类风湿关节炎中的外泌体及其作用研究进展

Abstract
Figure/Table
References (35)
Related Citation (15)

Download: PDF (496 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract In this paper, we reviewed and analyzed the findings related to exosomes in rheumatoid arthritis (RA). Exosomes can not only be used as disease biomarkers for RA, it also aggravates the inflammatory process and causes bone destruction to a certain extent by secreting inflammatory factors, expressing special membrane proteins and releasing inflammatory microRNA, participate in the occurrence and development of RA. On the other hand, some exosomes also have anti-inflammatory, promoting cartilage repair, delivering therapeutic drugs and other positive effects, it can be used as a tool and means to treat RA. This paper points out the direction for further research on how to curb the exosomes that are unfavorable to the occurrence and development of RA and how to utilize the exosomes that are beneficial to the treatment of RA.

Key words： Rheumatoid arthritis Exosome Extracellular vesicle MicroRNA Inflammation Bone destruction Drug delivery system

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SUN Yong1
	2 ZHAO Chuang3 LIU Zhidan1
	2

Cite this article:

SUN Yong1,2 ZHAO Chuang3 LIU Zhidan1,2. Advances in studies on exosomes and their roles in rheumatoid arthritis[J]. 中国医药导报, 2021, 18(26): 34-38.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I26/34

