENG Weishan1 LAN Rui2 WANG Baoqi1
		Objective To evaluate the efficacy and safety of traditional Chinese medicine in adjuvant treatment of posterior circulation ischemic vertigo. Methods Randomized controlled trials of traditional Chinese medicine in adjuvant treatment of posterior circulation ischemic vertigo in CNKI, Wanfang, VIP, SinoMed, Embase and PubMed databases were searched by computer. The search term was “posterior circulation ischemic vertigo, randomized controlled”. The retrieval period was from January 2015 to January 2021. The literature, extracted basic information and study bias risk assessment were screened by two participants independently. RevMan 5.4 software was used for meta analysis. Results A total of 15 literatures were included, including 2532 patients, 1332 cases in experimental group and 1200 cases in control group. Meta analysis results: clinical effect of experimental group was better than that of control group (RR = 1.25, 95%CI: 1.19-1.31, P ＜ 0.000 01), the velocity of left vertebral artery in experimental group was faster than that in control group (MD = 4.48, 95%CI: 2.92-6.05, P ＜ 0.000 01), the velocity of right vertebral artery in experimental group was faster than that in control group (MD = 4.30, 95%CI: 2.82-5.79, P ＜ 0.000 01), the velocity of basilar artery in experimental group was faster than that in control group (MD = 5.29, 95%CI: 4.56-6.01, P ＜ 0.000 01), the score of dizziness disorder scale in experimental group was lower than that in control group (MD = -6.09, 95%CI: -8.26 to -3.91, P ＜ 0.000 01). Conclusion Traditional Chinese medicine in adjuvant treatment of posterior circulation ischemic vertigo can improve clinical effect, quicken the blood flow velocity of vertebrobasilar artery and improve the symptoms of dizziness.
		2021 Vol. 18 (27): 129-133 [Abstract] ( 98 ) HTML (1 KB) PDF (1841 KB) ( 94 )

	134	Investigation on the fundus retinopathy with “fundus viscera syndrome differentiation” based on the combination of macro and micro syndrome differentiation
		LU Bingwen1,2 XIE Like2 WU Gaiping2 ZHAO Jian1 YUAN Hang2
		Because ancient traditional Chinese medicine (TCM) ophthalmologists are unable to see the fundus, traditional macroscopic syndrome differentiation and the holistic concept are greatly limited, so the curative effects of TCM therapies for retinal diseases are not ideal. With the rapid development of modern retinal imaging technology and modern biotechnology, ophthalmologists can clearly understand retinal morphological and functional changes, which makes it possible to differentiate retinal diseases microscopically. The comprehensive diagnosis and treatment mode of traditional macro-syndrome differentiation combined with micro-syndrome differentiation by modern medical technology is helpful to grasp the core pathogenesis and carry out precise treatment in the clinical practice of TCM ophthalmology. By using the new method of syndrome differentiation and treatment, combined with the classical ophthalmology five-wheel theory, syndrome differentiation of six channels theory and “inner five-wheel” hypothesis, the “fundus viscera syndrome differentiation” based on the combination of macro and micro syndrome differentiation is expected to become the modern syndrome differentiation system for fundus retinopathy, deepen the understanding of fundus retinopathy, and imove the clinical diagnosis and treatment level of TCM ophthalmologists.
		2021 Vol. 18 (27): 134-137,145 [Abstract] ( 167 ) HTML (1 KB) PDF (947 KB) ( 77 )

	138	Professor Deng Tietao’s experience in treating chest pain after percutaneous coronary intervention with “the relevance theory of five zang viscera”
		YANG Changhe1 LIU Zeyin1,2 SU Ziang1 CHEN Xiaoguang2
		Percutaneous coronary intervention (PCI) is an effective treatment for coronary heart disease at present, and it has been widely used in clinic. However, there is still a higher incidence of chest pain after PCI. Simple western medicine treatment has limitations. Professor Deng Tietao has a great advantage in treating chest pain after PCI by applying “the relevance theory of five zang viscera”, he proposes that the basic pathogenesis of the disease is “deficient root and excessive manifestation” and the pathological change is “first deficiency and then excess”. He advocates the use of traditional Chinese medicine emergency surgery to treat acute chest pain, based on “the relevance theory of five zang viscera”, simultaneous treatment of heart and spleen, simultaneous treatment of phlegm and blood stasis, combination of reinforcing and reducing, combination of internal and external. The purpose of this paper is to summarize Deng Tietao’s experience in treating chest pain after PCI from the perspective of “the relevance theory of five zang viscera”.
		2021 Vol. 18 (27): 138-141 [Abstract] ( 149 ) HTML (1 KB) PDF (788 KB) ( 107 )

