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2021 Vol. 18, No. 20 Published: 2021-07-15

	4	Network pharmacological study on the mechanism of action of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma couplet medicines on the intervention of ulcerative colitis
		DAI Mingming1 LIAO Dan2 CHENG Weiling1 WANG Chunpeng1 LIN Caizhi3
		Objective To analyze the mechanism of action of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma couplet medicines on the intervention of ulcerative colitis (UC) based on network pharmacology. Methods The active components and target genes of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma were screened by traditional Chinese medicine systems pharmacology database and analysis platform and bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine. UC-related genes were obtained using GeneCards, a human gene database. Cytoscape software was used to build the “drug-active component-target-disease” network. Proteinprotein interaction network diagrams of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma couplet medicines on disease targets were constructed by String database. GO functional enrichment and KEGG pathway enrichment analysis of key target genes were performed using R language software. Results A total of 16 active ingredients were screened out. A total of 4209 UC-related genes were retrieved. A total of 31 common targets of couplet medicines and disease-related were screened out. The main core genes included E1A binding protein P300, tumor necrosis factor-α, mitogen-activated protein kinase 1 (MAPK1), etc. The main signaling pathways included phosphoinositol-3 kinase/protein kinase B, nuclear factor-κB, human T-cell leukemia virus type 1, MAPK, hypoxia-inducible factor-1, etc. Conclusion By building a “drug-active component-target-disease” network, from multiple components, multiple targets, multiple pathways to interpret mechanism of action of Atractylodis Macrocephalae Rhizoma and Atractylodis Rhizoma couplet medicines to intervene in the UC, provide the basis for subsequent research and reference.
		2021 Vol. 18 (20): 4-9 [Abstract] ( 107 ) HTML (1 KB) PDF (1963 KB) ( 199 )

	10	Visualization analysis of literature on traditional Chinese medicine treatment for chronic atrophic gastritis based on CiteSpace
		LIU Shan1 FAN Qiongyin2 LIU Xiaoyao1 HU Yujie1 ZHU Peixuan1 SU Zeqi2,3 WANG Ting2,3
		Objective To explore the development status, research hotspot, and development trend of traditional Chinese medicine for the treatment of chronic atrophic gastritis (CAG) based on CiteSpace. Methods Literatures on traditional Chinese medicine treatment of CAG collected from China national knowledge infrastructure from January 2000 to April 2020 were retrieved, and CiteSpace software was used to perform visual map analysis of institutions, authors and keywords in the included literatures. Results A total of 1056 articles were included, and the number of published papers showed an increasing trend. The research institutions were mainly concentrated in North, East and South China, including Nanjing University of Chinese Medicine, Guangxi University of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, etc. Inter-institutional cooperation was mainly between the university and its affiliated hospitals, with inter-regional and inter-institutional cooperation was relatively sparse. Wei Muxin, Yuan Hongxia, Yang Jinxiang, Xie Jingri, Lin Shouning were the key researchers, and their collaboration were mainly within the team. The research focuses on the analysis of the etiology and pathogenesis of CAG and prescription, the study of the evaluation of the clinical efficacy of traditional Chinese medicine in the treatment of CAG, and the study of the mechanism of clinical effective prescriptions. Conclusion Research on the treatment of CAG with traditional Chinese medicine has received more and more attention. The phenomenon of weak cooperation between different institutions and their teams needs to be strengthened. The efficacy evaluation methods and the mechanism of famous medicine and prescription in clinical research still need to be explored in depth. On this basis, finding clinically effective protocols for the treatment of CAG with traditional Chinese medicine is the major research hotspot and direction for the future.
		2021 Vol. 18 (20): 10-15,20 [Abstract] ( 165 ) HTML (1 KB) PDF (1678 KB) ( 58 )

	16	Expression and clinical significance of Spondin 2 in gastric cancer
		HUANG Bin1 WANG Liping1 LIN Zhenmeng2▲
		Obective To detect the expression of Spondin 2 (SPON2) in cell lines, tissues and serums of gastric cancer, and investigate its value in gastric cancer. Methods The expression of SPON2 protein in gastric cancer cell lines BGC-823, MGC-803, SGC-7901 and normal gastric mucosal cells GES-1 were detected. From January 2013 to September 2015, the expression of SPON2 in the paraffins of 120 gastric cancer and corresponding para-carcinoma tissues archived by the Department of Pathology No. 900 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army were detected. The expression levels of SPON2, carcinoembryonic antigen (CEA) and carbohydrate antigen19-9 (Ca19-9) in serums of 70 patients with gastric cancer, 60 patients with chronic atrophic gastritis and 60 healthy subjects were detected from May 2019 to September 2020. Results The expression level of SPON2 in all gastric cancer cell lines was higher than that in normal gastric mucosa cell GES-1 (P ＜ 0.05). The positive rate of SPON2 in gastric cancer tissues was higher than that in adjacent normal tissues (P ＜ 0.05). Multivariate survival analysis showed that SPON2 was an independent risk factor for prognosis of gastric cancer (OR = 0.712, 95%CI: 0.431-0.978, P ＜ 0.05). The relative expression of serum SPON2 in gastric cancer patients was higher than that in chronic atrophic gastritis patients and healthy subjects (P ＜ 0.05). The area under the curve of the combined detection of serum SPON2, CEA and Ca19-9 was significantly different from that of the single detection (P ＜ 0.05). Conclusion SPON2 protein may be involved in the occurrence and development of gastric cancer. Combined detection of serum SPON2, CEA and Ca19-9 is beneficial to improve the diagnosis of gastric cancer.
		2021 Vol. 18 (20): 16-20 [Abstract] ( 199 ) HTML (1 KB) PDF (778 KB) ( 110 )

	21	Establishment and verification of a nomogram model of the risk of hypertension among the Kazakh herders in the Nanshan pastoral area of Xinjiang Uygur Autonomous Region
		YOU Shuping1 YANG Fei1 TAO Ning2 ZHENG Yanling3 CHEN Qingjie4 XIANG Yang2 FAN Qiongling1 ZHAN Huaifeng5
		Objective To explore the risk factors of hypertension among Kazakh herders in Nanshan pastoral area of Xinjiang Uygur Autonomous Region, and to construct the corresponding nomogram model. Methods From November 2016 to November 2018, a multi-stage stratified random sampling method was used to select 5213 resident herdsmen ≥18 years old from the Nanshan pastoral area of Urumqi County to collect baseline data, questionnaire surveys, and physical examination results. According to the multivariate logistic regression analysis, the risk factors related to hypertension were selected and determined; R software was used to construct a nomogram for the risk prediction of hypertension. Results The age, pulse rate, waist-to-hip ratio, neck circumference, daily salt intake and pulse pressure difference in the hypertension group were higher than those in the normal blood pressure group (P ＜ 0.05). The proportion of hypertension group with family history of hypertension, overweight and obesity, milk tea overdose, dyslipidemia and diabetes were higher than those of the normal blood pressure group (P ＜ 0.05). Multivariate logistic regression analysis showed that age, overweight and obesity, family history of hypertension, dyslipidemia, neck circumference, pulse rate, pulse pressure difference, and daily salt intake were risk factors for hypertension in Kazakh herders (OR ＞ 1, P ＜ 0.05). Incorporate these factors into and construct a nomogram; the initial C-index of the nomogram model was 0.769 (95%CI: 0.862-0.954), while the C-index was 0.722 (95%CI: 0.656-0.788) after 1000 internal verifications using the repeated Bootstrap self-sampling method. Conclusion The nomogram constructed based on the risk factors of hypertension among the Kazakh herders has good accuracy and clinical application value. It has guiding significance for identifying the high-risk groups of hypertension among the Kazakh herders and formulating intervention countermeasures.
		2021 Vol. 18 (20): 21-24,33 [Abstract] ( 172 ) HTML (1 KB) PDF (804 KB) ( 98 )

	25	Effect of total flavonoids of fructus choerospondiatis on arsenic trioxide-induced cardiomyocyte injury
		YANG Xiuhua1 ZHI Hui1 AI Dan1 XIAO Yunfeng2▲
		Objective To study the effect of total flavnoids of fructus choerospondiatis (TFFC) on arsenic trioxide (ATO)-induced cardiomyocyte injury, and to explore its mechanism of action. Methods Cardiomyocytes were isolated and cultivated by neonatal rats and the morphology of cardiomyocytes at different time periods was observed under an inverted microscope. Cardiomyocyte injure models were use established by 6 μg/ml ATO, the experiment set up blank group, model group, and TFFC low, medium, and high concentration groups. The CCK-8 method was used to detect the survival rate of each group of cells, the activity of glutamic oxaloacetic transaminase (GOT)，creatine kinase (CK) and lactate dehydrogenase (LDH) in cell culture medium were determined by automatic bio-chemical instrument; the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in the cells were detected by kit method. The degree of apoptosis was observed by Hoechst 33342 fluorescence staining. Cell apoptosis rates were measured by flow cytomety. Results The cells cultured for 48 hours were basically all attached to the wall. Most of the cells stuck out the pseudopodia and were accompanied by spontaneous beating, which can meet the experimental requirements. The cell survival rate was reduced by 6 μg/ml ATO. Compared with the model group, the cell survival rate of each TFFC concentration group significantly increased, the vitality of LDH, CK, and GOT in the cell culture fluid was significantly reduced, the vitality of SOD, GSH-Px, and CAT in the cell were significantly increased, and the apoptosis rate was significantly reduced, and the differences were statistically significant (P ＜ 0.05). Conclusion TFFC can improve the state of ATO-induced myocardial injury, thereby protecting the myocardium damaged by ATO.
		2021 Vol. 18 (20): 25-29 [Abstract] ( 157 ) HTML (1 KB) PDF (1013 KB) ( 75 )

