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2021 Vol. 18, No. 26
Published: 2021-09-15
 
 
4 Observation on the formation and division of multinucleated giant cells in cell damage microenvironment
WANG Jia YE Dongmei YUAN Xiaolin
Objective To observe the formation process of multinucleated giant cells (MGC) in cell damage microenvironment, and to provide scientific basis for the study of the mechanism of MGC formation. Methods Macrophages (RAW 264.7) and cardiomyocytes (HL-1) were co-cultured in the ratio of 1∶3 for 15 days. The experimental group did not change the fluid without passage, and the control group changed the fluid regularly. MGC formation in cell injury microenvironment was observed. The MGC formation process and the interaction between the two kinds of cells were observed by a live cell workstation. The cell fusion was confirmed by scanning electron microscopy. Results In the cell damage microenvironment, MGC was formed and the number of cells increased with the prolongation of the time of cessation of fluid change. The dynamic process of MGC formation was observed under light microscope. The whole process of MGC formation and division and the formation of MGC by the fusion of staining cells were observed at the living cell workstation. The unstained cells were observed to form MGC by scanning electron microscope. Conclusion Macrophages fuse with damaged cardiomyocytes to form MGC and can induce its division and proliferation.
2021 Vol. 18 (26): 4-7,23 [Abstract] ( 94 ) HTML (1 KB)  PDF (1246 KB)  ( 100 )
8 Discussion on the potential mechanism of Simiao Powder in the treatment of gouty arthritis based on network pharmacology
RONG Weiming1 YUAN Changshen2 DUAN Kan2 MEI Qijie2 GUO Jinrong2 LU Zhixian1
Objective To explore the potential mechanism of Simiao Powder in the treatment of gouty arthritis by network pharmacology approach. Methods The effective components and their targets of Simiao Powder were screened by the traditional Chinese medicine systems pharmacology database and analysis platform. Disease-related genes were screened using GeneGards and OMIM database, and target genes were obtained by intersection with drug targets. Then GO and KEGG enrichment analysis were performed for the target genes, and proteinprotein interaction network of the target genes was constructed using STRING database and key genes were screened out. Finally, the drug-gene-pathway network was constructed. Results There were 40 active components in Simiao Powder acting on 197 targets, 215 genes related to gouty arthritis, and 27 target genes were obtained through the intersection, which were mainly enriched in 622 GO entries and 109 signaling pathways such as IL-17 and TNF obtained by KEGG pathway analysis. Five genes, including PTGS2, PPARG and CCL2 were key genes. Conclusion Simiao Powder effectively controls the development of gouty arthritis mainly through PTGS2, PPARG, CCL2 and other genes as well as IL-17 and TNF signaling pathways.
2021 Vol. 18 (26): 8-11 [Abstract] ( 78 ) HTML (1 KB)  PDF (1171 KB)  ( 181 )
12 Effects and mechanism of Xuesaitong Injection on expressions of VEGF pathway in mice brain microvascular endothelial cells after OGD/R
GUO Yangyan SUN Xingyun MENG Fanxing WANG Le LI Nannan
Objective To study the effect of Xuesaitong Injection on the expression of vascular endothelial growth factor (VEGF), VEGFR-2 and soluble Fms-like tyrosine kinase 1 (sFlt-1) protein in brain microvascular endothelial cells of mice injured by oxygen glucose deprivation/reoxygenation (OGD/R), and to explore its influence on the expression of VEGF pathway and its possible mechanism. Methods The OGD/R method was used to establish a cell ischemia-reperfusion injury model, and the cell viability was detected by the CCK-8 method to determine the optimal cell seeding concentration, reoxygenation time and Xuesaitong Injection concentration. The experiment was divided into normal group, model building group, and experimental group. The normal group was cultured normally, and the model building group was only cultured without drugs, while the experimental group was cultured with Xuesaitong Injection after the model was built. Western blot method was used to detect the expression of VEGF, VEGFR-2, and sFlt-1 protein in the three groups of cells. Results After six hours of oxygen and glucose deprivation, the optimal cell seeding plate concentration was 2.5×104 cells/ml, the reoxygenation time was six hours, and the concentration of Xuesaitong Injection was 100 mg/L. Under this condition, compared with the normal group, the expression of VEGF, VEGFR-2, and sFlt-1 protein in the model and the experimental group were significantly increased, and the differences were statistically significant (P ＜ 0.05); compared with the model, the expression of VEGF and VEGFR-2 protein in the experimental group were significantly increased, and the differences were statistically significant (P ＜ 0.05), and the expression of sFlt-1 protein was significantly reduced, and the difference was statistically significant (P ＜ 0.05). Conclusion Xuesaitong Injection can up-regulate the expression of VEGF pathway signals in OGD/R-injured mouse brain microvascular endothelial cells. The mechanism of up-regulating VEGF pathway signal expression may be related to the inhibition of sFlt-1 protein expression.
2021 Vol. 18 (26): 12-16 [Abstract] ( 46 ) HTML (1 KB)  PDF (851 KB)  ( 109 )
17 Visual analysis of the relationship between sympathetic nerve and hypertension based on CiteSpace
ZHOU Yu1,2 HU Yuanhui2 CHAI Ruoning2 ZHANG Xuesong2 DU Yihang2 CHU Yuguang2
Objective To discuss the research status, hotspot and future development of the relationship between sympathetic nerve and hypertension in recent ten years. Methods The Web of Science core collection database was used as literature source, relevant literatures from 2010 to 2019 were collected and imported into CiteSpace software for co-occurrence analysis of authors, countries, institutions, and keywords as well as co-citation analysis of literatures and journals. Results A total of 2115 literatures were included, among which MARKUS P SCHLAICH was the author with the highest number of published literatures. The most important country in the cooperative network was the United States; the principal research institution was Monash University; key words: resistant hypertension, renal denervation, angiotensin Ⅱ, etc. Key words culsters: there were six clusters in total, they were renin receptor, renal dnervation, resting heart rate, sleep apnea, oxidative stress, and chronic intermittent hypoxia. Conclusion The application of CiteSpace software in the bibliometric analysis on the literature related to the relationship between sympathetic nerve and hypertension show the current research status and hot spots, predict the possible research direction in the future, and provide reference for clinical treatment.
2021 Vol. 18 (26): 17-23 [Abstract] ( 138 ) HTML (1 KB)  PDF (1705 KB)  ( 161 )
24 Discussion on the molecular mechanism of spatholive-mulberry parasitism in the treatment of diabetic peripheral neuropathy based on network pharmacology and molecular docking
HOU Yawei1 LI Yameng1 XU Yukun2 XIAO Zhenwei3
Objective To investigate the molecular mechanism of spatholive-mulberry parasitism in the treatment of diabetic peripheral neuropathy (DPN) based on network pharmacology and molecular docking. Methods The active ingredients and targets were obtained from traditional Chinese medicine systems pharmacology, traditional Chinese medicines integrated database, China national knowledge infrastructure and Wanfang collection from February 2017 to December 2020. DPN targets were searched through GeneCards, TTD, OMIM, and DRUGBANK databases; proteinprotein interaction analysis was performed on STRING platform, GO and KEGG signaling pathway analysis was performed on Metascape platform, and molecular docking was performed on Autodockvina combined with Pymol. Results A total of 23 active ingredients were obtained from spatholive-mullberry and two active components were obtained from parasitism, including quercetin, luteolin and formononetin, etc. A total of 64 core targets including EGFR, ESR1, and PARP1 were obtained, and these targets were mainly enriched in MAPK, JAK-STAT, PI3K-Akt and other pathways. Molecular docking verification showed that the active components had good docking activity with their targets. Conclusion Spatholive-mulberry parasitism plays a therapeutic role in DPN by improving glycolipid metabolism, protecting neurons and regulating cell apoptosis.
2021 Vol. 18 (26): 24-29 [Abstract] ( 113 ) HTML (1 KB)  PDF (2467 KB)  ( 25 )
30 Visual analysis of literature knowledge map of radiotherapy for endometrial carcinoma in China based on CiteSpace
WANG Yuanjing WU Yumei
Objective To analyze the main research contents, research frontier, author and institutional cooperation of radiotherapy for endometrial carcinoma in China and to provide ideas for follow-up studies. Methods China National Knowledge Network (CNKI) was used as the data source, and the retrieval time was From January 1990 to December 2020. A total of 520 literatures related to radiotherapy for endometrial cancer were retrieved and analyzed using Cite- Space visualization software, including keyword clustering and emergence analysis, as well as co-occurrence analysis between authors and research institutions. Results In 2000, the number of published articles gradually increased, and from 2001 to 2010, the number of published articles was basically stable at more than 20. A total of seven clusters were obtained by cluster analysis, mainly including radiotherapy, endometrial cancer, chemotherapy, comprehensive therapy, gynecological tumor, malignant tumor, postoperative radiotherapy, etc. Six emergent words were obtained by emergent analysis, which were malignant tumor, survival rate, pelvic lymph node metastasis, treatment, chemotherapy and radiotherapy. The authors’ collaboration network was mainly composed of three collaboration groups, namely Sheng Xiugui, Kong Weimin and Wang Jianliu. The map density of institutional cooperation network was 0.0034. Conclusion The foremost current research hotspots of radiotherapy for endometrial carcinoma are intensity-modulated radiotherapy, helical tomotherapy, three-dimensional brachytherapy, and biological intensity modulated radiotherapy. Although research institutions are widely distributed, the institutional cooperation is scattered.
