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| Clinical effect of Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium in the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid antibody syndrome |
| MA Fei1 LUO Songping2 GAO Jie2 LIU Yulei1 HE Shan3 NING Yan1▲ |
1.Department of Traditional Chinese Medicine, Affiliated Shenzhen Maternity ＆ Child Healthcare Hospital, Southern Medical University, Guangdong Province, Shenzhen 518028, China;
2.Department of Gynecology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China; 3.Department of Pharmacy, Affiliated Shenzhen Maternity ＆ Child Healthcare Hospital, Southern Medical University, Guangdong Province, Shenzhen 518028, China |
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Abstract Objective To observe the clinical efficacy and safety of Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium in the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome. Methods The clinical data of 138 patients with kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome admitted to Affiliated Shenzhen Maternity ＆ Child Healthcare Hospital, Southern Medical University from March 2017 to December 2019 were selected. According to the treatment method, they were divided into observation group (Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium treatment) and control group (Low Molecular Weight Heparin Calcium treatment), with 69 cases in each group. The course of treatment was seven weeks. Pregnancy outcome, clinical efficacy, improvement of traditional Chinese medicine symptom, negative conversion rate of antiphospholipid antibody, coagulation-fibrinolysis indexes and the occurrence of adverse reactions were recorded and compared between two groups. Results The success rate of abortion in the first and third trimester in observation group were higher than those in control group, and the differences were statistically significant (P < 0.05). After treatment, the traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). The total negative conversion rate of antiphospholipid antibody in observation group was higher than that in control group, and the difference was statistically significant (P < 0.05). After treatment, plasma prothrombin time and activated partial thrombin time in two groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P < 0.05); the levels of fibrinogen and D-dimer were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). The total incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P < 0.05). Conclusion Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium has a significant effect on the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid syndrome, which can improve the success rate of abortion and clinical efficacy, reduce the traditional Chinese medicine syndrome score, increase the negative conversion rate of antiphospholipid antibody, and improve the indexes of coagulation-fibrinolysis.
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| Cite this article: |
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MA Fei1 LUO Songping2 GAO Jie2 LIU Yulei1 HE Shan3 NING Yan1▲. Clinical effect of Anzi Tiaochong Decoction combined with Low Molecular Weight Heparin Calcium in the treatment of kidney deficiency and blood stasis type recurrent spontaneous abortion with antiphospholipid antibody syndrome[J]. 中国医药导报, 2021, 18(27): 88-92,109.
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| URL: |
| https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I27/88 |
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