脊椎蛋白2在胃癌中的表达及临床意义

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Abstract Obective To detect the expression of Spondin 2 (SPON2) in cell lines, tissues and serums of gastric cancer, and investigate its value in gastric cancer. Methods The expression of SPON2 protein in gastric cancer cell lines BGC-823, MGC-803, SGC-7901 and normal gastric mucosal cells GES-1 were detected. From January 2013 to September 2015, the expression of SPON2 in the paraffins of 120 gastric cancer and corresponding para-carcinoma tissues archived by the Department of Pathology No. 900 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army were detected. The expression levels of SPON2, carcinoembryonic antigen (CEA) and carbohydrate antigen19-9 (Ca19-9) in serums of 70 patients with gastric cancer, 60 patients with chronic atrophic gastritis and 60 healthy subjects were detected from May 2019 to September 2020. Results The expression level of SPON2 in all gastric cancer cell lines was higher than that in normal gastric mucosa cell GES-1 (P ＜ 0.05). The positive rate of SPON2 in gastric cancer tissues was higher than that in adjacent normal tissues (P ＜ 0.05). Multivariate survival analysis showed that SPON2 was an independent risk factor for prognosis of gastric cancer (OR = 0.712, 95%CI: 0.431-0.978, P ＜ 0.05). The relative expression of serum SPON2 in gastric cancer patients was higher than that in chronic atrophic gastritis patients and healthy subjects (P ＜ 0.05). The area under the curve of the combined detection of serum SPON2, CEA and Ca19-9 was significantly different from that of the single detection (P ＜ 0.05). Conclusion SPON2 protein may be involved in the occurrence and development of gastric cancer. Combined detection of serum SPON2, CEA and Ca19-9 is beneficial to improve the diagnosis of gastric cancer.

Key words： Spondin 2 Gastric cancer Prognosis Tumor marker

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	HUANG Bin1 WANG Liping1 LIN Zhenmeng2▲

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HUANG Bin1 WANG Liping1 LIN Zhenmeng2▲. Expression and clinical significance of Spondin 2 in gastric cancer[J]. 中国医药导报, 2021, 18(20): 16-20.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I20/16

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