2021 Vol. 18 (26): 30-33 [Abstract] ( 97 ) HTML (1 KB)  PDF (948 KB)  ( 94 )
34 Advances in studies on exosomes and their roles in rheumatoid arthritis
SUN Yong1,2 ZHAO Chuang3 LIU Zhidan1,2
In this paper, we reviewed and analyzed the findings related to exosomes in rheumatoid arthritis (RA). Exosomes can not only be used as disease biomarkers for RA, it also aggravates the inflammatory process and causes bone destruction to a certain extent by secreting inflammatory factors, expressing special membrane proteins and releasing inflammatory microRNA, participate in the occurrence and development of RA. On the other hand, some exosomes also have anti-inflammatory, promoting cartilage repair, delivering therapeutic drugs and other positive effects, it can be used as a tool and means to treat RA. This paper points out the direction for further research on how to curb the exosomes that are unfavorable to the occurrence and development of RA and how to utilize the exosomes that are beneficial to the treatment of RA.
2021 Vol. 18 (26): 34-38 [Abstract] ( 153 ) HTML (1 KB)  PDF (496 KB)  ( 154 )
39 Research progress on acupuncture in the treatment of post-stroke depression based on interdisciplinarity
SUN Zhongren1 YOU Xiaoqing1 CUI Yang1 LIANG Ji1 LUO Zheng1 GUO Zhichao1 ZHOU Xinyu1 YIN Hongna2
Post-stroke depression (PSD) is a common post-stroke disease, which not only affects the rehabilitation effect of patients, reduces their quality of life, but also increases the risk of stroke recurrence and leads to increased mortality. Although Western medicine is used as a routine treatment, but it is easy to cause tachycardia, urinary retention, limb tremor, and other adverse reactions. Acupuncture therapy in the field of traditional Chinese medicine has a long history and distinctive characteristics. It can be integrated with multi-disciplines to form a new comprehensive therapy, which can effectively improve patients’ depressive symptoms and reduce the side effects caused by Western medicine, and has excellent development prospects. In this paper, based on interdisciplinary research, comprehensive therapy is used as the carrier to review the relevant literature on the multidisciplinary treatment of PSD from the perspective of traditional Chinese medicine from the aspects of acupuncture, Western medicine, psychology, computer science, and physics, in order to provide reference for further research on PSD in the medical field.
2021 Vol. 18 (26): 39-42 [Abstract] ( 165 ) HTML (1 KB)  PDF (485 KB)  ( 98 )
43 Research progress on external treatment of knee osteoarthritis with traditional Chinese medicine
ZHAO Jiyang CHEN Liming GUO Shengjun LI Xiaoliang BAI Jing XU Genrong MA Yufeng WANG Qingpu
Knee osteoarthritis is a common orthopedic disease with a high incidence, with joint pain and dysfunction as the main clinical symptoms. Improper treatment leads to a high long-term disability rate, which brings a huge social and economic burden. Treatment of the this disease is aimed at improving symptoms and delaying the progression of the disease. Western medicine treatment has more side effects, poor patient compliance, surgical treatment trauma, heavy burden of patients. Relative to Western medicine, external application of traditional Chinese medicine, acupuncture and moxibustion, akupotomye, physical therapy, and functional exercise of traditional Chinese medicine external treatment, in the treatment of this disease has the characteristics of simple operation, less side effects, economic and practical, accurate curative effect and so on. Its mechanism of action has been continuously studied and revealed, making the external treatment of traditional Chinese medicine for knee osteoarthritis accepted by more and more doctors and patients. This paper reviews the application progress of common traditional Chinese medicine external treatment in knee osteoarthritis.
2021 Vol. 18 (26): 43-45,64 [Abstract] ( 197 ) HTML (1 KB)  PDF (759 KB)  ( 79 )
46 Investigation on the status quo of self-evaluation and influencing factors of competence of infection control personnel in secondary and above general hospitals in Xinjiang Uygur Autonomous Region
JIA Wei1 LI Yatan2 MA Yujiao1
Objective To conduct self-evaluation on the competence of hospital infection management professionals in secondary and above general hospitals in Xinjiang Uygur Autonomous Region, to analyze their influencing factors, to establish a predictive model, and to provide intervention basis for continuously improving the competence of infection control personnel. Methods From September to December 2019, the competency self-assessment questionnaire survey was conducted on 294 infection control personnel included in the criteria in nine secondary and above general hospitals at the secondary and above in Xinjiang Uygur Autonomous Region. Multi-factor analysis methods were used to explore the high-risk factors that affected the competence of hospital infection control personnel, and the scoring weight coefficient was established through the OR value, and the risk warning model was established. Results The total competency score of infection control personnel in general hospitals was (4.914±1.039) points. The highest score was the dimension of organization and collaboration ability, and the lowest was the dimension of personal characteristic quality. Marital status (OR = 0.31), average income (OR = 2.09), personnel category (OR = 2.29), and related training (OR = 2.85) were the influencing factors of overall competence (P ＜ 0.05). Non-married, hospital neglect of relevant training and personal monthly income ＜7000 yuan were the main factors predicting the overall low competence. Conclusion The competencies scores of hospital staff in general hospitals in Xinjiang Uygur Autonomous Region are low. Among them, non-marriage, hospital neglect relevant training, and personal monthly income of less than 7000 yuan are independent factors that lead to poor competence, and targeted interventions are needed to improve the level of competence.
2021 Vol. 18 (26): 46-49 [Abstract] ( 50 ) HTML (1 KB)  PDF (468 KB)  ( 100 )
50 Survey of illness uncertainty in family members of children with trilogy of Fallot in the waiting period for operation
TENG Sisi CHEN Si PENG Lihong
Objective To investigate the uncertainty of illness in the family members of children with trilogy of Fallot (TOF) during the waiting period for surgery. Methods Prospectively enrolled 200 family members of children with TOF who underwent elective surgical treatment in Hunan Children’s Hospital from January 2014 to December 2020. The parents of children with TOF were evaluated by the parent’s perception uncertainty in illness scale (PPUS) during waiting period. According to the survey level of disease uncertainty, they were divided into high-level group and low-level group. This article designed a baseline data questionnaire, counted the baseline data of all children with TOF and their families, included all possible factors, and the factors influencing the uncertainty of illness in the family members of children with TOF during the operation waiting period were found out through univariate and multivariate analysis. Results The 200 family members were all associated with varying degrees of disease uncertainty, of which 148 had a high level, accounting for 74%; and 52 had a low level, accounting for 26%. There were statistically significant differences between the two groups of children’s first admission, education level of family members, family monthly income per capita, and family members’ SSRS scores (P ＜ 0.05). Children’s first admission, family members’ education level of junior high school or below, low family monthly income, and low social support were all influencing factors for the high level of illness uncertainty in the waiting period of TOF children’s family members (OR ＞ 1, P ＜ 0.05). Conclusion Family members of children with TOF have varying degrees of disease uncertainty during the waiting period for surgery, and most of the family members have high levels of disease uncertainty. It may be related to the first admission of the child to the hospital, the family’s education level of junior high school or below, low family monthly income, and low family support.
2021 Vol. 18 (26): 50-53 [Abstract] ( 78 ) HTML (1 KB)  PDF (465 KB)  ( 121 )
54 Comparison of the value of serum FT3, cTnI and BNP in risk stratification and prognosis prediction to elderly patients with acute heart failure
LIU Yu1 WANG Sudan2 LUO Yuanyuan3 WU Sihui3
Objective To compare the application value of serum free triiodothyronine (FT3), cardiac troponin I (cTnI) and brain natriuretic peptide (BNP) in risk stratification and prognosis prediction of elderly patients with acute heart failure (AHF). Methods A retrospective study of 232 patients aged 65 and over with AHF in the First Affiliated Hospital of Guangzhou University of Chinese Medicine from October 2018 to March 2020 was performed. Clinical data of the patients were recorded and followed up for 90 days. According to the severity criteria, the patients were divided into critical group (92 cases) and non-critical group (140 cases). The general data of the critical group and the non-critical group were compared. Multivariate logistic regression analysis was used to evaluate the influencing factors of the critical severity of AHF patients, and receiver-operating characteristic curve was drawn to analyze the predictive effectiveness of relevant indicators for the critical severity of AHF patients. According to the survival within 90 days, patients were divided into death group (34 cases) and non-death group (198 cases). Compared with the general data of the death group and the non-death group, Cox regression was used to analyze the influence of related indicators on the all-cause death of AHF patients. Results The levels of FT3 and left ventricular ejection fraction (LVEF) in the critical group were lower than those in the non-critical group. The levels of creatinine, BNP, and cTnI in the critical group were higher than those in the non-critical group, the differences were statistically significant (P ＜ 0.05). The comparison of New York Heart Association (NYHA) cardiac function grading between the two groups showed statistical significance (P ＜ 0.05). Multivariate logistic regression analysis showed that FT3, LVEF and creatinine were the influencing factors for the severity of elderly AHF after adjusting for age, sex and body mass index (BMI) (P ＜ 0.01). The area under the curve (AUC) predicted by FT3 of critical group was 0.719, 95%CI: 0.653-0.786, sensitivity was 83%, specificity was 57%. cTnI predicted the AUC of critical group was 0.601, 95%CI: 0.526-0.675, sensitivity was 72%, specificity was 48%. BNP predicted the AUC of critical group was 0.623, 95%CI: 0.552-0.695, sensitivity was 69%, specificity was 56%. The level of FT3 in the death group was lower than that in the non-death group, and the level of cTnI was higher than that in the non-death group (P ＜ 0.05). Multivariate Cox regression analysis showed that FT3 and cTNI were the influencing factors of 90 d all-cause death in elderly patients with AHF after adjusting for age, sex, BMI, creatinine and NYHA cardiac function (P ＜ 0.01). Conclusion In terms of prognosis and prognosis, FT3, cTnI, and BNP have their own advantages and disadvantages, and FT3 is a better choice for elderly AHF patients with renal insufficiency.
