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2021 Vol. 18, No. 22 Published: 2021-08-05

	4	Study on the mechanism of treatment of ectopic pregnancy Ⅰ prescription based on network pharmacology
		QIU Jiahan1 YUAN Shuo1 ZHANG Jiaqi2 KUANG Zijun2
		Objective To study the effect of ectopic pregnancy Ⅰ prescription on the treatment target of ectopic pregnancy by network pharmacology. Methods Based on the traditional Chinese medicine systems pharmacology database and analysis platform, as well as the known effective active ingredients of ectopic pregnancy Ⅰ prescription in relevant literatures from January 2015 to January 2020 on CNKI, VIP and Wanfang websites, the active ingredients of the prescription were finally screened out. After obtaining all the traditional Chinese medicine ingredients, oral bioavailability and drug-likeness were taken as the screening conditions to obtain the effective gene targets of the above active ingredients through the Uniprot website. Finally, an “active ingredient-target” network was established with the help of Cytoscape 3.8.0. Disgenet database and GeneCards database were used to retrieve disease targets of ectopic pregnancy. The ectopic pregnancy Ⅰ prescription was intersected with the disease target. Proteinprotein interaction (PPI) networks were constructed and mapped using the Bisogenet plugin in Cytoscape 3.8.0 software. Top three degree value of the target proteins and effective components of the drug in the RSCB PDB database, Autodock Tolls software and Pymol software were used to make molecular docking operation. At the same time, the DAVID database was used for GO classification enrichment analysis and KEGG pathway enrichment analysis of key targets in PPI network diagram. Results A total of 159 effective targets for ectopic pregnancy Ⅰ prescription and 1362 disease targets for ectopic pregnancy were screened out. After the intersection of the two, 65 targets for ectopic pregnancy treatment were obtained. Based on molecular docking of the top 3 proteins and active components in the PPI network with degree values, it was concluded that the core component of ectopic pregnancy Ⅰ prescription had good binding activity with the target of ectopic pregnancy. GO enrichment analysis results showed that among the 220 related target genes, 207 core target genes were involved in enrichment, and a total of 518 enrichment results were obtained, including 174 molecular functions, 126 cell components, and 218 biological processes. KEGG analysis showed that there were 220 related target genes, among which 181 core target genes were involved in 111 signaling pathways. Molecular docking and enrichment analysis showed that ectopic pregnancy Ⅰ prescription was effective in the treatment of ectopic pregnancy mainly by acting on NTRK1 and other proteins through signaling pathways such as tumor signaling pathway. Conclusion The ectopic pregnancy Ⅰ prescription can act on multiple targets of ectopic pregnancy and participate in the regulation of multiple signaling pathways, which can provide a new direction for the study of its pharmacological mechanism.
		2021 Vol. 18 (22): 4-11 [Abstract] ( 59 ) HTML (1 KB) PDF (1831 KB) ( 51 )

	12	Mechanism of Erxian Decoction in the treatment of hypertension based on network pharmacology and molecular docking
		MENG Yuan1,2 LI Ping1 LIU Xin1 YUAN Jing1,2
		Objevtive To explore the mechanism of Erxian Decoction in the treatment of hypertension based on network pharmacology and molecular docking. Methods Traditional Chinese medicine systems pharmacology database and analysis platform was used to screen the main active ingredients and targets of Erxian Decoction. By means of GeneCards, Drugbank, on-line Mendelian inheritance in man, and Therapeutic target database, the targets of hypertension were collected. String online database was used to build proteinprotein interaction network. DAVID database was used to perform GO function enrichment analysis and KEGG pathway enrichment analysis. Autodock vina software was used to conduct molecular docking between targets and active ingredients. Results The effective components of Erxian Decoction were screened out, there were 23 effective components in Herba Epimedii, seven effective components in Rhizoma Curculigins, 20 effective components in Radix Morindae Officinalis, two effective components in Radix Angelicae Sinensis, 15 effective components in Rhizoma Anemarrhenae, 37 effective components in Cortex Phellodendri, and there were 218 action targets in total, 1073 hypertensive disease targets and 101 intersection targets. Through analysis, treatment of hypertension with Erxian Decoction might be related to key targets, such as interleukin-6, vascular endothelial growth factor A, tumor necrosis factor, serine/threonine-protein kinases 1, etc., and the biological pathways included apoptosis and proliferation, responsed to bacterium, etc., pathways mainly included Toll-like receptor signaling pathway, mitogen-activated protein kinase (MAPK) pathway, nucleotide binding oligomerization domain-like receptor signaling pathway, GnRH signaling pathway, etc. The results of molecular docking showed that ingredients in Erxian Decoction had high binding activities with the abovekey targets. Conclusion Erxian Decoction may mainly play a role in regulating endothelial function, smooth muscle cells proliferation, inhibiting inflammatory reactions and oxidative stress, etc., thereby reducing blood pressure levels through quercetin, luteolin, kaempferol and Toll-like receptor signaling pathway, MAPK pathway, nucleotide binding oligomerization domain-like receptor signaling pathway, and GnRH signaling pathway, etc.
		2021 Vol. 18 (22): 12-16,27 [Abstract] ( 146 ) HTML (1 KB) PDF (2046 KB) ( 54 )

	17	Clinicopathological characteristics and the differences analysis of expression of PR, ER and AR in different grades of meningiomas
		GAO Ping1 XIANG Qingming2 YANG Yi1 ZONG Yangru1
		Objective To study the clinicopathological characteristics of meningiomas (IM) and the expression differences of estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) in different grades of IM. Methods A retrospective study was conducted on 123 cases of IM treated in Hubei Provincial Hospital of Integrated Chinese & Western Medicine from May 2014 to November 2020. According to the different location, age, gender, tumor size, and invasion of IM, the tumor was re-classified and re-graded according to World Health Organization standards. The characteristics of recurrent cases were observed and the proliferation marker Ki67 was quantitatively analyzed. Immunohistochemical staining of ER, PR and AR was evaluated in some randomly selected cases. Results The proliferation index (PI) of Ki67 was highly positively correlated with grades of IM (r = 0.808, P ＜ 0.01), tumor size was slightly positively correlated with grades of IM (r = 0.257, P ＜ 0.01). The PI of grade Ⅱ IM was higher than that of grade Ⅰ with active cell growth, grade Ⅰ with active cell growth was higher than that of grade Ⅰ. The tumor size of grade Ⅱ IM was higher than that of grade Ⅰ, and there were statistically significant (P ＜ 0.05). The percentage of females was 79.7% (98 cases) was significantly higher than that of males 20.3% (25 cases). The positive rate of PR was 93.0% (53/57), the positive rate of AR was 63.3% (19/30), and no positive signal of ER was detected. There were no statistical differences in age distribution, location, invasion and histological types of patients with different grades (P ＞ 0.05). Conclusion PR may play an important role in the occurrence and development of IM. Some sex hormone drugs may affect the growth of the tumor. Individualized management is recommended. Relapsed cases have a tendency to increase tumor grades and PI. The combined analysis of PI, tumor size and histological morphology is helpful to comprehensively evaluate the biological behavior of IM.
		2021 Vol. 18 (22): 17-21 [Abstract] ( 121 ) HTML (1 KB) PDF (779 KB) ( 81 )

	22	Effect of lncRNA SNHG3 on the proliferation, apoptosis, migration and invasion of osteosarcoma cells by targeting miR-514a-5p
		TAN Xiaoqian MEI Haibo WU Jiangyan YAN An
		Objective To explore the effect of long non-coding RNA small nucleolar RNA host gene 3 (SNHG3) on the proliferation, apoptosis, migration and invasion of osteosarcoma cells and its mechanism. Methods The expression of SNHG3 and miR-514a-5p in osteoblasts hFOB1.19 and osteosarcoma cells SW-1353, HOS, U-2OS, and Saos-2 were detected by qRT-PCR. U-2OS cells in logarithmic growth phase were transfected. They were divided into si-NC group (transfected si-NC), si-SNHG3 group (transfected si-SNHG3), miR-NC group (transfected miR-NC), miR-514a-5p group (transfected miR-514a-5p), si-SNHG3+anti-miR-NC group (co-transfected si-SNHG3 and anti-miR-NC) and si-SNHG3 +anti-miR-514a-5p group (co-transfected with si-SNHG3 and anti-miR-514a-5p). CCK-8 assay and flow cytometry were used to check cell viability and apoptosis. The expression of c-Myc, Bax, and MMP-2 protein were detected by Western blot. Cell migration and invasion were tested by Transwell chamber experiment. The target relationship between SNHG3 and miR-514a-5p was analyzed by dual luciferase experiment. Results The expression of SNHG3 in osteosarcoma cells SW-1353, HOS, U-2OS, and Saos-2 were higher than those of osteoblasts hFOB1.19, and the expression of miR-514a-5p were lower than that of osteoblasts hFOB1.19, and the differences were statistically significant (P < 0.05). The SNHG3, cell viability, migrating cells, invasive cells, and the expression of c-Myc, MMP-2 protein in si-SNHG3 group were lower than those in si-NC group; while the apoptosis rate and the expression of Bax protein were higher than those in si-NC group, and the differences were statistically significant (P < 0.05). The miR-514a-5p expression, apoptosis rate, and the expression of Bax protein in miR-514a-5p group were higher than those in miR-NC group; while cell viability, migrating cells, invasive cells, the expression of c-Myc, MMP-2 protein were lower than those of miR-NC group, and the differences were statistically significant (P < 0.05). SNHG3 wild type luciferase activity of miR-514a-5p group was lower than that of miR-NC group, and the difference was statistically significant (P < 0.05), while SNHG3 mutant luciferase activity in miR-514a-5p group and miR-NC group showed no statistical significance (P > 0.05). The miR-514a-5p expression, apoptosis rate, and the expression of Bax protein in si-SNHG3+anti-miR-514a-5p group were lower than those in si-SNHG3+anti-miR-NC group, while cell viability, migrating cells, invaded cells, the expression of c-Myc and MMP-2 protein were higher than those in si-SNHG3+anti-miR-NC group, and the differences were statistically significant (P < 0.05). Conclusion Knockdown of SNHG3 can significantly inhibit the proliferation, invasion and migration of osteosarcoma cells, and also promote the apoptosis of osteosarcoma cells, the mechanism of which may be related to miR-514a-5p.
		2021 Vol. 18 (22): 22-27 [Abstract] ( 121 ) HTML (1 KB) PDF (1076 KB) ( 112 )

