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2019 Vol. 16, No. 1
Published: 2019-01-05
 
 
4 Effect of Ningdong Granules on metabolism of dopaminergic neurons
LI Mengying1 JIANG Liyuan1 SUN Kexing2 Xiaohong LI2 LI Jijun2▲
Objective To study the effect of Ningdong Granules on the metabolism of dopaminergic (DA) neurons. Methods Twelve 18-days-old fetuses were randomly divided into Ningdong Granules (NDG) group, control (CTR) group, haloperidol (Hal) group and normal (Normal) group, with 3 rats in each group. DA neurons of each group were separately isolated and cultured, and tyrosine hydroxylase (TH) anti-staining was performed on DA neuron cells by immunofluorescence indirect method. Neuron axon anti-Tau1 anti-labeling combination with FITC fluorescence (green light) Ⅱ anti-labeling, neuron axon anti-Tau1 labeling combined with Cy 3 fluorescence (red light) Ⅱ anti-labeling, DA neuron cells and neuron axons were identified by fluorescent staining. The contents of MAO, DA, 5-HT, HVA and 5-HIAA in DA neuron cell culture medium of 18-days-old fetuses before and 1, 6, 12 and 24 h after drug intervention were detected by ELISA, and the metabolism of metacells of DA energetic spirit in each group was recorded. Results Compared with 0 h, the contents of MAO, DA, 5-HT and HVA in the cell culture medium of NDG group increased significantly after 6 and 12 h of intervention (P < 0.05); compared with CTR group at the same time, there was no significant difference in the contents of MAO, DA, 5-HT and HVA in the cell culture medium of Hal group after 0-24 h of intervention (P > 0.05); after 0-24 h of intervention, the 5-HIAA content in cell culture of fetuses in each group had no significant difference (P > 0.05). Conclusion NDG can promote the metabolism of DA neurons, but has no significant effect on the metabolism of 5-HT.
2019 Vol. 16 (1): 4-7 [Abstract] ( 338 ) HTML (1 KB)  PDF (729 KB)  ( 229 )
8 Effect of Akt inhibitor MK-2206 on the biological behavior of hepatoma cell huh7 and its mechanism
XIONG Lin HE Xiaoqin FAN Li XU Ximing
Objective To investigate the effect of MK-2206 on the growth of hepatoma cells huh7 and its mechanism of action. Methods Human hepatoma cell line huh7 was cultured in vitro, and huh7 cells were treated with different concentrations (0, 2.5, 5, 10, 20, 40 μmol/L) MK-2206. Cell proliferation was detected by CCK-8; apoptosis was detected by flow cytometry; protein expression was detected by Western blot. Results Compared with the control group (0 μmol/L), MK-2206 significantly inhibited the proliferation of hepatoma cell line huh7 in a dose-and time-dependent manner. MK-2206 had the tendency to reduce the migration ability of huh7, but there was no statistically significant difference. MK-2206 induced apoptosis of huh7 cells (P < 0.05) and significantly inhibited Akt protein expression (P < 0.05). Conclusion The Akt inhibitor MK-2206 can regulates the biological behavior of hepatoma cell huh7 by regulating the PI3K/Akt signaling pathway.
2019 Vol. 16 (1): 8-11,15 [Abstract] ( 268 ) HTML (1 KB)  PDF (963 KB)  ( 158 )
12 The impact of back meridians manipulations on insomnia PCPA-treated rats′ behavior
JI Dengjun GU Fei LI Yunlong LI Yazhou NING Yuanshuai WANG Yichao CAO Xindi LIU Wentao
Objective To observe the impact of back meridians manipulations on insomnia para-chlorophenylalanine (PCPA)-treated rats′ behavior. Methods The random number table was generated by software SPSS 18.0 for Windows. The random function was Rvuiform and the seed number was 1234. According to the random number table, 30 male insomnia SD rats were divided into back meridians manipulation group (group A), blank control group (group B), drug treatment group (group C), with 10 rats in each group. Before and after the PCPA was successfully injected to the rats, 7 days after giving the corresponding interventions to each group, there were three time points at which data were collected from the rats′ behavior, including the data changes in the open field test (the total number of horizontal movements and vertical movements), exhaustive swimming test and tail suspension test. Results Before treatment, the differences among the three groups in exhaustive swimming time, total number of movements, struggling frequency and despair time were not statistically significant (P ＞ 0.05). After treatment, the exhaustive swimming time and despair time of group B were lower than those before treatment (P ＜ 0.05); comparing group A and group C before and after treatment, the differences on the exhaustive swimming time and despair time were all non-statistically significant (P ＞ 0.05). Compared with group B, the exhaustion time of group A and group C were increased, the differences were statistically significant (P ＜ 0.05); and there was no statistically significant difference in exhaustion time between group A and group C (P ＞ 0.05). After treatment, the struggling frequency of three groups were less than those before treatment, the differences were statistically significant (P ＜ 0.05). Conclusion There is abnormality in the behavior of insomnia PCPA-treated rats. It can be used in the basic experimental study tuina treatment for insomnia; in behavioral aspects, back meridians manipulations and Diazepam can both significantly alleviate the decline of movement ability, cardiopulmonary function and ability to explore new environment of insomnia rats, which objectively reflects that tuina manipulations can improve insomnia.
2019 Vol. 16 (1): 12-15 [Abstract] ( 259 ) HTML (1 KB)  PDF (562 KB)  ( 235 )
16 Study on miRNA-101 affecting liver firosis by targeting the transforming growth factor-β1 signalling pathway
BAI Jie1 JI Wenjing1 DING Yongnian1 PENG Yuanyuan1 Nuermaimaiti·Yeerxun1 Aziguli·Abulaiti1 CHEN Yuanwen2
Objective To explore the roles of miRNA-101 and transforming growth factor (TGF)-β1 signalling pathway in human liver fibrosis. Methods Twenty cases of liver fibrosis tissues from January 2013 to January 2018 of the Second Affiliated Hospital of Xinjiang Medical University were selected as observation group. Twenty cases of normal liver firosis were selected as control. The expression of TGF-β1 and α-smooth muscle actin (α-SMA) were detected by immunohistochemistry. The expression levels of TGF-β1 mRNA, α-SMA mRNA and miRNA-101 in liver tissues were detected by quantitative real time polymerase chain reaction (qRT-PCR). The correlation of TGF-β1 and α-SMA expression with miRNA-101 in the liver tissues was analyzed. Results The expression level of TGF-β1 mRNA was much higher in fibrotic liver than that in normal liver tissues (P ＜ 0.05), there was no statistically significant differencce on the expression level of α-SMA mRNA between fibrotic liver and normal liver tissues (P ＞ 0.05). The positive expression of TGF-β1 and α-SMA in hepatic fibrosis tissues increased with the degree of hepatic fibrosis, showing a positive correlation (r = 0.53, 0.57, all P ＜ 0.05). The mRNA expression level of TGF-β1 mRNA in fibrotic liver was positively correlated with α-SMA (r = 0.633, P ＜ 0.01). The expression level of miRNA-101 in liver fibrotic tissues was lower than that in normal liver tissues (P ＜ 0.05). The expression of miRNA-101 was negatively correlated with the mRNA expression levels of TGF-β1 and α-SMA (r = -0.442, -0.327, all P ＜ 0.01). Conclusion Downregulation of miRNA-101 may contribute to liver fibrosis by targeting TGF-β1.
2019 Vol. 16 (1): 16-19,23 [Abstract] ( 247 ) HTML (1 KB)  PDF (1061 KB)  ( 78 )
20 Study on chemical constituents and antitumor activity of Gentiana triflora Pall.
ZHOU Yanli1 WANG Dali2 ZHANG Yan1 ZHANG Ning1 LI Shuoxi1 WU Jiao3 LI Yang3
Objective To investigate the chemical constituents and antitumor activities in vitro of Gentiana triflora Pall. Methods The root of Gentiana triflora Pall. was extracted with 95% ethyl alcohol, which is extracted with petroleum ether, ethyl acetate and n-butanol, successively. The extracts were separated and purified by silica gel column chromatography and preparative high performance liquid chromatography. The compounds were structurally identified according to physicochemical properties and spectral data. The antitumor activities of the compounds were evaluated by microculture tetrozolium (MTT) method. Results Five compounds were isolated from the ethyl acetate and n-butanol extraction sites and identified as globuloside A (1), cornusoside A (2), cornolactone A (3), 6, 9-epi-8-O-Acetylshanziside methyl ester ( 4), 5,9-epi-Penstemoside (5); anti-tumor activity experiments showed that Compound 1 had a certain inhibitory effect on the proliferation of HepG2 cells in vitro, with an IC50 value of 6.7 μmol/L. Conclusion All the compounds are isolated from Gentiana triflora Pall. firstly. Compound 1 has significant inhibitory activity on the proliferation of HepG2 cells.
