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2018 Vol. 15, No. 3
Published: 2018-01-25
 
 
4 Radiation- protective effect of thymoquinone in mice
HOU Qinlian DONG Yinping DONG Hui LI Deguan DU Liqing
Objective To observe the protective effects of thymoquinone (TQ) against radiation injuries in mice. Methods C57BL/6J mice were randomly divided into three group (n=5): control group, irradiation group and irradiation + TQ group. The mice in the irradiation group and the irradiation + TQ group were accepted 7.5 Gy total body irradiation, and the mice in the control group was received sham irradiation. The irradiation + TQ group was administered orally the day before exposure (10 mg/kg), sustained administration for 3 days. The same volume normal saline was given to the mice in the control and irradiation group. Three days after irradiation, the samples were taken, and the indexes of spleen, lung, kidney, testes and liver of the mice were observed, and the contents of GSH, SOD and MDA in serum and liver tissues of each group were detected. Results Compared with the irradiation group, the GSH content in the liver tissues and SOD value in the serum in the irradiation + TQ group were increased, and the MDA level in the serum was decreased, with statistically significant difference (P < 0.05). Conclusion TQ can reduce radiation oxidation damage in the radiation mice, and it has certain protective effect on the radiation injury in mice.
2018 Vol. 15 (3): 4-7 [Abstract] ( 251 ) HTML (1 KB)  PDF (920 KB)  ( 236 )
8 Effects of miR-1203 and HOTAIR SNP rs7958904 on the growth of breast cancer cells
LIU Wenhui1 XIAO Jian2 SUN Weihua3 YANG Na3 LIU Boxuan3 GONG Jianping3
Objective To investigate the association between genetic variation of lncRNA HOTAIR SNP rs7958904 and miR-1203, as well as to explore their roles in the growth of breast cancer （BC） cells. Methods The wild type and mutant HOTAIR SNP rs-7958904 were both cloned into the Dual-Luciferase Reporter Vector and Over-expression vector, respectively. The Dual-Luciferase Reporter Vectors and miR-1203 mimics were co-transfected into the cells, and then the luciferase expression was detected. Furthermore, BC cells were transfected with the overexpression vector and/or miR-1203 mimics/inhibitors. And then, HOTAIR expression was detected by fluorescent quantitative PCR, cell proliferation was assessed by BrdU, cell apoptosis was tested by Annexin V-FITC/PI, and cell invasion was examined by Transwell Assay. Results The binding of miR-1203 and HOTAIR was enhanced by mutant HOTAIR; miR-1203 could down-regulate the expression of mutant HOTAIR （P < 0.01）, but such down regulation on wild-type HOTAIR was insignificant （P > 0.05）. The wild-type HOTAIR promoted the proliferation and invasion of BC cells significantly but inhibit their apoptosis （P < 0.01）; whereas such effect of the mutant HOTAIR declined obviously and could be blocked by miR-1203. miR-1203 had the opposite effect of HOTAIR; when the expression of miR-1203 was inhibited, the mutant HOTAIR exhibited a similar effect as wild-type HOTAIR. Conclusion The mutant HOTAIR rs7958904 can down-regulate the activity of HOTAIR, and such down regulation may probably associated with the increment of miR-1203 binding sites. This finding could provide a new direction for the future study in the function of lncRNA SNPs.