	142	Clinical effect of self-made Fuzheng Quxie Yukui Decoction in the treatment of ulcerative colitis with syndrome of intermingled heat and cold
		ZHU Weining1 WANG Liyuan2 JIANG Kun3
		Objective To observe and discuss the curative effect of self-made Fuzheng Quxie Yukui Decoction in the treatment of ulcerative colitis with syndrome of intermingled heat and cold. Methods A total of 120 ulcerative colitis patients with syndrome of intermingled heat and cold treated in Department of Spleen and Stomach, Weihai Hospital of Traditional Chinese Medicine from June 2019 to June 2020 were selected as research subjects. The patients were divided into control group and treatment group by random number table method, with 60 patients in each group. The control group was given Mesalazine, and the treatment group was additionally treated with self-made Fuzheng Quxie Yukui Decoction on the basis of the control group. The course of treatment was four weeks. The clinical effect, traditional Chinese medicine syndrome score and mucosal histological score were compared between the two groups. Results After treatment, the overall effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the traditional Chinese medicine syndrome scores, mucosal histological scores of the two groups were significantly lower than those before treatment (P < 0.05), which of the treatment group were significantly lower than those of the control group (P < 0.05). Conclusion Self-made Fuzheng Quxie Yukui Decoction can eliminate or improve the clinical symptoms, and promote the recovery of ulcerative colitis.
		2021 Vol. 18 (27): 142-145 [Abstract] ( 117 ) HTML (1 KB) PDF (785 KB) ( 87 )

	146	Clinical effect of small akupotomye in treatment of patients with Ⅱ or Ⅲ tenosynovitis stenosans of thumb
		LIU Qiqi1 GONG Yuecheng1 ZHU Junchen2
		Objective To observe clinical effect of small akupotomye in treatment of patients with Ⅱ or Ⅲ tenosynovitis stenosans of thumb. Methods A total of 60 patients who met the diagnostic criteria of Ⅱ and Ⅲ tenosynovitis stenosans of thumb were enrolled in the First Department of Orthopedics and Traumatology, the Second Affiliated Hospital of Anhui University of Chinese Medicine from November 2019 to November 2020. The patients were divided into control group and observation group by random number table method, with 30 cases in each group. The control group was treated with local occlusion, and the observation group was treated with small akupotomye, once a week, for one week. Visual analogue scale (VAS), Quinnell scale scores, and thumb range of motion were compared between the two groups before treatment, one day after treatment and three months after treatment. The clinical efficacy of the two groups after three months was compared. Results There were statistically significant differences in VAS, Quinnell scale scores, and thumb range of motion before, one day and three month after treatment, time point comparison and interaction between the two groups (P ＜ 0.05). Further pairwise comparison and intra-group comparison: one day and three month after treatment, the VAS and Quinnell scale scores of the two groups were lower than those before treatment, and the thumb range of motion was higher than that before treatment, with statistical significance (P ＜ 0.05). Comparison between groups: Three month after treatment, the VAS and Quinnell scale scores of the observation group were lower than those of the control group in the same period, and the thumb range of motion was higher than that of the control group in the same period, with statistical significance (P ＜ 0.05). The clinical effect of observation group was better than control group three months after treatment, the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of small needle knife for relieving stenosing tenosynovitis of thumb is remarkable, especially for stage Ⅱ and Ⅲ stenosing tenosynovitis.
		2021 Vol. 18 (27): 146-149 [Abstract] ( 126 ) HTML (1 KB) PDF (464 KB) ( 161 )