2019 Vol. 16 (1): 20-23 [Abstract] ( 216 ) HTML (1 KB)  PDF (605 KB)  ( 60 )
24 Study on quality standard of Jiannao Yishen Pills
LIU Shan1 MIAO Licheng1 MU Lina1 MENG Fanying1 HOU Mingyue1 TIAN Ming2
Objective To establish the quality standard of Jiannao Yishen Pills. Methods Microscopic identification of Prepared Radix Glycyrrhizae, Pueraria lobata, Semen Zizyphi Spinosae and Alpinia oxyphylla in Jiannao Yishen Pills was carried out. Thin layer chromatography (TLC) was used for qualitative identification of Ligusticum Chuanxiong and Pueraria lobata. The content of Puerarin in Jiannao Yishen Pills was determined by high performance liquid chromatography. The column was Agilent Zorbax Extend-C18, the column temperature was room temperature, the mobile phase was methanol-water (25:75), the flow rate was 1.0 mL/min, the detection wavelength was 250 nm, and the injection volume was 10 μL. Results The microscopic identification of the preparation was obvious; the spots in TCL were clear, and the negative samples had no interference; puerarin showed a good linear relationship with the peak area in the concentration range of 40-240 g/mL (r = 0.999), with an average recovery of 99.98% and RSD of 0.44%. Conclusion The method is stable, feasible and specific. It can effectively control the quality of Jiannao Yishen Pills.
2019 Vol. 16 (1): 24-27,32 [Abstract] ( 216 ) HTML (1 KB)  PDF (962 KB)  ( 70 )
28 Preparation of solid dispersion of Vladimiriae souliei sesquiterpenoids composition and determination of dissolution in vitro
QIANG Yongzai QU Xiaomei WANG Yang
Objective The sesquiterpene component of Vladimiriae souliei was extracted, separated and purified, and made into a solid dispersion to increase its dissolution rate in vitro. Methods An ultra performance liquid chromatography method for the determination of the content of sesquiterpene in Vladimiriae souliei was established. The chromatographic conditions were Acquity ultra-high performance liquid chromatography. The column was a Waters BEH-C18 column (2.1 mm × 50 mm, 1.7 μm). The mobile phase was acetonitrile-water (50:50); the flow rate was 0.4 mL/min; the detection wavelength was 225 nm. The sesquiterpenes were extracted by ultrasound-assisted extraction and purified by silica gel column chromatography. The solid dispersions were prepared by using polyethylene glycol and poloxamer as carrier materials, and characterized by differential scanning calorimetry. Results The solid dispersions prepared by different carriers could obviously accelerate the dissolution of costunolide and dehydrocostuslactone. The solid dispersions prepared by using Poloxamer 188 (P188) as carrier had the fastest dissolution rate, and the best mass ratio of sesquiterpene components to P188 was 1∶6. Conclusion The solid dispersion of Vladimiriae souliei sesquiterpene component can significantly improve the solubility and dissolution rate of the drug.
2019 Vol. 16 (1): 28-32 [Abstract] ( 231 ) HTML (1 KB)  PDF (769 KB)  ( 88 )
33 Study on separation and purification process of Gardenia jasminoides extract
CUI Long1,2 HU Shaoyin1,2 LIU Heping1,2 SHANG Qiang1,2 GAO Jin1,2
Objective To optimize the separation and purification process parameters of Gardenia jasminoides extract. Methods The transfer rate and color value of crocus sativus glycosides were used as comprehensive scoring indexes. The optimum separation and purification parameters of Gardenia jasminoides extract were optimized by single factor test and orthogonal design, and verified by industrial production. Results The optimum separation and purification process was as follows, the extract was adsorbed by HPD-100A resin at a concentration of 0.5 mg/mL, and then eluted with 12 BV purified water, 2 BV 35% ethanol at a flow rate of 1 BV/h. The Gardenia jasminoides extract was obtained by eluting with 65% ethanol of 4 BV at the same flow rate. Under the optimal process conditions, the pilot production was verified. The average transfer rate, color value and yield of saffron from the three batches of Gardenia jasminoides extract were 86.25%, 509.82 and 2.11%, respectively, and the RSD values were 1.56%, 0.39% and 2.33%. Conclusion The separation and purification process of Gardenia jasminoides extract has been verified by industrial production and is stable and reliable.
2019 Vol. 16 (1): 33-37 [Abstract] ( 221 ) HTML (1 KB)  PDF (677 KB)  ( 99 )
38 Research progress of apoptosis mechanism of tumor cells induced by bufotalin
LI Wei1 CUI Shengnan1 ZHOU Zhihui2 DONG Changhu2▲
Bufotalin is a compound extracted from the venom of toad, which belongs to bufadienolide. It not only has the effects of antiarrhythmic, stronging heart, antibacterial, local anaesthesia, antipyrexia and diuresis and so on, but also has a good inhibitory effect on many solid and nonsolid tumors. The mechanism of apoptosis induced by bufotalin is mainly related to mitochondrial pathway, death receptor pathway and endoplasmic reticulum stress. In this paper, we review the molecular mechanism of bufotalin inducing tumor cell apoptosis.
2019 Vol. 16 (1): 38-40,48 [Abstract] ( 616 ) HTML (1 KB)  PDF (595 KB)  ( 94 )
41 Progress in the research of NLRP3-（Caspase-1）/IL-1β signal pathway
PAN Xubiao1,3 LI Xiangyu2 WANG Zhixin3 WANG Hongbin3 XU Xiaolei1,3 FAN Haining3,4
Inflammation is a defense response that dangerous stimuli induce in the body. Nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is one of the hot spots in medical research field in recent years. The activated NLRP3 inflammatory corpuscle can regulate the inflammatory response by controlling the maturation and secretion of the downstream related inflammatory cytokines. In this paper, the structure, activation and regulation mechanism of NLRP3 inflammasome, the role of downstream related cytokines and diseases related to interleukin-1 beta (IL-1β) are reviewed in order to provide references for future studies in this field.
2019 Vol. 16 (1): 41-44 [Abstract] ( 1884 ) HTML (1 KB)  PDF (576 KB)  ( 136 )
45 Research progress on the correlation between insomnia and depression
LIU Jianfeng1 MENG Fanping2 ZHOU Yixin3
With the acceleration of the pace of modern society and the increase of work and life pressures, the incidence of insomnia and depression has increased year by year, which has brought a heavy burden to society. Insomnia and depression are the most common mental disorders, and they are often manifested in the form of comorbidities. Insomnia is not only a symptom of depression, but also an important cause of depression. Long-term insomnia will aggravate depression, affecting the rehabilitation and recovery of depression; the complaints of patients depression are often dominated by insomnia. The relationship between the two is relatively close. Defining the relationship between insomnia and depression is important for clinical diagnosis and treatment.
2019 Vol. 16 (1): 45-48 [Abstract] ( 764 ) HTML (1 KB)  PDF (614 KB)  ( 121 )
49 Research progress of induced pluripotent stem cells for osteogenesis and bone regeneration
HE Xufeng1 LOU Xiangxin2 ZHU Huafeng3 ZHANG Huimin1▲
Induced pluripotent stem cell (iPS cell) is a kind of pluripotent differentiated stem cells which is induced by artificial reprogramming. At present, iPS cells have been successfully differentiated into many different mature cells, including osteogenic differentiation. And recent discoveries have showed that iPS cells have the potential to advance future bone regenerative therapies. This article provides an review of the findings on osteogenic characteristics in vitro and in vivo. In addition, this article discusses the role of cytokines and microRNA (miRNA) in the differentiation of iPS cells. Finally, this article summarizes the effects of various kinds of scaffolds on the osteogenesis of iPS cells, which might contribute to the development of future research and experiment.
2019 Vol. 16 (1): 49-52 [Abstract] ( 228 ) HTML (1 KB)  PDF (581 KB)  ( 103 )
53 The process of MSCT examination in ovarian malignant tumors
YU Qian1,2 ZHAO Jianwu1,2 ZENG Xianchun3
Malignant ovarian tumor, its insidious onset and high recurence rate that leads to a high death rate, threatens women′s health. However, early discovery and treatment can obviously increase a patient′s life span, improve present situation and prevent future disease. So, the problem that image examination and clinical work face together is how to use image examination to find the primary affection, metastatic lesion as well as select appropriate treatment. With the rapid updated improvement of technology and equipment of multi-slice spiral CT, multi-slice spiral CT keeps the conventional CT′s basic function, and at the same time it has its superiorities, like high resolution of time and space, high scanning speed and multi-parameter imaging, which greatly improves the sensibility and accuracy of clinical diagnosis. The examination of multi-slice spiral CT provides basis for maliganat ovarian tumors′ diagnosis, clinical stages, post-treatment evaluation, and it can reduce total radiation dose without affecting image quality.
