Abstract Objective To analyze the risk factors of primary knee osteoarthritis in middle-aged and elderly population. Methods A case-control study was conducted with reference to the diagnostic criteria of knee osteoarthritis in the Guidelines for the Diagnosis and Treatment of Osteoarthritis (2007 edition) formulated by the Orthopaedic Society of Chinese Medical Association. Seventy-six patients with knee osteoarthritis who were admitted to the Department of Joint Surgery of the Second Affiliated Hospital of Harbin Medical University from January 2016 to January 2017 and 71 patients in the control group were selected as the research objects. The relevant influencing factors were screened by binary logistic regression analysis. Including single factor analysis, multi-factor stepwise screening and so on. Results Logistic regression analysis showed that age (OR = 1.074, 95%CI: 1.034-1.115, P < 0.001), use of aluminum cooking utensils (OR = 7.132, 95%CI: 1.508-33.718, P = 0.013) and stainless steel cooking utensils (OR = 2.163, 95%CI: 1.010-4.631, P = 0.047) were risk factors for knee osteoarthritis. Conclusion The incidence of knee osteoarthritis is affected by age and the use of aluminum and stainless steel cooking utensils. Therefore, according to the above influencing factors, corresponding intervention measures can be taken to prevent the occurrence of knee osteoarthritis.
WANG Shengyu LIN Yuan TAO Shuqing. Analysis of influential factors of knee osteoarthritis in middle-aged and old people[J]. 中国医药导报, 2021, 18(27): 80-83.
[1] Magnusson K，Kumm J，Turkiewicz A，et al. A naturally aging knee，or development of early knee osteoarthritis [J] Osteoarthritis Cartilage，2018，26（11）：1447-1452.
[2] 陈铿，方浩，徐苏洋，等.骨关节炎患者滑膜细胞对于成骨细胞骨向分化的影响及机制研究[J].临床和实验医学杂志，2020，19（12）：1303-1307.
[3] 李溪.膝关节骨性关节炎危险因素的病例对照研究[D].昆明：昆明医科大学，2019.
[4] Roos EM，Arden NK. Strategies for the prevention of knee osteoarthritis [J]. Nat Rev Rheumatol，2016，12（2）：92-101.
[5] Jamshidi A，Pelletier JP，Martel-Pelletier J. Machine-learning-based patient-specific prediction models for knee osteoarthritis [J]. Nat Rev Rheumatol，2019，15（1）：49-60.
[6] 中华医学会骨科学分会.骨关节炎诊疗指南（2007年版）[J].中华骨科杂志，2007，27（10）：793-796．
[7] Lars L. The Bone and Joint Decade 2000-2010 [J]. Bull World Health Organ，2003，81：629.
[8] 宋雄英，李雪峰，刘春阳，等.北京市丰台区长辛店地区老年人膝骨关节病现状调查及影响因素[J].中国老年学杂志，2011，31（4）：667-669.
[9] 王伟，王坤正，党小谦，等.中老年膝骨关节炎发病的相关因素[J].中国临床康复，2006，10（44）：15-18.
[10] Pereira D，Ramos E，Branco J. Osteoarthritis[J]. Acta Med Port，2015，28（1）：96-106.
[11] Jordan JM，Luta G，Renner JB，et al. Ethnic differences in self-reported functional status in the rural south：the Johnston County Osteoarthritis Project. [J]. Arthritis Care Res，1996，9：483-491.
[12] 沈明球，刘俊昌，王新军，等.新疆北疆牧区维、哈、汉族膝骨性关节炎致病因素的流行病学调查[J].中国组织工程研究，2015，19（29）：4614-4618.
[13] 郑兆宽，赵洪普，吕玉明，等.骨质疏松症与SD大鼠膝骨性关节炎的发病[J].中国组织工程研究，2018，22（32）：5104-5109.
[14] Zhang L，Choi HJ，Estrada K，et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density [J]. Hum Mol Genet，2014，23（7）：1923-1933.
[15] Zhang R，Yao J，Xu P，et al. A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee，hip and hand [J]. Inflamm Res，2015，64（6）：405-414.
[16] 李毅，伍骥，高丽伟，等.骨性关节炎与骨质疏松症相关性研究[J].中国骨质疏松杂志，2011，17（5）：397-399.
[17] 荣杰生，陶天遵，陶树清，等.高寒地区城市汉族人群膝骨关节炎情况调查[J].中国骨质疏松杂志，2007，13（10）：723-726.
[18] Berenbaum F，Wallace IJ，Lieberman DE，et al. Modern-day environmental factors in the pathogenesis of osteoarthritis [J]. Nat Rev Rheumatol，2018，14（11）：674-681.
[19] 崔福义，李名锐，王志红，等.饮用水中铝的危害、来源及现状[J].哈尔滨建筑大学学报，1997，6：51-54.
[20] 张万起，金蓉培，陈杰，等.铝制食具容器铝溶出情况研究[J].天津医科大学学报，1996，3：18-20，30.
[21] Xie D，Sheng Z. Low-Level Cadmium Exposure and Bone Health [J]. J Bone Miner Res，2017，32（3）：419.
[22] Scimeca M，Feola M，Romano L，et al. Heavy metals accumulation affects bone microarchitecture in osteoporotic patients [J]. Environ Toxicol，2017，32（4）：1333-1342.
[23] Bijlsma JW，Knahr K. Strategies for the prevention and management of osteoarthritis of the hip and knee [J]. Best Pract Res Clin Rheumatol，2007，21（1）：5976.