	28	Application of miR-9-5p in targeting UBE4B in regulating hypoxia-induced transcription factor 1α ubiquitination-mediated Warburg effect in glioma cells
		ZHANG Jingjing YALIKUN Nu’er’aihemaitijiang DU Peng
		Objective To explore the regulation and mechanism of miR-9-5p on Waburg effect in glioma. Methods Thirty patient’s glioma and paracancerous tissue samples diagnosed from May 2018 to October 2020 in the Second Affiliated Hospital of Xinjiang Medical University were selected. A control group, a miR-9-5p overexpression group, and a miR-9-5p inhibitor group were established. Quantitative real-time PCR was used to detect the expression of miR-9-5p and its correlation with the expression of glycolysis-related genes. Construction of ectopic tumor models and in vitro cell experiments, using quantitative real-time PCR, Western blot, glucose uptake analysis, lactic acid production detection and cell viability detection to determine the impact of miR-9-5p on glioma and Warburg effect, while the dual luciferase reporter gene was used to detect the targeting relationship between miR-9-5p and UBE4B. Results The expressions of Hypoxia inducible factor-1α(HIF1α) protein, glucose transporter 1 (Glut1), human hexokinase-2 (HK2), lactate dehydrogenase (LDHA) and vascular endothelial growth factor (VEGF) in the miR-9-5p overexpression group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05); while the mRNA level of HIF1α was not statistically significant (P ＞ 0.05). The expressions of HIF1α protein, Glut1, HK2, LDHA and VEGF in the miR-9-5p inhibitor group were significantly lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); while the mRNA levels of HIF1α were not statistically significant (P ＞ 0.05). Compared with the control group, the miR-9-5p overexpression group significantly enhanced metabolism and metastasis (P ＜ 0.05), while the miR-9-5p inhibitor group significantly reduced glucose uptake and lactate production in U251 cells (P < 0.05). The cell viability of the miR-9-5p overexpression group was significantly higher than that of the control group after treatment for 24 h and 48 h, and the differences were statistically significant (P ＜ 0.05); compared with the control group, the cell viability of the miR-9-5p inhibitor group decreased significantly at 24 h and 48 h, and the differences were statistically significant (P ＜ 0.05). The tumor volume and wet weight of the miR-9-5p overexpression group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The protein level of UBE4B in the miR-9-5p overexpression group was lower than that in the control group, and the difference was statistically significant (P < 0.05); the expression of HIF1α and glycolysis-related genes (Glut1, HK2 and LDHA) was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion miR-9-5p can regulate the Warburg effect of gliomas and promote the occurrence and development of gliomas through the UBE4B/HIF1α pathway.
		2021 Vol. 18 (22): 28-32，36 [Abstract] ( 36 ) HTML (1 KB) PDF (1043 KB) ( 140 )

	33	Visual analysis of the application status and trend of scenario simulation teaching in nursing field in China in the past decade
		LI Wufen1,2 LI Meng1 SUN Shanbin1 ZHANG Junchao2 ZHANG Yougui1 REN Chunxia3 LI Jing4 DING Panpan1
		Objective To understand the application status and trend of scenario simulation teaching in the nursing field in China, and to provide reference for the related research in teaching practice Methods CiteSpace software was used to collect the relevant data of China national knowledge infrastructure from January 2010 to July 2020, and the literature volume, study authors, research institutions and keywords of scenario simulation teaching application in the nursing field in China were analyzed. Results A total of 1504 effective literatures were obtained, and the number of published papers showed a steady increasing trend, reaching the peak in 2019. The high yield authors were WU Ying and WANG Yanling, the high yield organization was Suzhou Health Vocational and Technical College, the hot key words were practice nurse, operating room nursing, application and effect. The prediction of future research trends was in the standardized training of nurses and pediatric care applications. Conclusion CiteSpace software can be applied to carry out visual display of the application status and trend of scenario simulation teaching in nursing field in China, which preliminarily revealed the current leading authors and institutions in this field so as to provide certain direction guidance for the further research.
		2021 Vol. 18 (22): 33-36 [Abstract] ( 77 ) HTML (1 KB) PDF (861 KB) ( 62 )

	37	Study on the mechanism of Kechuanliuwei Oral Liquid prepared by new technology in the treatment of asthmatic mice
		YANG Fanping XI Yan▲
		Objective To observe the effect of Kechuanliuwei Oral Liquid prepared by new technology on asthmatic mice and to explore its anti-asthma mechanism. Methods According to the random number table method, the mice were divided into control group, asthma model group, Kechuanliuwei Oral Liquid (new technology) low-dose group (15.5 g/kg), Kechuanliuwei Oral Liquid (new technology) high-dose group (31 g/kg), Dexamethasone group (3 g/kg), with six mice in each group. Except for control group, the other groups were treated with ovalbumin (OVA) to establish asthma model. Each group was given intragastric administration of drug from day 21 of modeling, at the same time, atomization excitation was given. Airway reactivity was measured by pulmonary function meter; pathological changes of lung tissue were observed by HE staining; serum interleukin (IL)-13, IL-17 and interferon-γ (IFN-γ) were measured by enzyme-linked immunosorbent assay. Results Asthma model group, Kechuanliuwei Oral Liquid (new technology) low-dose group, Kechuanliuwei Oral Liquid (new technology) high-dose group and Dexamethasone group were all successfully atomized to induce asthma. When Acetylcholine concentration was 6.250, 12.500, 50.000 mg/ml, the Penh value of asthma model group were higher than those of control group, and the differences were statistically significant (P < 0.05); Penh values of Kechuanliuwei Oral Liquid (new technology) low-dose group, Kechuanliuwei Oral Liquid (new technology) high-dose group and Dexamethasone group were lower than those of asthma model group, and the differences were statistically significant (P < 0.05). In control group, the lung tissue structure was clear and complete, and the bronchus and alveoli were normal, without obvious inflammatory cells. In asthmatic model group, the lung tissue structure was disordered, and the bronchus became narrow and thick, surrounded by inflammatory cells. The lung tissues of mice in Kechuanliuwei Oral Liquid (new technology) low-dose group, Kechuanliuwei Oral Liquid (new technology) high-dose group and Dexamethasone group were slightly changed with good structure; and the bronchus were all deformed to different degrees, but the degree of narrowing and thickening was less than that of asthma model group, and there were a few inflammatory cells. There were no significant differences in serum IL-13, IL-17, and IFN-γ levels between asthma model group and control group (P > 0.05). The serum levels of IL-13, IL-17, and IFN-γ in Kechuanliuwei Oral Liquid (new technology) low-dose group, Kechuanliuwei Oral Liquid (new technology) high-dose group and Dexamethasone group were not significantly different from those in asthma model group (P > 0.05). Conclusion Kechuanliuwei Oral Liquid prepared by new technology can improve the airway reactivity, pathological damage of lung tissue and inflammatory response in asthmatic mice.
		2021 Vol. 18 (22): 37-40,45 [Abstract] ( 77 ) HTML (1 KB) PDF (837 KB) ( 81 )

	41	Evaluation of clinical application of the acceptance drug Levetiracetam Tablets volume-based procurement
		YANG Li1,2 DONG Xianzhe1 CUI Xiaohui1 LU Song2 LIU Wenna1 LI Lin1 YUE Xiaolin1 ZHANG Lan1
		Objective To preliminarily evaluate the clinical application consistency of the volume-based procurement of Jiyike of Levetiracetam (LEV) Tablets and Keppra from original LEV tablets based on prescription data. Methods Retrospective analysis was made on the prescription data of patients who used Jiyike and Keppra in outpatient department of Xuanwu Hospital, Capital Medical University before the implementation of the volume-based policy (March 2018 to January 2019) and after the implementation of the volume-based policy (March 2019 to January 2020). According to the 1∶1 nearest-neighbor propensity score matching method, the medication possession ratio, the continuous single drug use rate, the rate of continuous treatment for 3, 6 and 9 months, the abnormal upregulation rate of continuous treatment dose, and the continuous use rate after the first diagnosis were counted, and the drug replacement situation of the two was compared. The drug costs of Keppra and Jiyike after the implementation of the volume-based policy and the drug costs of LEV before and after the implementation of the volume-based policy were compared. Results There were no significant differences in the proportion of patients with ≥80%medication possession ratio between Jiyike group and Keppra group (P ＞ 0.05). The proportion of patients in Keppra group was higher than that in Jiyike group after 3, 6 and 9 months of continuous treatment (P ＜ 0.05). The abnormal upregulation rate of continuous treatment dose and continuous single drug use rate in Keppra group was significantly higher than that in Jiyike group (P ＜ 0.05). There was no significant difference in the continuous use rate between the two groups after the first diagnosis (P ＞ 0.05). There was no statistical significance in drug replacement between Jiyike group and Keppra group (P ＞ 0.05). The per capita annual drug cost in Jiyike group was lower than that in Keppra group, the difference was statistically significant (P ＜ 0.05). The per capita annual cost of LEV after the implementation of the volume-based policy was significantly lower than that before the implementation of the volume-based policy, with statistical significance (P ＜ 0.05). Conclusion The clinical application of Jiyike and Keppra is basically the same, and it can reduce the economic burden of patients to a large extent.
		2021 Vol. 18 (22): 41-45 [Abstract] ( 42 ) HTML (1 KB) PDF (576 KB) ( 116 )