2019 Vol. 16 (1): 53-56,60 [Abstract] ( 199 ) HTML (1 KB)  PDF (645 KB)  ( 90 )
57 Progress of metabolic in senescence research
LIU Chuanling WANG Jiahe
Metabolomics is one kind of "Omics" with rapid development in recent years. Its advantages lie in high sensitivity, high accuracy and low cost. Metabolomics have broad prospects for development and the application of discipline spans biotechnology and pharmaceutical technology. Cellular senescence is a process characterized by the irreversible loss of cell growth and proliferation. Metabolomics can dynamically monitor the changes of the metabolites in the body following cellular senescence，and it makes metabonomics being of great significance in senescence research. This review introduces the progress of metabonomics in senescence research which deepened people′s understanding of the process of cellular senescence and provides new research methods and ideas for the study of senescence mechanism and senescence related diseases.
2019 Vol. 16 (1): 57-60 [Abstract] ( 259 ) HTML (1 KB)  PDF (612 KB)  ( 122 )
61 Application of teaching case method in training of pain specialized nurses
YE Rong1 LI Dongmei1 ZHANG Qing1 JIA Yi2 LONG Ling1,2
The purpose of training of pain specialized nurse is cultivating applied nurse with strong capacity on analyzing and solving problems in clinic, containing pain assessment, pain management and pain management, etc. Different from diploma education, the training of pain specialized nurses pays more attention to the practical transformation of theoretical content in classroom, and requires more emphasis on integration of theory and practice in teaching. In order to achieve the integration of multidisciplinary pain related knowledge and clinical practice during the limited training time, representative clinical cases in our hospital were introduced into classroom for guiding the students to analyze and solve clinical problems via teaching case method. Through the case teaching course, the students′ ability on mastering and application of theoretical contents were greatly improved, which indicated that teaching case method is a good way for training of pain specialized nurses
2019 Vol. 16 (1): 61-64 [Abstract] ( 192 ) HTML (1 KB)  PDF (422 KB)  ( 90 )
65 Application of situational interactive PBL teaching in pathological experiment
ZHANG Yuanyi1 LI Pinyu1 WANG Min1 CAI Yuewei2
Objective To explore the application effect of situational interactive problem-based learning (PBL) in experimental course of pathology. Methods In March 2017, among 480 students of 8 clinical classes in 2016 grade of Zhaoqing Medical College, 120 students at two classes were randomly selected, 60 students of one class were given situational interactive PBL teaching method (experiment group), 60 students of another class were given traditional teaching method (control group). The effect of situational interactive PBL teaching was evaluated through experimental examination and questionnaire survey. Results The examination result of students in the experiment group was better than the control group, the difference was statistically significant (P < 0.01). The teaching effect of students in the experiment group was better than the control group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion Situational interactive PBL teaching can fully inspire the initiative of learning, train students′ ability of clinical pathological thinking, improve the teaching effect of pathology experiment course.
2019 Vol. 16 (1): 65-67 [Abstract] ( 206 ) HTML (1 KB)  PDF (439 KB)  ( 110 )
68 Meta analysis of the polymorphism of interleukin-8 gene promoter -251T＞A with the risk of acute pancreatitis
LIU Jianping LI Su SUN Yaxuan
Objective To investigate the relationship between the polymorphism of interleukin-8 (IL-8) gene promoter -251T＞A with the risk of acute pancreatitis (AP). Methods PubMed, Embase, Web of Science databases and WanFang were searched for studies on IL-8 promotor-251T＞A polymorphism and AP risk from January 1990 to December 2015. Results Finally, seven studies involving 2282 cases, among all the cases, 1013 in the AP group and 1269 in the control group. Among the population enrolled, IL-8 promoter-251T>A polymorphism was related to AP risk(OR = 1.56，95%CI: 1.41-2.13，P = 0.02). In the dominant models, A carrier increased AP risk (OR = 1.44，95%CI: 1.21-1.73，P = 0.01); in the recessive models, homozygote AA increased AP risk (OR = 1.65, 95%CI: 1.13-2.41, P = 0.02). Subgroup analysis indicated that the recessive gene model of MAP (OR = 2.01, 95% CI:1.25-3.24, P = 0.025) and all SAP gene models (OR = 1.80, 95% CI: 1.43-2.26, P = 0.022), the dominant model (OR = 2.17, 95% CI:1.54-3.06, P = 0.014) and the recessive model (OR = 2.39, 95% CI:1.49-3.81, P = 0.005) of IL-8 promoter-251T>A polymorphism increased the risk of AP. Conclusion IL-8 promoter-251T＞A is associated with increase of AP risk, but considering the limitations of this study, further research with better design and larger sample size is needed to confirm the conclusion.
2019 Vol. 16 (1): 68-73 [Abstract] ( 229 ) HTML (1 KB)  PDF (1171 KB)  ( 49 )
74 Analysis on risk factors of fungus infection in severe pulmonary tuberculosis ICU
ZHANG Nan1 LI Qi2 PAN Liping3 LUO Baojian1 LIU Qiuyue1▲
Objective To explore  risk factors contributing to fungus infection in severe pulmonary tuberculosis ICU. Methods Clinical data of 116 patients from Beijing Chest Hospital, Capital Medical University from January 2015 to September 2016 were collected and analyzed retrospectively. The patients were divided into fungus infected group 35 cases and non fungus infected group 81 cases. The risk factors contributing to fungus infection were analyzed by Logistic analysis. Results There were 35 cases in the 116 cases were fungus infected  and the incidence of fungal infection in tuberculosis patients in the ICU was 30.17%. Single factor analysis showed that 10 factors including complicated with diabetes, other diseases in the lung, hemoptysis, the lung lesion range > 3 pulmonary lobes, cavity, fibrosis, usage of antibiotics and glucocorticoid more than 1 week, traumatic operation and serum albumin level correlated with pulmonary fungal infection(P ＜ 0.05 or P ＜ 0.01). The Logistic regression analysis showed that independent predictive risk factors of fungus infection were usage of glucocorticoid and antibiotics over 1 week, traumatic operation, and serum albumin level was the protect factor(P ＜ 0.05 or P ＜ 0.01). Conclusion Patients with pulmonary tuberculosis in ICU has a higher rate of fungus infection. Patients with long-term glucocorticoids, invasive operations, and using broad-spectrum antibiotics and low albumin level should be aware of the risk of fungal infection, and should take early prevention, diagnosis and treatment.
2019 Vol. 16 (1): 74-76,81 [Abstract] ( 270 ) HTML (1 KB)  PDF (641 KB)  ( 108 )
77 The effect of bedside lung ultrasound in the diagnosis of patients with acute dyspnea
ZENG Jun
Objective To explore the effect of bedside lung ultrasound in the diagnosis of patients with acute dyspnea. Methods Clinical data of 84 cases with dyspnea from June 2016 to May 2018 in Chongqing People′s Hospital (the 3rd ward) were analyzed retrospectively. They were divided into bedside ultrasound group and routine inspection group according to different checking methods, with 42 cases in each group. The sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy, inspection time and inspection cost of the two groups were calculated. Results The examination time of the bedside ultrasound group was shorter than that of the routine inspection group (P ＜ 0.01), and the examination expenses of the two groups had no statistical difference (P ＞ 0.05). The sensitivity of the etiology and diagnostic accuracy in bedside ultrasound group were higher compared with those in the routine inspection group(P ＜ 0.05), the diagnosis specificity of severe pneumonia, pulmonary embolism, acute cardiogenic pulmonary edema was higher (P ＜ 0.05), but the diagnosis specificity of COPD, pneumothorax had no statistical difference (P ＞ 0.05). Conclusion Bedside ultrasound with the characteristics of efficiency, economy, and high diagnostic accuracy, can give individualized and dynamic assessment for severe patients, and it is safe with no radiation. It can provide timely and accurate guidance of  management and treatment for acute, critical and serious syndrome.
