通督调神针刺法联合多奈哌齐治疗血管性轻度认知障碍的临床效果

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Abstract Objective To observe the clinical effect of Tongdu Tiaoshen acupuncture combined with Donepezil in the treatment of patients with vascular mild cognitive impairment (VMCI). Methods Sixty four patients with VMCI admitted to the Department of Encephalopathy in Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2017 to September 2019 were included as the study subjects. According to the random number table method, they were divided into control group (Donepezil + conventional acupuncture) and observation group (Donepezil + Tongdu Tiaosen acupuncture), with 32 cases in each group, both groups were given conventional treatment. The treatment lasted for eight weeks, and the clinical efficacy of the two groups was compared. The cognitive ability of the two groups was assessed by mini mental status examination (MMSE) and Montreal cognitive assessment (MoCA). The activity of daily living scale (ADL) and neurological function defect scale (NFDS) were used to evaluate the living ability of the two groups, and the changes of serum cystatin C (CysC) and plasma homocysteine (Hcy) levels were observed before and after treatment. Results Two cases fell off in each group, and 30 cases were finally included in each group. The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the MMSE, MoCA, and ADL scores of two groups were higher than those before treatment, and the NFDS score was lower than that before treatment. The MMSE, MoCA, and ADL scores of the observation group were higher than those of the control group, and the NFDS score was lower than that of the control group, with statistical significance (P ＜ 0.05). After treatment, the levels of CysC and Hcy in two groups were lower than before, and the observation group was lower than the control group, with statistical significance (P ＜ 0.05). Conclusion Tongdu Tiaoshen acupuncture combined with Donepezil has a good effect in the treatment of VMCI, which can improve the cognitive ability and behavioral ability of VMCI patients, and regulate the levels of CysC and Hcy.

Key words： Vascular mild cognitive impairment Tongdu Tiaoshen acupuncture therapy Cystatin C Homocysteine

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	SHEN Zhiqiang CHENG Hongliang ZHANG Wendong BAI Lin

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SHEN Zhiqiang CHENG Hongliang ZHANG Wendong BAI Lin. Clinical effect of Tongdu Tiaoshen acupuncture combined with Donepezil in the treatment of vascular mild cognitive impairment[J]. 中国医药导报, 2021, 18(26): 68-72.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I26/68

