Research progress in the pathogenesis of premature ovarian insufficiency based on oxygen sensing pathway
ZHU Yixuan1 DONG Xiaoying2
1.School of Stomatology, Capital Medical University, Beijing 100069, China;
2.School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
Abstract Premature ovarian insufficiency (POI) is a tough disease that causes decreased ovarian function in women and is closely related to follicular granulosa cell apoptosis. The oxygen sensing pathway in the human body is one of important signaling pathways. As the core element of the oxygen sensing pathway, hypoxia-inducible factor-1 (HIF-1) α participates in a series of signal cross-linking related to POI and mediates granulosa cell apoptosis together with other molecules and signaling pathway elements. Overexpressed HIF-1α upregulates the BNIP3 expression, which may induce granulosa cell apoptosis. Meanwhile, HIF-1α can enhance granulosa cell autophagy through activated PI3K/Akt/mTOR pathway. Autophagy and apoptosis of granulosa cells are interrelated. They can jointly inhibit the development of oocytes and follicles, promote follicular atresia and lead to POI. In this paper, mechanisms and signaling pathways of apoptosis and autophagy induced by HIF-1α in granulosa cells are investigated to explore the pathogenesis of POI based on oxggen sensing pathway, which is aimed to provide a new approach for the research and treatment of POI.
ZHU Yixuan1 DONG Xiaoying2. Research progress in the pathogenesis of premature ovarian insufficiency based on oxygen sensing pathway[J]. 中国医药导报, 2021, 18(22): 55-59.
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