	30	Clinicopathological analysis of rare type of periocular basal cell carcinoma
		HOU Wenna1 CHEN Yang2 ZHAO Zhihui3 LU Yinglong3 NING Jian3
		Objective To investigate the clinicopathological features of a rare type of basal cell carcinoma around the eye. Methods Clinical and pathological data of 116 patients with periocular basal cell carcinoma were retrospectively analyzed in Tangshan Eye Hospital from January 2009 to June 2019. Results The pathological type of 116 patients was nodular basal cell carcinoma 64 cases (55.2%). Nodular mixed basal cell carcinoma with infiltration 18 cases (15.5%), squamous cell basal cell carcinoma 17 cases (14.7%), pigmented basal cell carcinoma 11 cases (9.5%), sclerosing type/pleomorphic basal cell carcinoma 6 cases (5.1%), the rare types of periocular basal cell carcinoma were squamous carcinoma, pigmented basal cell carcinoma and sclerosing/morphoeic basal cell carcinoma. Conclusion In the diagnosis of a rare type of basal cell carcinoma around the eye, attention should be paid to the differentiation between benign and malignant tumors with similar gross and histological morphology.
		2021 Vol. 18 (20): 30-33 [Abstract] ( 69 ) HTML (1 KB) PDF (905 KB) ( 83 )

	34	Research progress on the mechanism of acupuncture at nèiguān in the treatment of mental disorders based on functional magnetic resonance imaging
		LI Xiaoling1 NIE Shouping2 LI Ang3 LI Meng1 WANG Feng1 CAO Danna1,2 LIU Xiaohui2 CAI Li’na2
		Nèiguān is commonly used in the clinical treatment of mental disorders, with significant curative effect, but its neural mechanism is complex. In this paper, a review of recent studies on acupuncture of nèiguān based on functional magnetic resonance imaging (fMRI) technology found that the trend of activation of brain regions is different with different acupuncture methods at unilateral acupoints. Acupuncture on both sides of the acupoints, the changes of activated brain regions in different populations are closely related to their pathological states. Acupuncture at nèiguān and its acupoints can produce extensive activation of brain regions and overlap of specific functional brain networks, which may be the mechanism of acupuncture at nèiguān in the clinical treatment of mental disorders.
		2021 Vol. 18 (20): 34-37 [Abstract] ( 147 ) HTML (1 KB) PDF (482 KB) ( 113 )

	38	Research progress on quality of life assessment tools for lower limb lymphedema after gynecological malignant tumor surgery
		LIANG Feng1 CHEN Ying2 CHANG Xin3 HE Yingyu4 TAN Honghong4 YANG Qian1
		Lower limb lymphedema is one of the complications after lymph node dissection for gynecological malignant tumors. Once it occurs, it is difficult to cure and seriously affects the quality of life of patients. In recent years, researchers have considered quality of life as one of the prognostic factors of lower limb lymphedema, but there is no uniform standard for the use of assessment tools. Through extensive literature review, it is found that the commonly used assessment tools include the European organization for research and treatment of cancer quality of life questionnaire, the Mos 36-item short form health survey, lymphedema quality of life questionnaire, the functioning, disability and health questionnaire for lower limb lymphedema, and these tools have their own characteristics. In this paper, these tools are reviewed to provide references for finding appropriate assessment tools and further research.
		2021 Vol. 18 (20): 38-41 [Abstract] ( 137 ) HTML (1 KB) PDF (489 KB) ( 96 )

	42	Research progress of community integrated care models and needs assessment tools
		JIANG Qianqian SONG Jie WU Shulin XIAO Ping CHEN Ya’nan
		With the old and disabled population growth, the community care system is gradually getting more integrated rather than fragmented, and integrated care has become the general direction of the development of modern health service system. This article explains the types and characteristics of integrated care models in international communities, and introduces the content and application of common community integrated care needs assessment tools. It is proposed to build a people-centered integrated care model, develop an integrated care needs assessment tool suitable for national conditions, and build an integrated care information system for information sharing, aiming at providing a reference basis for developing the community integrated care models and needs assessment tools in China.
		2021 Vol. 18 (20): 42-45 [Abstract] ( 73 ) HTML (1 KB) PDF (484 KB) ( 108 )

	46	Correlation analysis of risk factors and coronary heart disease incidence in the cohort of Shanghai Pudong New Area
		KE Juzhong1 WU Kang1 LIU Xiaolin1 QIU Hua1 WANG Wenjing2 WANG Xiaonan1 YUAN Xiaonan1 LIN Tao1▲
		Objective To understand the incidence of coronary heart disease in Pudong New Area, and to explore the correlation between the level of coronary heart disease risk factors and the incidence. Methods Using a prospective cohort study method, a baseline survey of community residents over the age of 15 in Pudong New Area was conducted in 2013, and follow-up observations were conducted until December 31, 2016. The incidence of coronary heart disease during the follow-up period was recorded and correlation analysis with the level of risk factors was performanced. Results The median follow-up observation time of the cohort was 3.00 years. A total of 273 cases of coronary heart disease were followed up. The cumulative incidence of coronary heart disease was 3.96%, and the incidence density was 13.45 per thousand person-years. The incidence of coronary heart disease among people with old age, divorced or widowed, living in rural areas, sleep < 7 h, central obesity, and hypertension were significantly higher than those of the control population, and the differences were statistically significant (P ＜ 0.05). The levels of triacylglycerol, low-density lipoprotein, blood glucose, glycosylated hemoglobin, and C-reactive protein in patients with coronary heart disease were higher than those without coronary heart disease (P ＜ 0.05). Cox regression analysis showed that age ≥55 years, hypertension, sleep <7 h, and central obesity were the influencing factors of coronary heart disease (OR ＞ 1, P ＜ 0.05). Conclusion The prevention and control situation of coronary heart disease in Pudong New Area is severe. Interventions for hypertension, lack of sleep, and central obesity are the focus of coronary heart disease prevention.
		2021 Vol. 18 (20): 46-50 [Abstract] ( 95 ) HTML (1 KB) PDF (463 KB) ( 99 )

	51	Analysis of the influencing factors of occupational satisfaction of medical staff in affiliated hospital of university and their correlation with trade union recognition
		SUN Xin1 TAO Xudong2 LYU Chunmei1 ZHU Bin2 XU Longyu3 FU Fenghuan1 GUO Yue4 WANG Na1 YAO Longshan2
		Objective To discuss the influencing factors of the professional satisfaction of medical staff in affiliated hospitals of universities under the background of strengthening the party building of public hospitals and their correlation with the degree of union recognition. Methods In May 2020, a scale designed by the research team was used to survey 408 first-line medical staff in four affiliated hospitals of a university in Beijing to assess the factors that affect the professional satisfaction of medical staff and the correlation with the union recognition. Results There were statistically significant differences in the professional satisfaction of medical staff with different ages, working years, professional titles and welfare benefits (P ＜ 0.05). Working >1-5 years (OR = 2.730) and working >10-20 years (OR = 1.843), high professional titles (OR = 6.318), and satisfaction with welfare benefits (OR = 7.067) were risk factor of occupational satisfaction (P ＜ 0.05). The results of Spearman correlation analysis showed that occupational satisfaction was positively correlated with the recognition of the role of the trade union, the frequency of participation in trade union activities, and the awareness of rights protection (r ＞ 0, P ＜ 0.01). Conclusion The labor unions of affiliated hospitals of universities play an important role in improving the professional satisfaction of medical staff. The labor unions must actively accept the leadership of the party committee, actively perform their participation and construction functions, continuously improve their ability to perform their duties, build harmonious labor relations, and be the mothers of employees in the new era.
		2021 Vol. 18 (20): 51-54,58 [Abstract] ( 102 ) HTML (1 KB) PDF (686 KB) ( 62 )

	55	Risk factors for coronary artery calcification in patients with maintenance hemodialysis diabetic nephropathy
		SHAO Li’na LI Ye FAN Wei SONG Kai
		Objective To investigate the risk factors of coronary artery calcification (CAC) in patients with maintenance hemodialysis (MHD) diabetic nephropathy. Methods Clinical data of 91 patients with diabetic nephropathy who underwent MHD in Yixing People’s Hospital of Jiangsu Province from January to December 2018 were retrospectively analyzed. The clinical data of the patients were collected and they were divided into the no-CAC group (28 cases) and CAC group (63 cases) according to the coronary artery calcification score (CACs). The risk factors of CAC in patients with MHD diabetic nephropathy were analyzed. Results There were statistically significant differences in age, dialysis age, smoking history, serum calcium, intact parathyoid hormone (iPTH) and pruritus scores between the two groups (P < 0.05). Age >60 years old, smoking history, iPTH >302.71 pg/ml and pruritus score ≥4 points were risk factors for CAC in patients with MHD diabetic nephropathy (OR > 1, P < 0.05). Conclusion Age, smoking history, iPTH and pruritus score are independent risk factors for CAC in patients with MHD diabetic nephropathy. In the course of treatment, clinicians should pay attention to the identification of high-risk patients, early intervention, improve the clinical prognosis of patients, reduce the incidence of cardiovascular disease.
		2021 Vol. 18 (20): 55-58 [Abstract] ( 129 ) HTML (1 KB) PDF (394 KB) ( 114 )