2019 Vol. 16 (1): 77-81 [Abstract] ( 237 ) HTML (1 KB)  PDF (637 KB)  ( 115 )
82 Effects of continuous renal replacement therapy combined with Ulinastatin on the level of pulmonary and renal function in patients with burn complication of sepsis
QI Jun WU Yangyang
Objective To investigate the effect of continuous renal replacement therapy(CRRT) combined with Ulinastatin on the level of pulmonary and renal function in patients with severe burn complication of sepsis. Methods A total of 30 patients with severe burn complication of sepsis were enrolled in this study, from January 2014 to June 2017 in Affiliated  Hospital of Nantong University. They were divided into two groups CRRT (control group) and CRRT combined with Ulinastatin (observation group) treatment were used in the two groups respectively. According to random number table method with 15 cases in each group. The two groups′ hemodynamics were monitored by PICCO catheter. The levels of pulmonary and renal function were tested before and 1, 3, 5, 7 d after treatment. Results The observation group had decrease of ITBVI, EVLWI, SVRI and improvement of PaO2/FiO2 after 1 d treatment (P < 0.05). There was improvement in the control group as well, the expression of ITBVI, EVLWI decreased within 48 h and PaO2/FiO2 increased in the 3rd day of treatment, the differences in the same group and between the two groups were statistically significant (P ＜ 0.05). After treatment, the serum uric acid and creatinine of the two groups decreased while the 24 h urine volume increased in two groups (P ＜ 0.05). At different time points, the serum uric acid and creatinine in the observation group were lower than those in the control group, and 24 h urine volume was higher than the control group (P ＜ 0.05). Conclusion CRRT combined with Ulinastatin on burn sepsis could change the hemodynamics status, and improve the pulmonary and renal function in patients with severe burn complication of sepsis.
2019 Vol. 16 (1): 82-85 [Abstract] ( 196 ) HTML (1 KB)  PDF (629 KB)  ( 63 )
86 Effect of flexible ureteroscope combined with ureteroscope in the treatment of complicated upper ureteral calculi
LIANG Guifeng MI Qiwu LU Yuansheng
Objective To study and analyze the clinical effect of flexible ureteroscope combined with ureteroscope for the treatment of complicated ureteral calculi. Methods A total of 120 patients with complicated ureteral calculi treated in Dongguan People′s Hospital of Guangdong Province from February 2014 to February 2017 were selected, they were divided into observation group (60 cases) and control group (60 cases) by random number table method. The control group was treated with minimally invasive percutaneous nephroscopy, while the observation group was treated with flexible ureteroscope combined with ureteroscope. The operation time, the intraoperative blood loss, the time of hospitalization, the clearance rate of calculi postoperative for 1 and 3 months were compared between the two groups, the level of serum interleukin-6 (IL-6), C-reactive protein (CRP) before and 5 days after operation and the complications after operation were also compared. Results The operation time in observation group was longer than the control group obviously, and intraoperative blood loss was less than control group obviously, the time of hospitalization was significantly shorter than that of the control group, the differences were statistically significant (P ＜ 0.05). The clearance rate of calculi 1 month after operation in observation group was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05), however, there was no significant difference between the two groups 3 months after opetation (P ＞ 0.05). The levels of serum IL-6 and CRP in the observation group were significantly lower than the control group 5 days after operation, the differences were statistically significant (P ＜ 0.05). The incidence of lumbago, pyelonephritis and fever after operation patients in the observation group had no significant difference compared with those in the control group (P ＞ 0.05). Conclusion Flexible ureteroscopy combined with ureteroscope for complicated ureteral calculi has good clinical effect and high security, which is helpful to reduce the degree of inflammatory response of patients, and it is worthy of clinical application.
2019 Vol. 16 (1): 86-89 [Abstract] ( 213 ) HTML (1 KB)  PDF (624 KB)  ( 118 )
90 The influence of Orem self-care mode combined with language rehabilitation training on cerebral infarction with aphemia patients
ZHANG Ying
Objective To investigate the influence of Orem self-care mode combined with language rehabilitation training on cerebral infarction with aphemia patients. Methods The clinical data of 100 cases of cerebral infarction with aphemia patients in Affiliated Hospital of Qinghai University from March 2016 to March 2018 were collected and divided into control group and observation group according to different nursing methods, with 50 cases in each group. The control group was treated with acupuncture and drug therapy, and the observation group was treated with Orem self-care mode on the basis of the control group. The linguistic function score, aphasia quotient (AQ) score, aphasia assessment, daily life communication and communication ability score of two groups before and after treatment were observed. The clinical treatment total effective rate of two groups were observed. Results Before treatment, the language competence ability, reading ability, comprehensive ability, writing ability score, AQ score, aphasia assessment, daily life communication and communication ability score of two groups were compared, the differences were not statistically significant (P ＞ 0.05). After treatment, the language competence ability, reading ability, comprehensive ability, writing ability score, AQ score, daily life communication and communication ability score of two groups were higher than those before treatment, aphasia assessment were better than that before treatment; the language competence ability, reading ability, comprehensive ability, writing ability score, AQ score, daily life communication and communication ability score of observation group after treatment were higher than those of control group, aphasia assessment was better than that of control group; the clinical treatment total effective rate of observation group was higher than that of control group, all the differences were statistically significant (P ＜ 0.05). Conclusion The application of Orem self-care mode combined with language rehabilitation training on cerebral infarction with aphemia patients can strengthen linguistic function, daily life communication and communication ability, improve aphasia assessment, increase clinical treatment efficiency. It is worthy of clinical promotion and application.
2019 Vol. 16 (1): 90-93,97 [Abstract] ( 179 ) HTML (1 KB)  PDF (691 KB)  ( 139 )
94 Nutritional vascular anatomy and clinical application of great toe nail bed
ZHANG Hao NIU Lei▲
Objective To study the anatomical characteristics of the nutrient vessels of the great toe nail bed and explore the method and effect of repairing hand nail bed defects with the great toe nail flap. Methods From July 2009 to March 2016, 20 fresh foot specimens were selected to observe the distribution of nutrient vessels in the great toe nail bed and measure the related data. The clinical data of 45 patients with hand nail bed defect admitted by Department of Microscopic Orthopedics, the Second People′s Hospital of Hefei, Anhui Province from January 2013 to June 2016 were retrospectively analyzed. Adopt with the nutrient vessels of the great toe nail bed flap transplantation to repair the hand defected nail bed, postoperative follow-up and according to the Chinese medical association in to upper limb function evaluation trial standard function to assess the wounded finger. Results First dorsal plantar artery and transverse the great toe artery distal anastomosis formed an arch, arch vertical sent the great toe nail bed 3-6 branches nutrition artery. The fibular intrinsic artery of the great toe runs distally and has 3-5 vascular branches to nourish the nail bed. Several small veins join together at the interphalangeal joint to form a dorsal digital vein. A total of 45 cases of clinical patients were successfully completed surgery, the great nail flap survival after transplantation,and the rate of excellence in functional assessment was 96%. Conclusion With nutrient vessels of the great toe nail flap transplantation to repair nail bed defect treatment, it is a better method to repair hand nail bed.
2019 Vol. 16 (1): 94-97 [Abstract] ( 213 ) HTML (1 KB)  PDF (868 KB)  ( 135 )
98 Relationship between the levels of T helper cells, NKT cells, NK cells and disease development and prognosis in patients with pulmonary tuberculosis
LI Lijuan
Objective To study the relationship between the levels of T helper cells, natural killer T cells (NKT cell) natural killer cells (NK cell), and the development and prognosis of pulmonary tuberculosis. Methods A total of 100 cases of tuberculosis patients admitted to the West China-Guang′an Hospital of Sichuan University ("our hospital" for short) from December 2015 to December 2016 were selected, and 100 healthy people in the same period were selected. According to the initial diagnosis and tuberculin status, they were divided into four groups (Groups Ⅰ~Ⅳ were the newly dianosed tuberculosis group, retrospective tuberculosis group, tuberculin-positiue health group, tuberculin-negative health group). Flow cytometry was used to detect the expression rates of peripheral blood T cells, NKT and NK cells in the four groups before treatment. Results Compared with group Ⅲ, the expression rate of NKT cells in group Ⅰ was significantly increased, the difference was statistically significant (P < 0.05). There was no significant difference in the expression rates of T cells and NK cells between the two groups (P > 0.05). Compared with group Ⅳ, the expression rate of NKT cells in group Ⅰ was significantly increased, the difference was statistically significant (P < 0.05). There was no significant difference in the expression rates of T cells and NK cells between the two groups (P > 0.05); Compared with group Ⅱ, the T cell expression rate was significantly increased, the difference was statistically significant (P < 0.05), but there was no significant difference in the expression rate of NKT cells and NK cells between the two groups (P > 0.05); group Ⅲ and Ⅳ There was no significant difference in the expression rate of T cells, NK and NKT cells (P > 0.05). The expression rates of T cells in the mild, moderate and severe subgroups of group Ⅰ were statistically significant (P < 0.05), and the expression rate was: severe group > middle group > moderate mild group. There was no significant difference in the expression rates of NKT cells and NK cells between the three subgroups (P > 0.05). A total of 100 patients with pulmonary tuberculosis were followed up for 6 months after treatment, 2 cases of sputum re-yang, 1 case of lesions worsened, and the rest did not relapse. Conclusion The level of T cell expression in newly diagnosed patients is comparable to that of healthy individuals and is associated with disease severity. The expression rate of T cells was significantly increased in the patients who were reviewed. NKT cell expression increased in active tuberculosis patients. Therefore, NK and T cell assays can aid in the diagnosis of active tuberculosis.
