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2018 Vol. 15, No. 26 Published: 2018-09-15

	4	Effect of Tang-luo-ning on mitochondrial superoxide anion production and mitochondrial membrane potential in the dorsal root ganglion of diabetic rats
		LIU Qin1 LI Yixiao1 ZHANG Taojing2 GONG Yanbing2 ZHOU Hui2 XIE Peifeng2
		Objective To observe the effect of Chinese herbal compound Tang-luo-ning on oxidative respiratory function of the mitochondrial respiratory chain, superoxide anion production and membrane potential in diabetic rat dorsal root ganglion (DRG). Methods There were 80 SD male rats, 14 of them were randomly selected as the normal group. The rest 66 were used to established diabetic rats model by injected Streptozocin (STZ). According to the random number table, the 61 rats of the model were divided into model group with 19 rats, Western medicine group (alpha lipoic acid group) with 21 rats and traditional Chinese medicine group (Tang-luo-ning group) with 21 rats. They were given the medicine 8 weeks, then mitochondrial respiratory chain oxidative respiratory function, superoxide anion production and membrane potential levels were measured. Results Compared with the normal group, the mitochondrial respiratory function of the DRG in the model group was significantly decreased (P < 0.01). Compared with the model group, the mitochondrial respiratory function of the DRG in the Western medicine group was significantly improved (P < 0.01). Compared with the model group, the Chinese medicine group had no significant improvement in mitochondrial respiratory function in DRG（P ＞ 0.05）. Compared with the normal group, the mitochondrial superoxide anion of the DRG in the model group was significantly increased (P < 0.01). Compared with the model group, the mitochondrial superoxide anion level of the DRG in the Chinese medicine group and the Western medicine group was significantly reduced (P < 0.1). Compared with the normal group, the mitochondrial membrane potential of the model group was significantly decreased (P < 0.01). Compared with the model group, the mitochondrial membrane potential of the Chinese medicine group and the Western medicine group was significantly improved (P < 0.01). Conclusion Tang-luo-ning in hibits the generation of superoxide anion and ameliorates mitochondrial membrane potential in dorsal root ganglions of diabetic rats. This study provides a potential mechanism underlying protection of Tang-luo-ning on the injury of dorsal root ganglions in diabetic model.
		2018 Vol. 15 (26): 4-8 [Abstract] ( 221 ) HTML (1 KB) PDF (817 KB) ( 67 )

	9	Effect of electroacupuncture on behavior and pathomorphology of brain tissue in rats with chronic fatigue syndrome
		YANG Yan1 WANG Delong1 GUO Jing1 SHI Tianyu1 QU Yuanyuan1 WANG Yue1 SUN Weibo2 YANG Tiansong3
		Objective To observe the effect of head electroacupuncture on behavioral changes and morphological changes of hippocampus and hypothalamus in rats with chronic fatigue syndrome induced by composite factors stimulation. Methods Thirty-six SD rats were selected and divided into the normal group, the model group and the acupuncture group by random number table, with 12 rats in each group. The model group and the acupuncture group used the composite factors stimulation to establish the chronic fatigue syndrome model. The acupuncture group was treated with electroacupuncture of baihui, ningshen and bilateral sensory areas to observe the activity of rats in the open field and the changes of tissue morphology in hippocampus and hypothalamus of the rats. Results Before treatment, the horizontal activity and vertical activity of the rats in the model group and the acupuncture group were significantly reduced compared with the normal group (P ＜ 0.01). After treatment, the horizontal activity and vertical activity of the rats in the acupuncture group were significantly increased (P ＜ 0.01). HE staining showed that the hippocampus and hypothalamus neurons in the model group and the acupuncture group showed morphological and quantitative pathological changes before treatment. The number of apoptotic cells and capillary edema was increased in the model group and the acupuncture group. The pathological changes in the hippocampus and the hypothalamus of the rats in the acupuncture group were improved after treatment. Conclusion Head electroacupuncture can obviously improve the central fatigue state of model rats with chronic fatigue syndrome, which may be related to the repair of neurons in the hippocampus and hypothalamus by electroacupuncture.
		2018 Vol. 15 (26): 9-12 [Abstract] ( 226 ) HTML (1 KB) PDF (784 KB) ( 55 )

	13	The protective effect of CD47 antibody on myocardial cell injury induced by Isoproterenol in rats
		DAI Youjin FU Heling BAO Dan ZHENG Yuan HOU Daorong
		Objective To investigate the protective effect of CD47 antibody on Isoproterenol (ISO) induced primary cardiomyocytes injury in rats. Methods The myocardial cells were isolated from 40 SD rats (1-3 days old). The model of primary myocardial cells injury was induced by ISO. The myocardial cells of rats were divided into normal control group (control group), model group (ISO group) and treatment group (Anti-CD47+ISO group) by random number table. In control group, myocardial cells were cultured in the conventional medium; in ISO group, the conventional culture medium was added with ISO (10-5 mol/L) for 48 h; in Anti-CD47+ISO group, CD47 antibody (7 μg/mL) was added to the conventional culture medium for 12 h, followed by ISO (10-5 mol/L) for another 48 h. Cultured supernatants were collected to measure lactic dehydrogenase (LDH), creatine kinase (CK), superoxide dismutase (SOD), malonadehyde (MDA), nitric oxide (NO); the myocardial apoptosis rate was detected using Annexin-V and PI double staining and flow cytometry; dihydroethidium (DHE) staining was used to detecte reactive oxygen species (ROS) in cardiomyocytes; the expression of CD47, Bcl-2 and Bax was detected by Western blot. Results Compared with the control group, the myocardial cells apoptosis rate in ISO group was significantly increased (P < 0.01); compared with the ISO group, the cardiacmyocyte apoptosis rate in Anti-CD47+ISO group was significantly decreased (P < 0.01). Compared with the control group, the levels of LDH, CK, MDA and ROS in ISO group were significantly increased (P < 0.01), the levels of SOD and NO were significantly decreased (P < 0.01); compared with the ISO group, the levels of SOD and NO in Anti-CD47+ISO group were significantly increased (P < 0.01) and the levels of LDH, CK, MDA and ROS were significantly decreased (P < 0.01). The results of Western blot showed that compared with the control group, the expression of CD47 and Bax in ISO group was increased significantly (P < 0.05, P < 0.01), the expression of Bcl-2 in ISO group was decreased significantly (P < 0.01); compared with ISO group, the expression levels of CD47 and Bax in Anti-CD47+ISO group were decreased significantly (P < 0.01); the expression level of Bcl-2 in ISO group was increased significantly (P < 0.05). Conclusion CD47 antibody may inhibit myocardial apoptosis by inhibiting the production of ROS and regulating the expression rate of Bcl-2/Bax protein, thus playing a protective effect on ISO-induced primary myocardial cell injury in rats.
		2018 Vol. 15 (26): 13-17,21 [Abstract] ( 245 ) HTML (1 KB) PDF (725 KB) ( 48 )

	18	The relationship between CYP2C19 genetic polymorphism and Clopidogrel antiplatelet
		DING Yasuo YIN Chun GAO Guangzhong LU Jun ZHANG Qin SUN Bing▲
		Objective To explore the relationship between CYP2C19 Genetic Polymorphism and Clopidogrel in antiplatelet. Methods A total of 63 wide-necked intracranial aneurysm patients after stent-assist coiling embolization in the Neurosurgery Department of Jiangsu Taizhou People's Hospital of Nantong University were included in the study who took Clopidogrel (75 mg/d) and Aspirin (100 mg/d) orally. Gene chip kits were applied to test CYP2C19 gene types. In this research, six gene sub-types were tested（CYP2C19＊1/＊1 (636GG, 681GG), CYP2C19＊1/＊2 (636GG, 681GA), CYP2C19＊2/＊2 (636GG, 681AA), CYP2C19＊1/＊3 (636GA, 681GG), CYP2C19＊2/＊3 (636GA, 681GA), CYP2C19＊3/＊3 (636AA, 681GG). And they were divided into three subgroups based on the metabolic rate. CYP2C19＊1/＊1 (636GG, 681GG) was in the rapid subgroup. CYP2C19＊1/＊2 (636GG, 681GA) and CYP2C19＊1/＊3 (636GA, 681GG) were in the moderate subgroup. CYP2C19＊2/＊2 (636GG, 681AA), CYP2C19＊2/＊3 (636GA, 681GA) and CYP2C19＊3/＊3 (636AA, 681GG) were in the slow subgroup. Thrombelastograms were used to test the inhibition rate of platelet. Results CYP2C19＊1/＊1 and CYP2C19＊1/＊2 were the main gene sub-types, occupied 63.5% and 19.0% separately. There were 40 cases in rapid subgroup（63.5%), 12 cases in moderate subgroup (19.0%) and 11 cases in slow subgroup (17.5%). There was no statistical difference in the inhibition rate of ADP between rapid subgroup and slow subgroup (P > 0.05). Conclusion It is of little significance to adjust the amount of Clopidogrel in patients with wide-necked aneurysm stent after detecting genetype. Other indicators are needed to monitor the inhibition of plateles.
		2018 Vol. 15 (26): 18-21 [Abstract] ( 810 ) HTML (1 KB) PDF (531 KB) ( 169 )

