复方黄柏液治疗卡培他滨所致手足综合征的效果

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Abstract Objective To explore the therapeutic effect of Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome. Methods Eighty cases of patients with hand-foot syndrome in the Department of Oncology of a triple-A general hospital in Nanchang City from January 2017 to March 2018 were selected as research objects, and they were divided into the experimental group and the control group by random number table method, with 40 cases in each group. The experimental group was given hydropathic compress with Compound Cortex Phellodendri Liquid, and the control group was was given hydropathic compress with self-made liquid. Before hydropathic compress, the wound was cleaned with normal saline, and then the hydropathic compress was applied after the impregnation of aseptic gauze block. After 30 minutes, the gauze block was removed, 3 times a day. After 1 week of treatment, the changes of hand-foot syndrome grade, the therapeutic effect and the improvement of symptoms were observed. The quality of life was evaluated by Skindex-16 scale. Results After intervention, the changes of hand-foot syndrome grade in the experimental group were better than those of control group, the total effective rate was higher than that of control group, and the scores of Skindex-16 and symptoms were all lower than those of control group, the differences were all statistically significant (P ＜ 0.05). Conclusion Hydropathic compress with Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome has good effects, which can effectively improve the symptoms and the quality of life of the patients.

Key words： Compound Cortex Phellodendri Liquid Capecitabine Hand-foot syndrome

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	GUO Ting HE Hong HU Fengyang MEI Mengxue LIU Peirong

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GUO Ting HE Hong HU Fengyang MEI Mengxue LIU Peirong. Effect of Compound Cortex Phellodendri Liquid in the treatment of Capecitabine-induced hand-foot syndrome[J]. 中国医药导报, 2018, 15(26): 125-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I26/125

[1] Chen M，Zhang L，Wang Q，et al. Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy：a systematic review [J]. PLoS One，2013，8（8）：e72245.
[2] Miller KK，Gorcey L，McLellan BN. Chemotherapy-induced hand-foot syndrome and nail changes：a review of clinical presentation，etiology，pathogenesis，and management [J]. J Am Acad Dermatol，2014，71（4）：787-794.
[3] 钟美华，穆蕾蕾，刘冬梅，等.多磺酸粘多糖乳膏经超声电导联合护理干预防治手足综合征的有效性研究[J].中华现代护理杂志，2017，23（15）：1987-1990.
[4] Macedo LT，Lima JP，dos Santos LV，et al. Prevention strategies for chemotherapy-induced hand-foot syndrome：a systematic review and meta-analysis of prospective randomised trials [J]. Supportive Care Cancer，2014，22（6）：1585-1593.
[5] 应海峰，郭元彪，郑岚，等.五味宣痹汤早期干预防治卡培他滨所致手足综合征的临床观察[J].辽宁中医药大学学报，2014，16（10）：108-110.
[6] 张晓迪，陈嘉璐，高静东，等.温经化瘀方外治化疗相关性手足综合征的临床观察[J].浙江中医药大学学报，2017， 4（12）：142-145.
[7] 张榆.复方黄柏液联合萆薢渗湿汤对脂溢性脱发（脾胃湿热证）头皮油脂分泌的影响[D].成都：成都中医药大学，2015.
[8] Cintia Santos Braghiroli，Rodrigo Ieiri，Juliana Polizel Ocanha，et al. Do you know this syndrome？Hand-foot syndrome [J]. An Bras Dermatol，2017，92（1）：131-133.
[9] Chren MM. The skindex instruments to Measure the Effects of Skin Disease on Quality of Life [J]. Dermatol Clin，2012， 30（2）：231-236.
[10] Nardone B，Hensley JR，Kulik L，et al. The effect of hand-foot skin reaction associated with the multikinase inhibitors sorafenib and sunitinib on health-related quality of life [J]. J Drugs Dermatol，2012，11（11）：e61-e65.
[11] He Z，Lu C，Chren MM，et al. Development and psychometric validation of the Chinese version of Skindex-29 and Skindex-16 [J]. Health Qual Life Outcomes，2014， 12：190.
[12] 张仲昭.简体中文版Skindex-29和Skindex-16的建立和文化调适及信效度评价[D].广州：广州中医药大学.
[13] 杨文博.加味四妙勇安油外涂防治急性放射性皮炎的临床观察[D].北京：北京中医药大学，2016.
[14] Qiao J，Fang H. Hand-foot syndrome related to chemotherapy [J]. CMAJ，2012，184（15）：E818.
[15] McLellan B，Ciardiello F，Lacouture ME，et al. Regorafenib-associated hand-foot skin reaction：practical advice on diagnosis，prevention，and management [J]. Ann Oncol，2015，26（10）：2017-2026.
[16] Hofheinz RD，Gencer D，Schulz H，et al. Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome：A Randomized Phase Ⅲ Trial of the AIO Quality of Life Working Group [J]. J Clin Oncol，2015，33（22）：2444-2449.
[17] 李志明.加味仙方活命饮外用治疗卡培他滨所致手足综合征的临床研究[D].北京：北京中医药大学，2017.
[18] 姚俊，赵霞.复方黄柏液最新临床应用进展[J].中国新药杂志，2014，23（3）：308-312，337.
[19] 张坤，丁克.复方黄柏液对大鼠感染性创面TNF-α和IL-6表达的影响[J].中国新药杂志，2015，24（19）：2222-2226.
[20] 徐月明.复方黄柏液联合复方丙酸氯倍他索软膏治疗手部湿疹疗效观察[J].中国中西医结合皮肤性病学杂志，2014，13（5）：309-310.
[21] Anderson RT，Keating KN，Doll HA，et al. The Hand-Foot Skin Reaction and Quality of Life Questionnaire：An Assessment Tool for Oncology [J]. Oncologist，2015，20（7）：831-838.
[22] Sim?觔o DA，Lima ED，Souza RS，et al. Hand-foot syndrome induced by chemotherapy：a case study [J]. Rev Bras Enferm，2012，65（2）：374-378.
[23] Zhao C，Chen J，Yu B，et al. Effect of modified Taohongsiwu decoction on patients with chemo-therapy-induced hand-foot syndrome [J]. J Tradit Chin Med，2014，43（1）：10-14.
[24] 陈州华，周胜涟，徐婪，等.手足浸泡方防治卡培他滨相关性手足综合征的临床观察[J].中国中医药科技，2016， 23（3）：329-330.
[25] 陈红英，沙建飞，顾永伟.参地二仙汤治疗卡培他滨所致的手足综合征37例[J].陕西中医，2015，36（6）：714-715.
[26] 余英华，吴珊.中药湿敷联合特定电磁波治疗手足综合征的疗效观察及护理体会[J].河北中医，2014，36（7）：1099-1100.
[27] Sibaud V，Dalenc F，Chevreau C，et al. HFS-14，a Specific quality of life scale developed for patients suffering from hand-foot syndrome [J]. Oncologist，2011，16（10）：1469-1478.