	46	Skin test and economic analysis of cephalosporins in our hospital
		XU Bingfa WU Along HUANG Jian
		Objective To conduct an economic analysis on the cost of skin test and to provide a basis for the management of skin test of cephalosporins. Methods By using the clinical information system of Third Hospital Affiliated to Anhui Medical University (hereinafter referred to as “our hospital”), the basic information, skin test results and and the incidence of adverse drug reaction (ADR) among inpatients who received cephalosporin injections in our hospital from January 2018 to December 2019 were counted, and the positive rate of skin test, skin test related costs and the reduced cost of allergic reactions according to the skin test were calculated. Results The total number of cephalosporin skin test cases was 36 784, and the positive rate of skin test was 2.63%. The positive rate of the skin test varieties required by the instructions was significantly higher than that of the varieties not mentioned (P ＜ 0.05). There were 48 cases of cephalosporin-related ADRs, with an incidence of 0.13%. The incidence of ADRs of varieties requiring skin test was significantly lower than that of varieties without skin test (P ＜ 0.05). By economic comparison, the total expenditure of skin test was 2 052 321.75 yuan, while the allergic reaction cost reduced by skin test was 1 107 963.12 yuan, which was significantly higher than the allergic reaction cost reduced by skin test, among which, Cefperazone-Sulbactam, Cefuroxime, Cefoperazone Tazobactam, Ceftazidime and so on were more obvious. Conclusion The cost of cephalosporin skin test is very high, while the positive rate of skin test is very low. Medical institutions can gradually reduce cephalosporin skin test under the premise of safe medication, reduce costs, and promote the rational use of cephalosporin in clinical practice.
		2021 Vol. 18 (22): 46-49,66 [Abstract] ( 49 ) HTML (1 KB) PDF (918 KB) ( 74 )

	50	Research progress on the effect of traditional Chinese medicine to mitochondrial autophagy
		ZHOU Jun1 HU Ben2 JI Liwei2 YANG Lin1
		Mitchondria can selectively removes damaged mitochondria through autophagy, control the quality of mitochondria, and ensure the function of mitochondria, which is of great significance in the normal growth of cells. A growing number of studies have shown that the traditional Chinese medicine (TCM) can affect mitchondria autophagy to prevent and treat diseases. In recent years, TCM in mitchondria autophagy research more and more, this paper summarizes the literature at home and abroad in recent years, the summary of mitchondria autophagy main pathways and TCM effect on mitchondria autophagy in summary of the application of various diseases, provide a reference for other researchers summary information, for the subsequent TCM in the mitchondria autophagy research provides a better idea, to contribute to the modernization of TCM theory.
		2021 Vol. 18 (22): 50-54 [Abstract] ( 133 ) HTML (1 KB) PDF (482 KB) ( 305 )

	55	Research progress in the pathogenesis of premature ovarian insufficiency based on oxygen sensing pathway
		ZHU Yixuan1 DONG Xiaoying2
		Premature ovarian insufficiency (POI) is a tough disease that causes decreased ovarian function in women and is closely related to follicular granulosa cell apoptosis. The oxygen sensing pathway in the human body is one of important signaling pathways. As the core element of the oxygen sensing pathway, hypoxia-inducible factor-1 (HIF-1) α participates in a series of signal cross-linking related to POI and mediates granulosa cell apoptosis together with other molecules and signaling pathway elements. Overexpressed HIF-1α upregulates the BNIP3 expression, which may induce granulosa cell apoptosis. Meanwhile, HIF-1α can enhance granulosa cell autophagy through activated PI3K/Akt/mTOR pathway. Autophagy and apoptosis of granulosa cells are interrelated. They can jointly inhibit the development of oocytes and follicles, promote follicular atresia and lead to POI. In this paper, mechanisms and signaling pathways of apoptosis and autophagy induced by HIF-1α in granulosa cells are investigated to explore the pathogenesis of POI based on oxggen sensing pathway, which is aimed to provide a new approach for the research and treatment of POI.
		2021 Vol. 18 (22): 55-59 [Abstract] ( 130 ) HTML (1 KB) PDF (578 KB) ( 45 )

	59	Research progress of the management of organs respiratory motion during radiotherapy for abdominal tumors
		ZHU Die FU Qianfeng ZHANG Daxin
		Radiotherapy for abdominal tumors is inconclusive because of the breathing-induced movement of tumors and organs at risk. The management of tumors and organs movement in radiotherapy is crucial for abdominal precision radiotherapy. If the movement has not been properly considered during radiotherapy, delivered dose will deviate, which will affect the therapeutic effect. With the development of radiotherapy equipment and technology, many techniques have been developed and applied to manage the movement, such as motion-encompassing techniques, breath-hold techniques, forced shallow-breathing techniques, respiratory-gating techniques, and real-time motion tracking techniques. All kinds of technologies have their own characteristics. At present, several techniques are combined to achieve better therapeutic effect in clinic. This article reviews the research progress of the management of organs respiratory motion during radiotherapy for abdominal tumors.
		2021 Vol. 18 (22): 59-62 [Abstract] ( 38 ) HTML (1 KB) PDF (465 KB) ( 231 )

	63	Thoughts on strengthening medical support and teaching training of oral and maxillofacial surgery in military medical colleges
		WU Xi1 ZHANG Gang2 TAN Yinghui2
		Oral and maxillofacial surgery is indispensable for oral medical support and teaching training in military medical colleges, which directly affects the combat effectiveness of army. However, the current teaching and training mode can not meet the needs of the medical support task of oral and maxillofacial surgery in the new era. According to the actual combat requirements of medical support, this paper analyzes the new situation of medical support of oral and maxillofacial surgery in military medical colleges and its influence on teaching and training. And from peacetime training, wartime treatment, personnel training, hierarchical diagnosis and treatment, teaching thinking and ability, will be discussed to effectively accomplish the medical support task and teaching training of oral and maxillofacial surgery in military medical colleges under the new situation.
		2021 Vol. 18 (22): 63-66 [Abstract] ( 39 ) HTML (1 KB) PDF (684 KB) ( 84 )

	67	Practical research on the teaching mode of clinical teaching of spinal cord injury in rehabilitation specialty based on WCPT guidelines
		GAO Xiao1 YAN Chenmiao2 QI Deyu3 WANG Yanli3 DONG Shiqiu3
		Objective To explore the practice of the teaching mode of clinical teaching of spinal cord injury in rehabilitation specialty based on World Confederation for Physical Therapy (WCPT) guidelines. Methods A total of 50 undergraduate students which majoring in rehabilitation medicine and physiotherapy of Heilongjiang University of Chinese Medicine were selected from the clinical teaching of spinal cord injury arranged in the teaching plan from March to June 2019. According to random number table, they were divided into traditional group (25 students) and WCPT group (25 students). Traditional group apply traditional teaching mode. WCPT group applied the clinical teaching mode based on standardized patient (SP) designed according to the requirements of WCPT guidelines. The study time of both groups was 24 periods. After the teaching, the teaching effect was evaluated by practical theoretical knowledge, practical operation of spinal cord injury SP and comprehensive quality assessment. Results The results of practical theory examination and practical skills examination in WCPT group were all higher than those in the traditional group, with statistical significance (P ＜ 0.05). The score of clinical thinking ability, SP information analysis and induction ability, practical skills, patient management and psychological quality evaluation of WCPT group were all higher than those in the traditional group, with statistical significance (P ＜ 0.05). Conclusion The teaching mode based on WCPT guidelines can significantly improve the students’ ability to master the practical and theoretical knowledge in the clinical teaching of spinal cord injury and improve students’ practical operation ability of SP.
		2021 Vol. 18 (22): 67-70 [Abstract] ( 58 ) HTML (1 KB) PDF (683 KB) ( 112 )

	71	Application effect of post competency-oriented and research-based learning teaching mode in oral biology teaching
		LAI Yingzhen1 ZHENG Xiaodan2 PAN Xiawei2
		Objective To explore the effect of research-based learning (RBL) teaching mode on oral biology teaching and the post competency of students. Methods A total of 64 students were selected as the research subjects from two natural classes of 5-year stomatology major, Grade 2016 in Xiamen Medical College. According to the simple random drawing method, the two classes were divided into the experimental group (33 students) and the control group (31 students). The study period is from September 2019 to September 2020. The control group adopted the traditional teaching mode, the experimental group adopted the RBL teaching mode. After the teaching theory of performance test, the student satisfaction survey (including “satisfied with the existing teaching model”, “can enhance the interest in learning”, “enhancing scientific research capacity”) and post competency related indicators (including “improve autonomous learning ability”, “strengthen the team cooperation ability”, “improve the scientific research capacity”) were used to evaluate the effect. Results The theoretical scores in the experimental group were better than those in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of “satisfied with the existing teaching model”, “can enhance the interest in learning”, “enhancing scientific research capacity” in the experimental group were higher than those in the control group, with statistical significance (P ＜ 0.05). The proportion of “improve autonomous learning ability”, “strengthen the team cooperation ability”, “improve the scientific research capacity” in the experimental group were higher than those in the control group, with statistical significance (P ＜ 0.05). Conclusion RBL teaching mode is student-centered, which is beneficial to the teaching effect of oral biology and the post competence cultivation of students.
		2021 Vol. 18 (22): 71-74,87 [Abstract] ( 37 ) HTML (1 KB) PDF (973 KB) ( 62 )