	22	Progress in research on zebrafish tumor model
		LI Cuixia SU Xiulan
		Zebrafish have been successfully widely used as a research models for human-related diseases in the past decade due to their unique advantages in small-scale Organisms such as in vitro fertilization, embryo transparency and strong reproductive ability. At present, the gene manipulation technology for zebrafish has been quite mature, Targeting to induce or knock out certain genes in the body and change its expression level, it is easy to replicate some human tumor diseases on zebrafish, so various types of zebrafish tumor models can be established, and are suitable for conducfing reserch on related mechanisms. This article reviews the advantages of zebrafish as a tumor model and the research of various types of zebrafish tumor models, and the application value of zebrafish as a model animal in the study of anti-tumor drugs was analyzed.
		2018 Vol. 15 (26): 22-25 [Abstract] ( 1096 ) HTML (1 KB) PDF (339 KB) ( 223 )

	26	Analysis on the status of comprehensive management and related factors of diabetes in Shanghai community
		ZENG Yuanyuan XIAO Yuanyuan ZHU Chaoyu LIU Mengdan GAO Qingge XU Li JIANG Fusong WEI Li▲
		Objective To investigate the comprehensive management of diabetic patients in Shanghai Nicheng community and explore its influencing factors. Methods From March to April 2014, 541 diabetic patients over 40 years old in Nicheng community of Shanghai were selected. The clinical and laboratory data were collected and analyzed statistically. The control rate of blood sugar, blood pressure, and blood lipid were evaluated, and relevant factors were analyzed. Results The control rates of glycosylated hemoglobin, blood pressure and blood lipid in diabetic patients in Shanghai community were 72.27%, 43.44% and 38.82%, respectively, the proportion of all three indicators to reach the standard was 5.91%. Multivariate Logistic regression analysis showed that lack of exercise, poor diet control, lower frequency of blood glucose monitoring, high systolic blood pressure and triglyceride levels were risk factors of HbA1c target rate of diabetic patients （P < 0.05）; age, illiterate, high levels of HbA1c and triglyceride were risk factors of blood pressure target rate in diabetic patients （P < 0.05）; lack of exercise, irregular pharmacologic treatment and lower frequency of community blood glucose monitoring were risk factors of the blood lipids target rate in diabetic patients （P < 0.05）. Conclusion At present, the comprehensive management level of patients with type 2 diabetes in Shanghai community needs further improvement, especially for elderly patients with low education level, lack of exercise, no diet control and blood glucose monitoring.
		2018 Vol. 15 (26): 26-29 [Abstract] ( 802 ) HTML (1 KB) PDF (384 KB) ( 60 )

	30	Relationship between plane QRS-T angle and postoperative arrhythmia in patients with acute myocardial infarction
		YANG Jianye1 YU Xiongli2 FAN Jianping1 DENG Peng1
		Objective To study the relationship between plane QRS-T angle and postoperative arrhythmia in patients with acute myocardial infarction (AMI). Methods A total of 160 patients diagnosed with AMI treated with percutaneous coronary intervention (PCI) from March 2014 to December 2017 in Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology were selected. All the patients were divided into group A (42 cases) and group B (118 cases) according to the postoperative plane QRS-T angle. Postoperative plane QRS-T angle in group A was ＞90°, which in group B was ≤90°. The general data, postoperative data and postoperative medication status were compared between the two groups, and Logistic regression analysis was performed. Results The proportion of aged and hypertension in group A were significantly higher than group B, the differences were statistically significant (P ＜ 0.05). The incidence of postoperative arrhythmia, the proportion of left ventricular ejection fraction ＜45% and QTc interphase in group A were significantly higher than group B, the differences were statistically significant (P ＜ 0.05). The β blockers using proportion in group A was significantly lower than that in group B, and the difference was statistically significant (P ＜ 0.05). Single factor Logistic regression analysis promoted: age, hypertension and left ventricular ejection fraction＜45%, QTc interphase, application of β blockers, plane QRS-t angle＞90° were the factors affected postoperative arrhythmia in patients with AMI (P ＜ 0.05). The multi-factor Logistic regression analysis promoted: the use of β blockers was a protective factor for postoperative arrhythmia in AMI patients, and the plane QRS-T angle＞90° was the independent risk factor for postoperative arrhythmia in AMI patients (P ＜ 0.05). Conclusion Plane QRS-T angle＞90° is the independent risk factor for postoperative arrhythmia in AMI patients, and doctors should focus on QRS-T angle＞90° and patients without the application of β blockers in clinical work, to prevent the occurrence of arrhythmia.
		2018 Vol. 15 (26): 30-33 [Abstract] ( 241 ) HTML (1 KB) PDF (573 KB) ( 72 )

	34	The expression levels and clinical value of hypersensitive C-reactive protein, cystain C and interleukin 6-receptor in acute coronary syndrome
		LI Feixing1 YI Mengyang2 TAN Junhui2 WANG Xiaoyuan1 WANG Rui1 LI Fangjiang1
		Objective To explore the clinical value of detecting the expressions of hypersensitive C-reactive protein (hs-CRP), cystain C and interleukin 6-receptor (IL-6R) for early identification of acute coronary syndrome in coronary heart disease patients. Methods A total of 265 patients undergoing coronary arteriography in the Department of Cardiology of the First Affiliated Hospital of Hebei North University from October 2016 to March 2017 were consecutively selected. According to the patients′ history, clinical manifestations and coronary angiographic results, all the patients were divided into acute myocardial infarction (AMI) group (89 cases), unstable angina pectoris (UAP) group (87 cases), stable angina pectoris (SAP) group (41 cases) and 48 patients without coronary stenosis as control group. The serum levels of hs-CRP and Cystatin C levels were measured with Hitachi 7070 automatic biochemical analyzer, and the level of IL-6R in peripheral blood was detected by enzyme-linked immunosorbent assay (ELISA). The expression levels of hs-CRP, Cystain C and IL-6R among the four groups were compared. Results The serum levels of hs-CRP, Cystatin C and IL-6R in the UAP group and AMI group were significantly higher than the control group (P ＜ 0.05)．The serum levels of hs-CRP, Cystatin C and IL-6R in the AMI group and UAP group were significantly higher than the SAP group (P ＜ 0.05). The serum levels of IL-6R, hs-CRP in the AMI group were higher than the UAP group (P ＜ 0.05), but Cystatin C level had no difference between the two groups (P ＞ 0.05). Conclusion The expression levels of hs-CRP, Cystatin C and IL-6R are significantly higher in AMI and UAP patients, which promotes that the three inflammatory factors may be involved in the pathophysiological processes of AMI and UAP. Therefore, clinical detection of hs-CRP, Cystatin C, IL-6R levels have certain reference value for the early diagnosis of acute coronary syndrome．
		2018 Vol. 15 (26): 34-37 [Abstract] ( 233 ) HTML (1 KB) PDF (595 KB) ( 168 )

	38	Clinical efficacy of Atorvastatin combined with rhBNP in AMI patients with heart failure and its effects on cardiorenal function and levels of PⅢNP and hs-CRP
		Adilijiang·Tuohuti1 Alimujiang·Abulaiti2 LI Jie1 LI Guoqing1
		Objective To explore the clinical effect of Atorvastatin combined with recombinant human brain natriuretic peptide (rhBNP) in the treatment of acute myocardial infarction (AMI) with heart failure (HF), and its effects on cardiorenal function and levels of procollagen Ⅲ N-terminal peptide (PⅢNP) and high sensitive C reactive protein (hs-CRP). Methods Ninety cases of patients with AMI and HF in Xinjiang General Hospital of Armed Police Forces from October 2015 to October 2016 were divided into control group (45 cases) and treatment group (45 cases) by random number table method. On the basis of routine treatment, control group was treated by Atorvastatin Calcium Tablets, treatment group was treated by Atorvastatin Calcium Tablets and rhBNP. The cardiorenal function, levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), PⅢNP and hs-CRP as well as major adverse cardiovascular events (MACE) and adverse reactions before and after treatment were compared. Results Before treatment, there were no statistically significant differences of left ventricular ejection fractions (LVEF), left ventricular end systolic volume (LVESV) and left ventricular end diastolic volume (LVEDV) between the two groups (P > 0.05). After treatment, the levels of LVEF in the two groups were significantly higher than those before treatment (P ＜ 0.05), while the levels of LVESV and LVEDV were significantly lower than those before treatment (P ＜ 0.05), and the variation range of the treatment group was greater than that of the control group (P ＜ 0.05). Before treatment, there were no significant differences in the levels of creatinine (Cr), cystatin-C (Cys-C), blood urea nitrogen (BUN) and uric acid (UA) between the two groups (P > 0.05). After treatment, the levels of Cr and Cys-C in treatment group were significantly lower than those before treatment (P ＜ 0.05) , while there were no signfiicant differences of the levels of BUN and UA in the two groups compared with those before treatment (P ＞ 0.05). And the levels of Cr, Cys-C, BUN and UA also showed no significant differences between the two groups after treatment (P ＞ 0.05). Before treatment, there were no significant differences of NT-proBNP, PⅢNP and hs-CRP between the two groups (P > 0.05). After treatment, the levels of NT-proBNP, PⅢNP and hs-CRP in the two groups were significantly lower than those before treatment (P ＜ 0.05), and the variation range of the treatment group was greater than that of the control group (P ＜ 0.05). The risk of MACE and all-cause death in the treatment group were significantly lower than those of the control group (P ＜ 0.05), and there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Atorvastatin combined with rhBNP in treatment of patients with AMI and HF can significantly improve the cardiorenal function of the patients, effectively regulate the levels of PⅢNP and hs-CRP, and significantly reduce the risk of MACE and death of the patients.
		2018 Vol. 15 (26): 38-42 [Abstract] ( 180 ) HTML (1 KB) PDF (603 KB) ( 20 )

