持续性非卧床腹膜透析患者症状群与透析充分性的相关性研究

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Abstract Objective To investigate the symptom cluster classification of continuous ambulatory peritoneal dialysis (CAPD) patients and to analyze the correlation between symptom clusters and dialysis adequacy. Methods A total of 180 CAPD patients in the Peritoneal Dialysis Center of the First Affiliated Hospital of Guangxi Medical University from October 2018 to December 2019 were selected by convenience sampling method. The general information questionnaire and dialysis symptom assessment scale were used for the investigation. Results Fatigue, dry mouth, dry skin, difficulty sleeping and pruritus were the top five symptoms in the incidence of symptoms in CAPD patients, while pruritus, difficulty sleeping, headache, lower limb edema and dry skin were the most serious symptoms in CAPD patients. Exploratory factor analysis was used to extract five symptom groups, which were water and electrolyte symptom group, psychological symptom group, energy symptom group, gastrointestinal symptom group, and skin symptom group. Pearson correlation analysis showed that water and electrolyte symptom group was positively correlated with parathyroidin (r = 0.157, P ＜ 0.05), and negatively correlated with 24 h ultrafiltration volume (r = -0.157, P ＜ 0.05). Psychological symptom group was positively correlated with blood urea nitrogen (r = 0.168, P ＜ 0.05). The energy symptom group was positively correlated with serum phosphorus and blood urea nitrogen (r = 0.190, 0.209, P ＜ 0.05 or P ＜ 0.01), and negatively correlated with serum albumin and 24 h urine volume (r = -0.158, -0.263, P ＜ 0.05 or P ＜ 0.01). Gastrointestinal symptom group was negatively correlated with 24 h urine volume and total creatinine clearance (r = -0.242, -0.244, P ＜ 0.01). The skin symptom group was positively correlated with serum phosphorus, blood urea nitrogen, serum creatinine, and parathyroid hormone (r = 0.256, 0.169, 0.222, 0.172, P ＜ 0.05 or P ＜ 0.01), and negatively correlated with 24 h urine volume and total creatinine clearance (r = -0.382, -0.275, P ＜ 0.01). Conclusion CAPD patients experience a variety of symptoms with a high degree of distress, and the symptoms constitute a group of symptoms. Symptom clusters are associated with dialysis adequacy.

Key words： Continuous ambulatory peritoneal dialysis Symptom cluster Dialysis adequacy Correlation

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	LU Haizhen1 HUANG Yanlin2 LI Haoyu1 WU Yiping2 YANG Zhen2 WANG Han2 CHEN Guowei2

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LU Haizhen1 HUANG Yanlin2 LI Haoyu1 WU Yiping2 YANG Zhen2 WANG Han2 CHEN Guowei2. Study on the correlation between symptom clusters and dialysis adequacy in continuous ambulatory peritoneal dialysis patients[J]. 中国医药导报, 2021, 18(22): 104-108.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I22/104

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