	59	Analysis of the influencing factors of different degrees of depression associated with Parkinson disease
		JIANG Ying1 FENG Tao1,2,3 FANG Jinping4 WANG Xuemei1 MA Huizi1
		Objective To analyze the influencing factors of different degrees of depression associated with Parkinson disease. Methods A total of 322 patients with Parkinson disease who were admitted to the Department of Movement Disorders, Center of Neurology, Beijing Tiantan Hospital, Capital Medical University from May 2017 to December 2019 were selected. According to the Hamilton depressive scale score, the patients were divided into Parkinson disease group (130 cases), Parkinson disease mild depression group (136 cases), Parkinson disease moderate depression group (55 cases), and Parkinson disease major depression group (1 case). Since only one patient in Parkinson disease major depression group was enrolled, it was classified into Parkinson disease moderate depression group. The general clinical data of each group were compared, and the influencing factors of Parkinson disease associated with different degrees of depression were analyzed by logistic regression. Results There were no statistically significant differences among the three groups in age stratification (P ＞ 0.05), and there were statistically significant differences in disease course, unified Parkinson disease rating scale Ⅲ part score, mini-mental state examination, H-Y stage, gender, and onset form among the three groups (all P ＜ 0.05). Orderly logistic regression showed that long course of disease (OR = 1.067, 95%CI: 1.009-1.129) and high score of unified Parkinson disease rating scale Ⅲ part (OR = 1.051, 95%CI: 1.026-1.076) were independent risk factors for Parkinson disease associated with different degrees of depression (P ＜ 0.05). Conclusion Long course of disease and high score of unified Parkinson disease rating scale Ⅲ part are independent risk factors for Parkinson disease accompanied by different degrees of depression. Clinically, Parkinson disease depression patients should be screened and effectively intervened as soon as possible to improve patients’ motor symptoms and strengthen psychological communication.
		2021 Vol. 18 (20): 59-61,65 [Abstract] ( 152 ) HTML (1 KB) PDF (622 KB) ( 120 )

	62	Clinical effect of Shenmai Injection in the treatment of acute cerebral infarction
		ZHAO Zijun YANG Baolin YANG Junxing LYU Jingmin ZHANG Hua MA Dayong GAO Ying WEI Jingpei
		Objective To investigate the therapeutic effect of Shenmai Injection on acute cerebral infarction. Methods Retrospective analysis was performed on the clinical data of 122 patients with acute cerebral infarction who were treated in the first area of the Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine from June 2017 to June 2019. According to the treatment methods, the patients were divided into treatment group (66 cases) and control group (56 cases). Both groups were given conventional treatment such as antiplatelet, lipid-lowering, hypotensive, and glycemic control, while the treatment group was given intravenous infusion of Shenmai Injection on the basis of conventional treatment. The control group was given Danhong Injection intravenously, and both groups were treated for 14 days. National Institutes of health stroke scale (NIHSS) scores and the incidence of adverse events were compared between the two groups before and after 14 days of treatment. Results After 14 days of treatment, the NIHSS scores in both groups were lower than that before treatment, and the treatment group were lower than the control group, with statistical significance (P ＜ 0.05). There was no significant difference in unknown etiology (UE) subtype NIHSS scores between the two groups before and after treatment (P ＞ 0.05). After 14 days of treatment, NIHSS scores of cardioembolism (CS), large-artery atherosclerosis (LAA), penetrating artery disease (PAD) and other etiology (OE) subtypes in both groups were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05). The NIHSS score of LAA subtype in the treatment group was lower than that in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the NIHSS scores of CS, PAD, OE and UE subtypes between the two groups (P ＞ 0.05). No obvious adverse reactions were found in both groups during the treatment. Conclusion Shenmai Injection can effectively improve the degree of neurological impairment in patients with acute cerebral infarction, and its effect on LAA subtype cerebral infarction is obviously better than that of Danhong Injection, and its effect is similar to that of Danhong Injection in other subtypes.
		2021 Vol. 18 (20): 62-65 [Abstract] ( 85 ) HTML (1 KB) PDF (573 KB) ( 70 )

	66	Effect of Ezetimibe on patients with progressive stroke
		YANG Lan1 ZHAO Pingping2 ZHAO Jing1 WANG Juan1 WANG Xiaopeng1
		Objective To explore the effect of Ezetimibe on patients with progressive stroke. Methods A total of 423 patients with progressive stroke admitted to the Second Hospital of Hebei Medical University from January 2016 to December 2018 were selected as the research objects. They were divided into control (214 cases) and Ezetimibe group (209 cases) by random number table method. Control group was received basic treatment, and Ezetimibe group was received Ezetimibe treatment on the basis of control group and the course of treatment was 14 days. National institutes of health stroke scale (NIHSS) score, carotid plaque volume, interleukin-6 (IL-6), metallomatrix proteinase 9 (MMP-9), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triacylglycerol (TG), alanine aminotransferase (ALT) and total bilirubin (TBil) were compared between two groups before and after treatment. The self-care ability, home condition and death of two groups were compared after three months follow-up. Results Before treatment, there were no significant differences in NIHSS scores between two groups (P > 0.05). NIHSS scores in Ezetimibe group were lower than those in control group after treatment, and the differences were highly statistically significant (P < 0.01). There were no significant differences in self-care ability, home condition, and death rate between two groups after three months follow-up (P > 0.05). Before treatment, there were no significant differences in carotid plaque volume, IL-6, and MMP-9 levels between two groups (P > 0.05). After treatment, carotid plaque volume in two groups were smaller than those before treatment, and Ezetimibe group was smaller than control group, and the differences were statistically significant (P < 0.05). IL-6 and MMP-9 levels in two groups were lower than those before treatment, and Ezetimibe group was lower than control group, and the differences were statistically significant (P < 0.05). There were no significant differences in TG and HDL-C levels between two groups before and after treatment (P > 0.05). After treatment, the levels of TC and LDL-C in Ezetimibe group were lower than those before treatment, and Ezetimibe group was lower than control group, and the differences were statistically significant (P < 0.05). There were no significant differencea in ALT and TBil between two groups before and after treatment (P > 0.05). Conclusion Ezetimibe may be an effective drug for the treatment of progressive stroke.
		2021 Vol. 18 (20): 66-69,73 [Abstract] ( 146 ) HTML (1 KB) PDF (598 KB) ( 72 )

	70	Analysis of the status and influencing factors of postoperative quality of life in patients with intracranial aneurysm
		LU Jie1 LIU Suwei2 MAIMAITILI·Aisha1 CHEN Xiaohong1▲
		Objective To explore the status and influencing factors of postoperative quality of life in patients with intracranial aneurysm. Methods A total of 260 patients who underwent intracranial aneurysm operation in the First Affiliated Hospital of Xinjiang Medical University from January to September 2020 were selected by convenience sampling method. The general information questionnaire, the 36-item short-form health survey (SF-36) and the social support rating form were used to conduct the questionnaire survey. Univariate analysis and multiple linear regression were used to analyze the influencing factors. Results The SF-36 score of 260 patients undergoing intracranial aneurysm surgery was (356.14±72.83) points. Univariate analysis results showed that there were statistically significant differences in the total scores of SF-36 among patients with different genders, ages, educational levels, annual family income, the number of intracranial aneurysms, hypertension and hyperlipidemia (P ＜ 0.05). Multiple linear regression analysis showed that age, hypertension, educational level, annual family income, aneurysm number， and social support level were all important factors affecting the quality of life of patients with intracranial aneurysm (R2 = 0.375， F = 16.687, P ＜ 0.001). Conclusion The quality of life of patients undergoing intracranial aneurysm surgery is at a low level, and clinical medical personnel should formulate intervention measures to improve the prognosis according to the influencing factors of quality of life.
		2021 Vol. 18 (20): 70-73 [Abstract] ( 79 ) HTML (1 KB) PDF (603 KB) ( 71 )

	74	Effect of modified compulsory exercise therapy combined with individualized occupational therapy on limb disorders and cognitive function in patients with stroke and hemiplegia
		ZHENG Zhida1 LIU Ya2
		Objective To explore the effect of modified compulsory exercise therapy combined with individualized occupational therapy on limb disorders and cognitive function in patients with stroke and hemiplegia. Methods Eighty patients with stroke and hemiplegia admitted to the Affiliated Huai’an First Hospital of Nanjing Medical University were selected from July 2018 to January 2020 as research objects. They were divided into the control group and the combined treatment group according to the treatment method, with 40 cases in each group. The control group was received individualized occupational therapy for rehabilitation, and the combined treatment group was combined with modified compulsory exercise therapy for rehabilitation based on the control group. The motor function of the two groups of limbs (Fugl-Meyer assessment scale [FMA] and Carroll upper extremities functional test [UEFT]), quality of life (the MOS 36-item short from health survey [SF-36]), ability of daily living (Barthel index), neurological function (national institutes of health stroke scale [NIHSS]), cognitive function (Montreal cognitive assessment scale [MoCA]) were compared after three months of treatment. Results Before treatment, there were no significant differences in upper limb FMA score, lower limb FMA score, UEFT score, BI score, NIHSS score and MoCA score between the two groups (P > 0.05). After three months of treatment, upper limb FMA score, lower limb FMA score, UEFT score, BI score and MoCA score in two groups were higher than those before treatment, and the combined treatment group was higher than the control group; NIHSS score of two groups were lower than that before treatment, and the combined treatment group was lower than the control group, and the differences were statistically significant (P < 0.05). Before treatment, there was no significant difference in SF-36 score between the two groups (P > 0.05). After three months of treatment, SF-36 score in two groups were higher than those before treatment, and the combined treatment group was higher than the control group, and the differences were statistically significant (P < 0.05). Conclusion Modified compulsory exercise therapy combined with individualized occupational therapy can improve limb disorders, cognitive function and neurological function in patients with stroke and hemiplegia, and can also improve the quality of life and daily activity ability.
		2021 Vol. 18 (20): 74-77 [Abstract] ( 128 ) HTML (1 KB) PDF (570 KB) ( 33 )

