外周血巨噬细胞移动抑制因子、人类白细胞DR抗原表达对自身免疫性卵巢早衰的诊断价值

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Abstract Objective To investigate the value of peripheral blood macrophage migration inhibitory factor (MIF) and human leukocyte antigen DR (HLA-DR) in the diagnosis of autoimmune premature ovarian failure (APOF). Methods A total of 124 patients with POF admitted to Chengdu Xindu District Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from June 2018 to June 2020 were selected. According to the APOF diagnostic criteria, the patients were divided into APOF group (45 cases) and NAPOF group (79 cases), and 60 healthy women who underwent physical examination in the Department of Obstetrics and Gynecology of our hospital during the same period were selected as control group. The expression of MIF, HLA-DR+CD3+, HLA-DR+CD19+, anti ovarian antibodies (AOAb), anti-zona pellucida antibodies (AZpAb), and antinuclear antibody (ANA) in peripheral blood were detected. The relationship between the above indicators and the incidence of APOF and the diagnostic value of APOF were analyzed. Results The positive proportion of AOAb, AZpAb, ANA and MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in APOF group were higher than those in NAPOF group and control group (P < 0.05); and MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in NAPOF group were higher than those in control group (P < 0.05). MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in APOF patients with autoimmune disease, positive AOAb, positive AzpAb, and positive ANA were higher than those patients with no autoimmune disease, negative AOAb, negative AZpAb and negative ANA (P < 0.05). Autoimmune diseases, high MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels were risk factors for APOF (OR > 1, P < 0.05). The areas under the curve of MIF, HLA-DR+CD3+, HLA-DR+CD19+, and combined MIF and HLA-DR+CD3+, HLA-DR+CD19+ were 0.717, 0.736, 0.705, 0.934, respectively. Conclusion MIF, HLA-DR+CD3+, and HLA-DR+CD19+ levels in peripheral blood of APOF patients are increased, and the high levels of MIF, HLA-DR+CD3+, and HLA-DR+CD19+ are closely related to the pathogenesis of APOF, which can provide a reference for the diagnosis of APOF.

Key words： Macrophage migration inhibitory factor Human leukocyte DR antigen Autoimmune disease Premature ovarian failure Anti ovarian antibodies Anti-zona pellucida antibodies Antinuclear antibody

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	WANG Qun1 LUO Mingyan2

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WANG Qun1 LUO Mingyan2. Diagnostic value of macrophage migration inhibitory factor, human leukocyte DR antigen expression in peripheral blood for autoimmune premature ovarian failure[J]. 中国医药导报, 2021, 18(27): 93-97.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I27/93

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