|
|
|
| Correlation between homocysteinemia, glutamyltransferase and coronary heart disease and the degree of coronary artery stenosis |
| CHEN Min YANG Linfei SUN Guilan GAO Yu |
| Department of Cardiology, the Second People′s Hospital of Hefei, Anhui Province, Hefei 230000, China |
|
|
|
Abstract Objective To explore the correlation between homocysteinemia (HCY), glutamyltransferase (GGT) and coronary heart disease and the degree of coronary artery stenosis. Methods Patients who underwent coronary angiography in the Second People′s Hospital of Hefei from October 2015 to October 2016 were selected randomly as the research subjects. They were divided into normal group (115 cases) and coronary heart disease group (161 cases) based on the results of diagnostic coronary angiography. Results The two groups had significant differences in age, hypertension history, triacylglycerol, total cholesterol, high-density lipoprotein chdesterol, low density lipoprotein, apolipoprotein A, apolipoprotein B, uric acid, total bilirubin, indirect bilirubin, HCY and GGT (P ＜ 0.05). According to linear correlation analysis, the levels of HCY and GGT were positively correlated with coronary Gensini scores (r = 2.18, 2.42, P ＜ 0.05). Multivariate Logistic regression analysis showed that HCY and GGT were independent risk factors of coronary heart disease (P ＜ 0.01, 95%CI: 1.035-1.167; P ＜ 0.01, 95%CI: 1.083-1.175). In a receiver operating characteristic (ROC) curve, the HCY value of 11.80 mmol/l was identified as an effective cut-point in the coronary heart disease and the area under curve was 0.686. Conclusion HCY and GGT are independent risk factors of coronary heart disease and they are positively correlated with the degree of coronary artery stenosis. HCY is an indicator of diagnosis of coronary heart disease.
|
|
|
|
|
|
[1] Ka?覥ka D，?覵ukasz Karpiński，Gebala J，et al. Sexual health of male cardiac patients-present status and expectations of patients with coronary heart disease [J]. Archives of Medical Science Ams，2017，13（2）：302-310.
[2] Zhang X，Zhan Y，Liu J，et al. Chinese translation and psychometric testing of the cardiac self-efficacy scale in patients with coronary heart disease in mainland China [J]. Health and quality of life outcomes，2018，16（1）：43.
[3] Roberts R. Genetics in the prevention and management of coronary artery disease [J]. Curr Opin Cardiol，2018，33（3）：257-268.
[4] King W，Lacey A，White J，et al. Socioeconomic inequality in medication persistence in primary and secondary prevention of coronary heart disease - A population-wide electronic cohort study [J]. PLoS One，2018，13（3）：e0194081.
[5] Nettleton JA，Brouwer IA，Geleijnse JM，et al. Saturated Fat Consumption and Risk of Coronary Heart Disease and Ischemic Stroke：A Science Update [J]. Ann Nutr Metab，2017，70（1）：26-33.
[6] Woodside JV，Mcevoy C，Temple NJ. Nutrition Guide for Physicians [M]. New Hampshire：Humana Press，2010：301-310.
[7] 程国辉，钱剑宁，李友健.动脉粥样硬化性脑梗死急性期患者血浆脂蛋白相关磷脂酶A2与同型半胱氨酸水平的变化及临床相关性分析[J].中国医药科学，2018，8（4）：203-205，245.
[8] Kalra A，Bhatt DL，Rajagopalan S，et al. Overview of Coronary Heart Disease Risk Initiatives in South Asia [J]. Current Atherosclerosis Reports，2017，19（6）：25.
[9] Kim JK，Kang S. Neural Network-Based Coronary Heart Disease Risk Prediction Using Feature Correlation Analysis [J]. J Healthc Eng，2017.doi：10.1155/2017/2780501.
[10] Karolczak K，Kamysz W，Karafova A，et al. Homocysteine is anovel risk factor for suboptimal response of blood platelets toacetylsalicylic disease：a randomized multicenter study [J]. Pharmacol Res，2013，74：7-22.
[11] Li Y，Iso H，Cui R，et al. Serum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women [J]. J Atheroscler Thromb，2016，23（7）：792-799.
[12] 颜红兵，马长生，霍勇.临床冠心病诊断与治疗指南[M].北京：人民卫生出版社，2010.
[13] Liu C，Yang Y，Peng D，et al. Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease [J]. Saudi Med J，2015，36（7）：839-846.
[14] Kyung-Sun Han，Doo-Yeoun Cho，Young-Sang Kim，et al. Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men: Analysis of the Korea National Health and Nutrition Examination Survey（V-1，2010 and V-2，2011）[J].中华医学杂志：英文版，2015，128（15）：2006-2011.
[15] 刘光明，丘仲柳，陈世豪，等.不同心肌损伤生化标志物检验的临床价值分析[J].中国医药科学，2018，8（3）：150-152.
[16] Onat A，Can G，Örnek E，et al. Serum γ-glutamyltransferase：independent predictor of risk of diabetes， hypertension， metabolic syndrome， and coronary disease [J]. Obesity（Silver Spring），2012，20（4）：842-848.
[17] 张玲.血浆γ-谷氨酰转移酶与冠心病关系的研究[J].中国循证心血管医学杂志，2013，5（6）：633-634.
[18] 林斌.冠心病患者血清同型半胱氨酸水平与冠状动脉病变严重程度的关系[J].中国当代医药，2016，23（10）：36-38.
[19] 张文斌，唐其柱，马振国，等.血清γ-谷氨酰转肽酶与冠状动脉病变关系的研究[J].中国心血管病研究，2015， 13（12）：1078-1080. |
|
|
|
