白细胞介素-8基因启动子-251T＞A多态性与急性胰腺炎发病风险的Meta分析

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Abstract Objective To investigate the relationship between the polymorphism of interleukin-8 (IL-8) gene promoter -251T＞A with the risk of acute pancreatitis (AP). Methods PubMed, Embase, Web of Science databases and WanFang were searched for studies on IL-8 promotor-251T＞A polymorphism and AP risk from January 1990 to December 2015. Results Finally, seven studies involving 2282 cases, among all the cases, 1013 in the AP group and 1269 in the control group. Among the population enrolled, IL-8 promoter-251T>A polymorphism was related to AP risk(OR = 1.56，95%CI: 1.41-2.13，P = 0.02). In the dominant models, A carrier increased AP risk (OR = 1.44，95%CI: 1.21-1.73，P = 0.01); in the recessive models, homozygote AA increased AP risk (OR = 1.65, 95%CI: 1.13-2.41, P = 0.02). Subgroup analysis indicated that the recessive gene model of MAP (OR = 2.01, 95% CI:1.25-3.24, P = 0.025) and all SAP gene models (OR = 1.80, 95% CI: 1.43-2.26, P = 0.022), the dominant model (OR = 2.17, 95% CI:1.54-3.06, P = 0.014) and the recessive model (OR = 2.39, 95% CI:1.49-3.81, P = 0.005) of IL-8 promoter-251T>A polymorphism increased the risk of AP. Conclusion IL-8 promoter-251T＞A is associated with increase of AP risk, but considering the limitations of this study, further research with better design and larger sample size is needed to confirm the conclusion.

Key words： Interleukin-8 Acute pancreatitis Polymorphism Meta-analysis

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	LIU Jianping LI Su SUN Yaxuan

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LIU Jianping LI Su SUN Yaxuan. Meta analysis of the polymorphism of interleukin-8 gene promoter -251T＞A with the risk of acute pancreatitis[J]. 中国医药导报, 2019, 16(1): 68-73.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I1/68

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