	75	Study on nursing professional English teaching from the perspective of multimodal discourse analysis
		LI Yanwei1 BAO Lei2
		Nursing professional English is the key course that promotes the connection between Chinese nursing and international nursing and the exchanges of Chinese nursing and foreign nursing and to enhance Chinese nursing level and international competitiveness of Chinese nurses. In view of the significance of nursing English in improving nurses’ whole quality, this paper aims to transform nursing English teaching model from the perspective of multimodal discourse analysis. It is based on the theory of multimodal discourse analysis in sociolinguistics, non-verbal signs, such as pictures, videos and voice are applied in nursing professional English teaching, which breaks through traditional English teaching model, that is focused on grammar translation training and spoon-feeding teaching mode, it analyzes the advantages of traditional Chinese medicine nursing English. It will improve nursing majors’ English communication levels, and it can lay foundation for harmony relationships between nurses and patients, nurses and doctors, nurses and nurses. Cultural value of traditional Chinese medicine is spread on the basis of nurses’ professional knowledge and language skills mastering, which can enhance China’s international image and influence in the international community.
		2021 Vol. 18 (22): 75-78 [Abstract] ( 53 ) HTML (1 KB) PDF (852 KB) ( 119 )

	79	Application discussion on pharmaceutical chemistry WeChat public account in the teaching practice of medicinal chemistry
		WANG Na1 MENG Yuchao1 WANG Baoqi2 ZHENG Pengfei1
		Pharmaceutical chemistry is a compulsory basic course for pharmacy majors, which aims to help students master the chemical characteristics and structure-activity relationship of representative drugs for various diseases. As a supplement to classroom teaching, based on the author’s teaching practice, this article selects some of the high quality WeChat public account of pharmacy, and discusses how to use WeChat public account knowledge section, from three aspects, namely, expansion, summary and frontiers. This new learning method of browsing and reading can not only help students understand the frontier information of pharmaceutical chemistry, but also stimulate their enthusiasm to explore pharmaceutical research, so as to improve the teaching quality of pharmaceutical chemistry.
		2021 Vol. 18 (22): 79-82，91 [Abstract] ( 56 ) HTML (1 KB) PDF (1463 KB) ( 94 )

	83	Exploration of the innovative teaching model of “one-line, two-red, three-dimensional” in ideological and political education of systematic anatomy
		CHEN Xia1 CAI Shichang1 YU Penghui1 JU Xiaojun1 XIANG Sha1 CHEN Yiping1 JANG Jun2
		In order to achieve the goal of value guidance, knowledge impart and ability cultivation, it is necessary to excavate the ideological and political elements in professional courses. Systematic anatomy is an important compulsory course in medical professional courses, which has a profound historical and cultural background. Taking systematic anatomy as an example, this peper finds out the integration points of professional knowledge and integrates the ideological and political education with professional education, which breaks the traditional and single cultural input approach, and builds an innovative teaching mode of “one-line, two-red, three-dimensional”. The Innovative teaching mode takes central ideological and political education as the “main line”, improves the two “red” teaching plans of classroom theory teaching and experimental teaching, and builds a “three-dimensional” complementary learning environment of online classrooms, traditional classrooms and experimental classrooms, to cultivate talents with medical skills and medical ethics, enhance teachers’ moral qualities in preaching and teaching, and highlight the curriculum heritage of cultivating people with moral principles.
		2021 Vol. 18 (22): 83-87 [Abstract] ( 47 ) HTML (1 KB) PDF (1531 KB) ( 67 )

	88	Influences of scenario simulation education on psychological status and work adaptation of nursing students in internship in operating room
		CHEN Yan LI Gendi
		Objective To explore the influences of scenario simulation education on the psychological state and work adaptation of nursing students in internship in the operating room. Methods A total of 33 nursing students from seven groups were selected to take the internship in the operating room of Huashan Hospital Affiliated to Fudan University from July 2019 to January 2020. The groups were divided into experimental group (three groups with 16 students) and control group (four groups with 17 students) according to random number table method. The control group was given routine teaching, while the experimental group was given scenario simulation education for early intervention one week before the start of internship. The internship duration of both groups was four weeks. Symptom check list 90 (SCL-90) was used to evaluate the psychological state of the two groups before and after the internship, and the job adjustment disorder scale was used to evaluate the job adjustment of the two groups after the internship. Results After the internship, the SCL-90 scores of the experimental group were not significantly different from that before the internship (P ＜ 0.05). After the internship, the scores of SCL-90 in the control group were higher than before, and those in the experimental group were lower than those in the control group, with statistical significance (P ＜ 0.05). After the internship, the scores of the job adjustment disorder scale in the experimental group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Scenario simulation education can help nursing students in internship to establish psychological preparation for the special environment and work pressure in the operating room, better understand the various surgical instruments and equipment and nursing operations in the operating room, so as to reduce the occurrence of negative psychological state and work adjustment obstacle of nursing students during the internship.
		2021 Vol. 18 (22): 88-91 [Abstract] ( 87 ) HTML (1 KB) PDF (686 KB) ( 41 )

	92	Meta analysis of correlation between psoriasis and hypertension
		WANG Fang1 GUO Wen2 GONG Ke1 DU Kaiqing1 ZHANG Xianzhe1 GUO Jianhui2
		Objective To systematically evaluate the correlation between psoriasis and hypertension. Methods Relevant literatures about the correlation between psoriasis and hypertension published from inception to October 2020 were searched from CNKI, Wanfang Data, VIP, CBM, PubMed, Cochrane and Embase. Two investigators were independently responsible for screening literatures, extracting data and assessing the quality. The software version 16.0 of Stata was used for meta analysis. Results A total of 35 literatures were included. Meta-analysis results showed that the prevalence of hypertension in the psoriasis group was significantly higher than that in the control group, and the difference was statistically significant (OR = 1.75, 95%CI: 1.58-1.94, P ＜ 0.001). The prevalence of hypertension in mild (OR = 1.27, 95%CI: 1.24-1.30, P ＜ 0.001) and severe psoriasis group (OR = 1.54, 95%CI: 1.24-1.89, P ＜ 0.001) was higher than that in control group. Subgroup analysis according to published regions showed that the prevalence of hypertension in the psoriasis group was higher than that in the control group in all regions, with statistical significance (P ＜ 0.05). Conclusion Under the current data support, regardless of the severity of psoriasis, psoriasis is correlated with the prevalence of hypertension, suggesting that psoriasis may increase the risk of hypertension.
		2021 Vol. 18 (22): 92-96 [Abstract] ( 154 ) HTML (1 KB) PDF (1116 KB) ( 64 )

	97	Analysis on the influence factors of metabolically abnormal obesity
		TIAN Huixia1,2 HAN Huiwu1 ZHOU Shi2 CHEN Nengfeng2 SHEN Lu2
		Objective To explore the influencing factors of metabolic abnormality obesity. Methods A total of 563 outpatients and physical examination subjects in Xiangya Hospital of Central South University from March to December 2019 were selected as the research subjects by convenience sampling. According to whether they had metabolic abnormal obesity, they were divided into two groups, metabolic obesity group (59 cases) and non-metabolic obesity group (504 cases). The general information and the scores of diet and exercise self-efficacy of the two groups were collected, and the influencing factors of metabolic abnormality obesity were analyzed by multi-factorial logistics regression. Results The proportions of male, age ≥45 years old, junior high school education level or below, retired or unemployed, city of residence, abnormal waist-hip ratio in the metabolic abnormality obesity group were higher than those in the non-metabolic abnormality obesity group, and sports self-efficacy score was lower than that in the non-metabolic abnormality obesity group, with statistical significance (P ＜ 0.05). There was significant difference in body mass index between the two groups (P ＜ 0.05). In the multivariate logistic regression analysis, the results showed that male (OR ＞ 1, P ＜ 0.05) was an independent risk factor for metabolic abnormality obesity, while the high exercise self-efficacy score (OR ＜ 1, P ＜ 0.05) was a protective factor. Conclusion Health care workers should improve health literacy in various ways, with special attention to strengthening intervention in men and those with low sports self-efficacy scores.
		2021 Vol. 18 (22): 97-99,108 [Abstract] ( 89 ) HTML (1 KB) PDF (627 KB) ( 117 )

	100	Clinical effect of traditional Chinese medicine combined with antibiotics in the treatment of multiple myeloma complicated with pulmonary infection after chemotherapy
		CHU Nali1 LU Bingtong1 FAN Hong1 ZHANG Jingyu1 GUO Li2 ZHANG Hua2▲
		Objective To study the clinical effect of traditional Chinese medicine combined with antibiotics in the treatment of multiple myeloma (MM) patients complicated with pulmonary infection after chemotherapy. Methods A total of 80 patients with MM complicated with pulmonary infection who received chemotherapy in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province from October 2017 to October 2019 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with Cefazoxime antimicrobials, and the observation group was treated with Guilong Kechuaning Tablets on the basis of control group. The effective rate of treatment, time to improvement of clinical symptoms, the levels of respiratory indexes (dynamic lung compliance [CDyn], airway resistance [RAW], mean airway pressure [Pmean] and response frequency [Fres]) and inflammatory factors (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]) were compared between two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the time of fever, shortness of breath, cough and expectoration and wet rale-disappearing in the observation group was shorter than that in the control group, with statistical significance (P ＜ 0.05). Before treatment, there were no significant differences in respiratory indexes, IL-6 and TNF-α levels between the two groups (P ＞ 0.05). After treatment, CDyn levels in both groups were higher than those before treatment, and the observation group was higher than the control group, with statistical significance (P ＜ 0.05). The levels of RAW, Pmean, Fres, IL-6 and TNF-α in the observation group were lower than those in the control group, with statistical significance (P ＜ 0.05). Conclusion Guilong Kechuaning Tablets combined with Cefazoxime antimicrobials in the treatment of MM complicated with pulmonary infection after chemotherapy can effectively improve the duration of clinical symptoms and respiratory function indexes, reduce the expression level of serum inflammatory factors, and improve the clinical efficacy of patients.
		2021 Vol. 18 (22): 100-103,116 [Abstract] ( 115 ) HTML (1 KB) PDF (596 KB) ( 69 )