	43	Clinical study of drug-coated balloon with Paclitaxel for treatment of coronary in-stent restenosis
		LIANG Ying1 HUANG Hanhui1 LAI Tianxing1 ZOU Duan1 LIN Caiyan1 CHEN Ximing2 YAN Pengke1▲
		Objective To explore the clinical efficacy of drug-coated balloon with Paclitaxel for treatment of coronary in-stent restenosis. Methods Eighty-seven patients with coronary in-stent restenosis admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 2015 to December 2016 was divided into control group (43 cases) and treatment group (44 cases) by random number table method. Control group was treated with drug-eluting stent, while treatment group was treated with drug-coated balloon with Paclitaxel. The rate of cardiovascular adverse events after operation for 1, 6, 12 months and the incidence of coronary in-stent restenosis after operation for 12 months of the two groups were observed and compared. Results The total rate of cardiovascular adverse events and the incidence of coronary in-stent restenosis of treatment group (6.82%, 6.82%) were both lower than those of control group (23.26%, 27.91%) after operation for 12 months, the differences were statistically significant (χ2=4.623, P = 0.032; χ2=6.778, P = 0.009). Conclusion The drug-coated balloon with Paclitaxel is effective in the treatment of coronary in-stent restenosis, it can reduce the incidence of cardiovascular adverse events and avoid placing stents again, it is worthy of promotion and application in clinic.
		2018 Vol. 15 (26): 43-45 [Abstract] ( 340 ) HTML (1 KB) PDF (577 KB) ( 77 )

	46	Value of serum soluble E-selectin and glutamyl transpeptidase combined with carotid intima-media thickness in the diagnosis of coronary heart disease
		LIU Zuqiu YU Feihu YAN Biao CHEN Huashan CHEN Zhenyun
		Objective To investigate the value of serum soluble E-selectin and glutamyl transpeptidase (GGT) combined with carotid intima-media thickness (IMT) in the diagnosis of coronary heart disease. Methods A total of 134 patients with coronary heart disease who hospitalized in the 113rd Hospital of PLA from January 2016 to September 2017 were selected as the observation group. And according to different types the observation group was divided into subgroups, including 44 patients in unstable angina pectoris group, 49 patients in acute myocardial infarction group and 41 patients in stable angina pectoris group, and 50 healthy people that took physical examinotion in the same period were selected as the control group. Levels of serum soluble E-selectin, GGT and IMT were compared among the three groups, and the diagnostic efficiencies of single indicator and combined detection were analyzed respectively. Results The levels of serum soluble E-selectin, GGT and IMT in the observation group were significantly higher than those in the control group (P ＜ 0.05). Levels of serum soluble E-selectin, GGT and IMT in the unstable angina pectoris group and myocardial infarction group were significantly higher than those in stable angina pectoris group (P ＜ 0.05). GGT levels in the unstable angina pectoris group were significantly higher than those in the myocardial infarction group (P ＜ 0.05). The diagnosis positive rate of unstable angina pectoris, myocardial infarction, stable angina pectoris and coronary heart disease diagnosed by the combination of the three indicators were 95.45%, 97.95%, 97.56% and 97.01%, respectively, which were significantly higher than those of single indicator detection (P ＜ 0.05). Conclusion Serum soluble E-selectin, GGT and IMT may be related to the occurrence and development of coronary heart disease. The three indicators are suggested combined to diagnose coronary heart disease in clinic.
		2018 Vol. 15 (26): 46-49 [Abstract] ( 197 ) HTML (1 KB) PDF (555 KB) ( 63 )

	50	Correlation between homocysteinemia, glutamyltransferase and coronary heart disease and the degree of coronary artery stenosis
		CHEN Min YANG Linfei SUN Guilan GAO Yu
		Objective To explore the correlation between homocysteinemia (HCY), glutamyltransferase (GGT) and coronary heart disease and the degree of coronary artery stenosis. Methods Patients who underwent coronary angiography in the Second People′s Hospital of Hefei from October 2015 to October 2016 were selected randomly as the research subjects. They were divided into normal group (115 cases) and coronary heart disease group (161 cases) based on the results of diagnostic coronary angiography. Results The two groups had significant differences in age, hypertension history, triacylglycerol, total cholesterol, high-density lipoprotein chdesterol, low density lipoprotein, apolipoprotein A, apolipoprotein B, uric acid, total bilirubin, indirect bilirubin, HCY and GGT (P ＜ 0.05). According to linear correlation analysis, the levels of HCY and GGT were positively correlated with coronary Gensini scores (r = 2.18, 2.42, P ＜ 0.05). Multivariate Logistic regression analysis showed that HCY and GGT were independent risk factors of coronary heart disease (P ＜ 0.01, 95%CI: 1.035-1.167; P ＜ 0.01, 95%CI: 1.083-1.175). In a receiver operating characteristic (ROC) curve, the HCY value of 11.80 mmol/l was identified as an effective cut-point in the coronary heart disease and the area under curve was 0.686. Conclusion HCY and GGT are independent risk factors of coronary heart disease and they are positively correlated with the degree of coronary artery stenosis. HCY is an indicator of diagnosis of coronary heart disease.
		2018 Vol. 15 (26): 50-53 [Abstract] ( 220 ) HTML (1 KB) PDF (647 KB) ( 106 )

	54	Retrospective analysis of 29 cases of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis
		QIAN Ying1 CAO Bingzhen2
		Objective To explore the clinical characteristics of anti-NMDAR encephalitis, including clinical manifestation, magnetic resonance imaging (MRI) findings, cerebrospinal fluid changes (CSF) and treatment outcome. Methods Clinical data of 29 cases with anti-NMDAR encephalitis from January 2011 to March 2017 were collected in four medical centers, including Ji′nan Military General Hospital, Qilu Hospital of Shandong University, Shandong Provincial Hospital, and the Second Hospital of Shandong University. The characteristics of cases were analyzed and the patients were followed up. Results The age of 29 patients was ranged from 2 to 70 years, with a mean value of (27.8±13.46). There were 12 males and 17 females. Tumors were detected in 2 males and 3 females during the follow-up periods. The clinical manifestations included psychiatric symptoms (89.7%), seizures (69.0%), dyskinesia (65.5%), hypoventilation (20.7%), recognizant levels drop (44.8%) and autonomic instability (58.6%). Positive rate of CSF routine and biochemistry tests was 70.0%, 96.6% patients with positive anti-NMDA receptor antibodies in serum, and all patients with positive anti-NMDA receptor antibodies in CSF. The EEG records were abnormal in 82.8% patients, with mild degree (20.7%) and middle and serious degree (62.1%) in generalized or frontal to temporal areas. Abnormal MRI changes were observed in 55.2% patients, in which the most common manifestations were T2-FLAIR hyper intensities in frontal and temporal lobes. All patients were treated with immunotherapy, among of whom 5 patitents received immunosuppressive agent (Rituximab, Cyclophosphamide or Azathioprine), 1 patitent received plasmapheresis, 1 patitent diagnosed with small cell carcinoma received chemotherapy, 2 patitents were diagnosed with teratoma and received surgical resection. Death occurred in 3 patitents - during the follow-up period, the remaining 26 (89.7%) cases experienced well recoveries (modified Ranking scale 0-2). Conclusion In anti-NMDAR encephalitis patients, the positive anti-NMDAR antibody in CSF is the most common laboratory findings. The abnormal electroencephalogram (EEG) records occur in most cases and correlated with the severity of anti-NMDAR encephalitis. Most patients receive a substantial recovery by early stage first-line immunosuppressive treatments. Surgical resection and chemotherapy improve prognosis for the cases with tumors.
		2018 Vol. 15 (26): 54-57,65 [Abstract] ( 215 ) HTML (1 KB) PDF (511 KB) ( 43 )

