粒细胞缺乏症伴感染患者致病菌种类及耐药性分析

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Abstract Objective To analyze the distribution and drug resistance of pathogenic bacteria in agranulocytosis patients associated with infection. Methods The clinical data of 80 patients with agranulocytosis associated with infection admitted to Huaibei Miners General Hospital, Anhui Province from January 2016 to January 2019 were collected. According to the absolute number of neutrophils the patients were divided into three groups: group A, 24 cases with mild deficiency; group B, 34 cases with moderate deficiency; group C, 22 cases with severe deficiency. Clinical data and etiological data were analyzed, and the differences among each group were statistically analyzed. Results A total of 92 strains were identified, and the respiratory tract and blood sources accounted for 45.65% and 34.78%. Gram-negative bacteria were the most common pathogenic bacteria, with 57 strains, accounting for 61.96%. A total of 35 strains of Gram-positive bacteria, accounting for 38.04%. Among Gram-negative bacteria, Klebsiella pneumoniae, Escherichia coli and Sten-otrophomonas maltophila were common. Among the Gram-positive bacteria, Glucobacterium aureus and Enterococcus faecalis were common. In main Gram-negative bacteria, Klebsiella pneumoniae of Ampicillin, Piperacillin, Cefazolin, Cefuroxime, Sulfamethoxazole / Benzyl Methyl Oxygen organism, high percentages, Escherichia coli to Ampicillin, Piperacillin, Cefazolin, Gentamycin, Ciprofloxacin, Cefuroxime, Cefotaxime, Sulfamethoxazole / Benzyl Methyl Oxygen organism resistance rates were all ≥50%, three were Multiple drug resistance; no Escherichia coli resistant to Imipenem and Meropenem was found. Among the main Gram-positive bacteria, Staphylococcus aureus had high resistance to Penicillin and Gentamicin, and Enterococcus faecalis had high resistance to Levofloxacin, Moxifloxacin and Furantoin, with drug resistance rates ≥50%, and there were multiple drug resistance. Conclusion Gram-negative bacterial infections are the main infections associated with agranulocytosis. Pulmonary and bloodstream infections are the most common sites of infection. The distribution and drug resistance of pathogenic bacteria in different sites are different. Pathogenic bacteria have multiple drug resistance. The selection of antibiotics should consider various factors comprehensively, and then select the broad-spectrum antibiotics covering drug-resistant bacteria.

Key words： Agranulocytosis deficiency Infection Pathogenic bacteria Drug resistance

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	YANG Xuefei WANG Dezhen ZHANG Jun YAN Kan ZHU Yi’nan

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YANG Xuefei WANG Dezhen ZHANG Jun YAN Kan ZHU Yi’nan. Analysis of pathogenic bacteria and drug resistance in patients with agranulocytosis associated with infection[J]. 中国医药导报, 2021, 18(20): 104-107.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I20/104

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