|
|
|
| Effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell in sepsis patients |
| CHEN Mingke ZHU Yong LI Na XIE Xiaohong |
| Intensive Care Unit, Hainan General Hospital, Hainan Province, Haikou 570311, China |
|
|
|
Abstract Objective To investigate the effect of Xuebijing Injection combined with conventional treatment on the quality of life and the protein expression of regulatory T cell (Treg) in sepsis patients. Methods A total of 120 patients with sepsis admitted to Hainan General Hospital from October 2013 to October 2016 were selected and divided into control group and treatment group according to random number table method, 58 cases in the control group were treated with conventional treatment, 62 cases in the treatment group were treated with conventional treatment combined with Xuebijing Injection intravenous injection. The quality of life, the level of serum Treg and the expression of Treg protein between the two groups after treatment were observed. Results After treatment, 12 cases′ quality of life improved, 25 cases were stable and 21 cases declined in the control group; 45 cases′ quality of life improved, 15 cases were stable and 2 cases declined in the treatment group; the difference between the two groups was statistically significant (P ＜ 0.05). Before treatment, the level of serum Treg and the expression protein of Treg between the two groups had no significant difference (P ＞ 0.05). After treatment, the level of serum Treg and the expression protein of Treg in the two groups were lower than those before treatment, and the indices in the treatment group were significant lower than those in the control group, the differences were statistically significant (P ＜ 0.05). The survival rate of the control group was remarkably lower than that of the treatment group, and the difference was significant (P ＜ 0.05). Conclusion Xuebijing Injection combined with conventional treatment can effectively improve the quality of life of patients with sepsis, and inhibit the expression of serum Treg protein, that may be one of its action mechanisms, so as to regulate the immune function.
|
|
|
|
|
|
[1] Vincent JL，Sakr Y，Sprung CL，et al. Sepsis in European intensive care units：results of the SOAP study [J]. Crit Care Med，2006，34（2）：344-353.
[2] Singer M，Deutschman CS，Seymour CW，et al. The Third International Consensus Definitions for Sepsis and Septic Shock（Sepsis-3）[J]. JAMA，2016，315 （8）：775-787.
[3] 姚咏明，黄立峰，林洪远.《2008国际严重脓重症和脓毒性休克治疗指南》概要[J].中国危重病急救医学，2008（3）：135-138.
[4] 曾家耀，陈明科，江现强，等.消瘤汤联合腹腔热灌注化疗对胃癌患者术后生存质量及血清血管内皮生长因子表达的影响[J].中国全科医学，2010，13（30）：3447-3449.
[5] Dieckmann D，Bruett CH，Ploettner H，et al. Human CD4+CD25+ Regulatory，Contact-dependent T Cells Induce Interleukin 10-producing，Contact-independent Type 1-like Regulatory T Cells [J]. J Exp Med，2002，196（2）：247-253.
[6] Venet F，Chung CS，Monneret G，et al. Regulatory T cell populations in sepsis and trauma [J]. J Leukoc Biol，2008，83（3）：523-535.
[7] O′Garra A，Vieira P. Regulatory T cells and mechanisms of immune system control [J]. Nat Med，2004，10（8）：801-805.
[8] Venet F，Chung CS，Kherouf H，et al. Increased circulating regulatory T cells（CD4（+）CD25（+）CD127（-））contribute to lymphocyte anergy in septic shock patients [J]. Intensive Care Med，2009，35（4）：678-686.
[9] Monneret G，Debard AL，Venet F，et al. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis [J]. Crit Care Med，2003，31（7）：2068-2071.
[10] Nascimento DC，Alves-Filho JC，Sonego F，et al. Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis [J]. Crit Care Med，2010，38（8）：1718-1725.
[11] Von Boehmer H. Mechanisms of suppression by suppressor T cells [J]. Nat Immunol，2005，6（4）：338-344.
[12] 艾宇航，姚咏明，戴新贵.脓毒症大鼠调节性T细胞凋亡对效应T细胞增殖和分泌功能的影响及血必净注射液的干预作用[J].中华外科杂志，2009，47（1）：58-61.
[13] 戴新贵，姚咏明，艾宇航.血必净注射液对脂多糖刺激大鼠调节性T细胞凋亡及其介导效应T细胞免疫功能的影响[J].中华急诊医学杂志，2009，18（9）：932-936.
[14] 艾宇航，姚咏明，戴新贵.不同剂量血必净对内毒素诱导调节性T细胞凋亡的影响[J].中国中西医结合急救杂志，2010，17（3）：141-144.
[15] 戴新贵，姚咏明，艾宇航.脓毒症大鼠调节性T细胞凋亡对辅助性T细胞漂移的影响及血必净注射液的干预作用[J].中国危重病急救医学，2009（3）：135-138.
[16] 戴新贵，姚咏明，艾宇航，等.血必净促进内毒素/脂多糖刺激调节性T淋巴细胞凋亡并介导辅助性T淋巴细胞漂移的作用[J].中华烧伤杂志，2009，25（2）：106-110.
[17] Liu YC，Yao FH，Chai YF，et al. Xuebijing Injection Promotes M2 Polarization of Macrophages and Improves Survival Rate in Septic Mice [J]. Evid Based Complement Alternat Med，2015.doi：10.1155/2015/352642.
[18] 顼志兵，宋丽，赵外荣.脓毒症凝血功能障碍的发病机制及中医治疗的研究进展[J].中国医药导报，2017，14（18）：42-44.
[19] 杨昱，周慎，罗城，等.血必净联合盐酸氨溴索在急性百草枯中毒所致肺损伤大鼠中的应用[J].中国医药科学，2018，8（4）：7-9，46.
[20] 王若晖，李卉，梁群，等.中药通腑泻热灌肠剂联合抗生素对脓毒症患者细胞炎症及机体免疫功能的影响[J].中医药学报，2017，45（2）：58-60.
[21] 中国中西医结合学会急救医学专业委员会，《中国中西医结合急救杂志》编辑委员会.脓毒症中西医结合诊治专家共识[J].中华危重病急救医学，2013，25（4）：194-197.
[22] 王今达，李志军，李银平.从“三证三法”辨证论治脓毒症[J].中华危重病急救医学，2006，18（11）：643-644.
[23] 曹书华，王今达，李银平.从“菌毒并治”到“四证四法”——关于中西医结合治疗多器官功能障碍综合征辨证思路的深入与完善[J].中华危重病急救医学，2005，17（11）：641-643. |
|
|
|