2019 Vol. 16 (1): 98-101 [Abstract] ( 269 ) HTML (1 KB)  PDF (662 KB)  ( 90 )
102 Application effects of Ropivacaine combined with Sufentanil in painless labor
LI Mingliang1 YIN Jianyin2 ZOU Dingquan1▲
Objective To study the application effects of Ropivacaine combined with Sufentanil on painless childbirth. Methods From June 2016 to June 2018, 160 parturients delivered in the Second Xiangya Hospital of Central South University and Hu′nan Provincial Maternity and Child Health Care Hospital were selected, and they were divided into the Ropivacaine group and the combination group by random number table method, with 80 cases in each group. Ropivacaine group was treated by Ropivacaine for analgesia, and the combination group was treated by Sufentanil and Ropivacaine for analgesia. The analgesic effects of the two groups were compared. Prolactin (PRL) level was detected and lactation volume was compared between the two groups. Blood gas and Apgar scores of neonates were compared between the two groups. Results The analgesic effect time and complete block time of the combination group were shorter than those of Ropivacaine group, and the duration was longer than that of Ropivacaine group, the differences were statistically significant (P ＜ 0.05). The lactation initiation time of the combination group was shorter than that of Ropivacaine group, and the lactation volume and concentrations of PRL at postpartum 24 h and 48 h were higher than those of Ropivacaine group, the differences were statistically significant (P ＜ 0.05). The blood pH, artery blood oxygen partial pressure (PaO2) level of the fetus and Apgar score of neonates in the combination group were higher than those of Ropivacaine group, and artery blood partial pressure of carbon dioxide (PaCO2) level was lower than that of Ropivacaine group, the differences were statistically significant (P ＜ 0.05). The pain relief and breast distending pain relief in combination group were better than those in Ropivacaine group (P ＜ 0.05); the overall satisfaction of the combination group was higher than that of Ropivacaine group, and the total adverse reaction rate was lower than that of Ropivacaine group, the differences were statistically significant (P ＜ 0.05). Conclusion Ropivacaine combined with Sufentanil is more effective and safe for painless labor.
2019 Vol. 16 (1): 102-105 [Abstract] ( 209 ) HTML (1 KB)  PDF (559 KB)  ( 118 )
106 Application effect of disposable double tube laryngeal mask in patients with airway hyperresponsiveness during general anesthesia recovery period
SHAO Wei
Objective To explore the application effect of disposable double tube laryngeal mask in patients with airway hyperresponsiveness during general anesthesia recovery period. Methods Ninety-four patients of airway hyperresponsiveness treated in the Second Hospital of Baoding of Hebei Province from March 2016 to March 2017 were selected and divided into the observation group and the control group by random number table method, with 47 cases in each group. The control group was treated with tracheal intubation, the observation group was treated with disposable double tube laryngeal mask. The hemodynamics, postoperative recovery quality and incidence of adverse reactions were observed and compared between the two groups. Results The levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) before extubation of trachea or laryngeal mask (T2), at extubation of tracheal ductus or laryngeal mask (T3), 5 min of extubation of tracheal ductus or laryngeal mask (T4) in the observation group were significantly lower than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the level of pulse oxygen saturation (SpO2) and partial pressure of carbon dioxide in artery (PaCO2) before induction of anesthesia (T1), T2, T3, T4 between the two groups (P ＞ 0.05). There was no significant difference in the time of spontaneous breathing recovery, the time of eye opening, the time of full recovery of consciousness, and the time of extraction of the laryngeal mask or tracheal intubation between the two groups (P ＞ 0.05); while the Steward awakening score of the observation group was significantly higher than that of control group, the difference was statistically significant (P ＜ 0.05). The total incidence of adverse reactions in the observation group was 10.64%, which was significantly lower than that in the control group (29.79%), the difference was statistically significant (P ＜ 0.05). Conclusion The use of disposable double tube laryngeal mask in patients with airway hyperresponsiveness during general anesthesia recovery period can obviously improve the hemodynamics of the patients, improve the quality of postoperative recovery, reduce the incidence of adverse reactions and ensure the safety of the patients.
2019 Vol. 16 (1): 106-109 [Abstract] ( 233 ) HTML (1 KB)  PDF (518 KB)  ( 69 )
110 The effect of ultrasound-guided continuous paraspinal nerve block on postoperative recovery of elderly patients with esophageal cancer
BAO Shumin WANG Lixian SHAN Shiqiang
Objective To study the effect of ultrasound-guided continuous paraspinal nerve block on postoperative recovery of elderly patients with esophageal cancer. Methods Eighty-four cases of elderly patients with esophageal cancer enrolled in Cangzhou Central Hospital of Hebei Province from April 2016 to February 2018 were divided into observation group and control group according to the random number table method, with 42 cases in each group. The control group was treated with simple general anesthesia, the observation group was treated with ultrasound-guided continuous paraspinal nerve block combined with general anesthesia. The postoperative recovery, the changes of hemodynamic indexes and stress indicators at different time points, the postoperative pain situation at different time points, surgery time and dosage of Remifentanil and Propofol were compared in the two groups. Results The anal exsufflation time, defecation time and hospitalization time of the observation group were significantly shorter than those of the control group, the differences were statistically significant (P ＜ 0.05). The systolic blood pressure and diastolic blood pressure level in the observation group of intraoperative 1 h and 2 h were significantly higher than those in the control group, and the heart rate of the observation group of intraoperative 2 h and at the end of operation were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). The level of norepinephrine in the observation group of postoperative 24 h was significantly lower than that in the control group, and the levels of adrenaline and dopamine in the observation group of intraoperative 2 h, the end of operation and postoperative 24 h were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). The visual analog scores of postoperative 1, 4, 8 h and 24 h in the observation group were significantly lower than those in the control group, the differences were statistically significant (P ＜ 0.05). The dosage of Remifentanil and Propofol in the observation group were significantly lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Ultrasound-guided continuous paravertebral nerve block is effective in the treatment of elderly patients with esophageal cancer, it is effective to promote postoperative recovery of patients, maintain hemodynamic stability and inhibit the stress response, it can also relieve postoperative pain and the dosage of Remifentanil and Propofol, it is worthy of clinical application.
2019 Vol. 16 (1): 110-113,118 [Abstract] ( 173 ) HTML (1 KB)  PDF (540 KB)  ( 64 )
114 Effects of intravenous injection of Dezocine on the pain threshold, spontaneous breathing and consciousness in patients
HAO Dandan MU Feng WANG Baoguo WANG Shuangyan
Objective To investigate the effects of intravenous injection of Dezocine on the pain threshold, spontaneous breathing and consciousness in patients. Methods Eighty patients [18-60 years of age, 18-25 kg/m2 of body mass index (BMI), American Society of Anesthesiologists (ASA) class Ⅰ-Ⅱ] undergoing selective surgery in Sanbao Brain Hospital, Capital Medical University from April to November 2017 were divided into four groups according to the random number table method (n = 20). Before anesthesia, the patients were intravenously injected Dezocine 5 mg in group D1, Dezocine 10 mg in group D2, Fentanyl 0.1 mg in group F and equivalent normal saline in group NS. The respiratory rate per minute (RR), partial pressure of carbon dioxide in endexpiratory gas (PETCO2), oxygen saturation (SpO2), heart rate (HR), mean arterial pressure (MAP), observer′s assessment of alertness and sedation (OAA/S) score, pain and pain tolerance thresholds of patients for 2 Hz/100 Hz electrical stimulation were recorded before injection (T0) and at 5 min (T1), 10 min (T2), 15 min (T3) after injection. Dizziness, somnolence, respiratory depression and other adverse reactions were observed as well. Results Pain thresholds and pain tolerance thresholds at T1-T3 in four groups were significantly higher than those at T0 (P ＜ 0.05); compared with group NS, pain thresholds at T2-T3 in group D1, pain thresholds at T1-T3 and pain tolerance thresholds at T2-T3 in group D2, pain thresholds and pain tolerance thresholds at T1-T3 in group F were increased (P ＜ 0.05). RR and SpO2 at T1-T3 in group D2 and group F were dramatically decreased than those at T0, PETCO2 at T1-T2 in group D2 and at T1-T3 in group F increased than those at T0, the differences were statistically significant (P ＜ 0.05); compared with group NS, RR and SpO2 at T1-T3 in group F decreased significantly, while PETCO2 increased significantly, the differences were statistically significant (P ＜ 0.05); compared with group F, RR and SpO2 at T1-T3 in group D1 increased significantly, while PETCO2 decreased significantly, the differences were statistically significant (P ＜ 0.05). Moreover, the number of cases of decreased OAA/S score at T1-T2, the incidence of somnolence and respiratory depressionin in group F, and the incidence of respiratory depression in group D2 were higher than those in group NS (P ＜ 0.05). Conclusion Compared with Fentanyl 0.1 mg, the treatment of intravenous injection with Dezocine 10 mg can get comparative analgesic effect, while the analgesic effect of Dezocine 5 mg is slightly less than that of Fentanyl 0.1 mg. The intravenous injection of Dezocine 5 mg is safe and effective. However, when its dose increases to 10 mg, a short period of respiratory depression (≤10 min) can be seen, indicating that we should pay attention to the change of spontaneous breathing in case of related complications.
