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| Correlation analysis of risk factors and coronary heart disease incidence in the cohort of Shanghai Pudong New Area |
| KE Juzhong1 WU Kang1 LIU Xiaolin1 QIU Hua1 WANG Wenjing2 WANG Xiaonan1 YUAN Xiaonan1 LIN Tao1▲ |
1.Shanghai Pudong New Area Center for Disease Control and Prevention Pudong Institute of Preventive Medicine, Fudan University, Shanghai 200136, China;
2.Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, China |
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Abstract Objective To understand the incidence of coronary heart disease in Pudong New Area, and to explore the correlation between the level of coronary heart disease risk factors and the incidence. Methods Using a prospective cohort study method, a baseline survey of community residents over the age of 15 in Pudong New Area was conducted in 2013, and follow-up observations were conducted until December 31, 2016. The incidence of coronary heart disease during the follow-up period was recorded and correlation analysis with the level of risk factors was performanced. Results The median follow-up observation time of the cohort was 3.00 years. A total of 273 cases of coronary heart disease were followed up. The cumulative incidence of coronary heart disease was 3.96%, and the incidence density was 13.45 per thousand person-years. The incidence of coronary heart disease among people with old age, divorced or widowed, living in rural areas, sleep < 7 h, central obesity, and hypertension were significantly higher than those of the control population, and the differences were statistically significant (P ＜ 0.05). The levels of triacylglycerol, low-density lipoprotein, blood glucose, glycosylated hemoglobin, and C-reactive protein in patients with coronary heart disease were higher than those without coronary heart disease (P ＜ 0.05). Cox regression analysis showed that age ≥55 years, hypertension, sleep <7 h, and central obesity were the influencing factors of coronary heart disease (OR ＞ 1, P ＜ 0.05). Conclusion The prevention and control situation of coronary heart disease in Pudong New Area is severe. Interventions for hypertension, lack of sleep, and central obesity are the focus of coronary heart disease prevention.
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