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| Discussion on metastasis of colorectal cancer from Shaoyang theory |
| ZHAN Xiangyang JIN Jingyun LI Qi LIU Hui |
| Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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Abstract By systematically combing the theory of “Shaoyang” in traditional Chinese medicine, it is found that the theory of “Shaoyang” is closely related to the metastasis of colorectal cancer. Physiologically, shaoyang is the pivot of the body, communicating the inside and outside of the body, maintaining the movement of qi, regulating the flow of fluid, blood and emotions. If shaoyang is unfavorable, it will lead to poor communication inside and outside the human body, form the turbid phlegm and blood stasis, disturb qi’s rise and fall, cause emotional disorder and spiritual failure. “Shaoyang” theory can affect the metastasis of colorectal cancer in the following aspects: first, the cancer toxin such as turbid phlegm and blood stasis will be endogenous if Shaoyang qi is not favorable; second, the cancer toxin will be transferred if qi mechanism is not working properly; third, if the Shaoyang cardinal mechanism is unfavorable, the body will be blocked inside and outside, the cancer toxin has no place to be released, emotional disorder and the supernatural power will leak out, then healthy qi deficiency can’t prevent cancer. Further connecting the theory of “Shaoyang” with the modern research progress, it can be found that abnormal autophagy，intestinal flora disorder, tumor angiogenesis and immune disorder may be the biological basis of intestinal cancer metastasis caused by unfavorable Shaoyang. It is helpful to prevent and treat the metastasis of colorectal cancer in consideration of “Shaoyang”.
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