	58	Inspection of changes in cerebral hemodynamics after carotid artery stenting at different ages
		DAI Mingming1 SU Qingjie1 YU Hang2 LONG Faqing1 WU Yingman1 WANG Desheng1 WANG Bufei1 GAO Chang3
		Objective To compare the changes in cerebral hemodynamics after carotid artery stenting (CAS) at different ages. Methods A retrospective analysis of clinical date of 50 patients who had been received carotid artery stenting in the Department of Neurology of the Second Affiliated Hospital of Hainan Medical University from June 2015 to June 2017. The patients were divided into three groups according to the age: middle age-group(< 60 years old, n = 20), older age-group (60-＜ 80 years old, n = 68), and advanced age-group (≥ 80 years old, n = 12). Color Doppler imaging (CDFI) combined with transcranial Doppler ultrasound (TCD) was used to measure the local diameter of the narrow place of posterior carotid artery (D), the peak systolic velocity (PSV) of the narrow place, vascular resistance index (RI), the systolic peak velocity of the middle cerebral artery (PSV) in the affected side, the vascular pulsation index (PI) and cerebrovascular reactivity (CVR) before and 1 week after CAS, and then all these data were compared before and after operation at different ages. Results After the carotid artery stenting, the diameter of the original stenosis was significantly increased, and the levels of PSV and RI were significantly decreased (P < 0.05). The PSV and PI of the MCA in the affected side were higher than those before operation, and CVR was significantly improved (P < 0.05). Among the three groups, there was the most significant improvement of cerebral hemodynamics in middle age-group(P < 0.05). However, the changes in cerebral hemodynamics in older age-group was not significantly improved when compared with advanced age-group（P ＞ 0.05）. Conclusion CAS is an effective treatment in carotid artery stenosis in all the patients. Furthermore, the patients whose age < 60 years old have the most significant improvement in cerebral hemodynamics.
		2018 Vol. 15 (26): 58-61 [Abstract] ( 282 ) HTML (1 KB) PDF (473 KB) ( 63 )

	62	Risk factors on the severity of acute ischemic stroke and its relationship with lymphocyte/monocyte ratio
		LI Lingling1 LIN Yongjuan1 CHEN Zhibin2
		Objective To investigate the factors affected the severity of acute ischemic stroke and the relationship between lymphocyte/monocyte ratio (LMR) and acute ischemic stroke severity. Methods From January to December 2017, clinical data of 242 patients with acute ischemic stroke who admitted to the Department of Neurology or Geriatrics, Nanjing Drum Tower Hospital were analyzed retrospectively, including 154 males and 88 females. According to the National Institute of Health Stroke Scale (NIHSS), they were divided into mild cerebral infarction group (NIHSS ≤ 5, n = 181) and moderate-severe cerebral infarction group (NIHSS > 5, n = 61) score at the time of admission. Logistic regression analysis was used to analyze the influence factors of stroke severity. Results There was a statistically significant difference in age, gender, atrial fibrillation, alcohol consumption, fasting glucose, LMR, and CRP between the two groups (P < 0.05). LMR was significantly lower in the moderate-severe cerebral infarction group compared with the mild cerebral infarction group (3.25±2.20 vs. 4.37±1.87, P < 0.05). The multivariate Logistic regression analysis showed that LMR was influence factor of the severity of cerebral infarction patients (OR = 0.8, 95%CI： 0.650-0.985, P < 0.05). Conclusion LMR on admission can reflect the severity of cerebral infarction patients. The lower level of LMR on admission, the more severer condition of the cerebral infarction patients.
		2018 Vol. 15 (26): 62-65 [Abstract] ( 240 ) HTML (1 KB) PDF (462 KB) ( 52 )

	66	Clinical effect of recombinant human erythropoietin combined with gangliosides for neonatal hypoxic-ischemic encephalopathy
		ZHU Min SU Caiyun CHEN Qiaoling
		Objective To study the clinical effect of recombinant human erythropoietin (EPO) combined with gangliosides on neonatal hypoxic-ischemic encephalopathy (HIE). Methods A total of 80 cases of children with HIE were selected and divided into the control group (40 cases) and the study group (40 cases) in Huaibei Miner General Hospital from January 2016 to June 2017 according to the treatment. The control group was treated with Monosialoteterahexosyl ganglioside (GM-1). the study group was treated with GM-1 and recombinant human EPO, and the treatment lasted for 10-14 day. The NBNA scale was used to evaluate the neurobehavior on the 7th, 14th, and 28th day after birth. The CDCC and Gesell scales were used to evaluate the intellectual development and developmental quotients of the two groups at 3 months and 6 months of age, respectively, and the therapeutic efficacy and prognosis of the two groups were evaluated. Results There was no significant difference in NBNA scores between the two groups 7 d after birth (P > 0.05). The NBNA scores of the study group were significantly higher on the 14th and 28th day after birth than in the control group (P < 0.05). MDI, PDI scores and Gesell scores at 6 months of age in both groups were significantly higher than those at 3 months of age (P < 0.05). The MDI, PDI scores and Gesell scores of the study group at 3 months and 6 months of age were significantly higher than those of the control group (P < 0.05). The total effective rate in the study group was 92.50%, which was significantly higher than the 75.00% in the control group (P < 0.05). There was no significant difference in sequelae and prognosis between the two groups (P > 0.05). Conclusion The combination therapy of GM-1 and recombinant human EPO can significantly improve the neurobehavioral and central nervous system function in children with HIE. The treatment method has good clinical efficacy, high safety, and has great clinical application value.
		2018 Vol. 15 (26): 66-69,73 [Abstract] ( 220 ) HTML (1 KB) PDF (557 KB) ( 50 )

	70	Influence of mobile internet management mode on pregnancy outcome of maternal women
		LIU Wei1 XUE Huiping2▲ JIA Qian2 LI Suwei2
		Objective To explore the influence of mobile internet management mode on pregnancy outcome of maternal women. Methods A total of 118 pregnant women were selected from October 2015 to October 2016 in Affiliated Hospital of Hebei University, who were divided into control group and research group by simple randomization, and there were 59 cases in each group. The control group was implemented the traditional management mode of maternal women, while the research group was implemented the mobile internet management mode. The pregnancy complications, the delivery modes, the pregnancy outcomes of the two groups were compared. The postpartum recovery of maternal women and the development of neonatal were compared after 3 months of following-up. Results The total rate of pregnancy complications in the research group was lower than that of the control group (P < 0.05), and the rate of cesarean section in the research group was significantly lower than that of the control group (P < 0.05). The total incidences of adverse pregnancy outcome of maternal women and perinatal infants in the research group were 5.08%, 3.39% respectively, which were 16.95%, 13.79% in the control group, with statistically significant differences between the two groups (P < 0.05). The incidence of adverse postpartum recovery and neonatal dysplasia of the research group were significantly lower than those of the control group (P < 0.05). Conclusion The application of mobile internet management mode can significantly reduce the rate of maternal women pregnancy complication, improve maternal women and perinatal outcomes of pregnancy, help postpartum recovery and neonatal development, with high feasibility in the standard management of maternal women.
		2018 Vol. 15 (26): 70-73 [Abstract] ( 285 ) HTML (1 KB) PDF (598 KB) ( 52 )

	74	Effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy
		LEI Lingling LIANG Yu WANG Shuyu
		Objective To investigate the effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy (ICP). Methods Clinical data of 2256 pregnancy women after the treatment of assisted reproductive technology at Beijing Obstetrics and Gynecology Hospital from January 2013 to December 2015 were collected. According to different fertilization modes, patients were divided into in vitro fertilization group (IVF group, 1873 cases) and intracytoplasmic sperm injection group (ICSI group, 383 cases). According to different embryo transfer cycle, patients were divided into fresh embryo transfer (Fresh group, 1483 cases) and frozen-thawed embryo transfer group (FET group, 773 cases). Reasons of infertility and incidence of ICP of patients in each groups were analyzed. Results The incidence of ICP in the ICSI group was slightly higher than that in the IVF group, but the difference between the two groups was no statistically significant (χ2 = 0.01, P = 0.89). The incidence of ICP in the FET group was slightly higher than that in the Fresh group, but the difference between the two groups was no statistically significant (χ2 = 0.28, P = 0.59). Conclusion ICSI fertilization does not increase the risk of intrahepatic cholestasis during pregnancy. Whether or not frozen thawed prior to embryo transfer is not associated with intrahepatic cholestasis during pregnancy.
		2018 Vol. 15 (26): 74-76,89 [Abstract] ( 255 ) HTML (1 KB) PDF (858 KB) ( 172 )

