帕金森病伴发不同程度抑郁的影响因素分析

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Abstract Objective To analyze the influencing factors of different degrees of depression associated with Parkinson disease. Methods A total of 322 patients with Parkinson disease who were admitted to the Department of Movement Disorders, Center of Neurology, Beijing Tiantan Hospital, Capital Medical University from May 2017 to December 2019 were selected. According to the Hamilton depressive scale score, the patients were divided into Parkinson disease group (130 cases), Parkinson disease mild depression group (136 cases), Parkinson disease moderate depression group (55 cases), and Parkinson disease major depression group (1 case). Since only one patient in Parkinson disease major depression group was enrolled, it was classified into Parkinson disease moderate depression group. The general clinical data of each group were compared, and the influencing factors of Parkinson disease associated with different degrees of depression were analyzed by logistic regression. Results There were no statistically significant differences among the three groups in age stratification (P ＞ 0.05), and there were statistically significant differences in disease course, unified Parkinson disease rating scale Ⅲ part score, mini-mental state examination, H-Y stage, gender, and onset form among the three groups (all P ＜ 0.05). Orderly logistic regression showed that long course of disease (OR = 1.067, 95%CI: 1.009-1.129) and high score of unified Parkinson disease rating scale Ⅲ part (OR = 1.051, 95%CI: 1.026-1.076) were independent risk factors for Parkinson disease associated with different degrees of depression (P ＜ 0.05). Conclusion Long course of disease and high score of unified Parkinson disease rating scale Ⅲ part are independent risk factors for Parkinson disease accompanied by different degrees of depression. Clinically, Parkinson disease depression patients should be screened and effectively intervened as soon as possible to improve patients’ motor symptoms and strengthen psychological communication.

Key words： Parkinson disease Degree of depression Related factors Risk factors

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	JIANG Ying1 FENG Tao1
	2
	3 FANG Jinping4 WANG Xuemei1 MA Huizi1

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JIANG Ying1 FENG Tao1,2,3 FANG Jinping4 WANG Xuemei1 MA Huizi1. Analysis of the influencing factors of different degrees of depression associated with Parkinson disease[J]. 中国医药导报, 2021, 18(20): 59-61,65.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I20/59

[1] Raza C，Anjum R，Shakeel NUA. Parkinson’s disease：Mechanisms，translational models and management strategies [J]. Life Sci，2019，226：77-90.
[2] Del Rey NL，Quiroga-Varela A，Garbayo E，et al. Advances in Parkinson’s Disease：200 Years Later [J]. Front Neuroanat，2018，12：113.
[3] Marsili L，Rizzo G，Colosimo C. Diagnostic Criteria for Parkinson’s Disease：From James Parkinson to the Concept of Prodromal Disease [J]. Front Neurol，2018，9：156.
[4] Cilia R，Cereda E，Akpalu A，et al. Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa [J]. Brain，2020，143（8）：2490-2501.
[5] Burciu RG，Vaillancourt DE. Imaging of Motor Cortex Physiology in Parkinson’s Disease [J]. Mov Disord，2018，33（11）：1688-1699.
[6] Chaudhuri KR，Odin P，Antonini A，et al. Parkinson’s disease： the non-motor issues [J]. Parkinsonism Relat Disord，2011，17（10）：717-723.
[7] Zhang TM，Yu SY，Guo P，et al. Nonmotor symptoms in patients with Parkinson disease：A cross-sectional observational study [J]. Medicine（Baltimore），2016，95（50）：e5400.
[8] Seppi K，Ray Chaudhuri K，Coelho M，et al. Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders Society Evidence-Based Medicine Committee. Update on treatments for nonmotor symptoms of Parkinson’s disease-an evidence-based medicine review [J]. Mov Disord，2019，34（2）：180-198.
[9] Reijnders JS，Ehrt U，Weber WE，et al. A systematic review of prevalence studies of depression in Parkinson’s disease [J]. Mov Disord，2008，23（2）：183-189.
[10] 付朝伟，徐飚，詹思延，等.中国四城市综合医院神经内科患者抑郁、焦虑现况研究[J].中华流行病杂志，2006， 27（9）：803-807.
[11] Postuma RB，Berg D，Stern M，et al. MDS clinical diagnostic criteria for Parkinson’s disease [J]. Mov Disord，2015，30（12）：1591-1601.
[12] Primo de Carvalho Alves L，Pio de Almeida Fleck M，Boni A，et al. The Major Depressive Disorder Hierarchy：Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome [J]. PLoS One，2017，12（1）：e0170000.
[13] Ehlen F，Schindlbeck K，Nobis L，et al. Relationships between activity and well-being in people with parkinson’s disease [J]. Brain Behav，2018，8（5）：e00976.
[14] Chen CL，Liang TM，Chen HH，et al. Constipation and Its Associated Factors among Patients with Dementia [J]. Int J Environ Res Public Health，2020，17（23）：9006.
[15] Tysnes OB，Storstein A. Epidemiology of Parkinson’s disease [J]. J Neural Transm（Vienna），2017，124（8）：901-905.
[16] Santiago JA，Bottero V，Potashkin JA. Biological and Clinical Implications of Comorbidities in Parkinson’s Disease [J]. Front Aging Neurosci，2017，9：394.
[17] Liu K，Ma Q，Wang M. Comparison of Quantitative Electroencephalogram During Sleep in Depressed and Non-Depressed Patients with Parkinson’s Disease [J]. Med Sci Monit，2019，25：1046-1052.
[18] Mills KA，Greene MC，Dezube R，et al. Efficacy and tolerability of antidepressants in Parkinson’s disease：A systematic review and network meta-analysis [J]. Int J Geriatr Psychiatry，2018，33（4）：642-651.
[19] Schneider F，Althaus A，Backes V，Dodel R. Psychiatric symptoms in Parkinson’s disease [J]. Eur Arch Psychiatry Clin Neurosci，2008，258 Suppl 5：55-59.
[20] Frisina PG，Borod JC，Foldi NS，et al. Depression in Parkinson’s disease：health risks，etiology，and treatment options [J]. Neuropsychiatr Dis Treat，2008，4（1）：81-91.
[21] Nicoletti A，Vasta R，Mostile G，et al. Gender effect on non-motor symptoms in Parkinson’s disease： are men more at risk? [J]. Parkinsonism Relat Disord，2017，35：69-74.
[22] Han JW，Ahn YD，Kim WS，et al. Psychiatric Manifestation in Patients with Parkinson’s Disease [J]. J Korean Med Sci，2018，33（47）：e300.
[23] Klepac N，Trkulja V，Relja M. Nondemented Parkinson disease patients：is cognitive performance associated with depressive difficulties? [J]. Cogn Behav Neurol，2008，21（2）：87-91.
[24] Stefanova E，Potrebic A，Ziropadja L，et al. Depression predicts the pattern of cognitive impairment in early Parkinson’s disease [J]. J Neurol Sci，2006，248（1/2）：131-137.
[25] Lieberman A. Are dementia and depression in Parkinson’s disease related? [J]. J Neurol Sci，2006，248（1/2）：138-142.
[26] Kosti■ VS，Agosta F，Petrovi■ I，et al. Regional patterns of brain tissue loss associated with depression in Parkinson disease [J]. Neurology，2010，75（10）：857-863.