2021 Vol. 18 (26): 54-59 [Abstract] ( 79 ) HTML (1 KB)  PDF (607 KB)  ( 19 )
60 Meta-analysis of the effect of elastic band resistance exercise on improving cardiopulmonary function and exercise ability in patients with coronary heart disease
LU Shuyu HUANG Huiqiao LI Hong TAO Pinyue
Objective To systematically evaluate the effect of elastic band resistance exercise on improving cardiopulmonary function and exercise ability in patients with coronary heart disease. Methods A computer search was conducted on PubMed, Web of Science, Cochrane Library, CNKI, VIP, Wanfang and China Biomedical Database on the improvement of cardiopulmonary function and exercise ability of patients with coronary heart disease by elastic band resistance exercise. The retrieval time was from inception to October 2020. Two researchers independently conducted quality assessment and data extraction, and meta-analysis was performed using RevMan 5.3 software. According to the exercise intervention measures, they were divided into elastic band resistance exercise group and control group. Results A total of 12 randomized controlled trials were included. Compared with the control group, the peak oxygen uptake (MD = 4.01, 95%CI [2.62, 5.41], P < 0.000 01), anoxic threshold (MD = 2.35, 95%CI [2.01, 2.69], P < 0.000 01), left ventricular ejection fraction (MD = 8.35, 95%CI [5.42, 11.28], P < 0.000 01) in the elastic band resistance exercise group was significantly increased, and the distance of six minute walking test was extended (MD = 59.09, 95%CI [32.52, 85.66], P < 0.0001). Conclusion Compared with other forms of exercise, elastic band resistance exercise has a more significant effect on improving cardiopulmonary function and exercise ability of patients with coronary heart disease.
2021 Vol. 18 (26): 60-64 [Abstract] ( 53 ) HTML (1 KB)  PDF (1207 KB)  ( 119 )
65 Analysis of related factors of postconcussional syndrome after mild traumatic brain injury
HE Jianxun1 MENG Qinglong1 DUAN Guanghui1 GU Shuli1 MO Yanhong1 HE Ruifang2 WEI Hongtao1
Objective To analyze the related factors of postconcussional syndrome after mild craniocerebral injury, in order to provide clinical basis for the prevention and treatment of postconcussion syndrome. Methods Clinical data of 48 patients with postconcussional syndrome after mild head injury (case group) and 30 asymptomatic patients (control group) after mild head injury for three months were collected from the Affiliated Hospital of Northwest University for Nationalities from August 2016 to June 2019. Univariate analysis and logistic regression analysis were used to screen the influencing factors of postconcussion syndrome after mild head injury. Results In the case group, the proportion of occupational instability, the proportion of injury caused by violence, the proportion of life stress, the proportion of patients with physical disease before injury, and the proportion of no compensation or litigation after injury were all higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that occupational stability, other causes of injury, and compensation or litigation were protective factors of postconcussion syndrome after mild head injury (OR ＜ 1, P ＜ 0.05). Conclusion The cause of injury, compensation or litigation, and occupation may be the important influencing factors of postconcussion syndrome after mild brain injury.
2021 Vol. 18 (26): 65-67,72 [Abstract] ( 116 ) HTML (1 KB)  PDF (546 KB)  ( 114 )
68 Clinical effect of Tongdu Tiaoshen acupuncture combined with Donepezil in the treatment of vascular mild cognitive impairment
SHEN Zhiqiang CHENG Hongliang ZHANG Wendong BAI Lin
Objective To observe the clinical effect of Tongdu Tiaoshen acupuncture combined with Donepezil in the treatment of patients with vascular mild cognitive impairment (VMCI). Methods Sixty four patients with VMCI admitted to the Department of Encephalopathy in Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2017 to September 2019 were included as the study subjects. According to the random number table method, they were divided into control group (Donepezil + conventional acupuncture) and observation group (Donepezil + Tongdu Tiaosen acupuncture), with 32 cases in each group, both groups were given conventional treatment. The treatment lasted for eight weeks, and the clinical efficacy of the two groups was compared. The cognitive ability of the two groups was assessed by mini mental status examination (MMSE) and Montreal cognitive assessment (MoCA). The activity of daily living scale (ADL) and neurological function defect scale (NFDS) were used to evaluate the living ability of the two groups, and the changes of serum cystatin C (CysC) and plasma homocysteine (Hcy) levels were observed before and after treatment. Results Two cases fell off in each group, and 30 cases were finally included in each group. The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the MMSE, MoCA, and ADL scores of two groups were higher than those before treatment, and the NFDS score was lower than that before treatment. The MMSE, MoCA, and ADL scores of the observation group were higher than those of the control group, and the NFDS score was lower than that of the control group, with statistical significance (P ＜ 0.05). After treatment, the levels of CysC and Hcy in two groups were lower than before, and the observation group was lower than the control group, with statistical significance (P ＜ 0.05). Conclusion Tongdu Tiaoshen acupuncture combined with Donepezil has a good effect in the treatment of VMCI, which can improve the cognitive ability and behavioral ability of VMCI patients, and regulate the levels of CysC and Hcy.
2021 Vol. 18 (26): 68-72 [Abstract] ( 181 ) HTML (1 KB)  PDF (580 KB)  ( 111 )
73 Effect of median nerve electrical stimulation combined with computer-assisted cognitive training in the treatment of post-stroke cognitive dysfunction
ZHANG Xiaoqiong ZHANG Juan ZHANG Sisi ZHAO Qin▲
Objective To explore the effect of median nerve electrical stimulation combined with computer-assisted cognitive training in the treatment of post-stroke cognitive dysfunction. Methods A total of 94 patients with post-stroke cognitive dysfunction admitted to the First People’s Hospital of Lianyungang City, Jiangsu Province from June 2017 to May 2020 were selected as the study subjects. They were divided into control group (47 cases) and observation group (47 cases) according to random number table method. The control group was treated with computer-assisted cognitive training, and the observation group was treated with median nerve electrical stimulation based on the control group. The treatment time of both groups was six weeks. The cognitive function of the two groups was observed before and after treatment, the clinical efficacy of the two groups was compared, and the changes of oxygenated hemoglobin concentration in the brain area before and after median nerve electrical stimulation were compared in the observation group. Results After treatment, the scores of Montreal cognitive assessment (MoCA) scale in two groups were higher than those before treatment, and the observation group was higher than the control group, with statistical significance (P ＜ 0.05). There was statistically significant difference between the two groups (P ＜ 0.05). There was no significant difference in the oxygenated hemoglobin concentration of left motor area and right motor area in the observation group before and after electrical stimulation (P ＞ 0.05). The oxygenated hemoglobin concentration in left and right forehead of the observation group after electrical stimulation was higher than that before electrical stimulation, and the difference was statistically significant (P ＜ 0.05). Conclusion Median nerve electrical stimulation combined with computer-assisted cognitive training in the treatment of patients with post-stroke cognitive dysfunction has a significant effect, which can improve the cognitive function of patients, and electrical stimulation can increase the oxygenated hemoglobin concentration in the bilateral forehead regions of patients.
2021 Vol. 18 (26): 73-76 [Abstract] ( 410 ) HTML (1 KB)  PDF (529 KB)  ( 89 )
77 Effect of microsurgery in the treatment of drug-resistant epilepsy under the monitoring of electrocorticogram
LI Jialiang MIAO Pengfei YANG Quanxi HUANG Qi LIU Wenxiang SHEN Xianghui
Objective To investigate the effect of microsurgery in the treatment of drug-resistant epilepsy under the monitoring of electrocorticogram. Methods Clinical data of 30 patients with drug-resistant epilepsy admitted to the First People’s Hospital of Shangqiu, Henan Province from January 2014 to October 2019 were analyzed. In all patients, the lesions were removed by microsurgical technique under the monitoring of electroencephalogram. Head CT was reviewed on the first day after the operation, to understand the intracranial hemorrhage and cerebral edema, to observe the seizure and complications, and to monitor the vital signs. The postoperative follow-up was from three months to five years, and the results were evaluated by Tan’s classification. Results All the patients were followed up for an average of (2.78±1.46) years. One case of postoperative homohemianopsia occurred, accounting for 6.25% (1/16) of the patients undergoing temporal lobe epilepsy surgery. No surgical death, intracranial infection, intracranial hemorrhage, hemiplegia, aphasia, and other complications occurred. The results were satisfactory in 22 cases, significantly improved in five cases and good in three cases. Conclusion Microsurgical technique under electroencephalogram monitoring is an effective method to treat drug-resistant epilepsy.
