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| Effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy |
| LEI Lingling LIANG Yu WANG Shuyu |
| Department of Reproductive Center, Beijing Obstetrics and Gynaecology Hospital Capital Medical University, Beijing 100026, China |
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Abstract Objective To investigate the effect of different test-tube baby technology on the incidence of intrahepatic cholestasis of pregnancy (ICP). Methods Clinical data of 2256 pregnancy women after the treatment of assisted reproductive technology at Beijing Obstetrics and Gynecology Hospital from January 2013 to December 2015 were collected. According to different fertilization modes, patients were divided into in vitro fertilization group (IVF group, 1873 cases) and intracytoplasmic sperm injection group (ICSI group, 383 cases). According to different embryo transfer cycle, patients were divided into fresh embryo transfer (Fresh group, 1483 cases) and frozen-thawed embryo transfer group (FET group, 773 cases). Reasons of infertility and incidence of ICP of patients in each groups were analyzed. Results The incidence of ICP in the ICSI group was slightly higher than that in the IVF group, but the difference between the two groups was no statistically significant (χ2 = 0.01, P = 0.89). The incidence of ICP in the FET group was slightly higher than that in the Fresh group, but the difference between the two groups was no statistically significant (χ2 = 0.28, P = 0.59). Conclusion ICSI fertilization does not increase the risk of intrahepatic cholestasis during pregnancy. Whether or not frozen thawed prior to embryo transfer is not associated with intrahepatic cholestasis during pregnancy.
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