	78	Effect of immediate effect of yin yang balance acupuncture therapy on upper limb motor dysfunction after stroke
		ZHOU Liang1 BAO Chunling1 SHI Cheng2 ZHOU Lifang1 JIAO Zhihua1 MA Shuang1 DONG Hongsheng3 DONG Guirong1
		Objective To observe the immediate effect of yin yang balance acupuncture therapy on upper limb motor dysfunction after stroke. Methods A total of 66 stroke patients with upper limb motor dysfunction admitted to the Department of Acupuncture, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine from December 2017 to December 2018 were enrolled as the research subjects. They were divided into the experimental group (33 cases) and the control group (33 cases) according to the random number table method. The experimental group was used the yin yang balance acupuncture therapy, and the treatment plan of the control group was the same as that of the experimental group, but the biomechanical feedback manipulation was not performed. The upper limb simplified Fugl-Meyer assessment scale (FMA) scores were compared before treatment, 10, 20 and 30 min after treatment. Results FMA scores in two groups at 10, 20 and 30 min after treatment were higher than those before treatment; FMA scores in the experimental group at 20 and 30 min after treatment were lower than those at 10 min after treatment, and the differences were statistically significant (P < 0.05). Before treatment, there was no significant difference in FMA score between the two groups (P > 0.05). FMA scores in the experimental group were higher than those in control group at 10, 20 and 30 min after treatment, and the differences were statistically significant (P < 0.05). Conclusion Yin yang balance acupuncture therapy can effectively improve the upper limb motor dysfunction of patients with upper limb paralysis, and the immediate effect is the best 10 min after treatment.
		2021 Vol. 18 (20): 78-81,95 [Abstract] ( 97 ) HTML (1 KB) PDF (881 KB) ( 119 )

	82	Effect of Penicillin combined with cephalosporin on neonatal pneumonia and its influence on intestinal microbial environment
		WANG Xiang1 WENG Xiaowen2 WANG Jun3▲
		Objective To explore the effect of Penicillin combined with cephalosporin on neonatal pneumonia and its influence on intestinal microbial environment. Methods A total of 100 cases of neonatal pneumonia in Affiliated Hospital of Xuzhou Medical University from January 2018 to December 2019 were selected as the research object. They were divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with Penicillin, and the observation group was treated with Penicillin combined with cephalosporin. After one week of treatment, the clinical efficacy, safety and serum white blood cell (WBC), procalcitonin (PCT) and C-reactive protein (CRP) levels were compared between the two groups. In addition, 50 healthy newborns born in Affiliated Hospital of Xuzhou Medical University during the same period were selected as the reference group to compare the changes of intestinal microbial environment among each group. Results Bifidobacterium and Lactobacillus in the observation group were lower than those in the reference group, while Enterobacter and Streptomyces digestive were higher than those in the reference group, and the differences were statistically significant (P < 0.05); there was no significant difference in the intestinal microflora content between the observation group and the control group (P > 0.05). There was no significant difference in the total effective rate between the two groups after treatment (P > 0.05). After treatment, the serum WBC, PCT, and CRP levels of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P < 0.05). There were no significant differences in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Both of two antibiotic regimens can reduce the level of serum inflammation in children with pneumonia, and the clinical efficacy and safety are similar, but the combined use of antibiotics can destroy the balance of intestinal microbial environment in children.
		2021 Vol. 18 (20): 82-85 [Abstract] ( 110 ) HTML (1 KB) PDF (350 KB) ( 68 )

	86	Analysis of relationship between clinical and pathological characteristics and efficacy and prognosis of neoadjuvant chemotherapy in locally advanced breast cancer
		AI Yongbiao HUANG Jun ZHANG Shuming LI Wenfang ZHANG Danfeng
		Objective To investigate the relationship between clinical and pathological characteristics and the efficacy and prognosis of neoadjuvant chemotherapy (NAC) in locally advanced breast cancer. Methods The clinical and pathological data of 181 breast cancer patients receiving NAC in Shiyan Taihe Hospital, Hubei Province from January 2012 to December 2015 were analyzed. According to the clinical effect, they were divided into clinically effective group (149 cases) and clinically ineffective group (32 cases), and then into pathologically effective group (70 cases) and pathologically ineffective group (111 cases) according to the pathological effect. Patients with different clinical effects and different pathological effects were compared for clinical disease management index data. Multivariate logistic regression was used to analyze the influencing factors of clinical and pathological outcomes of NAC. Survival curves were used to analyze the prognosis of patients with different molecular types and different hormone receptor status after NAC. Results The clinical response rate of 181 patients was 82.3%, and the clinical complete response rate was 20.4%. The pathologic response rate was 38.7%, and the pathologic complete response rate was 14.4%. There was statistically significant difference in molecular typing between the clinically effective group and the clinically ineffective group (P ＜ 0.05). The difference of molecular typing between pathologically effective group and pathologically ineffective group was statistically significant (P ＜ 0.05). The proportion of progesterone receptor (PR) negative in the clinically effective group was lower than that in the clinically ineffective group, the proportion of Ki-67 positive and the proportion of p53 negative were higher than that in the clinically ineffective group, the difference was statistically significant (P ＜ 0.05). The percentages of estrogen receptor (ER) negative, PR negative and Ki-67 positive in pathologically effective group were all higher than those in pathologically ineffective group, with statistical significance (P ＜ 0.05). Multivariate analysis showed that Ki-67 positive and p53 negative were clinically effective independent risk factors for NAC (OR ＞ 1, P ＜ 0.05), and PR negative and triple negative breast cancer (TNBC) were its protective factors for NAC (OR ＜ 1, P ＜ 0.05). Ki-67 positive was a pathologically effective independent risk factor (OR ＞ 1, P ＜ 0.05), while PR negative and TNBC were its protective factors for NAC (OR ＜ 1, P ＜ 0.05). Survival analysis showed that the overall survival time of patients with different molecular subtypes after NAC treatment was statistically significant (P ＜ 0.05). After NAC treatment, the overall survival time of patients with Luminal type was longer than that of patients with non-luminal type, and the difference was statistically significant (P ＜ 0.05). Conclusion There are many factors affecting the efficacy of NAC, and the prognosis of breast cancer varies with different molecular types.
		2021 Vol. 18 (20): 86-90 [Abstract] ( 158 ) HTML (1 KB) PDF (475 KB) ( 93 )

	91	Effect of preventive ileostomy in minimally invasive radical operation on clinical efficacy and anal function in patients with rectal cancer
		SHI Jie HUA Shuqing CHEN Yun LI Xin WANG Wei
		Objective To investigate the effect of preventive ileostomy in minimally invasive radical operation on clinical efficacy and anal function in patients with rectal cancer. Methods A total of 91 patients with rectal cancer who were diagnosed and treated in the People’s Hospital of Chizhou, Anhui Province from September 2017 to May 2020 were selected as the research subjects, and they were divided into observation group and control group according to the operative methods. The observation group (32 cases) received laparoscopic radical resection combined with ileostomy, while the control group (59 cases) received laparoscopic radical resection alone. Perioperative indexes, changes in gastrointestinal function, postoperative recovery, laboratory indexes, anal function score and complications were compared between the two groups. Results There were no significant differences in intestinal sound recovery time, exhaust time, starting feeding time, operation time, intraoperative blood loss, length of resected lesions and total amount of lymph node dissection between the two groups (P ＞ 0.05). The time of getting out of bed for the first time, the number of days of fluid rehydration after operation and the length of hospital stay in the observation group were shorter than those in the control group, with statistical significance (P ＜ 0.05). The levels of white blood cells and C-reactive protein 2 and 5 d after operation were higher than those before operation, and the levels of pre-albumin were lower than those before operation. The levels of white blood cells and C-reactive protein 5 d after operation were lower than those 2 d after operation, and the levels of pre-albumin were higher than those 2 d after operation, with statistical significance (P ＜ 0.05). The levels of white blood cells in observation group were higher than those in control group at the same time point, and the levels of C-reactive protein and pre-albumin in observation group were lower than those in control group at the same time point. The levels of white blood cells and C-reactive protein at 5 d after operation were lower than those in the control group at the same time point, and the levels of pre-albumin were higher than those in the control group at the same time point, with statistical significance (all P ＜ 0.05). The scores of anal function at 14 d, 3 and 6 months after operation in both groups were higher than those before operation; those at 3 and 6 months after operation were higher than those at 14 d, and those at 6 months after operation were higher than those at three months after operation, with statistical significance (all P ＜ 0.05). The scores of anal function in the observation group at 14 d and 6 months after operation were higher than those in the control group at the same time point, and the scores at 3 months after operation were lower than those in the control group at the same time point, with statistical significance (P ＜ 0.05). There was no significant difference in the total incidence of complication between the two groups (P ＞ 0.05). Conclusion In patients with rectal cancer, the preventive of ileostomy during minimally invasive radical operation is beneficial to improve the anal function of patients and promote the improvement of life quality.
		2021 Vol. 18 (20): 91-95 [Abstract] ( 130 ) HTML (1 KB) PDF (431 KB) ( 88 )