2021 Vol. 18 (26): 77-80 [Abstract] ( 103 ) HTML (1 KB)  PDF (530 KB)  ( 48 )
81 Analysis of influencing factors of adverse prognosis of continuous renal replacement therapy in critically ill children with acute kidney injury
GUO Yanmei LI Jun’e SUN Hui HUO Ximin XU Meixian WANG Xiaodong
Objective To analyze the influencing factors of adverse prognosis of continuous renal replacement therapy (CRRT) in critically ill children with acute kidney injury. Methods Clinical data of 158 cases with CRRT in critically ill children with acute kidney injury in Hebei Children’s Hospital from January 2017 to December 2019 were retrospectively analyzed. The subjects were followed up for 28 days after entering the pediatric intensive care unit. According to the prognosis, the subjects were divided into the survival group (105 cases) and the death group (53 cases), and the factors affecting the adverse prognosis of CRRT in critically ill children with acute kidney injury were analyzed. Results Septic shock, multiple organ dysfunction, acute kidney injury stage, Serum creatinine (Scr) level at 2 h after admission, urine volume, Scr level before CRRT, cystatin C, microalbuminuria (MAU), transferrin (TRU), α1-microglobulin (α1-MG), N-acetyl-β-D-glucosaminosidase (NAG), acute physiology and chronic health evaluation scoring system Ⅱ (APACHE Ⅱ) score, and estimated glomerular filtration rate (eGFR) between the two groups were compared and the differences were statistically significant (P < 0.05). Septic shock, multiple organ dysfunction, acute kidney injury stage three, Scr level before CRRT≥300.00 μmol/L, cystatin C≥1.00 mg/L, MAU≥7.00 mg/L, α1-MG≥12.00 mg/L, NAG≥24.00 U/L, APACHEⅡ score≥20 points, urine volume<800 mL, and eGFR<100 mL/(min·1.73m2) were risk factors for adverse prognosis of CRRT in critically ill children with acute kidney injury (OR >1, P < 0.05). Conclusion For septic shock, multiple organ dysfunction, acute kidney injury stage three, Scr level before CRRT≥300.00 μmol/L, cystatin C≥1.00 mg/L, MAU≥7.00 mg/L, α1-MG≥12.00 mg/L, NAG≥24.00 U/L, APACHEⅡ score≥20 points, urine volume<800 ml, and eGFR<100 ml/(min·1.73m2) of CRRT in critically ill children with acute kidney injury should be vigilant, active treatment, to reduce the fatality rate of critically ill children with acute kidney injury.
2021 Vol. 18 (26): 81-84,89 [Abstract] ( 136 ) HTML (1 KB)  PDF (500 KB)  ( 126 )
85 Efficacy of Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease
DONG Zhaoqin1 ZHANG Juan1 ZHANG Guilian2
Objective To observe the efficacy of Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease. Methods A total of 100 patients with chronic pelvic inflammatory disease from Jinan Fourth People’s Hospital from February 2019 to October 2020 were selected. According to the random number table method, they were divided into control group and observation group, with 50 cases in each group. Control group received intravenous infusion of Ceftazidime for Injection, observation group was treated with Zhitong Huazheng Capsules on the basis of control group, both groups were treated for 14 days. The efficacy, pain, pelvic inflammatory mass diameter, high-sensitivity C-reactive protein (hs-CRP), human transforming growth factor receptor β1 (TGF-β1), malondialdehyde (MDA), superoxide dismutase (SOD), and the incidence of adverse reactions were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). After 14 days of treatment, the levels of hs-CRP and MDA in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05); the levels of TGF-β1 and SOD in two groups were higher than those before treatment, and observation group were higher than control group (P < 0.05). After 14 days of treatment, visual analogue scale score in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05); the pelvic inflammatory mass diameter in two groups were smaller than those before treatment, and observation group was smaller than control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease can effectively reduce oxidative stress, reduce the level of inflammatory factors, improve clinical symptoms, it is safe and reliable.
2021 Vol. 18 (26): 85-89 [Abstract] ( 50 ) HTML (1 KB)  PDF (474 KB)  ( 112 )
90 Clinical value of concurrent brain radiotherapy and targeted therapy for non-small cell lung cancer with driver gene mutations positive combined with brain metastasis
HONG Fu1 QIAN Liting2 ZHAN Bihong1 ZHANG Hongbo1
Objective To investigate the clinical value of concurrent brain radiotherapy (RT) and targeted therapy for non-small cell lung cancer (NSCLC) with driver gene mutations positive combined with brain metastases (BM). Methods Clinical data of 60 NSCLC patients with driver gene mutations positive combined with BM who admitted to Anhui Provincial Cancer Hospital from January 2017 to July 2020 were retrospectively analyzed. According to the treatment plan, they were divided into the concurrent therapy group (32 cases, received concurrent brain RT and targeted therapy) and the sequential treatment group (28 cases, received brain RT and targeted therapy sequentially ). Short-term efficacy and incidence of adverse reactions were compared between the two groups, and survival was assessed by Kalpan-Meier method. Results There were no statistically significant differences in the objective response rates, the incidence of adverse reactions and the median overall survival (OS) between the two groups (P > 0.05). The intracranial progression free survival (iPFS) in the concurrent therapy group was higher than that in the sequential treatment group, and the difference was statistically significant (P < 0.05). In the subgroup analysis, there were no significant differences in median OS and median iPFS between whole brain radiotherapy (WBRT), local RT, and WBRT+ local RT (P > 0.05). Conclusion The adverse reactions of NSCLC patients with driver gene mutations positive combined with BM can be controlled by concurrent brain RT and targeted therapy, and iPFS of patients can be improved.
2021 Vol. 18 (26): 90-94 [Abstract] ( 143 ) HTML (1 KB)  PDF (834 KB)  ( 76 )
95 Meta analysis of efficacy and safety of drug-eluting beads transarterial chemoembolization and conventional transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma
CAO Bo1 ZHANG Guangwen2
Objective To compare the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE) in the treatment of advanced hepatocellular carcinoma. Methods PubMed, EMbase, Cochrane library, CNKI, Wanfang and VIP databases were searched for the randomized controlled trials(RCT) of DEB-TACE and cTACE in the treatment of advanced hepatocellular carcinoma. The retrieval period was from establishment of the database to June 2020, and the data were analyzed by Stata 15.1 software. The disease control rate (DCR) after treatment,1-year survival rate, 2-year survival rate and adverse reaction rate were observed. Results A total of 13 RCTs with 1478 patients were included. The DCR after treatment of DEB-TACE group was higher than that of cTACE group, and the difference was statistically significant (OR = 2.18, 95%CI: 1.49-3.19, P < 0.001). The 1-year survival rate of DEB-TACE group was higher than that of cTACE group, and the difference was statistically significant (OR = 1.91, 95%CI: 1.32-2.75, P = 0.001). The 2-year survival rate of DEB-TACE group was higher than that of cTACE group, and the difference was statistically significant (OR = 1.70, 95%CI: 1.16-2.50, P = 0.006). There was no significant difference in the rate of adverse reactions between two groups (OR = 0.74, 95%CI: 0.53-1.02, P = 0.068). Conclusion DEB-TACE has better efficacy than cTACE in the treatment of advanced hepatocellular carcinoma, and its safety is not inferior to cTACE.
2021 Vol. 18 (26): 95-99 [Abstract] ( 150 ) HTML (1 KB)  PDF (1162 KB)  ( 129 )
100 Effect of accelerated rehabilitation surgical intervention on postoperative outcomes in patients with laparoscopic advanced colorectal cancer
WU Chengsi SUN Xuefeng ZHANG Xiaoshi MA Zhongfei LIU Zheng NING Changqing▲
Objective To investigate the effect of accelerated rehabilitation surgical intervention on postoperative outcomes in patients with laparoscopic advanced colorectal cancer. Methods A total of 85 patients with advanced colorectal cancer in Fuyang People’s Hospital of Anhui Province from October 2017 to January 2020 were selected, and they were divided into the experimental group (43 cases) and the control group (42 cases) according to random number table method. The experimental group received laparoscopic advanced colorectal cancer radical resection + accelerated rehabilitation surgical intervention, while the control group received laparoscopic advanced colorectal cancer radical resection + routine intervention. The first exhaust, getting out of bed, defecation and postoperative hospital stay were compared between the two groups; the levels of hemoglobin (Hb) and albumin (ALB) before surgery and seven days after surgery were compared between the two groups; the pain level of the two groups were compared 6 and 48 h after operation; EORTC QLQ-C30 was used to score the quality of life before surgery and one month after surgery; and the occurrence of complications and satisfaction were recorded in the two groups. Results The first exhaust time, getting out of bed time, defecation time and postoperative hospital stay in the experimental group were shorter than those in the control group (P < 0.05). Before surgery, there were no significant differences in the levels of ALB and Hb between the two groups (P > 0.05). Seven days after surgery, the levels of ALB and Hb in the experimental group were higher than those in the control group (P < 0.05). The visual analogue scale score of the experimental group was lower than that of control group 6 and 48 h after surgery (P < 0.05). Before surgery, there was no significant difference in EORTC QLQ-C30 score between the two groups (P > 0.05), one month after surgery, the scores of physical, emotional, role, cognitive and social function in the experimental group were higher than those in the control group (P < 0.05). The total incidence of postoperative complications in the experimental group was lower than that in the control group (P < 0.05). There was no significant difference in postoperative satisfaction between the two groups (P > 0.05). Conclusion The application of accelerated rehabilitation surgical intervention in laparoscopic advanced colorectal cancer resection can shorten exhaust time and hospital stay, reduce the postoperative pain and complications rate, and improve quality of life and satisfaction.