	104	Study on the correlation between symptom clusters and dialysis adequacy in continuous ambulatory peritoneal dialysis patients
		LU Haizhen1 HUANG Yanlin2 LI Haoyu1 WU Yiping2 YANG Zhen2 WANG Han2 CHEN Guowei2
		Objective To investigate the symptom cluster classification of continuous ambulatory peritoneal dialysis (CAPD) patients and to analyze the correlation between symptom clusters and dialysis adequacy. Methods A total of 180 CAPD patients in the Peritoneal Dialysis Center of the First Affiliated Hospital of Guangxi Medical University from October 2018 to December 2019 were selected by convenience sampling method. The general information questionnaire and dialysis symptom assessment scale were used for the investigation. Results Fatigue, dry mouth, dry skin, difficulty sleeping and pruritus were the top five symptoms in the incidence of symptoms in CAPD patients, while pruritus, difficulty sleeping, headache, lower limb edema and dry skin were the most serious symptoms in CAPD patients. Exploratory factor analysis was used to extract five symptom groups, which were water and electrolyte symptom group, psychological symptom group, energy symptom group, gastrointestinal symptom group, and skin symptom group. Pearson correlation analysis showed that water and electrolyte symptom group was positively correlated with parathyroidin (r = 0.157, P ＜ 0.05), and negatively correlated with 24 h ultrafiltration volume (r = -0.157, P ＜ 0.05). Psychological symptom group was positively correlated with blood urea nitrogen (r = 0.168, P ＜ 0.05). The energy symptom group was positively correlated with serum phosphorus and blood urea nitrogen (r = 0.190, 0.209, P ＜ 0.05 or P ＜ 0.01), and negatively correlated with serum albumin and 24 h urine volume (r = -0.158, -0.263, P ＜ 0.05 or P ＜ 0.01). Gastrointestinal symptom group was negatively correlated with 24 h urine volume and total creatinine clearance (r = -0.242, -0.244, P ＜ 0.01). The skin symptom group was positively correlated with serum phosphorus, blood urea nitrogen, serum creatinine, and parathyroid hormone (r = 0.256, 0.169, 0.222, 0.172, P ＜ 0.05 or P ＜ 0.01), and negatively correlated with 24 h urine volume and total creatinine clearance (r = -0.382, -0.275, P ＜ 0.01). Conclusion CAPD patients experience a variety of symptoms with a high degree of distress, and the symptoms constitute a group of symptoms. Symptom clusters are associated with dialysis adequacy.
		2021 Vol. 18 (22): 104-108 [Abstract] ( 44 ) HTML (1 KB) PDF (626 KB) ( 105 )

	109	Study of influence factors the prognosis of esophageal variceal sclerosis in patients with cirrhosis
		LIU Yuanzhi SUN Yanan LI Peng WU Yanjing WU Yongle ZENG Qinghuan ZHANG Shibin▲
		Objective To investigate the influence factors of survival prognosis in patients with cirrhosis undergoing sclerotherapy for esophageal varices (EVS). Methods Clinical data of 180 patients with cirrhosis complicated with esophageal varices who underwent EVS in Beijing YouAn Hospital, Capital Medical University from January 2016 to December 2017 were retrospectively analyzed, and the patients were divided into the death group (43 cases) and the survival group (137 cases) according to their three-year survival. The general data of the two groups were compared, and the multivariate Cox proportional risk model was used to analyze the influencing factors related to prognosis. Results There were statistically significant differences between the two groups in Child-Pugh grade of liver function, volume of abdominal water, portal trunk thrombosis, portal trunk diameter, albumin, total bilirubin and prothrombin activity (P ＜ 0.05). Multivariate Cox regression analysis showed that only Child-Pugh C grade in liver function was an independent risk factor for death (HR = 25.610, 95%CI:13.796-27.661, P < 0.001). Conclusion The severity of Child-Pugh grade of liver function is correlated with the survival prognosis of patients with cirrhosis after EVS, which has great clinical value in predicting the prognosis of patients.
		2021 Vol. 18 (22): 109-112 [Abstract] ( 58 ) HTML (1 KB) PDF (570 KB) ( 74 )

	113	Clinical effect of early ERCP combined with EST in the treatment of acute biliary pancreatitis with acute cholangitis
		HAN Su CHEN Xilan XU Mingyou YANG Xianfen
		Objective To study the clinical effect of early endoscopic retrograde cholangiopancreatography (ERCP) combined with endoscopic sphincterotomy (EST) in the treatment of acute biliary pancreatitis (ABP) with acute cholangitis. Methods A total of 90 patients with ABP complicated with acute cholangitis admitted to the Department of Hepatobiliary and Pancreatic Surgery, General Hospital of Anhui Wanbei Coal and Power Group, Anhui Province from June 2018 to June 2020 were selected as the research subjects. According to the random number table method, they were divided into study group and control group, with 45 patients in each group. The control group received conservative treatment, and the study group received early ERCP combined with EST on the basis of the control group. The levels of white blood cells (WBC), serum amylase (SAMY), total bilirubin (TBil), the recovery time of each index, the abdominal pain relief time, the length of postoperative hospital stay, the treatment cost and the incidence of complications were recorded before and 3 d after treatment in both groups. Results Before treatment, there were no significant differences in WBC, SAMY and TBil levels between the two groups (P ＞ 0.05). After treatment, WBC, SAMY and TBil levels in the two groups were lower than before treatment, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The recovery time of the levels of WBC, SAMY and TBil indexes in the study group was significantly shorter than that in the control group, with statistical significance (P ＜ 0.05). The abdominal pain relief time and the length of postoperative hospital stay in the study group were significantly shorter than those in the control group, but the treatment cost was significantly higher than that in the control group, with statistical significance (P ＜ 0.05). There was no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Early ERCP combined with EST has significant efficacy in the treatment of ABP with acute cholangitis, which can effectively shorten the treatment time. However, compared with the traditional conservative treatment, the treatment cost is relatively higher. Therefore, the appropriate treatment method can be selected according to the actual situation of patients.
		2021 Vol. 18 (22): 113-116 [Abstract] ( 44 ) HTML (1 KB) PDF (574 KB) ( 65 )

	117	Application of multimodal analgesia in early stage of elderly patients with artificial knee arthroplasty
		ZU Shufang1 XU Xiaodong1 TIAN Rui2
		Objective To explore the application effect of multimodal analgesia in early stage of elderly patients with artificial knee arthroplasty. Methods From January 2016 to April 2020, 80 elderly patients who underwent artificial knee arthroplasty in Hefei Third Clinical College, Anhui Medical University (the Third People’s Hospital of Hefei) were selected, and they were divided into routine group (40 cases, who were given patient-controlled intravenous analgesia [PCIA]) and study group (40 cases, who were given multimodal analgesia, that was PCIA + ultrasound-guided nerve block + physical analgesia). Postoperative dose of Celecoxib Capsules was compared between two groups. The resting pain scores (visual analogue scale [VAS]) were compared between two groups at 12, 24, 48, and 72 h after surgery. The changes levels of serum neurotransmitters and stress response were compared between two groups immediately after surgery, 24 h after surgery, and 72 h after surgery. Results The dose of Celecoxib Capsules in study group was lower than that in routine group, and the difference was statistically significant (P < 0.05). VAS scores were compared between two groups at each time point, and the differences were statistically significant (P < 0.05); and VAS score of study group was lower than that of routine group at each time point, and the differences were statistically significant (P < 0.05). There were significant differences in the levels of substance P, β-endorphin (β-EP), 5-hydroxytryptamine (5-HT), cortisol (Cor), C-reactive protein (CRP), and white blood cell count (WBC) at each time point between two groups (P < 0.05); and the levels of substance P, β-EP, 5-HT, Cor, CRP, and WBC in study group at 24 and 72 h after surgery were lower than those in routine group, and the differences were statistically significant (P < 0.05). Conclusion The application of multimodal analgesia in early stage of elderly patients with artificial knee arthroplasty can reduce severe pain attack, relieve postoperative pain, control neurotransmitter levels and stress response.
		2021 Vol. 18 (22): 117-120 [Abstract] ( 111 ) HTML (1 KB) PDF (432 KB) ( 55 )