	81	Effect evaluation of immediate reconstruction and delayed reconstruction in breast cancer modified radical mastectomy
		WANG Zhigang1,2 LEI Zehua1 QIAO Zhengrong3 LI Yuanping1
		Objective To compare the effect of immediate breast reconstruction and postoperative reconstruction in breast cancer patients. Methods From January 2014 to February 2017, in Leshan People's Hospital, Emeishan Foguang Hospital and Chongqing Eighth People′s Hospital, 62 female patients with radical mastectomy were selected, according to the list of simple digital method, they were divided into observation group and control group, with 31 cases in each group. In the observation group, the reconstruction of breast cancer was performed immediately. The control group delayed breast reconstruction after radical surgery. The operation time, length of hospitalization, intraoperative blood loss and complication rate were observed in the two groups. After 1 year follow-up, the treat excellent rate, postoperative complications, postoperative SF-36 life quality score in two groups were observed. Results There was no statistically significant difference between the two groups in operation time, length of hospital stay, intraoperative blood loss and complication rate (P > 0.05). After 1 year of postoperative follow-up, the treatment excellent rate, surgical satisfaction rate, SF-36 life quality score in the observation group were higher than the control group, the differences were statistically significant (P < 0.05). The postoperative complications in the two groups was compared, the difference was not statistically significant (P > 0.05). Conclusion Immediate breast reconstruction can improve the treatment satisfaction of patients after radical mastectomy, improve the quality of life of patients, and not increase surgical complications, it can be widely used in clinical.
		2018 Vol. 15 (26): 81-84 [Abstract] ( 193 ) HTML (1 KB) PDF (553 KB) ( 56 )

	85	Effects of caffeic acid on radiotherapy-induced bone marrow suppression in patients with esophageal cancer
		DU Zunmin1 JIA Haipeng2 YANG Lili1 CHEN Honglei1 CHEN Fangguo1
		Objective To investigate the clinical effects of caffeic acid (CFA) on bone marrow suppression induced by radiotherapy in patients with esophageal cancer. Methods From June 2014 to October 2017, in NO.88 Hospital of PLA, 72 patients with esophageal cancer were selected, they were divided into CFA group and control group by random number table, with 36 cases in each group. Patients in CFA group were given oral CFA tablet 300 mg/time, 3 times/d, lasted until the end of radiotherapy, for 6 weeks; patients in control group were given radiotherapy only, once the bone marrow suppression occured, according to the degree of leucopenia or thrombocytopenia, the patients were given recombinant human granulocyte colony stimulating factor and/or recombinant human interleukin-11 injection subcutaneously. The incidence rate of bone marrow suppression, number of white blood cells (WBC) , hemoglobin (Hb), platelet (PlT) were observed. Results The incidence rate of bone marrow suppression, incidence rate of Ⅲ and Ⅳ degree bone marrow suppression in the CFA group were significantly lower than the control group, the differences were statistically significant (P < 0.05). The number of WBC and PlT in the CFA group 1-6 weeks after radiotherapy were significantly higher than the control group, the differences were statistically significant (P < 0.05). The number of Hb in the CFA group 1-6 weeks after radiotherapy was significantly higher than the control group, the differences were statistically significant (P < 0.05). Conclusion Caffeic acid can effectively prevent and treat bone marrow suppression induced by radiotherapy in patients with esophageal cancer.
		2018 Vol. 15 (26): 85-89 [Abstract] ( 209 ) HTML (1 KB) PDF (560 KB) ( 128 )

	90	A Meta-analysis of diagnostic value of conventional ultrasound and new ultrasound techniques for thyroid nodules
		HE Xiaona1,2 YIN Lulu1 ZHANG Xiaopeng1 WANG Binru1,2 LIU Haipeng2,3 CHEN Xiao2,3
		Objective To evaluate the clinical value of conventional ultrasound, elastography and contrast-enhanced ultrasound in diagnosis of benign and malignant thyroid nodules with Meta analysis. Methods From Janurary 1990 to December 2017, PubMed, Cochrane Library, Embase, CNKI, VIP, CBM and Wanfang data were searched to include literatures, according to the inclusion and exclusion criteria of diagnostic research. QUADAS scale was used to evaluate the quality of the literature included. And Meta-Disc 1.4 software was used to merge sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and draw the summary receiver operating characteristic (SROC curve), and calculate the area under the curve. Results A total of 2174 nodules of 17 literatures studied by 3 diagnostic methods. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the AUC of the conventional ultrasound were 0.59 [95%CI (0.55-0.62)], 0.77 [95%CI (0.74-0.79)], 2.33 [95%CI (1.87-2.89)], 0.53 [95%CI (0.43-0.65)], 4.70 [95%CI (3.18-6.95)], 0.7459, respectively. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the AUC of elastography were 0.84 [95%CI (0.82-0.87)], 0.86 [95%CI (0.84-0.88)], 5.37 [95%CI (0.16-9.12)], 0.20 [95%CI (0.16-0.24)], 30.96 [95%CI (19.87-48.26)], 0.9148, respectively. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the AUC of contrast-enhanced ultrasound were 0.85 [95%CI (0.83-0.88)], 0.87 [95%CI (0.85-0.89)], 6.01 [95%CI (4.30-8.14)], 0.20 [95%CI (0.15-0.26)], 32.82 [95%CI (18.83-57.21)], 0.9070, respectively. Conclusion The accuracy of elastography and contrast-enhanced ultrasonography in distinguishing benign from malignant thyroid nodules is relatively high, while the accuracy of benign and malignant nodules in conventional ultrasound is generally acceptable. However, all three have important implications for the diagnosis of thyroid nodules. Conventional ultrasound remains the most ideal imaging modality for detecting thyroid nodules and describing nodular features. Elastography and contrast-enhanced ultrasonography are valuable in determining the nature of thyroid nodules and can be used as a supplemental diagnostic tool for routine ultrasound.
		2018 Vol. 15 (26): 90-95 [Abstract] ( 255 ) HTML (1 KB) PDF (1472 KB) ( 49 )

	96	Clinical characteristics and prognosis of splenic tumor
		ZHU Wenxiang1 WU Xianghua1▲ QIN Ya2
		Objective To analyse the clinical characteristics and prognosis of splenic tumor. Methods From January 2003 to June 2017, in the First Affiliated Hospital of Guangxi Medical University, the clinical data of 64 patients diagnosed splenic tumor were etrospectively analyzed and followed-up, the clinical characteristics, diagnose, therapy and prognosis were analyzed. Results Among 64 splenic tumors cases, 53 cases were benign tumors and 11 cases were malignant tumors. Malignant tumors contained 8 primary splenictumors cases and 3 metastatic splenic tumors cases. The benign tumors were given splenectomy, and malignant tumors were given splenectomy combined with adjuvant radiotherapy and chemotherapy. Thirty-five cases benign tumors were followed up, 33 cases had a good recovery. Four cases with primary malignant tumors were followed up, the longest follow-up case treated with splenectomy and chemotherapy had been alive 7 years until December 2017. One case with splenic metastatic tumors were followed up, the patient had been alive 2 years after surgery. Conclusion The splenic tumor has a low incidence, pathology is complex, CT and B-mode ultrasound are important imaging measures to diagnose splenic tumor. The benign splenic tumors have a better prognosis, but malignant ones have a poor prognosis. The main treatment for splenic tumor is surgery. Earlier diagnosed, radical operation and chemotherapy are important measures for primary splenic malignant tumors.
		2018 Vol. 15 (26): 96-99 [Abstract] ( 267 ) HTML (1 KB) PDF (520 KB) ( 53 )

	100	Effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell in sepsis patients
		CHEN Mingke ZHU Yong LI Na XIE Xiaohong
		Objective To investigate the effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell (Treg) in sepsis patients. Methods A total of 120 patients with sepsis admitted to Hainan General Hospital from October 2013 to October 2016 were selected and divided into control group and treatment group according to random number table method, 58 cases in the control group were treated with conventional treatment, 62 cases in the treatment group were treated with conventional treatment combined with Xuebijing Injection intravenous injection. The quality of life, the level of serum Treg and the expression of Treg protein between the two groups after treatment were observed. Results After treatment, 12 cases′ quality of life improved, 25 cases were stable and 21 cases declined in the control group; 45 cases′ quality of life improved, 15 cases were stable and 2 cases declined in the treatment group; the difference between the two groups was statistically significant (P ＜ 0.05). Before treatment, the level of serum Treg and the expression protein of Treg between the two groups had no significant difference (P ＞ 0.05). After treatment, the level of serum Treg and the expression protein of Treg in the two groups were lower than those before treatment, and the indices in the treatment group were significant lower than those in the control group, the differences were statistically significant (P ＜ 0.05). The survival rate of the control group was remarkably lower than that of the treatment group, and the difference was significant (P ＜ 0.05). Conclusion Xuebijing Injection combined with conventional treatment can effectively improve the quality of life of patients with sepsis, and inhibit the expression of serum Treg protein, that may be one of its action mechanisms, so as to regulate the immune function.
		2018 Vol. 15 (26): 100-102,124 [Abstract] ( 266 ) HTML (1 KB) PDF (662 KB) ( 128 )