	96	Analysis on predictive modeling constructing of worse compliance in patients with TB / HIV coinfection
		YANG Jing1,2 XUE Miao1,2 JI Yulin2 CAO Xinyu1,2 ZHANG Huan1,2 FENG Ping2▲
		Objective To explore the influencing factors of treatment compliance in patients with TB/HIV coinfection, and to construct and verify the prediction nomogram of treatment compliance. Methods A total of 168 patients with TB /HIV coinfection admitted to West China Hospital of Sichuan University from May 2017 to May 2020 were selected as the study subjects. Seven patients were lost to follow-up. At the end of follow-up, Morisky medication compliance questionnaire was used to evaluate their compliance. According to their scores, they were divided into good compliance group (≥6 points, 86 cases) and poor compliance group (＜6 points, 75 cases). Clinical data of two groups were collected, univariate analysis and multivariate logistic regression were conducted to analyze the influencing factors of treatment compliance, and a nomogram model was established and verified. Results The rural household registration ratio, Hamilton depression scale (HAMD) score and Hamilton anxiety scale (HAMA) score in the poor compliance group were higher than those in the good compliance group, and the social support rating scale (SSRS) score was lower than that in the good compliance group, with statistical significance (all P ＜ 0.05). There were statistically significant differences in education level and monthly family income between the two groups (all P ＜ 0.05). The results of multivariate logistic regression analysis showed that education level of junior middle school or below, monthly family income ＜5000 yuan, rural household registration, high HAMD score and high HAMA score were independent risk factors for poor treatment compliance of patients with TB / HIV coinfection (all OR ＞ 1, P ＜ 0.05). High SSRS score (OR ＜ 1, P ＜ 0.05) was the protective factor. The consistency index of nomogram for predicting treatment compliance was 0.914 (95%CI: 0.856, 0.930). Conclusion The treatment compliance of patients with TB / HIV coinfection is related to education, family income, social support and other factors, and the nomogram can be a good auxiliary tool for predicting the treatment compliance of patients.
		2021 Vol. 18 (20): 96-99,107 [Abstract] ( 129 ) HTML (1 KB) PDF (658 KB) ( 82 )

	100	Correlation between oxidative stress factor levels and cognitive impairment in patients with schizophrenia
		SHEN Yuze1 YAN Ci2 GAO Bin3▲ SUN Min1
		Objective To investigate the relationship between oxidative stress factor levels and cognitive impairment in patients with schizophrenia. Methods A total of 50 patients with first onset and unmedicated schizophrenia who were admitted to the First People’s Hospital of Yuhang District of Hangzhou(“our hospital” for short) from March 2019 to November 2020 were selected as case groups. A total of 50 healthy people who were admitted to our hospital during the same period were selected as control group. The levels of malondialdehyde (MDA), glutathione (GSH), homocysteine (Hcy), and superoxide dismutase (SOD) were measured. The MACTICS consensus cognitive battery (MCCB) was used to assess cognitive impairment in both groups, and the relationship between the above oxidative stress factor levels and cognitive impairment in schizophrenia was analyzed. Results The case group was significantly lower than the control group in terms of information processing speed, attention / alertness, working memory, word learning, visual learning, reasoning and problem solving obility, and social cognition (P ＜ 0.05). The levels of SOD and GSH in the case group were significantly lower than those in the control group (P ＜ 0.05). The levels of Hcy and MAD in the case group were significantly higher than those in the control group (P ＜ 0.05). The levels of Hcy and MDA in patients with schizophrenia were negatively correlated with attention / alertness (P ＜ 0.05). There was no obvious correlation between the levels of other oxidative stress factors and cognitive impairment (P ＞ 0.05). Conclusion Patients with schizophrenia are in oxidative stress state, and their antioxidant capacity is significantly reduced. The levels of Hcy and MDA affect cognitive impairment in patients with schizophrenia.
		2021 Vol. 18 (20): 100-103 [Abstract] ( 114 ) HTML (1 KB) PDF (568 KB) ( 44 )

	104	Analysis of pathogenic bacteria and drug resistance in patients with agranulocytosis associated with infection
		YANG Xuefei WANG Dezhen ZHANG Jun YAN Kan ZHU Yi’nan
		Objective To analyze the distribution and drug resistance of pathogenic bacteria in agranulocytosis patients associated with infection. Methods The clinical data of 80 patients with agranulocytosis associated with infection admitted to Huaibei Miners General Hospital, Anhui Province from January 2016 to January 2019 were collected. According to the absolute number of neutrophils the patients were divided into three groups: group A, 24 cases with mild deficiency; group B, 34 cases with moderate deficiency; group C, 22 cases with severe deficiency. Clinical data and etiological data were analyzed, and the differences among each group were statistically analyzed. Results A total of 92 strains were identified, and the respiratory tract and blood sources accounted for 45.65% and 34.78%. Gram-negative bacteria were the most common pathogenic bacteria, with 57 strains, accounting for 61.96%. A total of 35 strains of Gram-positive bacteria, accounting for 38.04%. Among Gram-negative bacteria, Klebsiella pneumoniae, Escherichia coli and Sten-otrophomonas maltophila were common. Among the Gram-positive bacteria, Glucobacterium aureus and Enterococcus faecalis were common. In main Gram-negative bacteria, Klebsiella pneumoniae of Ampicillin, Piperacillin, Cefazolin, Cefuroxime, Sulfamethoxazole / Benzyl Methyl Oxygen organism, high percentages, Escherichia coli to Ampicillin, Piperacillin, Cefazolin, Gentamycin, Ciprofloxacin, Cefuroxime, Cefotaxime, Sulfamethoxazole / Benzyl Methyl Oxygen organism resistance rates were all ≥50%, three were Multiple drug resistance; no Escherichia coli resistant to Imipenem and Meropenem was found. Among the main Gram-positive bacteria, Staphylococcus aureus had high resistance to Penicillin and Gentamicin, and Enterococcus faecalis had high resistance to Levofloxacin, Moxifloxacin and Furantoin, with drug resistance rates ≥50%, and there were multiple drug resistance. Conclusion Gram-negative bacterial infections are the main infections associated with agranulocytosis. Pulmonary and bloodstream infections are the most common sites of infection. The distribution and drug resistance of pathogenic bacteria in different sites are different. Pathogenic bacteria have multiple drug resistance. The selection of antibiotics should consider various factors comprehensively, and then select the broad-spectrum antibiotics covering drug-resistant bacteria.
		2021 Vol. 18 (20): 104-107 [Abstract] ( 85 ) HTML (1 KB) PDF (566 KB) ( 39 )

	108	Correlation between coping style and self perceived burden in patients with moyamoya disease after revascularization
		ZHENG Jing ZHENG Xiaohong GAN Lifen▲
		Objective To analyze the relationship between coping style and self-perceived burden (SPB) in patients with moyamoya disease (MD) after revascularization. Methods A total of 60 cases of MD patients admitted to Changhai Hospital of Shanghai from January 2017 to January 2020 were prospectively included, all patients were received revascularization for treatment; the coping styles (assessed by simple coping style questionnaire [SCSQ]) and SPB (assessed by self perceived burden scale [SPBS]) of the patients were evaluated after operation; the relationship between SPB and coping style of MD patients was analyzed. Results The total score of SPBS score in 60 cases of MD patients after operation was 24.00 (20.00, 30.00) points, of which the scores of physical burden, economic burden and emotional burden were 14.00 (13.00, 15.00) points, 2.00 (2.00, 2.00) points and 8.50 (7.25, 9.00) points, respectively; the scores of negative coping and positive coping were 16.00 (14.00, 17.00) points and 15.00 (14.50, 16.00) points respectively in 60 cases of MD patients after operation; through the general bivariate Spearman correlation test analysis, the results showed that the negative coping score of MD patients was positively correlated with each dimension and total score of SPBS (r ＞ 0, P ＜ 0.05), positive coping was negatively correlated with each dimension and total score of SPBS (r ＜ 0, P ＜ 0.05). Conclusion The coping style of MD patients after revascularization is related to SPB, with the change from negative coping to positive coping, the degree of SPB in patients are gradually decreased, it is suggested that clinical intervention should be carried out from the aspect of coping style of patients, by leading the positive coping of patients, the degree of SPB in MD patients after revascularization can be reduced.
		2021 Vol. 18 (20): 108-111 [Abstract] ( 89 ) HTML (1 KB) PDF (573 KB) ( 38 )

	112	Regularity of traditional Chinese medicine in the treatment of cough variant asthma
		WU Qing1 MA Xiaomeng1 LUO Yinhe1▲ WANG Mengqing2▲
		Objective To explore the regularity of traditional Chinese medicine in the treatment of cough variant asthma. Methods With traditional Chinese medicine and cough variant asthma as the main topics, the literatures collected from CNKI since inception to June 2020 were searched. The prescriptions recorded in literature were collected and a database was established. Excel 2003 and SPSS Modeler 18.0 software were used to statistically analyze the frequency, nature and flavour, channel tropism, efficacy and correlation degree of the included traditional Chinese medicine. Results A total of 55 journal articles that met the standards were included, containing 103 traditional Chinese medicines, with a total frequency of 637 times. Among the 103 traditional Chinese medicines included, there were 20 kinds of traditional Chinese medicines with frequency ≥ten, and the drugs with the highest word frequency were liquorice root, ephedra, cicada slough, bitter apricot seed, stiff silkworm, etc. The proportion of drugs in the “four nature of drugs” from large to small was cold, warm, calm, cool, hot. The proportion of drugs in the “five flavours” from large to small is bitter, sweet, pungent, sour, salty, astringent and tasteless. The frequency of drug channelization was lung, spleen, stomach, liver, heart, etc. Reducing phlegm, relieving cough and relieving asthma drugs, tonifying deficiency drugs, heat-clearing drugs, relieving exterior disorder drugs, suppressing hyperactive liver for calming endogenous wind drugs were the most common in the efficacy classification. Apriori association rule results showed that there were 14 combinations of drug pairs with the highest association strength, and reducing phlegm, relieving cough and relieving asthma drugs were the main ones, and most of them were used in combination with tonifying deficiency drugs. Conclusion Freeing lung and relieving asthma, relieving cough and relieving asthma, dispelling pathogenic wind for resolving convulsion are the core therapeutic principles for clinical treatment of cough variant asthma.
		2021 Vol. 18 (20): 112-115 [Abstract] ( 74 ) HTML (1 KB) PDF (1060 KB) ( 109 )