2021 Vol. 18 (26): 100-103，110 [Abstract] ( 40 ) HTML (1 KB)  PDF (644 KB)  ( 125 )
104 Influencing factors analysis of incision infection in patients with colorectal cancer after laparoscopic surgery
ZHAO Chang1 ZHOU Qiong2
Objective To analyze the influencing factors of incision infection in patients with colorectal cancer after laparoscopic surgery. Methods A retrospective study of 300 patients with colorectal cancer who underwent laparoscopic surgery in the Eighth Hospital of Wuhan from January 2018 to December 2020 were analyzed, and they were divided into the non-infected group (250 cases) and the infected group (50 cases) according to the occurrence of incision infection. The clinical data was collected, and logistic regression was used to analyze the influencing factors of incision infection in patients with colorectal cancer after laparoscopic surgery. Results There were statistically significant differences in smoking, body mass index (BMI), abdominal surgery history, diabetes history, operation time, and drainage time between the two groups (P < 0.05). Logistic regression analysis showed that abnormal BMI, abdominal surgery history, diabetes history, surgery time > 3 h, and drainage time > 7 d were the influencing factors of incision infection in patients with colorectal cancer after laparoscopic surgery (OR ＞ 1, P < 0.05). Conclusion The abdominal surgery history, diabetes history, surgery time, drainage time, and BMI are all related influencing factors of incision infection in patients with colorectal cancer after laparoscopic surgery.
2021 Vol. 18 (26): 104-106,120 [Abstract] ( 177 ) HTML (1 KB)  PDF (952 KB)  ( 172 )
107 Clinical significance and expression of PDHA1 and GBP1 in non-small cell lung cancer
LI Fenghuan KANG Lijun
Objective To investigate the expression and clinical significance of pyruvate dehydrogenase complex E1α subunit (PDHA1) and guanylate binding protein 1 (GBP1) in non-small cell lung cancer (NSCLC). Methods A total of 84 patients with NSCLC were selected from Yantaishan Hospital of Yantai City, Shandong Province from January 2016 to October 2017. The expressions of PDHA1 and GBP1 in the cancerous and adjacent tissues were compared. The patients were divided into PDHA1 positive group (30 cases) and PDHA1 negative group (54 cases) according to the expression of PDHA1 in cancer tissues, and then divided into GBP1 positive group (58 cases) and GBP1 negative group (26 cases) according to the expression of GBP1. The patients were followed up for three years, and the relationship between PDHA1 and GBP1 expression and prognosis was analyzed by survival curve. Results The expression of PDHA1 in the cancerous tissues of NSCLC patients was lower than that in the adjacent tissues, and the expression of GBP1 was higher than that in the adjacent tissues, with statistical significance (P ＜ 0.05). All 84 patients with NSCLC were followed up successfully, and no cases were lost to follow-up. During three years of follow-up, 31 cases died. The 3-year survival rate of PDHA1 positive group was higher than that of PDHA1 negative group, and the 3-year survival rate of GBP1 positive group was lower than that of GBP1 negative group, with statistical significance (P ＜ 0.05). Conclusion Low expression of PDHA1 and high expression of GBP1 in NSCLC tissues are expected to become new molecular markers for prognosis assessment of NSCLC.
2021 Vol. 18 (26): 107-110 [Abstract] ( 78 ) HTML (1 KB)  PDF (613 KB)  ( 91 )
111 Influencing factors of retinoblastoma children’s family members’ compliance with interventional surgery
ZHANG Zhenzhen SHEN Jie▲
Objective To investigate the influencing factors of retinoblastoma (RB) children’s family members’ compliance with interventional surgery. Methods A total of 500 children with RB admitted to Xinhua Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University (hereinafter referred to as “our Hospital”) from January to December 2020 were selected as the research objects, and one family member from each family was selected as the key objects. The compliance questionnaire made by our hospital was used to evaluate the compliance of all the children’s family members to the interventional surgery. According to the results, the children’s family members were divided into poor compliance group (＜ eight points, 42 cases) and good compliance group (≥ eight points, 458 cases). The baseline data of the children and their families were recorded and compared in detail, and the factors influencing the poor compliance of family members of RB children with interventional surgery were screened by univariate and multivariate analysis. Results The proportion of leucocoria and the proportion of monthly family income ≥5000 yuan in poor compliance group were lower than those in good compliance group, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in educational level and anxiety level between the two groups (P ＜ 0.05). Leucocoria and moderate and severe anxiety were independent risk factors for poor compliance with interventional surgery in the families of children with RB (OR ＞ 1, P ＜ 0.05), while the educational level of the family members was technical secondary school or high school or above, and the family income ≥5000 yuan was the protective factors (OR ＜ 1, P ＜ 0.05). Conclusion RB children with leucocoria as the main symptom, and moderate and severe anxiety may lead to poor compliance of family members to interventional surgery, which should be paid attention to.
2021 Vol. 18 (26): 111-114 [Abstract] ( 146 ) HTML (1 KB)  PDF (620 KB)  ( 104 )
115 Meta-analysis of the cause of Fatal injury in acute phase of neck trauma
ZHENG Zeyuan1 XIE Fen1 XIONG Xinghuan1 XU Shuogui2 YU Yigang1
Objective To systematic evaluation of the causes of fatal injury in the acute phase (prehospital and department of emergency) of neck trauma. Methods Databases such as CNKI, Wanfang, PubMed and EMbase were searched systematically, and all literatures providing death data of neck trauma patients during the acute period from inception to September 2020 were analyzed using Stata 15, and publication bias was evaluated by funnel plot. Results A total of 29 papers were included, including 1276 patients with neck trauma. Meta-analysis results showed that fatal causes of injury in patients with neck trauma in the acute period included cervical spinal cord injury, cervical macrovascular injury, and the mortality rates were 0.06(95%CI：0.04-0.08, P ＜ 0.05),0.06(95%CI：0.03-0.09, P ＜ 0.05),0.03(95%CI：0.01-0.06, P ＜ 0.05), respectively. Conclusion The fatal injury of neck trauma during the acute period mainly include cervical spinal cord injury, cervical macrovascular injury, and cervical airway injury. Aggressive and appropriate prehospital damage control resuscitation intervention is an effective program to further improve the prognosis of patients with neck trauma.
2021 Vol. 18 (26): 115-120 [Abstract] ( 44 ) HTML (1 KB)  PDF (1221 KB)  ( 102 )
121 Comparative analysis of laparoscopic transperitoneal hernia repair between hernia ring filling tension-free repair in adults with inguinal hernia
LYU Chenggang LIU Liangchao▲ WANG Yadong CHENG Xin TU Jia
Objective To compare and study the prognosis between different surgical ways of laparoscopic transabdominal preperitoneal (TAPP) hernia repair and mesh plug tension-free hernioplasty. Methods A total of 170 cases of inguinal hernia patients who underwent surgery in Traditional Chinese Medical Hospital of Wuhu City from January 2017 to April 2020 were selected. According to the surgical plan performed in the hospital, they were divided into hernia ring filling tension-free repair (control group, 84 cases) and TAPP (observation group, 86 cases). The operation time, postoperative pain score, time to return to normal activities, postoperative hospital stays, hospitalization expenses and total incidence of complications were compared between two groups. Results There was no significant difference in total incidence of complications between the two groups (P ＞ 0.05). There was no significant difference in operation time between two groups (P ＞ 0.05). The postoperative pain score of the observation group was lower than that of the control group, and the postoperative recovery time to normal activities, postoperative hospital stays and hospitalization expenses were shorter than those of the control group, the differences were statistically significant (P ＜ 0.05), but the hospitalization expenses of the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion TAPP is safer in application of adult inguinal hernia, and has the advantages of postoperative pain reduction and faster recovery of patients, and can be promoted and applied in clinical practice.
2021 Vol. 18 (26): 121-124 [Abstract] ( 62 ) HTML (1 KB)  PDF (541 KB)  ( 91 )
125 Evaluation on level of uncertainty in illness of family members of patients with multiple trauma combined with hemorrhagic shock
QIAN Yuanyuan ZHANG Li ZHOU Juan JI Xueli▲
Objective To analyze the level of uncertainty in illness of family members of patients with multiple trauma combined with hemorrhagic shock. Methods A total of 118 family members of patients with multiple trauma combined with hemorrhagic shock admitted to Jiangsu Province Hospital from October 2019 to December 2020 were selected as the research subjects, one case was randomly selected into groups from the family members of the patients, all the family members of patients were assessed with mishel uncertainty in illness scale （MUIS） on the day of admission, designed the filling form of baseline data, the related baseline data of family members of patients were recorded, the MUIS scores of family members of patients with different data characteristics were compared, the related factors that might affect the level of uncertainty in illness of family members of patients with multiple trauma combined with hemorrhagic shock were analyzed. Results The family members of 118 patients with multiple trauma combined with hemorrhagic shock had a moderate level of uncertainty in illness, with an average MUIS score of （91.53±10.71） points; the MUIS score of the family members of patients with multiple trauma combined with hemorrhagic shock who had junior high school education or below, low social support, family monthly income ＜3000 yuan and depression was higher than those of the family members of patients with multiple trauma combined with hemorrhagic shock who had technical secondary school or high school education, college education or above, medium or higher social support, family monthly income ≥3000 yuan and no depression, there was a statistical significant difference （P ＜ 0.05）; by multiple linear regression analysis, the results showed that junior high school education or below （X1）, low social support （X2）, family monthly income ＜3000 yuan （X3） and depression （X4） were the influencing factors for the high level of uncertain in illness of family members of patients with multiple trauma combined with hemorrhagic shock （P ＜ 0.05）, obtained the equation Y = 116.043+1.036X1+0.540X2+0.560X3+0.957X4. Conclusion The family members of patients with multiple trauma combined with hemorrhagic shock have certain degree of uncertainty in illness, which may be related to depression of family members, low education level, family monthly income ＜3000 yuan and low social support, the above factors should be paid attention to in clinic and given corresponding intervention.