	103	Effect comparison between minimally invasive and traditional surgery in the treatment of varicose veins of the lower extremities
		PANG Fengshun HUANG Liecheng CAI Beiyuan CHEN Jingbao ZHANG Xiaobo QIN You▲
		Objective To compare the effect between minimally invasive and traditional surgery in the treatment of varicose veins of the lower extremities. Methods A total of 189 patients with varicose veins of the lower extremities treated in Department of Minimally Invasive Surgery, Guangdong Province Traditional Chinese Medical Hospital from March 2009 to March 2016 were selected as study subjects and they were divided into two groups according to different operation methods. There were 85 cases in minimally invasive surgical treatment group (minimally invasive group) and 104 cases in traditional surgery treatment (traditional group). Operation time, the amount of bleeding during operation, postoperative hospitalization time, the hospitalization cost and the incidence of complications were compared between the two groups. Results All of the 189 cases were operated successfully. The operation time and postoperative hospitalization time of the minimally invasive group were shorter than those of the traditional group, and the amount of bleeding during operation was less than that of the traditional group (P ＜ 0.05). There was no significant difference in the hospitalization cost and postoperative incidence of complications between the two groups (P ＞ 0.05). Conclusion Minimally invasive surgery in the treatment of varicose veins of the lower extremities can shorten operation and hospitalization time, and the surgical trauma is little and the security is high.
		2018 Vol. 15 (26): 103-105,112 [Abstract] ( 253 ) HTML (1 KB) PDF (657 KB) ( 111 )

	106	Expression and significance of Toll-like receptor 9 and NF-κB in peripheral blood mononuclear cell of erythema nodosum patients
		YANG Xianlu1 WANG Haiyan2 TANG Huaxiao2 CONG Tao3 LI Lingfang4
		Objective To study the expression of Toll-like receptor 9 (TLR9) and nuclear factor-κB (NF-κB) in peripheral blood mononuclear cell of erythema nodosum patients and healthy controls and to explore the clinical significance of TLR9 and NF-κB in erythema nodosum. Methods From June 2014 to October 2017, 52 patients with erythema nodosum from Weihai Women and Children′s Hospital and Weihai Municipal Hospital of Shandong Province were enrolled as disease group, and 41 healthy physical examinees served as control group. The mRNA levels of TLR9 and NF-κB in peripheral blood mononuclear cell were detected by real-time fluorescence quantitative PCR technique. Results The level of TLR9 in disease group was lower than that of control group, the difference was highly statistically significant (P ＜ 0.01). The level of NF-κB in disease group was higher than that of control group, the difference was highly statistically significant (P ＜ 0.01). In disease group, there was a positive linear correlation between TLR9 mRNA and NF-κB mRNA (r = 0.89, P ＜ 0.01). Conclusion Compared with normal people, the level of TLR9 mRNA in erythema nodosum patients is significantly decreased, while the level of NF-κB mRNA is significantly increased, suggesting that TLR9 and NF-κB may play an important role in the occurrence and development of erythema nodosum.
		2018 Vol. 15 (26): 106-108 [Abstract] ( 261 ) HTML (1 KB) PDF (643 KB) ( 88 )

	109	Clinical discussion of Sodium Valproate combined with Levetiracetam in the treatment of epilepsy after stroke
		LI Junyi
		Objective To explore the clinical effect of Sodium Valproate combined with Levetiracetam in the treatment of epilepsy after stroke. Methods The clinical data of 90 cases of patients with epilepsy after stroke admitted to Tongchuan People's Hospital from February 2014 to March 2017 was analyzed retrospectively and the patients were divided into control group and observation group by different treatments, with 45 cases in each group. The control group was treated with Sodium Valproate, the observation group was treated with Sodium Valproate combined with Levetiracetam. The seizures number, generalized seizure duration, epileptiform discharges, involved lead number, levels of neuron-specific enolase (NSE), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2) and interleukin-6 (IL-6), clinical efficacy and adverse reactions of two groups before and after treatment were observed and compared. Results Before treatment, there were no significant differences in the seizures number, generalized seizure duration, epileptiform discharges, involved lead number, and NSE, TNF-α, IL-2 and IL-6 levels between the two groups (P ＞ 0.05). After treatment, the seizures number, generalized seizure duration, epileptiform discharges, involved lead number, NSE, TNF-α, IL-2 and IL-6 levels of two groups were lower than those before treatment (P ＜ 0.05), which of the observation group were significantly lower than those of the contol group (P ＜ 0.05). The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). There were no significant differences in the incidence of adverse reactions of rash, headache, drowsiness, nausea and vomiting, paresthesia between the two groups (P ＞ 0.05). Conclusion Sodium Valproate combined with Levetiracetam in the treatment of patients with epilepsy after stroke can improve clinical symptoms and clinical effect, which is worthy of clinical promotion.
		2018 Vol. 15 (26): 109-112 [Abstract] ( 323 ) HTML (1 KB) PDF (653 KB) ( 109 )

	113	Effect of microwave coagulation assisted intense pulsed light in the treatment of rosacea
		WANG Huaixiang LI Jianming▲
		Objective To evaluate the efficacy and safety of microwave coagulation assisted intense pulse light (IPL) in the treatment of rosacea. Methods From February 2014 to January 2017, 64 patients with rosacea in the Department of Dermatology in Lishilu Outpatient, General Hospital of the PLA Rocket Force were divided into observation group and control group according to random number table method, with 32 cases in each group. The observation group was treated with IPL and microwave to coagulate the dilated capillaries, while the control group was treated with IPL only. The clinical effects, side effects, symptom scores and dermatology life quality index (DLQI) scores before and after treatment in the two groups were observed and compared. Results The total effective rate of the observation group was significantly higher than that of the control group at 3, 6, 9 weeks after treatment (P ＜ 0.05), but there was no significant difference between the two groups at 12 weeks after treatment (P ＞ 0.05). The overall difference of effects between groups, time effects and interaction effects of total score of skin lesions and DLQI score was statistically significant in the two groups (P ＜ 0.05). Further comparison showed that the total score of skin lesions and DLQI score at each time point after treatment were significantly lower than those in the same group before treatment (P ＜ 0.05). The total score of skin lesions at 3, 6, 9, 12 weeks after treatment, and DLQI score at 3, 6, 9 weeks after treatment in the observation group were decreased more significantly than those of control group (P ＜ 0.05), however, there was no significant difference at 12 weeks after treatment in DLQI score between the two groups (P > 0.05). Conclusion Microwave coagulation assisted IPL in the treatment of rosacea patients with telangiectasia on the nasal and surrounding is effective, safe and reliable, the recovery time of the patients is short, the quality of life is obviously improved, which is worth popularizing in clinic.
		2018 Vol. 15 (26): 113-116 [Abstract] ( 251 ) HTML (1 KB) PDF (601 KB) ( 64 )

	117	Comparison of efficacy and security between pegaspargase and L-asparaginase in treatment of Ph-negative acute lymphoblastic leukemia
		JIA Tao WANG Ying ZHU Yuanxin MAO Jianping XUE Lianguo WEI Jifeng CHEN Ze ZHAO Lidong
		Objective To compare the efficacy and security between pegaspargase and L-asparaginase in the treatment of Ph-negative acute lymphoblastic leukemia. Methods Clinical data of 52 Ph-negative acute lymphoblastic leukemia cases admitted to the First People′s Hospital of Lianyungang from January 2007 to March 2018 were retrospectively analyzed. All the cases received VDCLP chemotherapy and were divided into the pegaspargase group (25 cases) and the L-asparaginase group (27 cases). The efficacy, adverse reactions and survival status between the two groups were compared. Results The general information between the two groups were homogeneous, there was no statistically significant difference (P ＞ 0.05). There was no statistically significant difference in the total effective rate between the two groups (P ＞ 0.05). The incidence of allergic reactions and hyperglycemia in the L-asparaginase group was higher than that in the pegaspargase group (P ＜ 0.05). The minimum value of fibrinogen (FIB) in the pegaspargase group was bigger than the L-asparaginase group, and the duration rise time of activated partial thromboplastin time in the pegaspargase group was shorter than the L-asparaginase group (P ＜ 0.05). Conclusion Pegaspargase is effective and safe in the treatment of Ph-negative acute lymphoblastic leukemia and it is worth of clinical promotion.
		2018 Vol. 15 (26): 117-120 [Abstract] ( 222 ) HTML (1 KB) PDF (676 KB) ( 42 )