2019 Vol. 16 (1): 114-118 [Abstract] ( 181 ) HTML (1 KB)  PDF (535 KB)  ( 118 )
119 Analysis of medication rules of TCM differentiation for radiation esophagitis
LI Xiaodong CAO Yuojun▲
Objective To explore the medication rules of TCM differentiation in the prevention and treatment of radiation esophagitis. Methods By searching for articles in three Chinese databases including China National Knowledge Internet (CNKI), VIP and Wanfang database from January 1990 to October 2017, 44 articles with TCM in the prevention and treatment of radiation esophagitis were screened out. The data on syndrome differentiation and prescription frequency in the articles was extracted and collated. Results The three most frequent syndromes in syndrome differentiation were “blazing heat-toxin”“yin depletion and consumption of body-fluid” and “blood stasis and heat accumulation”, accounting for 95.4%, 56.8% and 40.9%, respectively. The most frequent medications included “heat-clearing and detoxifying drug”, “nourishing yin and promoting the secretion of body-fluid drug” and “cooling blood and activating blood circulation drug”, accounting for 95.4%, 95.4% and 40.9%, respectively. Conclusion The main syndrome differentiation of TCM in radiation esophagitis includes “excessive heat and toxin” and “yin depletion and consumption of body-fluid”. In the late stage of radiation, blood stasis syndrome may occurs. Heat-clearing and detoxifying, nourishing yin and promoting the secretion of body-fluid and cooling blood and activating blood circulation drugs are mainly used in the treatment.
2019 Vol. 16 (1): 119-122 [Abstract] ( 214 ) HTML (1 KB)  PDF (615 KB)  ( 118 )
123 The characteristics of nerve electrophysiology in different TCM syndrome types of patients with carpal tunnel syndrome
XU Lihong WU Haike HUANG Tao PENG Liebiao HUANG Tingting LIANG Yangui HUANG Qiang
Objective To study the characteristics of nerve electrophysiology in different TCM syndrome types of patients with carpal tunnel syndrome(CTS). Methods From January to September 2017, 80 patients with CTS treated in Foshan Hospital of Traditional Chinese Medicine in Guangdong Province (“our hospital” for short) were selected as research objects. According to different TCM syndromes, the patients were divided into cold dampness blocking collaterals group (38 cases) and deficiency of qi and yin group (42 cases). In addition, 40 normal persons who received physical examination in our hospital at the same time were taken as control group. British Medelec Synerg / evoked potentiometer was used to detect the conventional nerve electrophysiology of the three groups. The motor nerve conduction velocity (MCV), compound muscle action potential (CMAP), sensory nerve conduction velocity (SNCV) and distal motor latency (DML) and the SNCV, DML of ulnar nerve in the three groups were measured. Results The levels of MCV and CMAP in deficiency of qi and yin group were lower than those of cold dampness blocking collaterals group and control group, and the CMAP of cold dampness blocking collaterals group was lower than the control group, the differences were all statistically significant (all P ＜ 0.05). The levels of SNCV of finger 1 to wrist and finger 3 to wrist in deficiency of qi and yin group were lower than those of cold dampness blocking collaterals group and control group, and cold dampness blocking collaterals group was lower than control group (all P ＜ 0.05); the DML in deficiency of qi and yin group was higher than the cold dampness blocking collaterals group and control group, and cold dampness blocking collaterals group was higher than the control group (all P ＜ 0.05). The differences of SNCV and DML levels of ulnar nerve in the three groups were not statistically significant (P ＞ 0.05). Conclusion There is a significant difference in median nerve MCV, CMAP, SNCV and DML levels in CTS patients with cold dampness blocking collaterals type and deficiency of qi and yin type, the above indexes can be detected in clinic, which are beneficial for TCM syndrome differentiation of CTS patients.
2019 Vol. 16 (1): 123-125,129 [Abstract] ( 204 ) HTML (1 KB)  PDF (634 KB)  ( 108 )
126 Application of the theory of “preventive treatment of disease” in the prevention and treatment of coronary heart disease
WANG Zheng1 LIU Rui1 ZHANG Hong2▲
In recent years, coronary heart disease has gradually become one of the diseases with high clinical incidence, and it has developed rapidly and has a poor prognosis, which seriously affects people′s quality of life. The prevention and treatment of coronary heart disease should always be the focus of relevant medical workers. Modern medicine focuses on prevention and post-cardiac rehabilitation, but it has many limitations and lags in clinical implementation. This article explores the application of “preventive treatment of disease” theory in the prevention and treatment of coronary heart disease in traditional medicine from the perspective of “no disease prevention first, disease prevention has occurred to prevent changes, prevent recurrence after illness”, and provides new ideas for clinical treatment of medical workers. It is expected to play an important role in the health management of patients with coronary heart disease, thereby improving clinical efficacy and the quality of life of patients.
2019 Vol. 16 (1): 126-129 [Abstract] ( 286 ) HTML (1 KB)  PDF (649 KB)  ( 106 )
130 Clinical study on self-made black sticking-plaster decocted by Shujin Huoxue Recipe in the treatment of lumbar disc herniation with syndrome of qi stagnation and blood stasis
XU Yunjie1 ZHANG Yunliang2 LI Ju1 WANG Teng2 HUO Junjie2
Objective To study the clinical effect of self-made black sticking-plaster decocted by Shujin Huoxue Recipe in the treatment of lumbar disc herniation with syndrome of qi stagnation and blood stasis. Methods According to the diagnostic criteria of lumbar disc herniation with syndrome of qi stagnation and blood stasis, 100 cases of patients with lumbar disc herniation admitted to Outpatient Department of Langfang Traditional Chinese Medicine Hospital of Hebei Province from April 2016 to April 2018 were selected and divided into treatment group and control group by random number table method, with 50 cases in each group. The treatment group was treated with self-maded Shujin Huoxue Recipe, and the control group was treated with Qizheng Xiaotong Plaster, one change every 2 d, 10 d was as a course of treatment, for 2 courses. The clinical efficacy and the changes of visual analogue scale (VAS) and modified Japanese Orthopaedic Association scores (M-JOA) of the two groups before and after treatment were observed. Results After treatment for 10, 20 d, the VAS, M-JOA scores of the two groups were lower than those before treatment (P ＜ 0.05), and the VAS, M-JOA scores of treatment group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of treatment group was better than that of control group, the difference was statistically significant (Z = 3.821, P ＜ 0.05). Conclusion Self-made black sticking-plaster decocted by Shujin Huoxue Recipe in the treatment of lumbar disc herniation with syndrome of qi stagnation and blood stasis has a definite curative effect, which can obviously relieve pain and improve patients′ dysfunction.
2019 Vol. 16 (1): 130-133 [Abstract] ( 189 ) HTML (1 KB)  PDF (655 KB)  ( 159 )
134 Clinical experience of floating acupuncture in the treatment of obstinate facial paralysis
YANG Xiaolin1 CAI Junsheng1 SUN Jian2
Obstinate facial paralysis is a common chronic disease, and the clinical treatment methods are various at present. This paper mainly describes the clinical experience of Professer Sun Jian in treating obstinate facial paralysis with floating acupuncture, and discusses from the following 5 aspects: treatment steps, pathogenesis, possible mechanism, advantage analysis and classic cases of floating acupuncture to obstinate facial paralysis. The rehabilitation of facial muscles for patients with obstinate facial paralysis is very important. Floating acupuncture therapy can help to improve the nutritional supply of sick muscles quickly and eliminate its pathological states of tension and spasm, thus promote the recovery of motor function of corresponding facial muscles by searching for the sick facial muscles and inserting the needles into sick muscles for sway them with doing reperfusion approach as supplementary.