	116	Discussion on “menstrual regulation focus on nourishing yin” by Professor He Fengjie based on natural period therapy
		WANG Haijing1 HE Fengjie1 ZHU Hongli1 LI Nan1 LI Xiaoning1 CHEN Mei1 BAI Jun1 PANG Yu2
		Professor He Fengjie more thinks that “closed and stop tendency menstrual disorder” is mainly pathogenesis characterized by yin deficiency, blood deficiency and fluid deficiency, and contains other symptoms. Clinical treatment should focus on nourishing yin and fluid and give consideration to other syndrome. In the treatment, it is advocated that menstrual regulation should be based on the natural period, and nourishing yin should be emphasized. Taking “nourishing blood and nourishing yin essence in the whole period, and seeking yang in the second half of the cycle to warm yang” as the method of clinical syndrome to add or subtract medication for conditioning, especially for stubborn and difficult “closed and stop tendency menstrual disorder”, such as retarded menstruation, hypomenorrhea, amenorrhea, infertility, etc, is particularly important. In this paper, a large number of literature and combined with clinical experience gain to further elaborate the theory.
		2021 Vol. 18 (20): 116-119,127 [Abstract] ( 79 ) HTML (1 KB) PDF (785 KB) ( 86 )

	120	Clinical experience of Professor Li Huashan in the treatment of ulcerative colitis
		ZHANG Guoxia LI Yufei WANG Xiaofeng LI Huashan▲
		This paper summarizes the clinical experience of my teacher, Professor Li Huashan, in the treatment of ulcerative colitis, and elaborates from three aspects of disease name, etiology and pathogenesis, and specific treatment experience. Professor Li Huashan believes that the name of the disease depends on its clinical manifestations. The pathogenesis of the disease is the root deficiency and manifestation excess. Root deficiency is deficiency of spleen and kidney and deficiency of vital qi. Manifestation excess is dampness-heat of large intestine and not smoothly of qi movement. The active period is mainly manifested as excess syndrome, while the remission period is mainly manifested as deficiency syndrome. The treatment should be combined with treatment based on syndrome differentiation and treatment based on stages, and both manifestation and root should be taken into account to removing stagnation and invigorating spleen. In addition, do not forget to regulate qi and blood, pay attention to regulate qi and channel block, promote blood circulation for removing blood stasis, balance the relationship between replenishing qi and regulating qi, promote blood circulation and hemostasis. Don’t forget the liver wood by soil, the active period of attention to sooth the liver and regulate spleen, regulate the mood, remission period to patients with psychological guidance, at the same time to guide patients to develop good eating habits and living habits, reduce recurrence.
		2021 Vol. 18 (20): 120-123 [Abstract] ( 305 ) HTML (1 KB) PDF (796 KB) ( 125 )

	124	Analysis of Chinese patent medicine for clearing heat, relieving cough and relieving asthma in Respiratory Outpatient
		LI Wenzhe WU Qian DONG Xuefeng MA Yuan XU Yitong WU Jiankun
		Objective To analyze the use of Chinese patent medicine for clearing heat, relieving cough and relieving asthma in Respiratory Outpatient of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University (“our hospital” for short), in order to promote clinical rational drug use. Methods The data related to the use of Chinese patent medicine for clearing heat, relieving cough and relieving asthma in Respiratory Outpatient from 2018 to 2020 were collected from the information center of our hospital. The utilizations of clearing heat, relieving cough and relieving asthma Chinese patent medicines were analyzed by drug variety, drug amount, drug frequency, defined daily cost and ranking ratio. Results Qingfei Pills, Jinhua Qinggan Granules and Compound Xianzhuli Juice were the top three Chinese patent medicines in our hospital, the frequency of drug use was 53 855, 33 004 and 30 432 respectively, and the average daily cost was 3.52, 26.54 and 7.21 yuan respectively. Conclusion Qingfei Pills, Jinhua Qinggan Granules and Compound Xianzhuli Juice are the most widely used Chinese patent medicine for clearing heat, relieving cough and relieving asthma in our hospital. It has definite clinical effect and is worthy of clinical promotion.
		2021 Vol. 18 (20): 124-127 [Abstract] ( 64 ) HTML (1 KB) PDF (758 KB) ( 115 )

	128	Experience of Professor Xu Hefen in the treatment of advanced gastric cancer
		MA Jiheng1 HUO Jiege2 HU Canhong2 XU Hefen2
		Advanced gastric cancer is a difficult point in clinical diagnosis and treatment. Based on the summary and analysis of Professor Xu Hefen’s clinical experience in the treatment of advanced gastric cancer, this paper holds that advanced gastric cancer belongs to the deficiency of origin and the excess of sign, the deficiency of both qi and yin is the main cause, and the cancer toxin is the sign. It damages qi and yin and has the characteristics of multiple blood stasis and stagnation. The treatment includes invigorating the spleen and kidney, supplementing qi and yin, strengthening the body and strengthening the foundation, clearing away cancer toxin, removing blood stasis and removing stagnation. The combination of Chinese and Western medicine and the treatment of both body and mind can turn decay into magic.
		2021 Vol. 18 (20): 128-131 [Abstract] ( 346 ) HTML (1 KB) PDF (761 KB) ( 159 )

	132	Analysis of Professor Shen Shuwen’s academic experience in the application of opposite and complementary thinking
		YE Zhengrong1 WU Lin2 SHEN Shuwen1
		The opposite and complementary relationship between the two aspects of the unity of opposites determines the growth, change and extinction of things. In the diagnosis and treatment of diseases, maintaining the unity of opposites within the body has a very important value and position. This paper summarizes Professor Shen Shuwen’s academic experience on the maintenance of the relationship of unity of opposites, the application of opposite and complementary thinking in the interpretation of Chinese medicine related theories, the understanding of pathogenesis and treatment, and the application of prescription and medicine compatibility.
		2021 Vol. 18 (20): 132-134,139 [Abstract] ( 102 ) HTML (1 KB) PDF (777 KB) ( 109 )

	135	Meta analysis of fire acupuncture in treating gouty arthritis
		LI Xiaoyu GAO Yu YUAN Shasha ZHANG Shujun
		Objective To evaluate the effect of fire acupuncture in treating gouty arthritis. Methods Randomized controlled trials of gouty arthritis treated with fire acupuncture in databases of CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library and EMbase from January 2010 to June 2020 were searched. The key words were “gouty arthritis” and “fire needle or burnt needle” and “randomized controlled trials”. The quality of the selected literature was evaluated and the data extraction table was designed. Finally, RevMan 5.3 software was used to analyze the literature. Results A total of 137 articles were retrieved and nine randomized controlled trials were selected. Meta analysis results showed that clinical effective rate (OR = 3.67, 95%CI: 2.08 to 6.45, P < 0.000 01) of experimental group was higher than that of control group, and visual analogue scale score (SMD = -1.23, 95%CI: -1.62 to -0.83, P < 0.000 01) and serum uric acid level (SMD = -0.57, 95%CI: -1.05 to -0.09, P = 0.02) of experimental group were lower than those of control group. Conclusion From the existing research reports at home and abroad, the effect of fire acupuncture in the treatment of gouty arthritis is acceptable, and it is worthy of clinical promotion.
		2021 Vol. 18 (20): 135-139 [Abstract] ( 328 ) HTML (1 KB) PDF (1528 KB) ( 99 )

	140	Explanation of yin and yang theory in intervertebral disc degeneration and its clinical significance
		SUN Daoxi1 WANG Nan2 XIE Lin1
		Intervertebral disc degeneration is a complex process. At present, it is considered that the dynamic balance of catabolism and anabolism in the intervertebral disc environment is broken by many factors, which eventually leads to the apoptosis of nucleus pulposus cells. This complicated process coincides with the view of disease caused by “imbalance of yin and yang” in the theory of yin and yang. In the process of intervertebral disc degeneration, dynamic state, decreased blood vessels, increased osteoclasts, inflammatory factors, catabolism and apoptosis belong to yang, while static state, vascular proliferation, inflammatory factor inhibitory enzyme, anabolism and cell growth belong to yin. The explanation of yin and yang theory of intervertebral disc degeneration can develop the micro syndrome differentiation theory of traditional Chinese medicine, guiding clinical medication and functional exercise. Modern research guides the exploration of the mechanism of multi-target balance and the consideration of various factors of disease. This paper analyzes the mechanism of intervertebral disc degeneration from the theory of yin and yang, and constructs a bridge between the theory of traditional Chinese medicine and microstructure, which provides a new idea for the diagnosis and treatment of intervertebral disc degeneration.
		2021 Vol. 18 (20): 140-143,163 [Abstract] ( 73 ) HTML (1 KB) PDF (1179 KB) ( 135 )

