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| Effect comparison of Tanshinone ⅡA Sodium Sulfonate Injection and Shuxuening Injection on angina pectoris and coronary heart disease of qi-stagnancy and blood stasis |
| JIANG Hairui1 HAO Liguo2 |
1.No. 5 Department of Cardiology, the Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, Qiqihar 161000, China;
2.School of Medical Technology, Qiqihar Medical University, Heilongjiang Province, Qiqihar 161000, China |
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Abstract Objective To compare the efficacy of Tanshinone ⅡA Sodium Injection and Shuxuening Injection in the treatment of angina pectoris and coronary heart disease of qi-stagnancy and blood stasis. Methods From October 2016 to December 2017, 168 patients with coronary heart disease and angina pectoris were selected. All patients were diagnosed by syndrome differentiation based on traditional Chinese medicine, they were divided into group A and group B by random number table method, 84 patients in each groups. Group A was treated with Shuxuening Injection on the basis of routine treatment, and group B was treated with Tanshinone ⅡA Sodium Injection on the basis of routine treatment. The treatment effects and changes of hemorheology indexes in the two groups were compared. Results Before treatment, the number of episodes of angina pectoris, duration, and symptom scores of traditional Chinese medicine in two groups were compared, the differences were not statistically significant (P > 0.05); after 2, 4 weeks of treatment, these in two groups were significantly lower than before treatment, and after 2 weeks of treatment, the number of episodes of angina pectoris, and symptom scores of traditional Chinese medicine in group B were lower than group A, and the duration of angina pectoris was shorter than the group B, the differences were statistically significant (P < 0.05); after 4 weeks of treatment, the number of episodes of angina pectoris, duration, and symptom scores of traditional Chinese medicine in two groups were compared, the differences were not statistically significant (P > 0.05). After 4 weeks of treatment, the total effective rate of angina pectoris treatment, total effective rate of ECG in two groups were compared, the differences were not statistically significant (P > 0.05). No serious adverse drug reactions and complication happened during treatment. Conclusion Both Tanshinone ⅡA Sodium Sulfonate Injection and Shuxuening Injection have good efficacy and safety in the treatment of angina pectoris and coronary heart disease of qi-stagnancy and blood stasis, the effect of Tanshinone ⅡA Sodium Injection is more rapid.
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