	150	Clinical study of hydraulic dilatation combined with akupotomye by ultrasound-guided in the treatment of patients with periarthritis humeroscapularis
		SUN Pengfei1 ZHANG Chang2 HU Xiangdong1 QIAN Linxue1
		Objective To investigate the clinical effect of hydraulic dilatation combined with akupotomye by ultrasound-guided in the treatment of patients with periarthritis humeroscapularis. Methods A total of 80 patients with periarthritis humeroscapularis during unilateral freezing period admitted to Beijing Friendship Hospital, Capital Medical University and Aerospace Center Hospital from January 2019 to January 2021 were selected. According to random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group adopted the traditional blind hydraulic dilation and akupotomye therapy, while the observation group adopted the hydraulic dilatation combined with akupotomye by ultrasound-guided. Both groups were treated once a week, three times/ course of treatment, after one course of treatment, both groups were given functional exercise. The efficacy of the two groups was compared. Visual analogue scale (VAS) and Constant-Murley shoulder function score (CM) were compared between the two groups before and after treatment, and one month after treatment. Results There were statistically significant differences in VAS and CM scores before and after treatment, and one month after treatment, time point comparison and interaction between the two groups (P ＜ 0.05). Further pairwise comparison and intra-group comparison: after treatment and one month after treatment, the VAS score of the two groups was lower than that before treatment, and the CM score was higher than that before treatment, with statistical significance (P ＜ 0.05). Comparison between groups: One month after treatment, the VAS score of the observation group was lower than that of the control group in the same period, and the CM score was higher than that of the control group in the same period, with statistical significance (P ＜ 0.05). There was no significant difference in the total effective rate between the two groups (P ＞ 0.05). Conclusion Hydraulic dilation combined with akupotomye by ultrasonic-guided release for the treatment of periarthritis humeroscapularis can realize visualization and improve shoulder function.
		2021 Vol. 18 (27): 150-153 [Abstract] ( 132 ) HTML (1 KB) PDF (453 KB) ( 100 )

	154	Effect of subject-based diversified psychological interventions on the depression degree, mood state and quality of life of women with postpartum depression
		ZHANG Haiyan1 ZHANG Junru1 SUN Bailing2 CHEN Yan2▲
		Objective To explore the effects of subject-based diversified psychological interventions on the degree of depression, mood state and quality of life of patients with postpartum depression. Methods A total of 137 patients with postpartum depression admitted to the First Affiliated Hospital of the Air Force Military Medical University from January 2015 to December 2019, and they were divided into the observation group of 69 cases and the control group of 68 cases according to the random number table method. The control group was given routine nursing intervention, and the observation group was combined with the subject-based diversified psychological interventions. Followed up for six months, the depression degree, mood state and quality of life were compared between the two groups. Results The observation group actually included 67 patients, and the control group actually included 63 patients. Follow-up for six months, the Hamilton depression scale (HAMD) scores of the two groups were lower than before the intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05); the profile of mood states (POMS) scores of the two groups were lower than before the intervention, while the energy-vitality scores of the observation group was significantly higher than that of the control group, and the scores of tension-anxiety, depression-depression, fatigue-indulgence were significantly lower than those of the control group, and the differences were statistically significant (P ＜ 0.05); the quality of life scores of the two groups were higher than before the intervention, while the physical function, role function, emotional function, cognitive function, and social function scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Subjec-tbased diversified psychological intervention can help relieve the clinical symptoms of patients with postpartum depression, adjust their mental state, and improve the quality of life of patients.
		2021 Vol. 18 (27): 154-157 [Abstract] ( 163 ) HTML (1 KB) PDF (661 KB) ( 282 )

	158	Effect of parent-child self-disclosure intervention on post-traumatic growth of adolescent patients with osteosarcoma
		WEI Rongquan1 SHAO Xiao1 LIAO Dan1 YANG Jin1 CHEN Ying2
		Objective To explore the effect of parent-child self-disclosure on improving the post-traumatic growth of adolescent patients with osteosarcoma. Methods Sixty adolescent patients with osteosarcoma who were hospitalized in the Affiliated Tumor Hospital of Guangxi Medical University from February 2019 to February 2020 were selected. The patients were divided into experimental group and control group according to the order of admission, 30 cases in each group. The control group was given routine care, and the experimental group received 12 weeks of parent-child self-disclosure intervention on the basis of routine care. The post-traumatic growth inventory (PTGI) was used to evaluate the effect before and after the intervention. Results After the implementation of parent-child self-disclosure intervention, the scores of each dimension and total PTGI score in the experimental group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the scores of each dimension and total PTGI score of control group between before and after the intervention (P ＞ 0.05); the the scores of each dimension and and total PTGI score of test group were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). 93.3% of patients showed moderate to high compliance. Conclusion Parent-child self-disclosure intervention can improve the PTG level of adolescent patients with osteosarcoma to a certain extent.
		2021 Vol. 18 (27): 158-161 [Abstract] ( 145 ) HTML (1 KB) PDF (667 KB) ( 93 )