	144	Effect of Yiqi Quyu Tongluo Decoction in the adjuvant treatment of neurotoxicity induced by Oxaliplatin chemotherapy in patients with qi deficiency and blood stasis syndrome and its influence on peripheral nerve injury
		FANG Jinshu ZHU Baolong▲ ZHAI Pingping
		Objective To investigate the effect of Yiqi Quyu Tongluo Decoction in the adjuvant treatment of neurotoxi-city induced by Oxaliplatin chemotherapy in patients with qi deficiency and blood stasis syndrome and its influence on peripheral nerve injury. Methods Sixty patients with neurotoxicity induced by Oxaliplatin chemotherapy in Taizhou Hospital of Traditional Chinese Medicine from January 2015 to December 2019 were selected and divided into two groups according to random number table method, with 30 cases in each group. Observation group was treated with Yiqi Quyu Tongluo Decoction, and control group was treated with Mecobalamin. Both groups were treated for 15 days. The grade of peripheral neurotoxicity, efficacy of traditional Chinese medicine syndrome, Karnofsky performance score (KPS), hemoglobin and adverse reactions were compared between two groups. Results After treatment, the peripheral neurotoxicity grades of two groups were better than those before treatment, and observation group was better than control group, the difference was statistically significant (P < 0.05). Total effective rate of traditional Chinese medicine syndrome in observation group was higher than that in control group (P < 0.05). There were no significant differences in KPS and hemoglobin level on comparison within and between groups before and after treatment (P > 0.05). During the treatment, routine examination of blood, urine and stool, electrocardiogram, liver and kidney function were normal in both groups, and no serious adverse reactions and adverse events occurred in both groups. Conclusion Yiqi Quyu Tongluo Decoction can effectively improve the severity of peripheral neurotoxicity induced by Oxaliplatin chemotherapy, improve the therapeutic effect, and has high drug safety, which is worthy of clinical promotion.
		2021 Vol. 18 (20): 144-147 [Abstract] ( 42 ) HTML (1 KB) PDF (760 KB) ( 56 )

	148	Effects of visual health education on rehabilitation self-efficacy and rehabilitation training behavior in patients after total knee arthroplasty
		GUO Ying1 HUANG Yanhong1 LI Li1 WANG Niu2 LI Fu3
		Objective To investigate the effects of visual health education on rehabilitation self-efficacy and rehabilitation training behavior in patients with total knee arthroplasty (TKA). Methods A total of 145 patients undergoing TKA admitted to Huaibei People’s Hospital from January 2017 to December 2019 were selected and they were divided into control group ( January 2017 to June 2018) 71 cases and observation group (July 2018 to December 2019) 74 cases according to the time of admission. The control group was given regular health education, and the observation group was combined with visual health education. Follow up for six months, the rehabilitation self-efficacy, rehabilitation training behavior, and functional independence of the two groups were compared. Results After six months of follow-up, there were four cases of abscission in the control group and three cases in the observation group. The self-efficacy scores of the two groups were significantly higher than those of the same group before intervention, and the difference was statistically significant (P ＜ 0.05). The exercise self-efficacy, coping self-efficacy, and rehabilitation self-efficacy scale total scores of the observation group were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05), the rehabilitation training behavior scores of the two groups were higher than those of the same group before the intervention, and the differences were statistically significant (P ＜ 0.05). The observation group’s rehabilitation training action accuracy and exercise intensity scores were significant higher than the control group, the rehabilitation training time was significantly longer than the control group, the differences were statistically significant (P ＜ 0.05); the functional independence score of the two groups was significantly higher than the same group before the intervention, the difference was statistically significant (P ＜ 0.05), the scores of self-care ability, sphincter control, transfer, and walking of the observation group were significantly higher than those of the control group, and the difference were statistically significant (P ＜ 0.05). Conclusion Visual health education can promote the development of self-efficacy in rehabilitation training for patients after TKA, standardize rehabilitation behavior, improve patient functional independence.
		2021 Vol. 18 (20): 148-151 [Abstract] ( 77 ) HTML (1 KB) PDF (655 KB) ( 89 )

	152	Effects of standardized path health education on oral health behavior and quality of life in patients with chronic periodontal disease
		WANG Jieru YUE Ping YAN Chunling▲
		Objective To explore the application effect of standardized path health education in patients with chronic periodontal disease. Methods A total of 100 patients with chronic periodontal disease admitted to the Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University from January 2018 to June 2019 were selected. According to random number table method, they were divided into observation group 50 cases and control group 50 cases. The control group received routine health education, while the observation group received standardized path health education. The oral health behaviors and oral health quality of life were compared between the two groups after six months follow-up. Results After six months of follow-up, there were two cases of abscission in the observation group and four cases in the control group, the compliance rate of oral health behavior in the two groups was higher than that before education (P ＜ 0.05). The standard reaching rates of adopted the vertical brush with appropriate strength, used dental floss or irrigator, and regular tooth cleaning of obersvation group were higher than those of the control group (P ＜ 0.05); the scores of oral health quality of life in two groups were lower than those before education (P ＜ 0.05), the scores of functional limitation, ability limitation, physical and mental deficiency, and the total scores of Chinese version of oral health impact profile scale in the observation group were lower than those in the control group (P ＜ 0.05). Conclusion Standardized path health education can provide clear path guidance for patients with chronic periodontal disease, promote the formation of oral health care behaviors, and improve the oral life quality of patients.
		2021 Vol. 18 (20): 152-155 [Abstract] ( 82 ) HTML (1 KB) PDF (614 KB) ( 28 )

	156	Application effect of WeChat-led follow-up management in patients with epilepsy after craniocerebral surgery
		ZHANG Sujuan ZHANG Chaochao JIN Sushuang
		Objective To explore the effect of WeChat-led follow-up management on self-care ability and quality of life of patients with epilepsy after craniocerebral surgery. Methods A total of 92 patients with epilepsy after craniocerebral surgery admitted to the Affiliated Kangning Hospital of Wenzhou Medical University from January 2017 to December 2017 were selected, they were divided into treatment group and control group according to random number table method, with 46 cases in each group. The control group was given regular guidance and follow-up, and the treatment group combined with follow-up management based on WeChat, the self-care ability, poor prognosis and quality of life were compared between the two groups follow up for six months. Results The treatment group included 45 cases, and the control group actually included 41 cases. Follow-up for six months, the self-care ability scores of the two groups were significantly higher than those of the same group at discharge (P ＜ 0.05). The health knowledge level, self-concept, self-responsibility, and self-care skills scores of the treatment group were significantly higher than those of the control group (P ＜ 0.05), there was no statistically significant difference in the poor prognosis between the two groups (P ＞ 0.05), the quality of life scores of the two groups were significantly higher than those of the same group before discharge (P ＜ 0.05), the worrying about seizures, emotional health, cognitive function, and life satisfaction scores of the treatment group were significantly higher than those of the control group (P ＜ 0.05). Conclusion Follow-up management based on WeChat is helpful to promote the development of self-care ability of patients with epilepsy after craniocerebral surgery and improve the quality of life.
		2021 Vol. 18 (20): 156-159 [Abstract] ( 87 ) HTML (1 KB) PDF (615 KB) ( 101 )

	160	Evaluation of effect of empowering health education model applied to patients after knee replacement
		LI Junying YUAN Li RUAN Shumin CUI Ya’nan
		Objective To explore the effect of empowering health education model on knee replacement patients’ compliance with rehabilitation training and knee joint function. Methods A total of 86 patients undergoing knee replacement surgery admitted to Zibo Municipal Hospital, Shandong Province from January to December 2019 were selected. According to the random number table method, they were divided into treatment group and control group, with 43 cases in each group. The control group was given routine care during the perioperative period of knee replacement, and the treatment group was given health education on the basis of control group. Follow-up to 12 weeks after operation, the compliance of the two groups with rehabilitation training was observed, and the hospital for special surgery knee score (HSS) was used to evaluate the knee joint function of the two groups. Results At the time of 12 weeks, after the surgery the treatment group’s compliance rate of rehabilitation exercise was significantly higher than that of the control group (P ＜ 0.05); the HSS scores of the two groups were significantly higher than those of this group before the operation (P ＜ 0.05); the joint pain, function, muscle strength, joint stability score and total HSS score of the treatment group were significantly higher than those of the control group (P ＜ 0.05). Conclusion The empowering health education model is helpful to improve the compliance of patients with knee replacement to rehabilitation training and further improve knee joint function, which is of great significance for improving the prognosis.
		2021 Vol. 18 (20): 160-163 [Abstract] ( 89 ) HTML (1 KB) PDF (654 KB) ( 60 )

	164	Application effect of cognitive behavioral intervention based on health managers in the high-risk groups of stroke
		LAN Yan FAN Jianni ZHU Lehu▲
		Objective To explore the impact of cognitive behavioral intervention based on health managers-led on the cognitive level of stroke prevention knowledge and health behaviors of people at high-risk groups of stroke. Methods A total of 124 high-risk groups of stroke patients admitted to the 987th Hospital of the Joint Service Support Unit of the Chinese People’s Liberation Army from September 2019 to March 2020 were selected and divided into an intervention group and a control group with 62 cases each by random number table method. The control group was given regular health education, and the observation group was given cognitive behavioral intervention based on health managers. Follow-up for six months, the cognitive level of stroke prevention knowledge, health behavior, blood pressure level of two groups were compared. Results After six months of follow-up, the scores of the cognitive level of stroke prevention knowledge in the two groups were higher than those before the intervention, and the intervention group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Follow-up for six months, the health behavior scores of the two groups were higher than those before the intervention (P ＜ 0.05), and the interpersonal relationship, nutrition, personal goals, health responsibility, and exercise scores of the intervention group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Follow-up for six months, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose (Glu) and triacylglycerol (TG) of the observation group were lower than before the intervention, the BMI, SBP, Glu, and TG of the control group were lower than those before the intervention, the BMI, SBP, and Glu of the intervention group were significantly lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Cognitive behavior intervention led by health managers can help raise the knowledge level of stroke prevention and treatment in high-risk populations, improve healthy behaviors, and control risk factors for stroke.
		2021 Vol. 18 (20): 164-167 [Abstract] ( 155 ) HTML (1 KB) PDF (616 KB) ( 121 )

