结核感染T细胞斑点试验在肺结核和肺外结核诊断中的价值

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Abstract Objective To evaluate the value of T-SPOT.TB in diagnosis of tuberculosis and extrapulmonary tuberculosis. Methods From June 2014 to June 2017, 200 patients suspected to be active tuberculosis and extrapulmonary tuberculosis who were hospitalized in the South Hospital of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University were selected for the detection of peripheral blood T-SPOT.TB, skin tuberculin test (PPD) and addendum antacid fast staining (AFB), and the diagnostic values of the three methods were compared. Results The sensitivity, specificity, negative predictive value and accuracy of T-SPOT.TB, PPD and AFB tests in the diagnosis of tuberculosis were compared, and the differences were statistically significant (P ＜ 0.05).The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of T-SPOT. TB diagnosis of tuberculosis were higher than those of PPD and AFB (P ＜ 0.05). T-SPOT.TB had higher sensitivity, negative predictive value and accuracy in the diagnosis of extrapulmonary tuberculosis than PPD and AFB (P ＜ 0.05), while the difference between PPD and AFB was not statistically significant (P > 0.05). Conclusion T-SPOT.TB diagnosis of tuberculosis and extrapulmonary tuberculosis has a high sensitivity and specificity, and is an effective means of rapid diagnosis of tuberculosis infection, which is worthy of clinical application and promotion.

Key words： T-SPOT.TB test Pulmonary tuberculosis Extrapulmonary tuberculosis

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	SONG Ruihong SHEN Wei LU Liwen▲

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SONG Ruihong SHEN Wei LU Liwen▲. Study on T-SPOT.TB test in the diagnosis of pulmonary tuberculosis and extrapulmonary tuberculosis#br#[J]. 中国医药导报, 2019, 16(1): 157-161.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I1/157

[1] World Health Organization. Global tuberculosis control：WHO Report 2010 [M]. Geneva：WHO，2010：5-7.
[2] 刘梅，李娜娜，王建华，等.肺结核和肺外结核药物敏感分析[J].中国老年学杂志，2017，37（23）：5869-5870.
[3] 杨松，严晓峰，曾晓刚，等.结核抗体检测对活动性肺结核的诊断价值评价[J].中国防痨杂志，2018，40（1）：47-52.
[4] 陈大川，王在义.肺结核诊断的研究进展[J].临床肺科杂志，2016，21（1）：145-148.
[5] Lee HW，Lee YJ，Kim SJ，et al. Comparing tuberculin skin test and interferon γ release assay （T-SPOT.TB） to diagnose latent tuberculosis infection in household contacts [J]. Korean J Intern Med，2017，32（3）：486-496.
[6] Tanabe M，Nakamura A，Arai A，et al. The Direct Comparison of Two Interferon-gamma Release Assays in the Tuberculosis Screening of Japanese Healthcare Workers [J]. Intern Med，2017，56（7）：773-779.
[7] Auguste P，Tsertsvadze A，Pink J，et al. Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis：systematic review and meta-analysis [J]. BMC Infect Dis，2017，17（1）：200.
[8] 雷红鸽，张敏，韩丰娟，等.疑似结核患者T-SPOT.TB检测结果分析[J].河北医药，2015，37（10）：1523-1526.
[9] 张娴．萋-尼氏抗酸染色法的操作改良及效果[J].浙江预防医学，2010，22（10）：95-96.
[10] 刘纯成，刘林飞，李桂珍，等.T-SPOT.TB在结核感染诊断中的应用研究[J].中国卫生检验杂志，2015，25（16）：2644-2646.
[11] 秦庆，胡瑛，吕永强.痰涂片抗酸染色、结核抗体试验、荧光PCR、T-SPOT.TB在肺结核诊断中的临床意义[J].中国医药科学，2017，7（21）：130-133.
[12] 储新民，孔建新.酶联免疫斑点试验诊断结核的敏感性和特异性研究[J].安徽医科大学学报，2012，47（5）：613-615.
[13] 陈芳，项忠元.T淋巴细胞干扰素释放试验在检测结核杆菌感染中的应用[J].实用预防医学，2017，24（3）：272-274.
[14] 徐茜，贺家勇，常炜，等.结核感染T细胞斑点实验在结核病诊断中的价值[J].新疆医科大学，2018，41（3）：308-314.
[15] 余亚丽，刘红.T-SPOT.TB在肺结核诊断中的应用价值[J].中国实用医刊，2015，42（7）：123-125.
[16] 张士才.T.spotTB联合结核抗体检测在结核病诊断中的应用价值[J].中国现代医生，2018，1（1）：127-129.
[17] 何玲慧，陈晓琴，傅文.T-SPOT.TB检测技术在临床结核病中的应用进展[J].医学前沿，2016，6（6）：23-24.
[18] 李强，饶常红，黄渤.γ-干扰素释放试验、荧光定量PCR、结核菌素皮肤试验联合检测对涂阴性肺结核的诊断价值[J].中国医学创新，2017，14（33）：4-8.
[19] 班立芳.结核感染T细胞斑点试验在结核病患者诊断中的应用[J].中国民康医学，2017，29（5）：13-14.
[20] 蔺景双，蔺晨，郝兴亮，等.结核感染T细胞斑点试验诊断肺结核的临床应用[J].山东医药，2016，56（48）：94-96.
[21] Singh J，Dinkar A. Positive outcome of pulmonary tuberculosis associated with extraordinary extensive extrapulmonary tuberculosis in an immunocompetent adult [J]. nt J Mycobacteriol，2018，7（2）：183-185.
[22] 张雨相，熊将军.T-SPOT．TB、痰涂片和TB-DNA在检测肺结核诊断中的比较研究[J].当代医学，2015，21（28）：55-56.
[23] 胡钰卿，潘爱珍，王静，等.感染T细胞斑点试验在耐多药肺结核诊断中的应用价值[J].中国医药科学，2016，6（21）：147-150.
[24] Leung CC，Yam WC，Ho PL，et al. T-Spot.TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts [J]. Respirology，2015，20（3）：496-503.
[25] Spicer KB，Turner J，Wang SH，et al. Tuberculin skin testing and T-SPOT.TB in internationally adopted children [J]. Pediatr Infect Dis J，2015，34（6）：599-603.