[1] 袁俊亮，杨淑娜，陈宇丹，等.2016《中国血管性轻度认知损害诊断指南》解读[J].中华老年心脑血管病杂志，2017， 19（1）：108-110.
[2] 张守字.血管性认知障碍的诊断与治疗[J].中国临床保健杂志，2020，23（2）：161-164.
[3] 崔颖，刘斌，董亚楠，等.缺血性脑小血管病患者脂蛋白a、纤维蛋白原和D-二聚体与血管性认知障碍的相关性[J].中华行为医学与脑科学杂志，2019，28（4）：331-336.
[4] 梁翠梅，潘良，胡慧，等.不同时程针刺干预血管性轻度认知障碍疗效观察[J].上海针灸杂志，2018，37（4）：403-407.
[5] 程红亮，耿飞，胡培佳，等.针刺督脉组穴治疗血管性认知障碍临床观察[J].安徽中医药大学学报，2018，37（4）：55-58.
[6] 郗欧，焦富英，马进，等.头皮针联合康复训练对脑卒中后轻度认知障碍患者脑血流动力学及血管内皮功能的影响[J].世界中医药，2019，14（2）：477-480.
[7] Larner AJ. Mini-Mental State Examination：diagnostic test accuracy study in primary care referrals [J]. Neurodegener Dis Manag，2018，8（5）：301-305.
[8] Kang JM，Cho YS，Park S，et al. Montreal cognitive assessment reflects cognitive reserve [J]. BMC Geriatr，2018，18（1）：261.
[9] 高树中，杨骏.针灸治疗学[M].4版.北京：中国中医药出版社，2016.
[10] 张道宗.张道宗通督调神实用针灸技术[M].合肥：安徽科学技术出版社，2016.
[11] Qing Zhang，Karunanithi M，Bradford D，et al. Activity of Daily Living assessment through wireless sensor data [J]. Annu Int Conf IEEE Eng Med Biol Soc，2014：1752-1755.
[12] Meijers JC，Tekelenburg WL，Bouma BN，et al. Highlevels of coagulation factor Ⅺ as a risk factor for venous thrombosis [J]. N Engl J Med，2000，342（10）：696-701.
[13] 黄珊，张敏，黄宽宽，等.血管周围间隙扩大与轻度认知障碍患者的关系[J].中国脑血管病杂志，2020，17（12）：726-733.
[14] 朱玲玲，常红，蔡卫新，等.认知-运动双重任务训练对血管性轻度认知障碍老年患者的效果[J].中国康复理论与实践，2021，27（1）：37-42.
[15] 彭思思，章军建.血管性认知障碍的血液生物标志物研究进展[J].神经损伤与功能重建，2017，12（5）：423-426.
[16] Zhang Y，Sun L. Cystatin C in Cerebrovascular Disorders [J]. Curr Neurovasc Res，2017，14（4）：406-414.
[17] 王晓宇，武琳，吴丽萍，等.针灸治疗老年轻度血管性认知障碍合并睡眠障碍临床研究[J].河北中医药学报，2020，35（4）：51-53.
[18] 刘秀敏.丹参酮ⅡA治疗血管性认知障碍患者的临床研究[J].中国临床药理学杂志，2020，36（9）：1073-1075， 1103.
[19] 黄丽，徐建，吴焕淦，等.针刺治疗血管性认知障碍的临床进展及机制[J].老年医学与保健，2018，24（1）：85-88.
[20] 陈悦琦，吴焕淦，尹平，等.“通督调神”组穴针刺治疗轻度认知功能障碍：随机对照研究[J].中国针灸，2019，39（11）：1141-1145.
[21] 孙培养，储浩然，李佩芳，等.通督调神针法结合夹脊穴治疗脑卒中后痉挛性瘫痪[J].安徽中医药大学学报，2019，38（2）：44-47.
[22] 白琳，程红亮，张闻东，等.通督调神针刺法对血管性轻度认知障碍患者血清脑源性生长因子和血浆同型半胱氨酸的影响[J].安徽中医药大学学报，2021，40（1）：54-58.
[23] 张立志，许能贵.通督调神针刺法治疗缺血性中风的研究进展[J].上海针灸杂志，2018，37（9）：1096-1099.
[24] 季莉莉，黄婷婷.多奈哌齐联合艾地苯醌治疗早期血管性认知功能障碍的临床效果[J].中国医药导报，2020， 17（35）：84-87.
[25] 孟凡颖，万颖.以督脉大椎、百会为主穴治疗血管性轻度认知损害的临床效果[J].中国当代医药，2021，28（17）：176-179.
[26] 谭景斐，许秀，张中平，等.活血法联合针刺治疗血管性认知障碍的meta分析[J].中国医药导报，2020，17（26）：139-144.
[27] 王振垚，张虎，王新伟，等.针刺联合认知康复训练治疗卒中后认知障碍疗效及对细胞因子的影响[J].上海针灸杂志，2019，38（10）：1098-1102.
[28] 孟令和，夏凡，刘子彧.通督调神针法联合多奈哌齐治疗脑卒中后轻度血管性认知障碍疗效观察[J].现代中西医结合杂志，2020，29（23）：2572-2575.
[29] 马春丽，张本卓，王强，等.缺血性脑小血管病患者血清一氧化氮、内皮素-1和抑胱素C与血管性认知障碍的相关性分析[J].中国医药科学，2020，10（15）：16-19.
[30] Calhoun A，King C，Khoury R，et al. An evaluation of memantine ER+ donepezil for the treatment of Alzheimer’s disease [J]. Expert Opin Pharmacother，2018，19（15）：1711-1717.