2021 Vol. 18 (26): 125-128,146 [Abstract] ( 81 ) HTML (1 KB)  PDF (1023 KB)  ( 83 )
129 Professor Yao Chunhai’s experience gained extraction in the treatment of localized scleroderma
ZHANG Junbi1 YAO Chunhai2 CHEN Shaojun2 WANG Jingjing2
Professor Yao Chunhai believes that the pathogenesis of localized scleroderma is “root deficiency and manifestation excess”, among which “stasis and obstruction of vessel and collateral” runs through the disease. The treatment are divided into acute progression stage, sclerosis stage and atrophy stage, which are treated in three stages. At the same time, the skin lesion syndrome differentiation is combined with the whole body syndrome differentiation, and the micro syndrome differentiation is combined with the macro syndrome differentiation. The use of ointment prescription for internal administration based on syndrome differentiation and the introduction of fire needle for external treatment, the organic combination of the whole and local treatment, attention to the treatment of collateral, the formation of a unique reason, method, prescription and medicine, in the clinical treatment of localized scleroderma has achieved a good effect.
2021 Vol. 18 (26): 129-132,156 [Abstract] ( 89 ) HTML (1 KB)  PDF (780 KB)  ( 85 )
133 Analysis of the connotation of the pungent flavor effect of warming interior medicine
FENG Xiuzhi1 WU Jilei2 REN Yanling1
Among the five flavors of traditional Chinese medicine, the pungent flavor has the most close relationship with the main effect of warming interior medicine. The pungent flavor has the function characteristics of activating and dispelling, which is consistent with the warmth of warming interior medicine. It plays the role of warming interior for dispelling cold, warming and assisting yangqi, warming meridian and warming womb and channels and relieving pain. According to the theory of traditional Chinese medicine property, combined with the records of related contents in previous dynasties of materia medica monographs, as well as the results of modern traditional Chinese medicine pharmacology research and clinical practice of traditional Chinese physician, the role connotation studies of the function of the pungent flavor in the warming interior medicine is mainly manifested in the aspects of warming interior for dispelling cold, promoting blood circulation for removing blood stasis, warming middle for activating qi-flowing, warming womb and channels and relieving pain, warming and assisting yangqi and and the power of promoting medicine. The pungent flavor of warming interior medicine has a specific material basis, the related pharmacological action is mainly for anti-ulcer, regulating gastrointestinal movement resistance, anti-diarrhea, anti-inflammatory, analgesic, enhancing body heat production, dilating blood vessels, strengthening heart, increasing cardiac output, promoting glucose and lipid metabolism, inhibiting platelet aggregation, prolonging prothrombin time, anti-thrombosis, improving myocardial ischemia and so on.
2021 Vol. 18 (26): 133-136 [Abstract] ( 43 ) HTML (1 KB)  PDF (667 KB)  ( 43 )
137 Discussion on the evolution of acupuncture and moxibustion based on the “combination of acupuncture and medicine”
GAO Kai ZHOU Yanli YUAN Shixin LIU Jiangtao ZHOU Hongtu
This article discusses the evolutionary history of acupuncture and moxibustion from the perspective of “combination of acupuncture and medicine”, which are the therapeutic effects of acupuncture and moxibustion combined with various drugs. The cross application of acupuncture and moxibustion with multiple dissiplines has great significance for the continuous innovation of medicine and the breaking of barriers and collaborative development between disciplines. Acupuncture and moxibustion therapy is a treasure of traditional Chinese medicine. From ancient times to the present, acupuncture and moxibustion physicians have continued to inherit and innovate. “Combination of acupuncture and medicine”, as a cross-cutting therapy, invisibly promotes the advancement of acupuncture and moxibustion. The article analyzes the content and existing problems of the law of combination of acupuncture and medicine, explores its essential connotation, and hopes to contribute to the future interdisciplinary development of acupuncture and moxibustion.
2021 Vol. 18 (26): 137-140 [Abstract] ( 99 ) HTML (1 KB)  PDF (663 KB)  ( 76 )
141 Study on the medication regularity and mechanism of Chinese herbal compounds in the treatment of dyslipidemia based on data mining
ZHAO Zhibin1,2 LI Li1 CHEN Xinyan2 LIN Yanzhao2
Objective To explore the medication regularity and mechanism of Chinese herbal compounds in the treatment of dyslipidemia based on data mining and network pharmacology methods, so as to provide medication basis for clinical treatment of dyslipidemia. Methods The literatures of CNKI, CBM, Wanfang and VIP databases from January 2010 to December 2020 were retrieved. The ancient and modern consilia cloud platform was used for data analysis to obtain core drugs. The active ingredients and targets of the core drugs were screened by traditional Chinese medicine systems pharmacology database and analysis platform, combined with literatures and Swiss Target Prediction database. Disease targets were obtained through relevant databases, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed by DAVID 6.8 after taking the intersection, and a network of core drug-active ingredients-target-pathway was constructed. Results A total of 969 literatures were included, involving 790 prescriptions and 316 Chinese herbs. The data analysis results showed that, the core drugs were included, which were Fructus Crataegi, Radix Salvia Miltiorrhiza, Alismatis Rhizoma, Poria, Cassiae Semen, Atractylodis Macrocephalae Rhizoma. There were 420 active ingredient targets for core drugs, 1767 targets for dyslipidemia diseases, and 132 targets for the intersection. The network of core drug-active ingredients-target-pathway had 62 active ingredients, including quercetin, alisol A 24-acetate, tanshinone ⅡA, pachymic acid, atractylenolide Ⅰ, etc. There were 91 KEGG enrichment pathways, among which, HIF-1 signaling pathway, insulin signaling pathway, AMPK signaling pathway and others were related to the treatment of dyslipidemia. Conclusion In traditional Chinese medicine treatment of dyslipidemia, the herbs of invigorating spleen and benefiting qi are often used for treating deficiency, and the herbs of promoting blood circulation and removing blood stasis, reducing dampness and turbidity, and clearing liver and purging constipation are often used for treating symptoms. There are theoretical and experimental basis for the treatment of core drugs on dyslipidemia at the level of molecular targets and chemical pathways. The drug use rules and drug action mechanism obtained in this study can be referred for clinical treatment, so as to improve the clinical efficacy.
2021 Vol. 18 (26): 141-146 [Abstract] ( 57 ) HTML (1 KB)  PDF (1588 KB)  ( 83 )
147 Clinical effect of copper-bian scraping therapy in the treatment of primary dysmenorrhea with syndrome of cold congelation and blood stasis
WANG Shurong1 DUAN Zhiyu2 DIAO Wangping2 WU Dan2 ZHANG Tianchan2 WANG Yufei2 ZOU Xiangni3
Objective To explore the clinical effect of copper-bian scraping therapy in the treatment of primary dysmenorrhea with syndrome of cold congelation and blood stasis. Methods A total of 80 primary dysmenorrhea patients with syndrome of cold congelation and blood stasis who met the inclusion and exclusion criteria and were admitted to Department of Gynecology in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from August 2019 to August 2020 were selected as the study subjects. According to the random number table method, they were divided into the treatment group (40 cases) and the control group (40 cases). The control group was treated with Ibuprofen Tablets from the first day of menstruation until the pain was relieved; the treatment group was treated with copper-bian scraping therapy on the first day of menstruation on the basis of the control group, and the next treatment was carried out after the scraping. Both groups were treated for three menstrual cycles. The score of pain visual analogue scale (VAS), dysmenorrhea degree score and traditional Chinese medicine symptoms (hypogastrium psychroalgia, less menstrual volume, atropurpureus menstruation with blood stasis, fear of cold and cold limbs, greenish and pale complexion) score of the two groups were observed before and after treatment, and the clinical efficacy of the two groups was evaluated. Results VAS scores: there were all statistically significant differences between the two groups in comparison, time point comparison and interaction (P < 0.05). Intra-group comparison: after the first, second and third menstrual cycles of treatment, the VAS scores were all lower than those before treatment, and the differences were all statistically significant (P < 0.05). Comparison between groups: after the first menstrual cycle of treatment, the difference of VAS scores between the two groups was not statistically significant (P > 0.05). After the second and third menstrual cycles of treatment, the VAS scores in the treatment group were lower than those in the control group, the differences were all statistically significant (P < 0.05). After treatment, dysmenorrhea degree score and traditional Chinese medicine symptom score of the two groups were lower than those before treatment, the differences were all statistically significant (P < 0.05); and dysmenorrhea degree score and traditional Chinese medicine symptom score of the treatment group were significantly lower than those of the control group, the differences were all statistically significant (P < 0.05). The total effective rate in the treatment group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Copper-bian scraping method can significantly relieve the pain degree and traditional Chinese medicine symptoms of primary dysmenorrhea patients with syndrome of cold congelation and blood stasis, and improve the quality of life of patients, which is worthy of clinical promotion and application.