	162	Application effect of health education based on the concept of strength in patients with colostomy after rectal cancer surgery
		ZHANG Haihong1 LIU Lili1 WANG Qingqing2▲
		Objective To explore the clinical effect of health education based on the concept of strength applied to patients with colostomy after rectal cancer surgery. Methods A total of 100 patients with colostomy after rectal cancer surgery in the Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University were selected from January 2018 to December 2019, and they were divided into intervention group and control group according to the random number table method, with 50 cases in each group. The control group was given regular health education, and the intervention group was combined with health education based on the concept of strength on the basis of the control group. Follow-up for 12 weeks, the ostomy adjustment inventory-20 (OAI-20), the exercise of self-care agency (ESCA), and quality of life questionnaire colorectal cancer module (QLQ-CR38) were used to assess the social and psychological adaptability, self-nursing ability and quality of life of the two groups. Results Follow-up for 12 weeks, the OAI-20 scores of the two groups were higher than before the intervention, while the intervention group was higher than the control group, and the differencess were statistically significant (P ＜ 0.05); the ESCA scores of the two groups were higher than before the intervention, while the intervention group was higher than the control group, and the differences were statistically significant (P ＜ 0.05); the QLQ-CR38 scores of the two groups were higher than before the intervention, and the intervention group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Health education based on the concept of strong will help to enhance the psychosocial adaptability of patients with colostomy after rectal cancer surgery, enhance their self-care ability, and improve the quality of life, which is of great significance for improving the prognosis.
		2021 Vol. 18 (27): 162-165 [Abstract] ( 77 ) HTML (1 KB) PDF (615 KB) ( 54 )

	166	Application effect of nursing model led by brain-heart health managers in post-stroke sleep disorders
		MA Dan LI Feng▲
		Objective To explore the application effect of the nursing model led by brain-heart health managers in post-stroke sleep disorders. Methods A total of 97 patients with post-stroke sleep disorders admitted to People’s Hospital of Lu’an City in Anhui Province from January 2019 to December 2020 were selected and divided into observation group (49 cases) and control group (48 cases) according to the random number table method. Both groups were given the same treatment plan. The control group was given routine care based on the above treatments, while the observation group was given nursing model led by brain-heart health managers based on the control group. Both groups were followed up for four months to compare the sleep status, Pittsburgh sleep quality index (PSQI), negative emotions, and stroke recurrence before and after nursing. Results The sleep latency after nursing in the observation group was shorter than that of the control group, the total sleep time was longer than that of the control group, while the number of awakenings was less than that of the control group, and the differences were statistically significant (P ＜ 0.05). The sleep latency after nursing of two groups were shorter than those before nursing, the total sleep time of two groups were longer than those before nursing, and the number of awakenings of two groups were less than those before nursing, and the differences were statistically significant (P ＜ 0.05). The PSQI score of two groups after nursing were lower than those before nursing, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The anxiety and depression scores of the two groups after nursing were lower than those before nursing, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the recurrence rate of stroke between the two groups (P ＞ 0.05). Conclusion The nursing model led by brain-heart health managers can significantly improve the sleep conditions and negative emotions of patients with sleep disorders after stroke, and is worthy of clinical application.
		2021 Vol. 18 (27): 166-169 [Abstract] ( 87 ) HTML (1 KB) PDF (619 KB) ( 40 )

