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| Analysis on risk factors of fungus infection in severe pulmonary tuberculosis ICU |
| ZHANG Nan1 LI Qi2 PAN Liping3 LUO Baojian1 LIU Qiuyue1▲ |
1.Department of Intensive Care Unit, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
2.Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
3.Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China |
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Abstract Objective To explore risk factors contributing to fungus infection in severe pulmonary tuberculosis ICU. Methods Clinical data of 116 patients from Beijing Chest Hospital, Capital Medical University from January 2015 to September 2016 were collected and analyzed retrospectively. The patients were divided into fungus infected group 35 cases and non fungus infected group 81 cases. The risk factors contributing to fungus infection were analyzed by Logistic analysis. Results There were 35 cases in the 116 cases were fungus infected and the incidence of fungal infection in tuberculosis patients in the ICU was 30.17%. Single factor analysis showed that 10 factors including complicated with diabetes, other diseases in the lung, hemoptysis, the lung lesion range > 3 pulmonary lobes, cavity, fibrosis, usage of antibiotics and glucocorticoid more than 1 week, traumatic operation and serum albumin level correlated with pulmonary fungal infection(P ＜ 0.05 or P ＜ 0.01). The Logistic regression analysis showed that independent predictive risk factors of fungus infection were usage of glucocorticoid and antibiotics over 1 week, traumatic operation, and serum albumin level was the protect factor(P ＜ 0.05 or P ＜ 0.01). Conclusion Patients with pulmonary tuberculosis in ICU has a higher rate of fungus infection. Patients with long-term glucocorticoids, invasive operations, and using broad-spectrum antibiotics and low albumin level should be aware of the risk of fungal infection, and should take early prevention, diagnosis and treatment.
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