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| Effect of Penicillin combined with cephalosporin on neonatal pneumonia and its influence on intestinal microbial environment |
| WANG Xiang1 WENG Xiaowen2 WANG Jun3▲ |
1.Department of Clinical Medicine, Xuzhou Medical University, Jiangsu Province, Xuzhou 221006, China;
2.Department of Pediatrics, Binhai People’s Hospital, Jiangsu Province, Binhai 224500, China;
3.Department of Pediatrics, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221006, China |
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Abstract Objective To explore the effect of Penicillin combined with cephalosporin on neonatal pneumonia and its influence on intestinal microbial environment. Methods A total of 100 cases of neonatal pneumonia in Affiliated Hospital of Xuzhou Medical University from January 2018 to December 2019 were selected as the research object. They were divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with Penicillin, and the observation group was treated with Penicillin combined with cephalosporin. After one week of treatment, the clinical efficacy, safety and serum white blood cell (WBC), procalcitonin (PCT) and C-reactive protein (CRP) levels were compared between the two groups. In addition, 50 healthy newborns born in Affiliated Hospital of Xuzhou Medical University during the same period were selected as the reference group to compare the changes of intestinal microbial environment among each group. Results Bifidobacterium and Lactobacillus in the observation group were lower than those in the reference group, while Enterobacter and Streptomyces digestive were higher than those in the reference group, and the differences were statistically significant (P < 0.05); there was no significant difference in the intestinal microflora content between the observation group and the control group (P > 0.05). There was no significant difference in the total effective rate between the two groups after treatment (P > 0.05). After treatment, the serum WBC, PCT, and CRP levels of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P < 0.05). There were no significant differences in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Both of two antibiotic regimens can reduce the level of serum inflammation in children with pneumonia, and the clinical efficacy and safety are similar, but the combined use of antibiotics can destroy the balance of intestinal microbial environment in children.
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