	121	Sedative effect of different doses of Remazolam in patients with mechanical ventilation in ICU and its effect on hemodynamics
		YE Chongchong1 XIE Yongpeng2 LUO Jiye1 CHEN Xiaobing1 WANG Jing3 LU Siye1 WANG Yanli1▲
		Objective To observe the sedative effect of different doses of Remazolam in patients with mechanical ventilation in ICU and its effect on hemodynamics. Methods A total of 90 cases with mechanical ventilation in ICU of the First People’s Hospital of Lianyungang from August to December 2020 were selected. They were divided into study group 1, study group 2 and study group 3 according to the random number table method, with 30 cases in each group. Rimazolam was administered intravenously with 0.2, 0.3 and 0.4 mg/(kg·h), respectively. The sedative effect of three groups were compared. Changes in mean arterial pressure (MAP) and heart rate (HR) at before administration (T0), immediately after administration (T1), 1 h after administration (T2) and 6 h after administration (T3) of three groups were recorded. The incidence of adverse reactions in three groups was recorded. Results The target sedation time of study group 2 and study group 3 were shorter than those of study group 1, and the recovery time after drug withdrawal were longer than those of study group 1, and the differences were statistically significant (P < 0.05); the target sedation time of study group 3 was shorter than that of study group 2, and the recovery time after drug withdrawal was longer than that of study group 2, and the difference was statistically significant (P < 0.05). In three groups, MAP and HR at T2 were lower than those at T0 and T1, and MAP and HR at T3 were higher than those at T2, and the differences were statistically significant (P < 0.05). There was no statistically significant difference in MAP and HR of the same points among three groups (P > 0.05). The incidence of adverse reactions in study group 3 was higher than that in study group 1 and study group 2, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between study group 1 and study group 2 (P > 0.05). Conclusion The sedative effect of Remazolam in ICU patients with mechanical ventilation is satisfactory, and it has little effect on hemodynamics and good safety. The best dose is 0.3 mg/(kg·h).
		2021 Vol. 18 (22): 121-124 [Abstract] ( 94 ) HTML (1 KB) PDF (429 KB) ( 60 )

	125	Study on the law of acupoint selection of acupuncture and moxibustion in treating dysmenorrhea based on CNKI database
		GONG Chunrong
		Objective To explore the law of acupoint selection of acupuncture and moxibustion in treating dysmenorrhea, and to provide a reference for optimizing clinical treatment method. Methods Clinical research literatures of acupuncture and moxibustion in treating dysmenorrhea from January 2007 to January 2017 in CNKI database were searched. The database of included literature was established with excel 2007. The frequency analysis, association rule analysis, point pair analysis, cluster analysis and other data mining methods of Chinese medicine medical record knowledge service and sharing system (V1.2.8) were used to analyze acupoint meridian tropism, single acupoint selection and the law of acupoint selection of acupuncture and moxibustion in treating dysmenorrhea. Results A total of 301 acupuncture prescriptions were included, in which, there were 71 acupoints with a total frequency of 1210. Guānyuán was the acupoint with the highest frequency in acupoint selection (196 times, 65.12%). The combination with the highest confidential interval in association rule analysis was guānyuán-zúsānlǐ-sānyīnjiāo, and the combination with the highest support was sānyīnjiāo-guānyuán. The cluster analysis showed that there were two main groups. Total frequency of ren meridian, foot taiyin and spleen meridian was the most. The frequency of single acupoint application was the highest in shénquē. Conclusion Guānyuán-zúsānlǐ-sānyīnjiāo combination can be used for acupuncture and moxibustion in treating dysmenorrhea. It can be combined with other acupoints according to the symptoms in clinical practice. Shénquē is the most used single acupoint.
		2021 Vol. 18 (22): 125-128 [Abstract] ( 113 ) HTML (1 KB) PDF (808 KB) ( 72 )

	129	Historical evolution on alopecia of diagnosis and treatment with Chinese medicine
		WANG Aijuan1 HU Hui2 FENG Fang1 LUO Sha1 HOU Zongnan1 YANG Dingquan3
		The earliest written records of alopecia in Chinese medicine can be found in Huangdi Neijing period, developed in Han and Sui Dynasties, matured in Tang, Song, Jin and Yuan Dynasties, until Ming and Qing Dynasties clearly proposed the names of the diseases of alopecia areata and androgenetic alopecia that have been used until now. The evolution process from deficiency to fullness, until modern times, the formation of syndromes represented by liver and kidney deficiency, damp-heat fumigation, phlegm and blood stasis, blood-heat and wind-dryness are represented. Clinical treatment has been greatly developed in Tang and Song Dynasties, and dozens of prescriptions have appeared. Modern treatment is to use multiple methods, combine acupuncture and medicine, combined treatment and prevention, and take care of the whole and part. This article check carefully the opinion from famous Chinese medical scientists since the writing of Huangdi Neijing to modern times, clarifies the historical cognition, and summarizes the clinical law of Chinese medicine for the treatment of alopecia. It hopes to provide some ideas for the treatment of alopecia by Chinese medicine and provides some basis for modern research on classic prescriptions.
		2021 Vol. 18 (22): 129-132,136 [Abstract] ( 114 ) HTML (1 KB) PDF (781 KB) ( 190 )

	133	Professor Guo Jun’s clinical experience in treating idiopathic oligozoospermia with acupuncture and medicine
		DU Guanchao GUO Jun ZHAO Feng DENG Yingjun WANG Hao WANG Fu GUO Jun
		Idiopathic oligozoospermia is the main cause of male infertility, its clinical etiology is complex, lack of clear pathogenic factors, for this kind of patients, there is still a lack of specific treatment. Chinese medicine therapy has unique advantages in the treatment of this disease, individual cutting, flexible treatment, can not only improve semen quality, but also significantly improve the clinical pregnancy rate. According to the pathogenesis and characteristics of the disease, Professor Guo Jun believes that the treatment of the disease is located in the seminal chamber and kidney, which is closely related to the liver and spleen. The disease is characterized by deficiency and substantial evidence, and the treatment should strengthen the spleen and tonify the kidney, regulate qi, take self-made Linggui Prescription as the main prescription, and use medicine based on syndrome differentiation. In the treatment, acupuncture adopts the comprehensive therapy of acupuncture combined with the method of regulating tong and du to introduce qi to return to yuan, and cooperate with pick-up treatment, various methods cooperate to achieve the effect of reconciling yin and yang, producing essence and promoting education, and the clinical effect is remarkable.
		2021 Vol. 18 (22): 133-136 [Abstract] ( 162 ) HTML (1 KB) PDF (750 KB) ( 142 )

	137	Discussion on the dose effect relationship of Zingiberis Rhizoma Recens in Zhang Zhongjing’s classical prescription
		MA Yuan LIN Xueyu LI Jian CUI Miao ZHANG Wenfeng
		There are as many as 71 classical prescriptions containing Zingiberis Rhizoma Recens in Shanghan Lun and Jingui Yaolue. Zhang Zhongjing uses the medicine to compare the image, takes more Zingiberis Rhizoma Recens in the classical prescription compatibility for dilute the medicinal. Different dosage can play a different role in the classic prescription. This paper summarizes the different effects of Zingiberis Rhizoma Recens in different dosage levels from the four dosage levels of Zingiberis Rhizoma Recens used by Zhang Zhongjing: the dosage of Zingiberis Rhizoma Recens in Zhang Zhongjing’s classic prescription is more than eight liang, which is mainly used to dispel cold evil and aproll; four to six liang of Zingiberis Rhizoma Recens is mainly used to disperse evil qi and activate yin and yang; three liang of Zingiberis Rhizoma Recens is to help warm medicine xuanfa weiyang; two liang or less of Zingiberis Rhizoma Recens is the main source of pathogenic factors. By comparing the quantity and effect of Zingiberis Rhizoma Recens in Zhang Zhongjing’s classical prescriptions, we can explain the principle, method and medicine of Zhang Zhongjing’s classical prescriptions from the perspective of Zingiberis Rhizoma Recens.
		2021 Vol. 18 (22): 137-140,144 [Abstract] ( 78 ) HTML (1 KB) PDF (789 KB) ( 168 )

	141	Analysis on prescription rules of China Diabetes Prescription in the treatment of diabetic peripheral neuropathy based on data mining
		LIN Xiaoshi1 WANG Gaolei2 LU Bo2▲
		Objective To analyze medication rules of China Diabetes Prescription in the treatment of diabetic peripheral neuropathy based on traditional Chinese medicine inheritance system (V2.5). Methods The database of Chinese medicine for treating diabetic peripheral neuropathy was constructed. By using data mining methods, such as cluster analysis and association rule analysis, the frequency statistics, drug pairs, formula rules and new formula analysis of the database were studied. Results A total of 186 prescriptions for treating diabetic peripheral neuropathy were screened, involving 201 traditional Chinese medicines. Astragali Radix and Angelicae Sinensis Radix were the two most frequently used herbs. There were 20 core combinations and nine new prescriptions. The therapeutic drugs were warm in nature, with sweet, bitter and pungent taste, mainly belonging to liver, spleen, heart and kidney channels. Conclusion Based on the existing prescriptions, a systematic analysis of the law of traditional Chinese medicine in the treatment of diabetic peripheral neuropathy can provide a new reference for the treatment of Chinese medicine.
		2021 Vol. 18 (22): 141-144 [Abstract] ( 121 ) HTML (1 KB) PDF (829 KB) ( 72 )

	145	Feng Chonglian’s experience in the syndrome differentiation and treatment of non-alcoholic fatty liver disease
		NIE Zhaoyuan1 FENG Chonglian1 PAN Weiyu2 LIU Jia1 LIANG Weihao3 LUO Meiting1 LI Lingyun1
		With the improvement of people’s living standard and the change of dietary structure, the incidence of non-alcoholic fatty liver disease is increasing year by year, and Chinese medicine has unique advantages in the prevention and treatment of liver disease. This paper summarizes and analyzes the understanding of the etiology and pathogenesis of non-alcoholic fatty liver disease and the thought of syndrome differentiation and treatment of Feng Chonglian, a famous traditional Chinese medicine director in Guangdong Province, in order to provide clinical guidance for syndrome differentiation and treatment of traditional Chinese medicine. Feng Chonglian believes that the traditional Chinese medicine pathogenesis of the disease is mainly liver stagnation and spleen deficiency, phlegm and blood stasis. Clinical expert in the use of Lingnan authentic Chinese herbal medicine, and according to the different stages of the disease syndrome changes, the combination of symptoms, syndrome treatment, combine traditional Chinese and Western medicine. In addition, also pay attention to health education, diet care.
		2021 Vol. 18 (22): 145-148 [Abstract] ( 163 ) HTML (1 KB) PDF (757 KB) ( 92 )