[1] Barile L，Vassalli G. Exosomes：Therapy delivery tools and biomarkers of diseases [J]. Pharmacol Ther，2017，5（174）：63-78.
[2] Ding Y，Wang L，Wu H，et al. Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance [J]. Exp Biol Med，2020，245（14）：1177-1186.
[3] Maeda Y，Farina NH，Matzelle MM，et al. Synovium-derived microRNAs regulate bone pathways in rheumatoid arthritis [J]. J Bone Miner Res，2017，32（3）：461-472.
[4] 桑成晨，钱龙.类风湿关节炎患者血浆外泌体miR-16-5p和miR-223-3p的表达及临床意义[J].安徽医科大学学报，2020，55（10）：1628-1632.
[5] Wang Y，Zheng F，Gao G，et al. MiR-548a-3p regulatesinflammatory response via TLR4/NF-κB signaling pathway in rheumatoid arthritis [J]. J Cell Biochem，2019，120：1133-1140.
[6] Lim MK，Yoo J，Sheen DH，et al. Serum Exosomal miRNA-1915-3p Is Correlated With Disease Activity of Korean Rheumatoid Arthritis [J]. In Vivo，2020，34（5）：2941-2945.
[7] Song J，Kim D，Han J，et al. PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis [J]. Clin Exp Med，2015，15（1）：121-126.
[8] Tsuno H，Arito M，Suematsu N，et al. A proteomic analysis of serum-derived exosomes in rheumatoid arthritis [J]. BMC Rheumatol，2018，2：35.
[9] Rhys HI，Dell’Accio F，Pitzalis C，et al. Neutrophil microvesicles from healthy control and rheumatoid arthritis patients prevent the inflammatory activation of macrophages [J]. EBIO Med，2018，29：60-69.
[10] Boilard E，Nigrovic PA，Larabee K，et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production [J]. Science，2010，327（5965）：580-583.
[11] Ohara RA，Edhayan G，Saunders TL，et al. Regulation of rheumatoid arthritis synovial fibroblast cytokine production by inhibitor of dna binding-1 via crispr /CAS9 transfection [J]. Arthritis Rheumatol，2016，68：1456-1457.
[12] Hu Q，Su H，Li J，et al. Clinical applications of exosome membrane proteins [J]. Precis Clin Med，2020，3（1）：54-66.
[13] Zhang HG，Liu C，Su K，et al. A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death [J]. J Immunol，2006，176（12）：7385-7393.
[14] Lehmann SM，Krüger C，Park B，et al. An unconventional role for miRNA：let-7 activates Toll-like receptor 7 and causes neurodegeneration [J]. Nat Neurosci，2012，15（6）：827-835.
[15] Kim SJ，Chen Z，Essani AB，et al. Identification of a novel Toll-like Receptor 7 endogenous ligand in rheumatoid arthritis synovial fluid that can provoke arthritic joint inflammation [J]. Arthritis Rheumatol，2016，68（5）：1099-1110.
[16] Wang L，Wang C，Jia X，et al. Circulating exosomal miR-17 inhibits the induction of regulatory T cells via suppressing TGFBR II expression in rheumatoid arthritis [J]. Cell Physiol Biochem，2018，50（5）：1754-1763.
[17] Liu D，Fang Y，Rao Y，et al. Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4 [J]. J Mol Med （Berl），2020，98（3）：409-423.
[18] Li D，Liu J，Guo B，et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation [J]. Nature Communications，2016，7（1）：10872-10872.
[19] Chen Z，Wang H，Xia Y，et al. Therapeutic Potential of Mesenchymal Cell-Derived miRNA-150-5p-Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF [J]. J Immunol，2018，201（8）：2472-2482.
[20] Meng Q，Qiu B. Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression [J]. Front Physiol，2020，11：441.
[21] Xu D，Song M，Chai C，et al. Exosome-encapsulated miR-6089 regulates inflammatory response via targeting TLR4 [J]. J Cell Physiol，2019，234（2）：1502-1511.
[22] Zheng J，Zhu L，Iok In I，et al. Bone marrow-derived mesenchymal stem cells-secreted exosomal microRNA-192-5p delays inflammatory response in rheumatoid arthritis [J]. Int Immunopharmacol，2020，78：105985.
[23] Cosenza S，Toupet K，Maumus M，et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis [J]. Theranostics，2018，8（5）：1399-1410.
[24] Cai Z，Zhang W，Yang F，et al. Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells [J]. Cell Res，2012， 22（3）：607-610.
[25] Yang C，Robbins PD. Immunosuppressive exosomes：a new approach for treating arthritis [J]. Int J Rheumatol，2012， 2012：573528.
[26] Blazquez R，Sanchez-Margallo FM，de la Rosa O，et al. Immunomodulatory Potential of Human Adipose Mesenchymal Stem Cells Derived Exosomes on in vitro Stimulated T Cells [J]. Front Immunol，2014，4（5）：556.
[27] Chen J，Liu M，Luo X，et al. Exosomal miRNA-486-5p derived from rheumatoid arthritis fibroblast-like synoviocytes induces osteoblast differentiation through the Tob1/BMP/Smad pathway [J]. Biomater Sci，2020，8（12）：3430-3442.
[28] Zhang S，Chu WC，Lai RC，et al. Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration [J]. Osteoarthritis Cartilage，2016， 24（12）：2135-2140.
[29] Zhao C，Chen JY，Peng WM，et al. Exosomes from adipose derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR 145 and miR 221 [J]. Mol Med Rep，2020，21（4）：1881-1889.
[30] Familtseva A，Jeremic N，Tyagi SC，et al. Exosomes：cell-created drug delivery systems [J]. Mol Cell Biochem，2019， 459（1/2）：1-6.
[31] Yan F，Zhong Z，Wang Y，et al. Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis [J]. J Nanobiotechnology，2020，18（1）：115.
[32] Sun D，Zhuang X，Xiang X，et al. A novel nanoparticle drug delivery system：the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes [J]. Mol Ther，2010，18（9）：1606-1614.
[33] Tran TH，Mattheolabakis G，Aldawsari H，et al. Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases [J]. Clin Immunol，2015，160（1）：46-58.
[34] Momen-Heravi F，Bala S，Bukong T，et al. Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages [J]. Nanomedicine，2014，10（7）：1517-1527.
[35] Meng HY，Chen LQ，Chen LH. The inhibition by human MSCs-derived miRNA-124a overexpression exosomes in the proliferation and migration of rheumatoid arthritis-related fibroblast-like synoviocyte cell [J]. BMC Musculoskelet Disord，2020，21（1）：150.