2021 Vol. 18 (26): 147-151 [Abstract] ( 86 ) HTML (1 KB)  PDF (725 KB)  ( 191 )
152 Study on the rule of traditional Chinese medicine in treating gastroesophageal reflux disease with syndrome of disharmony between liver and stomach
XU Jingxin CHEN Hongci
Objective To study the medication rule of traditional Chinese medicine in the treatment of gastroesophageal reflux disease with syndrome of disharmony between liver and stomach, and explore the ideas and theoretical basis of the application of high-frequency core prescription. Methods The clinical journal literatures collected from CNKI, Wanfang, VIP and CBM from January 2010 to December 2020 were taken as data source. “Traditional Chinese medicine inheritance computer system v3.0” was used for data mining, and association analysis and cluster analysis were conducted on the included prescriptions of Chinese medicine, so as to explore high-frequency drugs and usage rules of gastroesophageal reflux disease with syndrome of disharmony between liver and stomach. Results Among the 108 traditional Chinese medicine prescriptions finally included, most of the medicinal characters were “cold” and “warm”, meanwhile, the bitter and pungent were main medical taste. The frequently channel tropism of drugs was spleen, lung, stomach, liver. The function of the medicine was mainly regulating qi-flowing and tonifying, the most frequently used drug was Radix Bupleuri, Radix Paeoniae Alba, and Rhizoma Pinelliae. The high-frequency drug combinations were mainly Radix Glycyrrhizae-Radix Bupleuri, Radix Paeoniae Alba-Pericarpium Citri Reticulatae-Radix Bupleuri, Radix Glycyrrhizae-Rhizoma Cyperi-Radix Bupleuri, 20 core Chinese herbs and 3 groups of new drug-formulations were explored. Conclusion Facing with gastroesophageal reflux disease with syndrome of disharmony between liver and stomach, modern traditional Chinese medicine mostly uses “dispersing stagnated liver qi for regulating stomach, nourishing spleen and stomach” as the main therapeutic ideas, balancing cold and heat, and taking into account both deficiency and excess, so as to achieve the therapeutic effect of “balancing liver-qi and regulating stomach-qi”.
2021 Vol. 18 (26): 152-156 [Abstract] ( 80 ) HTML (1 KB)  PDF (923 KB)  ( 116 )
157 Effectiveness evaluation of pharmaceutical care network Europe classification system for solving drug-related problems in intensive care unit
FAN Fangfang1,2 ZHAO Shengjun1,2 YAO Li1,2 HU Lan1,2 ZHENG Lili1,2 JIANG Qian1,2
Objective To evaluate the effectiveness of pharmaceutical care network Europe （PCNE） classification system for solving drug-related problems (DRPs) in intensive care unit (ICU). Methods Clinical pharmacists interfered with DRPs in 283 ICU patients admitted to the Affiliated Traditional Medical Hospital, Xiniang Medical University from January 2018 to December 2019. PCNE-DRPs classification system V9.0 was used to classify the “problem” “cause” “intervention plan” “acceptance of intervention plan” “DRPs status” of patients with DRPs, and JMP software was used for statistical analysis. Results DRPs occurred in 90 patients. The DRPs question categories focused on “safety of treatment” and “efficacy of treatment”. The reason categories mainly focus on“drug selection” “dose selection” “treatment course” “drug use process”. All interventions were at the “doctor level”. Among the acceptance category of intervention programs, “intervention acceptance” accounted for 97.8%; in the status category of intervention programs,“problem solving” accounted for 87.8%. Conclusion The introduction of PCNE classification system can improve the ability of clinical pharmacists to discove and solve DRPs, improve the ability and efficiency of clinical pharmacists in pharmaceutical care, promote clinical rational drug use, inhance the quality of pharmaceutical service, and ensure the safe drug use of patients.
2021 Vol. 18 (26): 157-160 [Abstract] ( 47 ) HTML (1 KB)  PDF (375 KB)  ( 94 )
161 Effects of continuous nursing based on WeChat platform on the incision of first-time cesarean section
YANG Xiaoli LIU Lin LI Jie CHEN Xinhua
Objective To explore the influence of continuous nursing based on WeChat platform on the recovery of surgical incision in women with first-time cesarean section. Methods A total of 152 parturients who underwent the first cesarean section in the Obstetrics Department of the First People’s Hospital of Wuhu City from October 2019 to June 2020 were selected. The patients were divided into control group and observation group, with 76 cases in each group. The control group were received routine nursing and telephone fellow-up after discharge, while the observation group were received continuous nursing based on WeChat platform after discharge on the basis of routine nursing. All the patients in both groups were fellowed up for six months. The incidence of incision complications (including incision infection, incision fat liquefaction, incision dehiscing, incision hematoma, incision hernia, etc.) after discharge was observed and compared between the two groups, patient and observer scar evaluation scale (POSAS) score and nursing satisfaction at six months postoperatively. Results After six months of follow-up, in the control group, there were three cases of incision infection, three cases of incision fat liquefaction and two cases of incision local skin dehysis after discharge, while in the observation group, there was one case of incision fat liquefaction after discharge, the incidence of incision complications in the observation group was lower than that in the control group after discharge, the different was statistical significance (P ＜ 0.05). POSAS score of the observation group was lower than that of the control group six months after operation, and the difference was statistically significant (P ＜ 0.05), and the nursing satisfaction of observation group was higher than control group six months after operation, the difference was statistically significant (P ＜ 0.05). Conclusion Continuous nursing based on WeChat platform can reduce the incidence of surgical incision complications, reduce POSAS scar score of patients’ surgical incision, and improve nursing satisfaction, which is worthy of clinical application and promotion.
2021 Vol. 18 (26): 161-164 [Abstract] ( 103 ) HTML (1 KB)  PDF (629 KB)  ( 182 )
165 Application of 4C continuous nursing model based on internet platform in patients with enterostomy
WANG Shuaiying1 LIU Qin1 LUAN Tao2 WANG Qingxi3 XIAO Meiyu3 HAN Yuan1
Objective To explore the application effect of 4C continuous nursing model based on internet platform in patients with enterostomy. Methods A total of 96 patients with enterostomy admitted to the Department of Colorectal Surgery and the Department of Gastroenterology and Intestinal Surgery in the Third Affiliated Hospital of Kunming Medical University from December 2019 to August 2020 were selected, according to the random number table method, they were divided into control group and experimental group, with 48 cases in each group. The control group was given routine care, and the experimental group was given 4C continuous nursing model based on the internet platform, the quality of life, self-care ability, and the incidence of ostomy complications were compared between the two groups before discharge, one month and three months after discharge. Results Overall analysis showed that there were statistically significant differences between groups, time points and interaction of quality of life evaluation at one and three months after discharge before discharge (P ＜ 0.05). In addition to social health, the scores and total scores of physical, psychological and mental health of the control group were all higher than before discharge three months after discharge, and the scores of mental health and total scores of three months after discharge were higher than that of one month after discharge, and the scores of one month after discharge were higher than that of before discharge, the differences were statistically significant (P ＜ 0.05). The scores of quality of life in the experimental group one and three months after discharge were higher than those before discharge, and the scores of psychological, social and mental health at three months after discharge were higher than those at one month after discharge, with statistical significance (P ＜ 0.05), comparison between groups: except the mental health score one month after discharge, the other dimensions and total scores of the experimental group were higher than those of the control group one and three months after discharge, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the scoring time, inter-group and interaction of self-care ability between the two groups (P ＜ 0.05), further pairwise comparison and intra-group comparison: there was no statistically significant difference at each time point in the control group (P ＞ 0.05). In the experimental group, the scores of self-care concept, self-care responsibility, self-care skills, health knowledge level and total score were all higher than those before discharge, with statistical significance (P ＜ 0.05). Comparison between groups: there was no significant difference between the two groups before discharge (P ＞ 0.05). The scores and total scores of the experimental group were higher than those of the control group in the same period except for self-care responsibility and self-care skills one month after discharge (P ＜ 0.05). The incidence of total ostomy complications in the experimental group was lower than that in the control group one month and three morehs after discharge, the difference was statistically significant (P ＜ 0.05). Conclusion The 4C continuous nursing model based on the internet platform is helpful to improve the self-care ability of enterostomy patients, reduce the complications of enterostomy, and improve the quality of life.