	170	Application effect of nursing based on FMEA model in emergency cane of patients with severe trauma
		SONG Xin HE Qianfeng ZHANG Cuicui WU Yixuan JIAO Damai GAO Yanling▲
		Objective To explore the application effect of failure mode and effect analysis (FMEA) model nursing in emergency care of severe trauma patients. Methods A total of 122 severe trauma patients admitted to Second Affiliated Hospital of Air Force Military Medical University between October 2017 and October 2020 were selected as the research objects. The patients were divided into observation group and control group by random number table method, with 61 cases in each group. Patients in the observation group were treated with a nursing plan based on the FMEA model, and patients in the control group were treated with a conventional nursing plan. The emergency response time, rescue success rate, complications of the two groups to evaluate the application effects of different emergency care models were observed and studied. Results The emergency room stay time, pre-treatment inspection time, pre-operative waiting time, and the interval between admission and rescue in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). The rescue success rate of the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05); the incidence of complications in the observation group was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The emergency nursing scheme based on FMEA model has good clinical application value for patients with severe trauma. It can effectively improve the emergency response speed of the hospital, improve the success rate of rescue, and effectively control the occurrence of emergency related complications, which is worthy of popularization and application in nursing practice.
		2021 Vol. 18 (27): 170-173 [Abstract] ( 69 ) HTML (1 KB) PDF (615 KB) ( 99 )

	174	Application value of health education mode of information-knowledge-belief-behavior in acute pancreatitis
		QUE Jing XUE Xiu LI Hua
		Objective To explore the application value of health education mode of information-knowledge-belief-behavior in acute pancreatitis. Methods A total of 130 patients with acute pancreatitis admitted to 3201 Hospital of Hanzhong City, Shaanxi Province from January to October 2020 were selected, according to random number table method, the patients were divided into control group and observation group, with 65 cases in each group. The control group received routine health education, and the observation group receuved the health education concept of information-knowledge-belief-behavior on the basis of the control group, the compliance behavior, self-care ability and quality of life of the two groups were compared. Results After the interrention, the compliance of the observation group was higher than that of the control group (P ＜ 0.05). Scores of self-care ability in both groups were higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05). The scores of all dimensions in the short from health survey-36 in both groups were higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05). Conclusion In nursing intervention of patients with clinical acute pancreatitis, the application of health education mode of information-knowledge-belief-behavior can improve patients’ compliance behavior, self-care ability and quality of life.
		2021 Vol. 18 (27): 174-177 [Abstract] ( 69 ) HTML (1 KB) PDF (664 KB) ( 23 )

	178	Clinical nursing pathway combined with ERAS high quality nursing in children with hirschsprung disease after resection
		ZHANG Yu
		Objective To research the effect of clinical nursing pathway combined with enhanced recovery after surgery (ERAS) high quality nursing in children with Hirschsprung disease after resection. Methods A total of 100 cases of children with Hirschsprung disease resection who underwent surgery in Pediatric Intensive Care Unit in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from June 2017 to June 2020 were selected as the objects, according to the random number table method they were devided with observation group and control group, with 50 cases in each group. The control group was given nursing intervention of traditional rehabilitation concept after operation. The observation group was given nursing intervention of clinical nursing pathway combined with ERAS high quality nursing on the basis of the control group. The pain degree, first exhaust time, first defecation time, postoperative eating time, hospitalization time, hospitalization expenses, postoperative complications and hursing satisfaction of the two groups were compared during postoperative hospitalizat. Results The degree of pain in the observation group was significantly lighter than that in the control group, and the difference was statistically significant (P ＜ 0.05). The first exhaust time, first defecation time, postoperative eating time and hospitalization time of the observation group were significantly shorter than those of the control group, and the hospitalization cost was significantly lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of postoperative complications in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total satisfaction of the parents of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The clinical nursing pathway combined with ERAS high quality nursing after children’s Hirschsprung disease resection can significantly accelerate the recovery speed of children after operation, and effectively reduce the occurrence of postoperative complications, which has high clinical application value.
		2021 Vol. 18 (27): 178-181 [Abstract] ( 122 ) HTML (1 KB) PDF (617 KB) ( 96 )