	121	Comparison of the emergency curative effect and the changes of plasma B-type natriuretic peptide and procalcitonin levels between lung cancer and pneumonia with pleural effusion patients
		LI Xiao1 XU Jing2
		Objective To compare the emergency curative effect and the changes of plasma B-type natriuretic peptide (BNP) and procalcitonin (PCT) levels between lung cancer and pneumonia with pleural effusion patients. Methods A total of 52 patients with lung cancer with pleural effusion admitted to the People′s Hospital of Gaoxin District in Chongqing City from May 2015 to May 2017 were selected as lung cancer group; and 52 patients with pneumonia with pleural effusion were selected as pneumonia group during the same period. Two groups of patients were treated with strengthening the heart, diuresis, anti-inflammatory, anti-infection and limiting fluid intake therapies. The chest CT scan was conducted before the treatment and 7 days after treatment. The therapeutic effect of pneumonitis, pleural effusion and plasma PCT and BNP levels before and after treatment were observed between the two groups. Results The total effective rate of pneumonia treatment in the pneumonia group and the lung cancer group was 96.15% and 82.69%， respectively（P ＞ 0.05）. The total effective rate of pleural effusion in the pneumonia group and the lung cancer group was 84.62% and 44.23%, respectively（P ＜ 0.05）. The plasma BNP and PCT levels of patients in pneumonia group after treatment were significantly lower than those before treatment, while the plasma PCT level in lung cancer group after treatment was significantly lower than that before treatment (P ＜ 0.05). Conclusion In contrast to the patients with lung cancer with pleural effusion, the clinical conventional treatments, such as strengthening the heart, diuresis, anti-inflammatory, anti-infection and limiting fluid intake, are more suitable in the treatment for patients with pneumonia with pleural effusion, which can effectively improve heart function and relieve inflammatory response.
		2018 Vol. 15 (26): 121-124 [Abstract] ( 230 ) HTML (1 KB) PDF (598 KB) ( 59 )

	125	Effect of Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome
		GUO Ting HE Hong HU Fengyang MEI Mengxue LIU Peirong
		Objective To explore the therapeutic effect of Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome. Methods Eighty cases of patients with hand-foot syndrome in the Department of Oncology of a triple-A general hospital in Nanchang City from January 2017 to March 2018 were selected as research objects, and they were divided into the experimental group and the control group by random number table method, with 40 cases in each group. The experimental group was given hydropathic compress with Compound Cortex Phellodendri Liquid, and the control group was was given hydropathic compress with self-made liquid. Before hydropathic compress, the wound was cleaned with normal saline, and then the hydropathic compress was applied after the impregnation of aseptic gauze block. After 30 minutes, the gauze block was removed, 3 times a day. After 1 week of treatment, the changes of hand-foot syndrome grade, the therapeutic effect and the improvement of symptoms were observed. The quality of life was evaluated by Skindex-16 scale. Results After intervention, the changes of hand-foot syndrome grade in the experimental group were better than those of control group, the total effective rate was higher than that of control group, and the scores of Skindex-16 and symptoms were all lower than those of control group, the differences were all statistically significant (P ＜ 0.05). Conclusion Hydropathic compress with Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome has good effects, which can effectively improve the symptoms and the quality of life of the patients.
		2018 Vol. 15 (26): 125-128 [Abstract] ( 246 ) HTML (1 KB) PDF (390 KB) ( 52 )

	129	Effect of clinical pathway nursing on postoperative coping style and level of hope in patients with pituitary tumor
		XU Ying CHENG Yu WANG Yingying
		Objective To explore the effect of clinical pathway nursing on postoperative behavior and social support of pituitary tumors. Methods From January 2015 to January 2017, in the First Affiliated Hospital of Harbin Medical University, 98 patients with pituitary adenoma were selected, according to the time sequence, they were divided into routine nursing group (from January 2015 to January 2016) and clinical pathway nursing group (from February 2016 to January 2017), with 49 cases in each group. The preoperative waiting time, total length of hospital stay, hospital expenses, patients′ understanding of the disease and nursing satisfaction, postoperative coping styles and hope of patients in two groups were compared. Results In clinical pathway nursing group, the hospitalization cost was less than the conventional nursing group, the preoperative waiting time and the total hospitalization time were shorter than routine nursing group, the differences were statistically significant (P < 0.05). The degree of understanding of the disease and nursing satisfaction of patients in clinical pathway nursing group were higher than routine nursing group, the differences were statistically significant (P < 0.05). The postoperative coping styles scores in clinical pathway nursing group were higher than routine nursing group, the scores of avoidance and high yield in clinical pathway nursing group were lower than routine nursing group, the scores of hope on the future of reality and positive attitude, keeping close relationship with others, taking positive action in clinical pathway nursing group were higher than routine nursing group, the differences were statistically significant (P < 0.05). Conclusion Clinical pathway nursing can effectively improve the perioperative index in patients with pituitary tumor, promote the improvement of postoperative treatment of the disease, boost the level of hope and improve the prognosis.
		2018 Vol. 15 (26): 129-132 [Abstract] ( 276 ) HTML (1 KB) PDF (614 KB) ( 68 )

	133	Analgesic effect of analgesic management led by anesthetized nurses on parturient
		GAO Ping1 TANG Yuanyuan2 GAo Xiaozeng1
		Objective To explore the effect of anesthesia management led by anesthesia nurses on the analgesic effect of delivery women. Methods From September to November 2017, in the Affiliated Hospital of North China Polytechnic University, 100 parturients were selected and randomly divided into anaesthesia care group and midwifery care group by envelope method, with 50 cases in each group. The midwifery care group was given routine nursing delivery, the analgesia was carried according to predefined by the anesthetist, without anesthesia nurses participating. The anesthesia care group was given analgesia management during the perinatal period of the anesthesia nurses. The pain condition, satisfaction degree of analgesia and incidence of adverse drug reactions in two groups were compared. Results The pain scores of latent period, active period, near full dilatation of the uterine orifice and full dilatation of the uterine orifice in anesthesia care group were significantly lower than those in midwifery care group(P < 0.05); the analgesia satisfaction in anesthesia care group was significantly higher than that in midwifery care group(P < 0.05); the rate of adverse drug reaction occurrence in anesthesia care group was lower than that in midwifery care group(P < 0.05). Conclusion The anesthesia management led by anesthesia nurses can relieve the pain during childbirth, improve the satisfaction of the management of the pain, and ensure the safety of the mother and infants, it is worthy of clinical promotion.
		2018 Vol. 15 (26): 133-136 [Abstract] ( 241 ) HTML (1 KB) PDF (616 KB) ( 64 )

	137	Application of continuity nursing intervention based on Omaha system in patients with colorectal cancer
		YANG Jiayi QUAN Daxiang WANG Wanli ZOU Jian▲
		Objective To evaluate the effects of continuity nursing intervention based on Omaha system in patients with colorectal cancer. Methods From January 2015 to June 2016, in Chengdu Fifth People′s Hospital, 62 patients with colorectal cancer underwent surgery were enrolled, and they were divided into observation group and control group by random number table method, with 31 cases in each group. The control group was given routine discharge instruction and follow-up, the observation group was given continuity nursing intervention based on Omaha system. The knowledge-behavior-status scores in two groups were compared. Results The knowledge-behavior-status scores of social and mental health, digestive, ectopic defecation, skin, infection, self-care and living condition 3, 6 months after the intervention in observation group were significantly higher than before discharge and control group, the differences were statistically significant (P < 0.05). Conclusion The application of continuity nursing intervention based on Omaha system can significantly strengthen the rehabilitation prognosis of patients with colorectal cancer.
		2018 Vol. 15 (26): 137-141 [Abstract] ( 214 ) HTML (1 KB) PDF (631 KB) ( 113 )

	142	Current situation of occupational plateau and relevant influencing demographic factors among undergraduate nurses in a comprehensive Grade-A Tertiary hospital in Chongqing
		TONG Li1 TIAN Lu2 LIU Wenwen3
		Objective To understand the current situation of occupational plateau and relevant influencing demographic factors among undergraduate nurses in the First Affiliated Hospital of Chongqing Medical University ("our hospital" for short). Methods From September to October 2017, 160 undergraduate nurses from our hospital were surveyed using career plateau scale prepared by Xie Baoguo. Results A total of 151 valid questionnaires were recovered, the effective recovery rate was 94.3%. For the undergraduate nurses in our hospital, the total score of occupational altitude was (3.52±0.67) scores, the level plateau dimension score was (3.65±0.84) scores, the plateau dimension score was (2.99±0.92) scores, and the central plateau dimension score was (3.97±0.87) scores. The multiple linear regression analysis results showed that technical title was the significant influencing factor in all dimensions of occupational plateau (all P < 0.01), while age and employment attributes were the influencing factors in the dimensionality of plateau (all P < 0.05). Conclusion The undergraduate nurses in our hospital are in the risk of plateau state, with the highest score in central plateau dimension, the lowest score in content plateau dimension. Organizations and individuals should take full account of the influencing factors, especially for job title, age, employment characteristics, in the intervention of occupational plateau among nurses.
		2018 Vol. 15 (26): 142-146 [Abstract] ( 227 ) HTML (1 KB) PDF (623 KB) ( 92 )