2019 Vol. 16 (1): 134-137 [Abstract] ( 203 ) HTML (1 KB)  PDF (728 KB)  ( 58 )
138 The role of echocardiography in the screening of complex congenital heart malformations in middle and late pregnancy
LI Lan1 XIE Hairong2 RAO Jing1 FENG Guojuan1 FENG Xin1 YANG Hongmei1 ZHAO Xiaodong1▲
Objective To analyze the role of echocardiography in the screening of complex congenital heart malformations in middle and late pregnancy. Methods From July 2016 to January 2018, 600 high-risk pregnant women admitted to Jiangyou People′s Hospital were selected as the study subjects. All the subjects underwent echocardiography in the middle and late pregnancy, and the test results were compared with the postpartum pathological results to compare the diagnostic accuracy of echocardiography. Results A total of 23 cases (3.83%) of 600 pregnant women with complex congenital heart malformation were detected by color doppler ultrasonography. Postpartum pathological examination showed that there were 26 cases of complicated cardiac malformation among the subjects, accounting for 4.33%.There was no significant difference in detection rate between the two group (P > 0.05). The accuracy of echocardiographic screening was 88.46%, and among 23 cases of abnormal fetuses detected by ultrasound, tetralogy of fallot was the main one, followed by right ventricular double outlet and complete endocardial cushion defect. Among the 23 patients with complex congenital heart malformation revealed by color doppler ultrasonography, 9 cases (39.1%) had wider fetal diameter, 7 cases (30.4%) had narrow diameter, and 7 cases (30.4%) had normal diameter. Conclusion The application of echocardiography in screening complicated congenital heart malformations of fetuses in middle and late pregnancy is of high value and can be popularized in clinical practice.
2019 Vol. 16 (1): 138-140,144 [Abstract] ( 196 ) HTML (1 KB)  PDF (489 KB)  ( 55 )
141 Cause analysis of large amount of contrast media extravasation at CT enhanced scanning and prevention measures.
FENG Jianqiu SUN Xiaoli▲
Objective To explore the causes and preventive measures of a large number of contrast agent overflowing in CT enhanced scanning. Methods A total of 2500 patients with CT enhanced scan in Beijing Shijitan Hospital, Capital Medical University from July 2013 to November 2015 were selected to observe whether a large number of contrast agent spillovers appeared during the scan. Through single factor description analysis and multivariate Logistic regression analysis, the causes of contrast agent overflow were analyzed, and preventive measures were discussed. Results A large number of contrast agent overflows were found in 21(0.84%) of 2500 patients after CT enhanced scan. Single factor analysis showed that in the age, disease typ, injection vessel site, injection velocity, osmotic pressure, poor compliance of patients and nurses are not skilled were related to a large number of contrast agent overflowing (P ＜ 0.05). Multivariate Logistic regression analysis showed that age (OR = 1.825), disease type (OR = 2.054), injection velocity (OR = 3.024) and osmotic pressure (OR = 2.687), Compliance (OR = 1.953) and skill level of nurses (OR = 2.547) were independent risk factors affecting the extravasation of a large number of contrast agents. Conclusion The influence factors of a large number of contrast agent spillovers in CT scan are interacted. Strengthening nursing intervention according to the related factors, improve the skill of puncture, improve the security of enhanced scan.
2019 Vol. 16 (1): 141-144 [Abstract] ( 280 ) HTML (1 KB)  PDF (463 KB)  ( 95 )
145 Effect comparison of Tanshinone ⅡA Sodium Sulfonate Injection and Shuxuening Injection on angina pectoris and coronary heart disease of qi-stagnancy and blood stasis
JIANG Hairui1 HAO Liguo2
Objective To compare the efficacy of Tanshinone ⅡA Sodium Injection and Shuxuening Injection in the treatment of angina pectoris and coronary heart disease of qi-stagnancy and blood stasis. Methods From October 2016 to December 2017, 168 patients with coronary heart disease and angina pectoris were selected. All patients were diagnosed by syndrome differentiation based on traditional Chinese medicine, they were divided into group A and group B by random number table method, 84 patients in each groups. Group A was treated with Shuxuening Injection on the basis of routine treatment, and group B was treated with Tanshinone ⅡA Sodium Injection on the basis of routine treatment. The treatment effects and changes of hemorheology indexes in the two groups were compared. Results Before treatment, the number of episodes of angina pectoris, duration, and symptom scores of traditional Chinese medicine in two groups were compared, the differences were not statistically significant (P > 0.05); after 2, 4 weeks of treatment, these in two groups were significantly lower than before treatment, and after 2 weeks of treatment, the number of episodes of angina pectoris, and symptom scores of traditional Chinese medicine in group B were lower than group A, and the duration of angina pectoris was shorter than the group B, the differences were statistically significant (P < 0.05); after 4 weeks of treatment, the number of episodes of angina pectoris, duration, and symptom scores of traditional Chinese medicine in two groups were compared, the differences were not statistically significant (P > 0.05). After 4 weeks of treatment, the total effective rate of angina pectoris treatment, total effective rate of ECG in two groups were compared, the differences were not statistically significant (P > 0.05). No serious adverse drug reactions and complication happened during treatment. Conclusion Both Tanshinone ⅡA Sodium Sulfonate Injection and Shuxuening Injection have good efficacy and safety in the treatment of angina pectoris and coronary heart disease of qi-stagnancy and blood stasis, the effect of Tanshinone ⅡA Sodium Injection is more rapid.
2019 Vol. 16 (1): 145-148,152 [Abstract] ( 215 ) HTML (1 KB)  PDF (463 KB)  ( 168 )
149 Clinical study of Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets in the treatment of mild and moderate anxiety depression
HUANG Xueping1 YANG Hui1 WEN Yan1 WU Xiangmei2
Objective To explore the clinical efficacy and safety of Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets in the treatment of mild and moderate anxiety depression. Methods From January 2015 to December 2017, in Chongqing Mental Health Center, 105 patients with mild and moderate anxiety depression were selected, according to the random indicator method, they were divided into control group (52 cases) and treatment group (53 cases). The control group was treated with Flupentixol and Melitracen Tablets, the treatment group was treated with Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets, two groups were treated for 8 treatment periods. The clinical curative effect after treatment, the SAS scores, SDS scores and levels of serum MPO, 5-HT, LH, FSH, E2 in two groups before and after treatment were was detected and compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of treatment group was significantly higher than the control group, the difference was statistically significant (P < 0.05). After treatment, the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the two groups were significantly lower than before treatment, the levels of serum 5-HT, E2 in the two groups were significantly higher than before treatment, and the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the treatment group were significantly lower than the control group, the levels of serum 5-HT, E2 were significantly higher than the control group, the differences were statistically significant (P < 0.05). No serious adverse reactions occurred in the two groups during the treatment. Conclusion Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets for the treatment of mild and moderate anxiety depression has good efficacy and low adverse reactions, it can reduce the anxiety depression symptoms, improve the serum MPO, 5-HT and sex hormone levels, and it is worthy clinical application.
2019 Vol. 16 (1): 149-152 [Abstract] ( 220 ) HTML (1 KB)  PDF (479 KB)  ( 118 )
153 Changes and clinical significance of TLR4 and TNF-α levels in peripheral blood of patients with acute myocardial infarction
HU Wei WANG Guobing HU Xiaobin▲ LIU Xiang
Objective To investigate the changes of toll-like receptor 4 (TLR4) and trmor necrosis factor-α (TNF-α) in peripheral blood of patients with acute myocardial infarction (AMI) and their clinical significance. Methods From June 2015 to March 2018, 103 AMI patients admitted to Yibin Second People′s Hospital of Sichuan Province were selected as the research group. According to the complications, the patients were divided into uncomplicated group (29 cases), complication group (55 cases) and death group (19 cases). According to the treatment effect, the patients were divided into the cured group (43 cases), the improved group (40 cases) and the ineffective group (20 cases). In addition, 51 patients with chest pain who participated in physical examination in the same period were selected as the control group. Meanwhile, the effects of TLR4, TNF-α and Gensini scores in peripheral blood of subjects in the study group and the control group on AMI subgroup and efficacy were observed. In addition, the correlation between TLR4 and serum TNF-α and Gensini scores in peripheral blood were analyzed. Results TLR4, TNF-α and Gensini scores in the peripheral blood of the study group were significantly higher than those of the control group (P ＜ 0.05); The scores of TLR4, TNF-α and Gensini in the peripheral blood of patients in the complication group and the death group were significantly higher than those in the non-complication group, and the scores of TLR4, TNF-α and Gensini in the peripheral blood of patients in the death group were significantly higher than those in the complication group, with statistically significant differences (P ＜ 0.05). Compared with the treatment group, the scores of TLR4, TNF-α and Gensini in peripheral blood of patients in the improved group and the ineffective group were significantly higher than those in the improved group (P ＜ 0.05). TLR4 in peripheral blood of AMI patients was positively correlated with serum TNF-α and Gensini score (r = 0.751, 0.703, P ＜ 0.05), while serum TNF-α was positively correlated with Gensini score (r = 0.729, P ＜ 0.05). Conclusion TLR4 and TNF-α are involved in the occurrence and development of AMI, and can also evaluate the clinical therapeutic effect and provide new therapeutic targets for the clinical treatment of AMI. TLR4 and TNF-α are involved in the occurrence and development of AMI, and they can evaluate the clinical efficacy and provide new therapeutic targets for clinical treatment of AMI.