	149	Effect of Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis and its influence on HSP70 expression level
		WANG Nan1 LI Yan2▲ GAO Xue1
		Objective To explore the effect of Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis and its influence on HSP70 expression level. Methods One hundred and twenty patients with chronic atrophic gastritis in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from April 2018 to April 2020 were selected and divided into conventional group and combined group according to random number table method, with 60 cases in each group. Conventional group was treated with Western medicine, and combined group was treated with Jianpi Huatan traditional Chinese medicine on the basis of conventional group. The overall clinical efficacy, the efficacy of gastric mucosal gland atrophy, traditional Chinese medicine syndrome score and the scanning peak area of HSP70 in gastric mucosa homogenate before and after treatment were compared between two groups. Results Total clinical effective rate of combined group was higher than that of conventional group, and the difference was statistically significant (P < 0.05). The effect of gastric mucosal gland atrophy in combined group was higher than that in conventional group, and the difference was statistically significant (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and combined group was lower than conventional group, and the differences were statistically significant (P < 0.05). After treatment, the scanning peak area of HSP70 in gastric mucosa homogenate of two groups was larger than that before treatment, and combined group was larger than that conventional group, and the differences were statistically significant (P < 0.05). Conclusion Jianpi Huatan traditional Chinese medicine intervention in the treatment of chronic atrophic gastritis can effectively improve the related clinical symptoms, promote the atrophy of gastric mucosal glands, and regulate the expression level of HSP70.
		2021 Vol. 18 (22): 149-152 [Abstract] ( 80 ) HTML (1 KB) PDF (792 KB) ( 89 )

	153	Discussion on pathogenesis and treatment of follicular dysplasia syndrome based on “collateral disease theory”
		ZHOU Qun1 LIU Qingyuan1 YANG Cuijuan2
		Follicular dysplasia syndrome belongs to the categories of “menstruation disease” “ amenorrhea” and “infertility” in traditional Chinese medicine. The main cause and pathogenesis of traditional Chinese medicine is kidney deficiency, liver stagnation and phlegm stasis block, according to “collateral disease theory”, its position is in the uterine and collateral, the basic pathogenesis is collateral deficiency and collateral stasis. The basic principle of treatment is to tonify the kidney and dredge the collaterals, mainly from three aspects: tonifying the kidney and filling the essence to nourish the cellular collaterals, regulating the liver qi to make the accumulation and diarrhea have a certain degree, resolving phlegm and removing blood stasis to make chong and ren reach. Three methods can choose one or more methods in different dialectics or different stages, so that the follicles can develop and discharge normally. In this paper, we will start from the pathogenesis, treatment principles and prescriptions, and elaborate the academic thought of “collateral disease theory” in the treatment of follicular dysplasia syndrome.
		2021 Vol. 18 (22): 153-155 [Abstract] ( 41 ) HTML (1 KB) PDF (744 KB) ( 65 )

	156	Diagnostic efficacy of fully digital molybdenum target X-ray, ultrasound and magnetic resonance imaging in elderly patients with breast tumors
		LIN Jiping TONG Taoran ZHAO Xiping HU Xianjin▲
		Objective To explore the diagnostic efficiency of fully digital mammography, ultrasound and magnetic resonance imaging in elderly patients with breast tumors. Methods The 101 elderly patients with breast tumors admitted to Tongling People’s Hospital in Anhui Province from January 2016 to September 2020 were selected as the research subjects. All patients received fully digital mammography, ultrasound and magnetic resonance imaging. The imaging data of all patients were retrospectively analyzed. Pathological results as the “gold standard” were used, and the diagnostic efficacy of the three diagnostic methods for malignant breast tumors were compared. Results A total of 101 elderly patients with breast tumors were diagnosed with 34 cases of malignant tumors by pathological examination. There were 28, 19, 26, and 33 malignant tumors detected by fully digital mammography, ultrasound, magnetic resonance imaging and combined diagnosis, respectively. The area under the curve (AUC) of different diagnostic methods for malignant breast tumors was combined diagnosis (0.960), fully digital mammography (0.795), ultrasound (0.669), and magnetic resonance imaging (0.640). The combined diagnosis of AUC was compared with fully digital mammography, ultrasound, and magnetic resonance imaging, and the differences were statistically significant (P ＜ 0.05). The sensitivity, specificity and accuracy of the combined diagnosis of the three were 97.06%, 89.55% and 92.08%, respectively, which were higher than those of various single tests. Conclusion Fully digital mammography and ultrasound can be used as the first choice for early screening of advanced breast cancer in clinical. For patients with suspicious screening results, the results of magnetic resonance imaging can be further clarified, thereby improving the accuracy of their diagnosis.
		2021 Vol. 18 (22): 156-158,163 [Abstract] ( 106 ) HTML (1 KB) PDF (581 KB) ( 69 )

	159	Impact of replacing business tax with value-added tax on financial management of public hospitals and countermeasures
		XU Lingqian1 DU Jun2 XU Yuanyuan1▲
		Replacing business tax with value-added tax is a new business of hospital management, in the tax burden change, business process, accounting treatment and other aspects have had a far-reaching impact. This paper mainly analyzes the tax burden and management status quo of public hospitals before and after the implementation of replacing the business tax with a value-added tax in three years by means of investigation and statistical analysis, summarize the impact of replacing the business tax with a value-added tax on hospitals, explore the corresponding tax planning strategy, it is suggested that public hospitals should start from financial accounting, process standardization, establishment of tax specialist post, standardization of contract management, and strengthening of quality training of financial personnel, comprehensively improve the ability of financial and tax planning, and help the hospital run smoothly and orderly economy.
		2021 Vol. 18 (22): 159-163 [Abstract] ( 99 ) HTML (1 KB) PDF (455 KB) ( 58 )

	164	Influence of psychological intervention based on personality characteristics on mental health and quality of life of patients with post-traumatic syndrome
		ZHU Beibei1 TAO Yuanyuan2▲ TONG Zirong1 YAO Zhijuan1 BAO Xiuxia1
		Objective To explore the application effect of psychological intervention based on personality characteristics in patients with post-traumatic syndrome. Methods A total of 110 patients with post-craniocerebral trauma syndrome admitted to the First Affiliated Hospital of Nanjing Medical University from October 2017 to April 2020 were selected and divided into experimental group and control group with 55 cases each according to the random number table method. Excluding the falling patients, 53 cases were actually included in the experimental group and 47 cases were actually included in the control group. The control group was given conventional therapeutic nursing and psychological intervention, and the experimental group was combined with psychological intervention based on personality characteristics. Follow-up for six months, mental health status, quality of life, and nursing satisfaction of two groups were compared. Results After six months of follow-up, the scores of somatization, depression, anxiety, phobia, psychosis and SCL-90 of the experimental group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05); the scores of SCL-90 items and total score in two groups were significantly lower than before the intervention, and the differences were statistically significant (P ＜ 0.05). The physical function, mental function score and overall health score of the experimental group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the quality of life scores of the two groups were significantly higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The nursing satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Psychological intervention based on personality characteristics can help improve the mental health of patients with post-traumatic syndrome, enhance the quality of life of patients, and increase psychological care satisfaction.
		2021 Vol. 18 (22): 164-167 [Abstract] ( 105 ) HTML (1 KB) PDF (672 KB) ( 94 )

	168	Effect of diversified nutrition education on the knowledge, belief, practice and glucose and lipid metabolism of elderly patients with metabolic syndrome
		ZHAO Xin1 ZHANG Rong2▲
		Objective To explore the effect of diversified nutrition education on the level of knowledge, belief, practice and glucose and lipid metabolism of elderly patients with metabolic syndrome. Methods A total of 148 elderly patients with metabolic syndrome admitted to the First Affiliated Hospital of Air Force Military Medical University were selected from July 2018 to December 2019, and they were divided into intervention group and control group, with 74 cases in each group according to the random number table method. The control group was given routine nursing intervention, and the intervention group was combined with diversified nutrition education. Followed up for six months, the two groups were compared with the health and nutrition knowledge, knowledge, behavior, total blood glucose load (GL) and the intake ratio of the three major nutrients, and the level of glucose and lipid metabolism. Results Follow-up for six months, the health and nutrition knowledge, attitude, and behavior scores of the two groups were significantly higher than those of the same group before the intervention, and the intervention group was higher than that of the control group, the differences were statistically significant (P ＜ 0.05). The total GL, carbohydrate, and fat of the two groups were lower than the same group before the intervention, and the intervention group was lower than that of the control group; the proportion of protein was higher than that of the intervention group of the same group, and the protein of the intervention group was higher than the control group, the differences were statistically significant (P ＜ 0.05). The fasting blood glucose, 2 h postprandial blood glucose, and triacylglycerol of the two groups were significantly lower than the same group before the intervention, and the intervention group was lower than that of the control group; the high-density lipoprotein cholesterol was higher than the same group before the intervention, and the intervention group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Diversified nutrition education helps to promote the ability of elderly patients with metabolic syndrome to develop knowledge, beliefs, and behaviors of healthy nutrition, and improve glucose and lipid metabolism indicators.
		2021 Vol. 18 (22): 168-171 [Abstract] ( 109 ) HTML (1 KB) PDF (635 KB) ( 28 )