	182	Effect of collaborative nursing in the treatment of severe pulmonary infection with fiberoptic bronchoscope
		YANG Ying
		Objective To explore the effect of collaborative nursing in the treatment of severe pulmonary infection with fiberoptic bronchoscopy. Methods A total of 68 patients with severe pulmonary infection admitted to the First Affiliated Hospital of Zhengzhou University from March 2017 to March 2019 were selected, and they were devided into the control group and the intervention group, with 34 cases in each group. Patients in the control group were given routine nursing care, and patients in the intervention group were given collaborative nursing intervention. The blood gas analysis indexes, complication rate and nursing satisfaction of the two groups of patients were compared. Results After two weeks of intervention, the arterial oxygen partial pressure index and arterial oxygenation value of the two groups were both higher than those before nursing, and the intervention group were significantly higher than those in the control group (P ＜ 0.05). The arterial partial pressure of carbon dioxide index of the two groups were lower than those before nursing, and in the intervention group was lower than that in the control group (P ＜ 0.05). The cooperation and nursing satisfaction of the intervention group were higher than those of the control group (P ＜ 0.05). Conclusion When fiberoptic bronchoscopy used to treat severe pulmonary infections, collaborative nursing can effectively improve the level of blood gas analysis indicators, the patient’s cooperation and patient satisfaction.
		2021 Vol. 18 (27): 182-185 [Abstract] ( 72 ) HTML (1 KB) PDF (659 KB) ( 73 )

	186	Misdiagnosis of left adrenal gland occupying was reported in one case and literature review
		BAO Shiqi YI Faxian REN Chao
		To explore the reasons for misdiagnosis and preventive measures of space-occupying lesions in the left adrenal gland area, improve the level of diagnosis and treatment, and broaden the diagnosis ideas. This article retrospectively analyzes the clinical data of a patient with left adrenal area occupying in the Department of Urology, Affiliated Hospital of Inner Mongolia Medical University, preoperative serum cortisol, aldosterone, adrenal enhanced CT and ultrasound were analyzed, and relevant literature was reviewed and referenced. To provide clinical diagnosis and treatment experience for left adrenal space occupying lesions. In this case, the left adrenal accessory spleen was misdiagnosed as a left adrenal adenoma before the operation, and the left adrenal accessory spleen was found during laparoscopic surgery. The left adrenal gland was resected during the operation and the accessory splenectomy was not performed. The postoperative pathological report was nodular hyperplasia of the left adrenal cortex. As the differential diagnosis of adrenal adenoma, accessory spleen and adrenal nodularhyperplasia in the adrenal area is clinically rare, but it should cause high attention. Through comprehensive patient clinical symptoms and rational application of imaging evaluation programs, careful consideration can reduce misdiagnosis and standardize diagnosis and treatment.
		2021 Vol. 18 (27): 186-188,196 [Abstract] ( 90 ) HTML (1 KB) PDF (757 KB) ( 137 )

	189	Evaluation of Chinese medical resource allocation efficiency from the perspective of hierarchical medical system
		SHAO Yiying MO Yingning JIAO Aonan
		Objective To analyze the efficiency of the hierarchical allocation of medical resources in China (except Hong Kong, Macao and Taiwan) since the formal implementation of the hierarchical medical system and to provide reference for optimizing resource allocation and promoting hierarchical medical system. Methods The BCC model and the Malmquist index of data envelopment analysis were used to analyze the efficiency of Chinese medical resource allocation from January 2015 to December 2019. Results The resource allocation efficiency of primary medical and health institutions was lower than that of hospitals and showed a downward trend in efficiency. Technical level and innovation ability were the main reasons restricting its efficiency. Conclusion There are hierarchical and regional differences in the efficiency of medical resource allocation, the development trend of primary medical resource allocation efficiency is not good. It is recommended to strengthen planning to improve the rationality and coordination of the distribution of medical resources.
		2021 Vol. 18 (27): 189-192 [Abstract] ( 114 ) HTML (1 KB) PDF (607 KB) ( 412 )

	193	Research on the innovation and development of “Internet + medical health” industry in Shenyang
		ZHANG Siwen JIANG Qingdan ZHAO Di JIANG Yijiao
		“Internet + medical health” can solve the problems of uneven distribution of medical resources, high difficulty of expensive medical treatment problem, and can also meet the objective needs of improving the national health quality and integrating the residents’ health information under the background of healthy China strategy. Starting from the condition of medical resources and policy background in Shenyang, this paper introduces the implementation status of “Internet + medical health” service, analyzes the problems and deficiencies in the development of “Internet + medical health” service in Shenyang, and puts forward corresponding countermeasures and suggestions.
		2021 Vol. 18 (27): 193-196 [Abstract] ( 80 ) HTML (1 KB) PDF (565 KB) ( 182 )

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