	147	Effects of families involved pain education on resilience and satisfaction of pain control in rectal cancer patients with preoperative chemoradiotherapy
		WANG Lu ZHOU Jie LIAN Kaihua
		Objective To explore the effects of families involved pain education on resilience and satisfaction of pain control in rectal cancer patients with preoperative chemoradiotherapy. Methods From April 2014 to April 2016, in Qingdao Center Hospital, 115 rectal cancer patients with preoperative chemoradiotherapy were selected, by random number table method, they were divided into observation group (58 cases) and control group (57 cases). The observation group was given families involved pain education, the control group was given normal pain education, the resilience and satisfaction of pain control were evaluated and compared before and after intervention (the last radiotherapy was over) by resilience scale and Houston pain outcome instrument (HPOI). Results There were no statistically significant differences on the score of total and 4 dimension in resilience scale before intervention between two groups (P > 0.05); after the intervention, the scores of 4 dimension and total of resilience scale were higher than before intervention, and those in observation group were higher than control group, the differences were statistically significant (P < 0.01). There was no statistically significant difference on the score of total and each dimension in HPOI before intervention between two groups (P > 0.05); after the intervention, the scores of each dimension and total of HPOI were higher than these before intervention, and those in observation group were higher than control group, the differences were statistically significant (P < 0.01 or P < 0.05). Conclusion Pain education can improve the resilience level and pain control satisfaction of rectal cancer patients with preoperative concurrent chemoradiotherapy, the effect of family involved pain education is more obvious.
		2018 Vol. 15 (26): 147-150 [Abstract] ( 211 ) HTML (1 KB) PDF (618 KB) ( 143 )

	151	Application effect of blood circulation and blood stasis nursing intervention in diabetic patients with apoplexy
		LIU Jing ZHANG Jing ZHANG Xuejian ZHANG Mi LI Shan▲
		Objective To explore the application effect of blood circulation and blood stasis nursing intervention in diabetic patients with apoplexy. Methods From September 2015 to April 2017, in Department of Endocrine, the Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine, 86 patients with diabetes combined with stroke were selected, according to random number table method, they were observe group and control group, with 43 cases in each group. The control group was given routine nursing intervention, the observation group was routine nursing combined with the method of activating blood and removing stasis, the nursing effect of the two groups was compared. Results There was no significant difference in the levels of FBG and PBG after intervention between the two groups (P > 0.05). The level of LDL-C after intervention in the observation group was lower than the control group, and the level of HDL-C was higher than the control group, there were significant differences (P < 0.05). There was no significant difference in the levels of TC and TG between the two groups before or after intervention, and there was no statistical significance (P > 0.05). The scores of upper limb function, lower limb function, and hand function scores in the observation group after intervention were higher than the control group, and the differences had statistical significance (P < 0.05).Conclusion The effect of promoting blood circulation and removing blood stasis nursing intervention on diabetes patients with stroke is better, can obviously reduce blood sugar and blood lipid levels, can significantly improve the function of patients, and is worthy of clinical application.
		2018 Vol. 15 (26): 151-154 [Abstract] ( 252 ) HTML (1 KB) PDF (617 KB) ( 87 )

	155	Discussion on the pathogenesis and treatment of uterine leiomyoma based on emotional factors
		LIU Yu LI Donghua CHEN Chao WANG Wenna ZHOU Jie
		With the rapid development of today′s society, people′s living pace is accelerating, and the diseases caused by emotional factors are increasing. Research shows that the occurrence and development of uterine leiomyoma are mostly related to sadness, anger and other emotions. Chinese medicine believes that intense emotion or incomprehension can lead to dysfunction of viscera and qi and blood, and eventually induce hysteromyoma. Its pathogenesis can be divided into "worry impairing heart" and "worry impairing spleen" and "anger-in impairing liver". In addition, in the treatment of uterine fibroids, the therapeutic idea of "combination of Xing and Shen" of traditional Chinese medicine also plays a prominent advantage, it pays attention to "adjusting the mind" on the basis of "curing the body", which can not only alleviate the negative emotion of patients, but also can greatly improve the patients′ physiological function.
		2018 Vol. 15 (26): 155-158 [Abstract] ( 245 ) HTML (1 KB) PDF (666 KB) ( 58 )

	159	The application and effect evaluation of lean management in Good Pain Management Ward
		TANG Yanqing WAN Yonghui▲ CHEN Sanmei MA Hongmei
		Objective To explore the application of lean management in the Good Pain Management Ward and the effect evaluation. Methods A total of 138 patients with cancer pain treated in Renmin Hospital of WuHan University from January to December 2017 were selected as subjects. According to different management method, patients were divided into control group (68 cases) and observation group (70 cases). The control group implemented general management, including health education and following doctor′s orders with analgesic drugs. The observation group applied lean management in the standardized treatment unit for cancer pain, and the effects of pain management were compared between the two groups. Results After lean management method was used in the observation group to create the demonstration ward for the standardized treatment of cancer pain, the drug regulation of doctor, the compliance of patients for prescription, pain remission rate and patients′ satisfaction were significantly increased compared to the control group (P ＜ 0.05). Conclusion The application of lean management in the Good Pain Management Ward can increase the compliance of cancer pain patients and improve their quality of their life and satisfaction.
		2018 Vol. 15 (26): 159-163 [Abstract] ( 213 ) HTML (1 KB) PDF (889 KB) ( 156 )

	164	The rehabilitation experience of acute patella dislocation of one young volleyball athlete
		ZHAO Defeng ZHANG Peng QIAN Fenglei▲
		In this paper, the treatment of one young volleyball player′s acute patellar dislocation is taken as an example. During emergency period, the treatment was done strictly according to the RICE principle. The joint activity and proprioceptive training were carried out by hydrotherapy during the early stage of rehabilitation. Proprioceptive training and strength training were carried out by hydrotherapy in the middle to late stages of rehabilitation. The training of proprioception was done based on training from easy to difficult, from single close movement to multi joint movement, from single plane to multi plane training. Ultrasonic therapy was applied during the whole course of rehabilitation to promote the elimination of inflammation and the recovery of damaged tissues. In the late stages of rehabilitation, psychological rehabilitation was applied to eliminate the fear of injury. After 14 days′ comprehensive treatment above, knee joint pain of the athlete disappeared, and he could take part in the match. After 20 days, the strength of knee joint and other indices recovered to the level before injury.
		2018 Vol. 15 (26): 164-167 [Abstract] ( 207 ) HTML (1 KB) PDF (772 KB) ( 60 )

	168	The three dimensions and its practice of the spread of health qigong in Chinese medicine colleges
		LIU Jiali GONG Bomin
		To response to the call of The Opinions on the Implementation of China′s Excellent Traditional Cultural Heritage Development Project, Chinese medicine colleges should study health qigong from three dimensions including value concept, system design and action strategy. The research suggests that, at present, to inherit traditional national sports culture, Chinese medicine colleges should first emphasize the looseness, cleanness and softness of health qigong, observe their physical and mental state and further the concept of keeping healthy through the practice of mind and body. Secondly, Chinese medicine colleges should make good policy and norms of good health qigong campus and cultural interpretation and inheritance in terms of system design. In addition, Chinese medicine colleges should deal well with the communication between the spread of the educational value of school in leading health qigong and the spread of the humanistic value of community in leading health qigong in terms of action strategy.
		2018 Vol. 15 (26): 168-171 [Abstract] ( 243 ) HTML (1 KB) PDF (663 KB) ( 76 )

	176	How to improve the enthusiasm of the youth to participate in the Communist Youth League activities in public hospitals
		LI Qin1 YAO Jin2 LIN Fangfang3 LI Yudan4 LI Rui1
		Objective To analyze the current status and problems of Communist Youth League (CYL) work in public hospitals comprehensively, and arousing the youth′s enthusiasm to participate in the committee activities targeted. Methods The survey was conducted to investigate CYL work in Fuwai Hospital Chinese Academy of Medical Sciences ("our hospital" for short) from February 13th to 28th in 2017. A total of 220 questionnaires were distributed to young employees ＜35-year-old in the hospital through an electronic survey platform, 5 leaders of CYL among brother hospitals and 20 leaders of CYL department in Fuwai Hospital were invited to conduct a focused interview. Statistical analysis was conducted on the 215 effective questionnaires by EXCEL, and a comprehensive analysis of the current status and existed problems about the CYL in public hospitals were conducted by combining the results of focused interview. Results Among 215 effective respondents of the questionnaire survey, only 91 people were aware of the framework of CYL work; 52.56% of the respondents had never participated in any committee activities, 79.07% of them were due to time arrangement. In terms of suggestions for CYL activities, activities that can enrich the youth′s spare time life were highly anticipated by 85.58% of the respondents, especially outdoor activities (80.00%), followed by voluntary activites (54.88%), and recreational and sports activities (53.95%). The results of focused interview showed that, besides the Secretaries of CYL, there were only 3 leaders of CYL from the management departments were acquainted with the organizational structure of CYL in their hospitals, and all the 25 leaders of CYL responded that the time arrangements and the limited energy were the biggest obstacle for committee activities, and they also recommended to organize those recreational activities that were popular in the youth. Conclusion On the basis of the survey, our hospital CYL has made significant efforts to motivate the youth to participate in the committee activities, including building publicity platform, implementing rewarding and punishing measurements, satisfying the needs of the youth, innovating the way of activities, as well as classified activities, which contributes new ideas for the work of CYL in the new era.
		2018 Vol. 15 (26): 176-180 [Abstract] ( 239 ) HTML (1 KB) PDF (732 KB) ( 75 )

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