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| Progress in the research of NLRP3-（Caspase-1）/IL-1β signal pathway |
| PAN Xubiao1,3 LI Xiangyu2 WANG Zhixin3 WANG Hongbin3 XU Xiaolei1,3 FAN Haining3,4 |
1.Graduate School, Qinghai University, Qinghai Province, Xi′ning 810000, China;
2.Department of Pneumology, the First Affiliated Hospital of Zhengzhou University, He′nan Province, Zhengzhou 450000, China;
3.Department of Hepatopancreatobiliary Surgery, the Afliated Hospital of Qinghai University, Qinghai Province, Xi′ning 810000, China;
4.Key Laboratory of Hydatid Disease Research in Qinghai Province, Qinghai Province, Xi′ning 810000, China |
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Abstract Inflammation is a defense response that dangerous stimuli induce in the body. Nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is one of the hot spots in medical research field in recent years. The activated NLRP3 inflammatory corpuscle can regulate the inflammatory response by controlling the maturation and secretion of the downstream related inflammatory cytokines. In this paper, the structure, activation and regulation mechanism of NLRP3 inflammasome, the role of downstream related cytokines and diseases related to interleukin-1 beta (IL-1β) are reviewed in order to provide references for future studies in this field.
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