	168	Analysis of the current status and influencing factors of the psychological distress of patients with cervical cancer
		HUANG Ling WANG Yan WANG Hongwei CHEN Yan’e
		Objective To understand the current status of the psychological distress of patients with advanced cervical cancer and to analyze its related influencing factors. Methods A total of 350 patients with advanced cervical cancer who were diagnosed and treated in Haikou City Maternity and Child Health Hospital from January 2019 to January 2020 were selected, and general information questionnaires, psychological distress survey tools, general anxiety scales and patient health questionnaires were used to describe and analysis. Results A total of 350 questionnaires were distributed in this survey, and 328 were returned. The psychological distress score was (4.37±1.62) points, which was in moderate distress. There were statistical differences in the psychological distress scores of patients with different ages, education backgrounds, children’s conditions, average monthly income and treatment methods (P ＜ 0.05). Pearson correlation analysis showed that the anxiety and depression scores of patients with advanced cervical cancer were positively correlated with the degree of psychological pain (r = 0.417, 0.56, P ＜ 0.05). Multiple linear regression analysis showed that age, children’s condition, average monthly income, anxiety and depression were the influencing factors of their psychological distress (P ＜ 0.05). Conclusion Lower age, fewer children, lower average monthly income, higher anxiety and depression scores are related factors affecting the psychological distress of patients with advanced cervical cancer. Medical staff must strengthen comfort and care for these patients, and formulate positive intervention measures can effectively reduce the psychological pain of patients and maintain their physical and mental health.
		2021 Vol. 18 (20): 168-171 [Abstract] ( 136 ) HTML (1 KB) PDF (662 KB) ( 66 )

	172	Application of seamless connection nursing model between operating room and ward under the mind map in the operation of critically ill patients
		GUO Yunqing1 HU Ling2 JIN Xianrong1▲
		Objective To explore the application effect of the seamless connection nursing model between the operating room and the ward under the mind map in the operation of critically ill patients. Methods Prospectively selected 480 critically ill patients who received elective surgical treatment from June 2019 to June 2020 in Jiangjin Distict Central Hospital. They were divided into observation group (240 cases) and control group (240 cases) by random number table method. The nursing model of the control group was conventional nursing, and the nursing model of the observation group was the seamless connection nursing model between the operating room and the ward under the mind map. The operation efficiency and operating room management quality of the two groups were compared, the occurrence of postoperative complications of the two groups were counted and compared, and the nursing satisfaction of the two groups were compared after the nursing. Results The preparation time and operation time of the observation group were shorter than those of the control group, and the differences were statistically significant (P ＜ 0.05). The first aid supplies in the observation group were intact, the equipment was counted correctly, and the equipment sterilization qualified scores were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The nursing satisfaction of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The seamless connection nuring model between the operating room and the ward under the mind map is applied to critically ill patients undergoing surgical treatment. Compared with conventional care, it is more conducive to improving the efficiency of surgery and the quality of surgical management, reducing postoperative complications and improving nursing satisfaction.
		2021 Vol. 18 (20): 172-175 [Abstract] ( 91 ) HTML (1 KB) PDF (655 KB) ( 84 )

	176	Application of evidence recovery after surgery nursing in patients with scoliosis during perioperative period
		WANG Jing1 WU Qunfang2 ZHANG Peipei3 ZHAO Huili1▲
		Objective To explore the effect of evidence recovery after surgery (ERAS) nursing in patients with scoliosis during perioperative period. Methods A prospective selection of 74 patients with scoliosis who underwent surgical treatment at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2019 to June 2020 were divided into control group and observation group by random number table method, with 37 cases in each group. The control group used conventional ERAS nursing, and the observation group used evidence-based ERAS nursing. The related indicators of postoperative recovery were compared between the two groups; the visual analogue scoring method (VAS) was used to assess the pain levels of the two groups at 6, 12, 24 h and 48 h after surgery; the incidence of complications during the postoperative hospital stay was compared between the two groups. Results The time of drainage, drainage tube removal, first anal exhaust and postoperative hospitalization in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The difference between the two groups in VAS scores at different time points, time and interaction between groups were statistically significant (P ＜ 0.05). The VAS scores of the two groups at 12, 24 h, and 48 h after surgery were lower than that at 6 h after surgery, and the VAS scores of the observation group were lower than those of the control group at all time points, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion The implementation of evidence-based ERAS nursing intervention for scoliosis patients during perioperative period is more conducive to promote postoperative recovery and reduce postoperative pain of patients than conventional ERAS nursing.
		2021 Vol. 18 (20): 176-179,187 [Abstract] ( 86 ) HTML (1 KB) PDF (1010 KB) ( 85 )

	180	A report on four cases with non-healing wounds caused by postcardiac surgery treated by the combination of ulcer oil and nano-silver
		LIU Shouyao1 YUAN Quan1 ZHAO Ruisong2 ZHAO Qichao3 XIA Zhongyuan1
		The complications of postcardiac surgery such as wound infection, cracking, hematoma and delayed union, etc. The chest wall and lower limb blood vessel donor sites have high incidence rates, limited therapeutic methods and high difficulty in wound healing, and they are clinical problematic issues. Ulcer oil and nano-silver were used to treat the wound cracking of postcardiac surgery and found that the combination could accelerate the wound healing. The four clinical cases reported in this paper had been treated in hospitalization of China-Japan Friendship Hospital during the period from 2018 to 2020 (three males and one female), who had been performed open chest surgery, but their wounds had not been healed for one month after the surgery. The main expressions were wound dehiscence, wound edge necrosis, formation of hard scab, inactivation of wound internal tissue, sternum cracking and fester accumulation. Two cases were also with Acinetobacter baumanii planting; three cases were with the non-healing wounds of chest wall, two cases were with non-healing wounds of lower limb blood vessel donor site, one case was with sternum cracking of sternum, and the internal fixator was loosen. The wound was treated with the external application of ulcer oil combined with nano-silver after debridement surgery, and the dressings were changed every other day. The four cases’ wounds were healed on 65, 45, 40 and 65 days later, with the average healing time of 53.75 days. The combination of ulcer Oil and nano-silver could accelerate the healing progress of the delayed healing of wounds caused by postcardiac surgery. It is mainly applicable for superficial wounds of sternum surface and wounds of El Oakley Ⅰ Type and Ⅱa Type and wounds in lower limbs blood vessel donor site.
		2021 Vol. 18 (20): 180-183,192 [Abstract] ( 92 ) HTML (1 KB) PDF (871 KB) ( 50 )

	184	Medical staff’s intrinsic driving and its model construction
		ZHANG Yuqing HAN Youli LI Jun
		From the perspective of internal factors, this study puts forward the concept of “intrinsic driving of medical staff” based on psychological drive and the characteristics of medical staff. Through analyzing literature and related materials, a driving model with five dimensions of professional ideal, self-confidence, responsibility, gratitude and perceived organizational support is constructed to visualize the intrinsic driving and provide a grasping tool for the research, measure and apply of the driving, and to compare the intrinsic driving of psychology, education and medical field, so as to comprehensively understand the medical staff’s intrinsic driving, guide the practice better and from the inside out, long-term stably drive medical staffs work actively.
		2021 Vol. 18 (20): 184-187 [Abstract] ( 40 ) HTML (1 KB) PDF (549 KB) ( 208 )

	188	Research on the joint service mode of medical social morkers in the new era and university student volunteers of Chinese medicine university
		ZHANG Yu1 LI Baohe1 JIA Hongtao1 XIAO Yang2 FU Bosiyuan1 ZHANG Yuxin1
		In order to promote the professional skills of students of Chinese medicine university, improve the quality of hospital services, realize mutual assistance and mutual benefit between universities and hospitals, the linkage service between medical social workers and student volunteers in university of Chinese medicine has far-reaching significance. It has profound spiritual connotations in promoting noble quality and inheriting the culture of Chinese medicine, especially in the new era of mutual cooperation in various fields and complementing each other, the model conforms to the form of resource utilization, the trend of social development, the country’s requirements for quality training, and the people’s needs for a better life. Although there are still many problems, the service model will be better implemented, developed and carried forward through the efforts of colleges, hospitals, society and even the country. Therefore, this subject is based on the actual status quo, and explores the service model from the aspects of specific service measures, advantages and disadvantages, solutions, significance and value.
		2021 Vol. 18 (20): 188-192 [Abstract] ( 81 ) HTML (1 KB) PDF (553 KB) ( 176 )

	193	Summary of Phase Ⅰ data for MEK inhibitors approved
		GUO Yuying TIAN Hongqi
		The mitogen-activated extracellular signal-regulated kinase (MEK) is a dual specificity kinase that selectively phosphorylates serine/threonine and tyrosine residues on target protein. MEK has become an attractive target because inhibiting its activity can prevent cell proliferation and induce cell apoptosis. Phase Ⅰ clinical trials of new anti-tumor drugs have great risk, high fatality rate and is one of the key factors that affect the launch of the drug. Four MEK inhibitors have been approved by the U.S. Food and Drug Administration (FDA), including Trametinib, Cobimetinib, Binimetinib and Selumetinib. In this review, phase Ⅰ clinical trial data of these drugs are summarized to provide some references for other MEK inhibitors that are going to conduct phase Ⅰ clinical trials or are in clinical trials.
		2021 Vol. 18 (20): 193-196 [Abstract] ( 53 ) HTML (1 KB) PDF (564 KB) ( 82 )

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