2021 Vol. 18 (26): 165-169 [Abstract] ( 48 ) HTML (1 KB)  PDF (681 KB)  ( 145 )
170 Effects of rehabilitation training on anxiety, depression, and functional status of patients with ankylosing spondylitis
WANG Honghua1 GENG Tianjun2
Objective To analyze the effects of rehabilitation training on anxiety, depression, and functional status in patients with ankylosing spondylitis. Methods Eighty patients with ankylosing spondylitis who received treatment in the Fourth People’s Hospital of Jinan, Shandong Province from December 2015 to December 2019 were selected as the study subjects. Patients were divided into control group and observation group by random number table method, with 40 cases in each group. The control group carried out routine nursing mode, and the observation group carried out rehabilitation training on the basis of the control group. The self-rating anxiety scale (SAS), self-rating depression scale (SDS) and International Pythonic ankylosing spondylitis function index were used to evaluate the anxiety and depression before and after the intervention and the rehabilitation efficacy of the functional state after the intervention, and compared the between two groups. Results After the intervention, the scores of anxiety and depression and the rehabilitation effect of functional state in both groups were lower than those before the intervention (P ＜ 0.05), the SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P ＜ 0.05), and the scores of the international Pythagoras ankylosing Spondylitis function index scale (standing without support, standing in supine position, touching height, wearing stockings, bending to pick up a pen, standing in sitting position, stepping on steps and standing upright looking back) in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of rehabilitation training in patients with ankylosing spondylitis to correct the previous bad exercise habits, improve the psychological negative situation in the process of rehabilitation training, and promote the recovery of patients’ functional state is worthy of clinical promotion and use.
2021 Vol. 18 (26): 170-173 [Abstract] ( 85 ) HTML (1 KB)  PDF (661 KB)  ( 89 )
174 Effect of collective exercise combined with family follow-up intervention in patients with gestational diabetes mellitus
LI Xiaomin JIA Xiaotian▲ FU Jinyan
Objective To explore the effect of collective exercise combined with family follow-up intervention in patients with gestational diabetes mellitus. Methods From October 2018 to October 2019, 150 patients with gestational diabetes were selected from the diabetes clinic of Wuxi Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University. They were divided into control group and observation group according to the random number table, with 75 in each group. The control group performed routine intervention, and the observation group implemented collective exercise combined with family follow-up intervention. The changes of blood glucose level, compliance behavior and pregnancy outcome were compared between the two groups before and after the intervention. Results The levels of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin in the two groups after intervention were lower than those before intervention; the levels of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin in the observation group after intervention were lower than those in the control group (P ＜ 0.05). The proportion of regular monitoring of blood glucose, moderate exercise, reasonable diet, and regular return visit in the observation group was higher than that in the control group (P ＜ 0.05); the incidence of cesarean section, polyhydramnios, premature rupture of membranes, hypertensive pregnancy, babies, premature delivery, hypoglycemia, and fetal distress were lower in the observation group than in the control group (P ＜ 0.05). Conclusion The application of collective exercise combined with family follow-up intervention in patients with gestational diabetes can effectively reduce blood glucose levels, improve compliance with medical practices, and improve pregnancy outcomes, which is worth promoting.
2021 Vol. 18 (26): 174-177 [Abstract] ( 96 ) HTML (1 KB)  PDF (663 KB)  ( 119 )
178 Application effect of non thermal CommScope irradiation in patients with internal fistula puncture guided by B-ultrasound
CHEN Cancan1 LI Huiping2▲ HUANG Weifeng1 LI Yuanyuan1 XU Xia1 WU Jingjin1 SONG Jing1
Objective To investigate the effect of non thermal CommScope irradiation in patients with internal fistula puncture guided by B-ultrasound. Methods A total of 100 patients with internal fistula puncture under the guidance of B-ultrasonic were selected from the Second People’s Hospital of Hefei from January 2019 to September 2020. According to the method of random drawing, they were divided into control group and observation group, with 50 cases in each group. The control group was given conventional nursing care, and the observation group was given non thermal CommScope irradiation on the basis of conventional nursing care, the incidence of repeated fistula puncture, oozing blood, hematoma, pain degree, and patient satisfaction were compared between the two groups. Results The incidence of repeated fistula puncture, oozing and hematoma in the observation group were lower than those in the control group, with statistical significance (P ＜ 0.05); the pain score of the two groups after intervention was lower than that before intervention, and the pain score of the observation group was lower than that of the control group, with statistical significance (P ＜ 0.05); nursing satisfaction of observation group was higher than control group, the difference was statistically significant (P ＜ 0.05). Conclusion Non thermal CommScope irradiation can reduce the incidence of complications in patients with internal fistula puncture guided by B-ultrasound.
2021 Vol. 18 (26): 178-180,188 [Abstract] ( 28 ) HTML (1 KB)  PDF (644 KB)  ( 143 )
181 Application effect of preventive nursing intervention with neonatal respiratory distress syndrome
HU Jinmei WANG Zhen
Objective To explore the application effect of preventive nursing intervention with neonatal respiratory distress syndrome (NRDS). Methods A total of 113 children with NRDS admitted to Suzhou Hospital Affiliated to Anhui Medical University from July 2017 to June 2020 were selected, and they were divided into an observation group of 57 cases and a control group of 56 cases according to the random number table method. The control group was given routine treatment and nursing intervention for children with NRDS, and the observation group was combined with preventive nursing intervention. The use time of non-invasive ventilator, hospitalization time and hospitalization expenses, oxygenation function before and a week after treatment, and complications during hospitalization were compared between the two groups. Results The non-invasive ventilator use time, hospitalization time, and hospitalization expenses in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After a week of treatment, the pH and pulse oxyqen saturatron (SpO2) of the two groups were higher than those of the same group before treatment, while partial pressure of carbon dioxide (PaCO2) was lower than that of the same group before treatment, and the differences were statistically significant (P ＜ 0.05). The pH and SpO2 in the observation group were higher than those of the control group, while PaCO2 was lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in the mortality between the two groups (P ＞ 0.05). Conclusion Preventive nursing intervention can help shorten the use time of non-invasive ventilator and hospital stay, improve lung oxygenation function, and reduce the occurrence of complications.
2021 Vol. 18 (26): 181-184 [Abstract] ( 118 ) HTML (1 KB)  PDF (629 KB)  ( 141 )
185 Observation on the effect of finger grip ball applied to mechanically ventilated patients in ICU
YAO Lixian CHEN Meiyang TANG Wenqi ZHANG Zuoyan
Objective To observe the effect of finger grip ball applied to mechanically ventilated patients in intensive care unit (ICU). Methods Prospectively enrolled 100 mechanically ventilated ICU patients admitted to Shanghai Sixth People’s Hospital from July 2018 to January 2019. According to the random number table method, they were divided into the conventional group and the experimental group, with 50 cases in each group. Routine intervention was used in the routine group, and the experimental group was used routine intervention + finger grip ball. The offline time of the two groups was recorded, the comfort (using the Digital Pain Rating [NRS] for evaluation) of restraint of the two groups was evaluated, and the occurrence of adverse events (redness and swelling at the wrist restraint, skin injury at the wrist restraint, venous thromboembolism [VTE]) in the two groups was counted. Results The offline time of the experimental group was shorter than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). The total restraint comfort of the experimental group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). The incidence of redness and swelling at the wrist restraint and skin damage injury at the wrist restraint in the experimental group were lower than those in the conventional group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of VTE between the two groups (P ＞ 0.05). Conclusion ICU mechanically ventilated patients have high restraint comfort with finger grip ball intervention, which can shorten the offline time and reduce the redness, swelling and injury of the wrist restraint.
2021 Vol. 18 (26): 185-188 [Abstract] ( 60 ) HTML (1 KB)  PDF (667 KB)  ( 14 )
189 Thoughts on the internal control of public hospitals accepting donations
XU Lingqian1 DU Jun2 XU Yuanyuan1▲

With the continuous implementation of the reform of the medical and health system and the continuous development of social public welfare undertakings, public hospitals have received a significant increase in donations. As a key part of the internal control of public hospitals, the legality and compliance of donation business and the use of donation objects have attracted much social attention. This article embarks from the current public hospital donation management present situation analysis, combined with the health medical institutions internal control specification donations of related regulations and health industry, identifying the key risk points of public hospital donation management process, in combination with the practical situation of medical institutions put forward specific risk prevention control strategy, aims to provide a reference for the standardization of the hospital management and strengtheming hospital internal control to ensure the smooth progress of donation business.
2021 Vol. 18 (26): 189-192 [Abstract] ( 107 ) HTML (1 KB)  PDF (459 KB)  ( 48 )
193 Exploration and practice of appointment consultation service in multidisciplinary comprehensive outpatient
CHEN Qilin LI Zhenxiang WEI Xuan FENG Xiuping FENG Yujie
To facilitate the diagnosis and treatment of patients with difficult diseases, the Multidisciplinary Comprehensive Clinic of Provincial Hospital Affiliated to Shandong First Medical University has innovatively carried out a variety of appointment consultation methods, including online (official website, WeChat, alipay), inter—clinic, on-site and telephone appointment. Ensuring the smooth development of multidisciplinary appointment diagnosis and treatment through improving the management system, setting up fixed multidisciplinary comprehensive clinic, allocating full-time nurses, carrying out workload statistics and supervision, and increasing the publicity of consultation appointment. The development of multidisciplinary comprehensive clinic consultation service has achieved remarkable results, which has been widely recognized by experts and patients, in improving both doctors’ and patients’ convenience and enthusiasm for consultation appointment, promoting consultation efficiency and service ability, and improving patients’ satisfaction.
2021 Vol. 18 (26): 193-196 [Abstract] ( 72 ) HTML (1 KB)  PDF (483 KB)  ( 49 )
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