	172	Application effect of health education based on the theory of reaching standards in patients with chronic kidney disease and hyperuricemia
		ZHUANG Jing TANG Jingfeng▲ SHI Zhenzhen
		Objective To explore the application effect of health education based on the theory of reaching standards in patients with chronic kidney disease (CKD) combined with hyperuricemia (HUA). Methods Ninety-three patients with CKD and HUA who were admitted to Huai’an First People’s Hospital from February 2018 to March 2020 were selected and divided into observation group 47 cases and control group 46 cases by random number table method. The control group was given regular health education, and the observation group jointly applied health education based on the theory of reaching standards. The control group was given regular health education, and the observation group jointly applied health education based on the theory of reaching standards. Follow-up for three months, disease uncertainty, the rate of achieving healthy life direction, and blood uric acid levels of two groups were compared. Results After three months of follow-up, the total scores of uncertainty, inconsistency, complexity, unpredictability and disease uncertainty in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); the disease ambiguity scores of the two groups were lower than those of the same group before education, and the differences were statistically significant (P ＜ 0.05). The healthy diet, suitable exercise, and weight control compliance rate of observing group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the rate of achieving healthy lifestyle standards between the two groups was higher than that before education in the same group, and the difference was statistically significant (P ＜ 0.05). The blood uric acid level of the observation group was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05); the blood uric acid level of the two groups was lower than the same group before education, and the difference was statistically significant (P ＜ 0.05). Conclusion Health education based on the theory of compliance can help alleviate the uncertainty of disease in patients with CKD and HUA, promote the development of a healthy lifestyle, and control the blood uric acid level.
		2021 Vol. 18 (22): 172-175,184 [Abstract] ( 120 ) HTML (1 KB) PDF (692 KB) ( 67 )

	176	Application of comprehensive swelling treatment with manual drainage in patients with upper limb lymphedema after breast cancer surgery
		ZHANG Huizhen ZHANG Lijuan ZHONG Qiaoling LUO Qinghua ZHANG Liping LI Yue TANG Hailin
		Objective To explore the application effect of manual drainage and comprehensive swelling treatment in the treatment of upper limb lymphedema after breast cancer surgery. Methods Fifty patients with modified radical mastectomy for breast cancer from January 2017 to January 2018 in the Lymphedema Clinic of Sun Yat-sen University Cancer Prevention and Treatment Center were selected as control group for routine care. From January 2019 to January 2020, a total of 50 patients with modified radical mastectomy for breast cancer were selected as observation group were given targeted skin care, and they were given manual drainage and comprehensive swelling treatment, including professional hand-held drainage of lymph, making full use of elastic bandages during compression bandaging, and urging patients to exercise the affected limbs. The lymphedema and the occurrence of axillary network syndrome were compared between the two groups. Results There was a statistically significant difference in the proportion of lymphedema between the two groups (P < 0.05). The incidence of axillary network syndrome in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Manipulative drainage and comprehensive swelling treatment can effectively treat upper limb lymphedema after modified radical mastectomy. It is non-invasive, painless, and has no side effects, and can reduce the occurrence of axillary network syndrome. It is worth recommending.
		2021 Vol. 18 (22): 176-179 [Abstract] ( 99 ) HTML (1 KB) PDF (787 KB) ( 92 )

	180	Influence of targeted nursing intervention on psychological state, disease uncertainty and family function of patients with systemic lupus erythematosus
		LI Liwen1 CAI Fulin2
		Objective To explore the effects of targeted nursing intervention on the psychological state, disease uncertainty and family function of patients with systemic lupus erythematosus. Methods A total of 84 patients with systemic lupus erythematosus who were hospitalized in the Department of Rheumatology and Immunology of the First Affiliated Hospital of Anhui University of Science and Technology from March 2018 to August 2020 were selected as the research subjects. By random number table method, they were divided into control group and observation group, with 42 cases in each group. The control group was treated with routine nursing, while the observation group was treated with targeted nursing intervention. After three months of nursing intervention, psychological state, disease uncertainty and family function were compared between the two groups. Results After intervention, anxiety and depression scores in both groups were decreased, and observation group was lower than control group (P ＜ 0.05). The score of disease uncertainty in both groups was lower than that before intervention, the score of disease uncertainty in observation group was lower than that in control group (P ＜ 0.05). The proportion of family dysfunction in observation group was lower than that in control group (P ＜ 0.05). Conclusion Targeting nursing intervention can effectively improve the psychological state of patients with systemic lupus erythematosus, reduce the sense of uncertainty about the disease, and improve their family function
		2021 Vol. 18 (22): 180-184 [Abstract] ( 85 ) HTML (1 KB) PDF (678 KB) ( 167 )

	185	Application of nursing intervention guided by evidence-based concept in enteral nutrition support for severe patients in neurosurgery
		CHEN Jinyuan1 WU Juan2▲ LI Na1 YUE Zhen1 ZHANG Shasha1
		Objective To explore the application effect of nursing intervention guided by evidence-based concept in enteral nutrition support for severe patients in neurosurgery. Methods A total of 136 severe neurosurgical patients admitted to the First Affiliated Hospital of Nanjing Medical University from January to October 2020 were selected. According to the treatment time, the patients were divided into the experimental group (from June to October 2020) 72 cases, and the control group (from January to May 2020) 64 cases. The control group was given routine parenteral and enteral nutrition support, and the experimental group was given enteral nutrition support under the guidance of evidence-based concept. After one and two weeks of intervention, the nutritional status, complications and prognosis of the two groups were compared. Results Comparison of serum albumin (ALB) and hemoglobin (Hb) contents between two groups, time point comparison and interaction, the differences were statistically significant (all P ＜ 0.05). Further pairwise comparison showed that the serum ALB and Hb contents of the two groups were significantly lower than before one and two weeks after the intervention, and after intervention for two weeks, serum ALB and Hb contents in two groups were significantly higher than those in the same group after intervention for one week (P ＜ 0.05). After one and two weeks of intervention, the contents of ALB and Hb in experimental group were significantly higher than those in control group (P ＜ 0.05). The gastrointestinal dysfunction in the experimental group was significantly lower than that in the control group (P ＜ 0.05). The prognosis of the experimental group was significantly better than that of the control group (P ＜ 0.05). Conclusion Enteral nutrition support guided by the evidence-based concept is helpful to correct the nutritional status of severe patients in neurosurgery, reduce complications and improve the prognosis of patients.
		2021 Vol. 18 (22): 185-188 [Abstract] ( 82 ) HTML (1 KB) PDF (637 KB) ( 111 )

	189	Application of comfortable nursing based on humanistic care concept in observing patients in anesthesia recovery room
		XU Xiaoyan1 WANG Shengfeng2 LI Qing1
		Objective To analyze the application effect of comfortable nursing based on the concept of humanistic care in observing patients in anesthesia recovery room. Methods From June 2016 to July 2019, 145 patients in Nantong Hospital of Traditional Chinese Medicine who underwent elective general anesthesia and entered the anesthesia recovery room for observation were divided into observation group of 73 cases and control group of 72 cases by random number table method. The control group was given routine nursing intervention, and the observation group was combined with comfort nursing based on humanistic care. The physiological function recovery, complications and patient satisfaction of the two groups were compared. Results Consciousness blood pressure, breathing and mobility scores of the two groups were higher than those of the same group when they entered the room (P ＜ 0.05). The consciousness, blood pressure, breathing and mobility scores of the observation group were higher than those of the control group (P ＜ 0.05). The incidence of complications in the observation group was lower than that of the control group (P ＜ 0.05); the observation group satisfaction was higher than that of the control group (P ＜ 0.05). Conclusion Comfortable nursing based on humanistic care can help to promote the recovery of physiological functions of patients in the anesthesia recovery room, reduce postoperative complications, and improve patient satisfaction.
		2021 Vol. 18 (22): 189-192 [Abstract] ( 82 ) HTML (1 KB) PDF (636 KB) ( 146 )

	193	Effect of diversified health education based on the all-media concept on the effect of respiratory function training for patients undergoing cardiac surgery
		SHI Na1 GAO Jiao2▲
		Objective To explore the effect of diversified health education based on the all-media concept on the effect of respiratory function training for patients undergoing cardiac surgery. Methods A total of 125 cases of elective cardiac surgery patients admitted to the First Affiliated Hospital of Air Force Military Medical University from May 2019 to August 2020 were selected. According to the random number table method, they were randomly divided into 64 cases in the treatment group and 61 cases in the control group. The control group was given regular health education, and the treatment group jointly applied diversified health education based on the omnimedia concept. The respiratory function training compliance behavior, lung function and complications of the two groups were compared. Results At discharge, the respiratory function training compliance behavior scores of the two groups were significantly higher than those of the same group at admission (P ＜ 0.05). The observation group’s respiratory function training, active seeking help, respiratory function training precautions, and respiratory function training compliance behavior total scores were significantly higher in the control group (P ＜ 0.05); at discharge, the forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and maximum expiratory volume per minute (MVV) in the two groups were significantly lower than those in the same group at admission (P ＜ 0.05). The FVC, FEV1, and MVV of the treatment group were significantly higher than those of the control group (P ＜ 0.05); the total incidence of complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion Diversified health education based on the concept of all-media is beneficial to improve the compliance behavior of respiratory function training in cardiac surgery patients, promote postoperative lung function recovery, and reduce the occurrence of complications such as atelectasis.
		2021 Vol. 18 (22): 193-196 [Abstract] ( 46 ) HTML (1 KB) PDF (637 KB) ( 57 )

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