2019 Vol. 16 (1): 153-156,161 [Abstract] ( 253 ) HTML (1 KB)  PDF (491 KB)  ( 100 )
157 Study on T-SPOT.TB test in the diagnosis of pulmonary tuberculosis and extrapulmonary tuberculosis#br#
SONG Ruihong SHEN Wei LU Liwen▲
Objective To evaluate the value of T-SPOT.TB in diagnosis of tuberculosis and extrapulmonary tuberculosis. Methods From June 2014 to June 2017, 200 patients suspected to be active tuberculosis and extrapulmonary tuberculosis who were hospitalized in the South Hospital of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University were selected for the detection of peripheral blood T-SPOT.TB, skin tuberculin test (PPD) and addendum antacid fast staining (AFB), and the diagnostic values of the three methods were compared. Results The sensitivity, specificity, negative predictive value and accuracy of T-SPOT.TB, PPD and AFB tests in the diagnosis of tuberculosis were compared, and the differences were statistically significant (P ＜ 0.05).The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of T-SPOT. TB diagnosis of tuberculosis were higher than those of PPD and AFB (P ＜ 0.05). T-SPOT.TB had higher sensitivity, negative predictive value and accuracy in the diagnosis of extrapulmonary tuberculosis than PPD and AFB (P ＜ 0.05), while the difference between PPD and AFB was not statistically significant (P > 0.05). Conclusion T-SPOT.TB diagnosis of tuberculosis and extrapulmonary tuberculosis has a high sensitivity and specificity, and is an effective means of rapid diagnosis of tuberculosis infection, which is worthy of clinical application and promotion.
2019 Vol. 16 (1): 157-161 [Abstract] ( 201 ) HTML (1 KB)  PDF (475 KB)  ( 52 )
162 Selection strategy for medical collectivization of public hospitals based on PEST-SWOT analysis
QIU Heng1 ZHOU Qian2▲
With the deepening of public hospital reform, large-scale public hospitals are exploring medical collectivization strategy actively based on the demand of sustainable development. In the pattern of tightly-organized medical group bonded by assets, medical institution could be area of core hospital or branch of core hospital according to its subordination relations with core hospital. Through a PEST-SWOT analytical matrix based on the theory of PEST and SWOT, this study provides some references for the public hospital administrators to develop tightly-organized medical group.
　
2019 Vol. 16 (1): 162-165 [Abstract] ( 290 ) HTML (1 KB)  PDF (379 KB)  ( 109 )
166 The influence of 4C continuous nursing on the quality of life of esophageal carcinoma patients with anxiety
SU Lin1 WANG Miaoqin1 TAN Min1 ZOU Zixiang1 WANG Airu2
Objective To explore the influence of 4C continuous nursing on the quality of life of esophageal carcinoma patients with anxiety. Methods From June to September 2015, 80 esophageal cancer diagnosed patients with anxiety self-rating scale (SAS) score ≥ 50 in department of thoracic surgery and oncology of a tertiary hospital in Nanchong City, Sichuan Province were selected. 4C continuous nursing was implemented three days before discharge, and anxiety and quality of life were compared and analyzed six months later. Results After the implementation of 4C continuous nursing intervention for 6 months, the SAS score of esophageal cancer patients was significantly lower than that before the intervention, with statistically significant differences (P ＜ 0.05), and the quality of life score was significantly higher than that before the intervention, with statistically significant differences (P ＜ 0.05). Conclusion 4C continuous nursing intervention can improve the anxiety of patients with esophageal cancer and improve the quality of life of patients.
2019 Vol. 16 (1): 166-169 [Abstract] ( 224 ) HTML (1 KB)  PDF (548 KB)  ( 106 )
170 Effect of the time-sensitive incentive theory-guided extended service on blood glucose control and delivery outcomes in gestational diabetes mellitus patients
REN Wei WANG Xinchun QIN Jiying
Objective To explore the effect of the time-sensitive incentive theory-guided extended service guided by timeliness incentive theory on blood glucose control and delivery outcome of gestational diabetes mellitus (GDM) patients. Methods Ninety-eight cases of gestational diabetes patients admitted to the outpatient department of obstetrics of Xinjiang Uygur Autonomous Region People′s Hospital from June 2016 to December 2017 were selected as the research objects. According to the random number table, they were divided into the intervention group and the control group, with 49 cases in each group. In the control group, the outpatient pregnant women′s school of Xinjiang Uygur Autonomous Region People′s Hospital has signed in for more than 6 lectures, while the intervention group was provided with the time-sensitive incentive theory-guided extended service on the basis of education in the pregnant women school. The fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, and pregnancy weight gain of patients in the two groups at the time of admission and delivery were observed, respectively, the number of cases of hyperhydramnios, premature rupture of membranes, cesarean section, neonatal hypoglycemia, macrosomia, fetal growth restriction, and neonatal respiratory distress were collected. Results After the intervention, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin and pregnancy weight gain in the intervention group were all lower than those in the control group at admission, with statistically significant differences (P < 0.05). The incidence of hyperhydramnios, premature rupture of membranes, hypoglycemia, macrosomia and fetal growth restriction in the intervention group was lower than that in the control group, with statistically significant differences (P < 0.05). Conclusion GDM continuous care team can effectively help GDM patients control blood glucose during pregnancy, reduce the occurrence of GDM complications and reduce the occurrence of adverse pregnancy outcomes through extended services guided by the time-sensitive incentive theory, which is of great significance to the protection of maternal and infant health.
2019 Vol. 16 (1): 170-173 [Abstract] ( 195 ) HTML (1 KB)  PDF (501 KB)  ( 66 )
174 The application effect of comfort nursing in transjugular intrahepatic portosystemic shunt
HE Ximei
Objective To explore the application effect of comfortable nursing in transjugular intrahepatic portosystemic shunt (TIPS). Methods A total of 77 cases of patients treated with TIPS in Department of Interventional Complex Surgery, Hu′nan Provincial People′s Hospital from January to December 2017 were selected, and they were divided into two groups according to random number table method, 38 cases in the control group were given conventional nursing, 39 cases in the comfortable group were given comfortable nursing on the basis of nursing in the control group. The quality of life, intraoperative coordination, complications and nursing satisfaction of the patients of the two groups were compared before and after performing nursing. Results After intervention, the scores of life quality of both groups improved compared to that before intervention, and the comfortable group was higher than the control group, the differences were statistically significant (P ＜ 0.05). The coordination degree of the comfortable group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The rate of abdominal hemorrhage during and after operation, postoperative fever and operative puncture site complications in the comfortable group were lower than those in the control group, the differences were highly statistically significant (P ＜ 0.01). The total satisfactory rate of patients in the comfortable group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Comfortable nursing in TIPS can effectively decrease psychological pressure, improve the overall quality of life, improve the patient′s intraoperative cooperation degree and satisfaction, reduce the incidence of complications and ensure the operation smoothly, which is worthy of application in clinic.
2019 Vol. 16 (1): 174-177 [Abstract] ( 220 ) HTML (1 KB)  PDF (538 KB)  ( 89 )
178 Effect of continuous nursing service on postoperative rehabilitation and quality of life in gastroesophageal junction cancer patients undergoing laparoscopic resection
SUN Jing1 LIU Li2 GAO Meng1 LUO Liping1
Objective To investigate the effect of continuous nursing service on postoperative rehabilitation and quality of life in gastroesophageal junction cancer patients undergoing laparoscopic resection. Methods A total of 144 patients receiving gastric and esophageal cancer resection from March 2015 to March 2017 in Ezhou Central Hospital were selected as the subjects. All the patients were divided into control group and study group by random number table method with 72 cases in each group. The control group was given routine nursing, while the study group was given routine nursing combined with continuous nursing. The two groups were given continuous nursing service for 3 months. The postoperative rehabilitation, quality of life and nursing satisfaction degree were compared between the two groups. Results After nursing, weight, serum albumin, hemoglobin and total protein levels in the two groups were significantly higher than those before nursing, and the indices in the study group were significantly higher than those in the control group (P ＜ 0.05). After nursing, the summary of health survey (SF-36) scores in the two groups were significantly higher than those before nursing, and scores in the study group was significantly higher than that in the control group (P ＜ 0.05). The satisfactory rate of nursing care in the study group was significantly higher than that in the control group (P ＜ 0.01). Conclusion The continuous nursing service can effectively promote the postoperative rehabilitation of patients with laparoscopic gastroesophageal cancer resection, and obviously improve the quality of life and nursing satisfaction of the patients. It is worthy of clinical application.
2019 Vol. 16 (1): 178-181 [Abstract] ( 222 ) HTML (1 KB)  PDF (651 KB)  ( 95 )
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