2018 Vol. 15 (3): 8-12 [Abstract] ( 333 ) HTML (1 KB)  PDF (1189 KB)  ( 128 )
13 Effects of overexpression of galectin-9 protein on proliferation, migration and apoptosis of ovarian cancer cells
CHENG Yayu1 TAN Xueying2 HUANG Fei2 ZHANG Ping3
Objective To investigate the effects of overexpression of galectin-9 on the proliferation, migration and apoptosis of ovarian cancer cells. Methods The ovarian cancer cells SKOV-3 were divided into pcDNA3.1-galectin-9 transfection group, pcDNA3.1 group and blank control group, Western blot was used to detect the expression of galectin-9 protein, CCK-8 was used to detect the effects of galectin-9 protein for multiplication capacity of SKOV-3, scratch test was used to verify the effects of galectin-9 protein for transfer ability of SKOV-3, Annexin-V-FITC/PI double staining method was used to detect the effects of galectin-9 protein for apoptosis of SKOV-3. Results The results of Western blot showed that the expression of galectin-9 protein in pcDNA3.1-galectin-9 transfection group was significantly higher than those in blank control group and pcDNA3.1 group, the differences were all highly statistically significant (all P ＜ 0.01). The results of CCK-8 showed that the multiplication capacity of galectin-9 in pcDNA3.1-galectin-9 transfection group was significantly lower than those in blank control group and pcDNA3.1 group, the differences were all highly statistically significant (all P ＜ 0.01), galectin-9 could significantly inhibit the multiplication capacity of cells, and the capacity of inhibiting proliferation would increase with the extension of time. The results of cell scratch assay showed that the healing rate of pcDNA3.1-galectin-9 transfection group was significantly higher than that of pcDNA3.1 group and blank control group, the differences were all highly statistically significant (all P ＜ 0.01). The results of flow cytometry showed that the apoptosis rate of pcDNA3.1-galectin-9 transfection group was significantly higher than that of pcDNA3.1 group and blank control group, the differences were highly statistically significant (all P ＜ 0.01). Conclusion The overexpression of galectin-9 can inhibit the proliferation and migration of ovarian cancer cell lines and promote its apoptosis.
2018 Vol. 15 (3): 13-16 [Abstract] ( 301 ) HTML (1 KB)  PDF (573 KB)  ( 93 )
17 Study on the protective effect of ginsenoside Rg1 on optic nerve injury in rats
HU Chuxuan LI Suihua ZHANG Xia MEI Qinghua
Objective To observe the protective effect of ginsenoside Rg1 on optic nerve injury in rats and its protective mechanism. Methods Wistar rats were randomly divided into control group, model group and treatment group, with 30 rats in each group. Rats in the control group were injected intraperitoneally with saline without modeling. Rats in the model group were intraperitoneally injected with saline. Rats in the treatment group were intraperitoneally injected with ginsenoside Rg1 (50 mg/kg) for 7 d. The model of optic nerve injury was established by occlusion of the optic nerve. After 5 days of modeling, fluorescein-labeled retinal ganglion cells (RGCs) were injected into the right superior colliculus on the right side of the rats. Flash visual evoked potentials were detected before the rats were sacrificed. RGCs density, apoptosis of RGCs, P1 wave of evoked potential, optic nerve cholesterol content, silent information regulator 1 (SIRT1) protein and HMG-CoA reductase (HMGCR) expression were detected after the rats were sacrificed. Results At 7, 14, 21 days after sacrifice, the visual evoked potentials and the number of retinal apoptotic cells in the control group did not change significantly with the prolongation of sacrifice time. The visual evoked potentials and the number of retinal apoptotic cells in the model group and treatment group were increased gradually (P ＜ 0.05). At the same time point, the number of visual evoked potentials and retinal apoptotic cells in the model group were significantly higher than those in the control group, the visual evoked potential, the number of retinal apoptotic cells in the treatment group were lower than those in the model group (P ＜ 0.05). The RGCs density, optic nerve cholesterol, SIRT1 and HMGCR protein levels in the model group and treatment group were increased gradually with the prolongation of sacrifice time (P ＜ 0.05); at the same time, RGCs density, optic nerve cholesterol, SIRT1 and HMGCR protein levels in the model group were significantly higher than those in the control group, the RGCs density, optic nerve cholesterol, SIRT1 and HMGCR protein levels in the treatment group were lower than those in the model group (P ＜ 0.05). Conclusion Ginsenoside Rg1 has a significant protective effect on optic nerve injury in rats, the mechanism may be related to the up-regulation of the expression of SIRT1 and HMGCR genes and the synthesis of optic nerve cholesterol.
2018 Vol. 15 (3): 17-21 [Abstract] ( 269 ) HTML (1 KB)  PDF (568 KB)  ( 181 )
22 Relevant research progress of lactic acidosis
HU Baoji1 BO Lulong2▲ DENG Xiaoming2 DUAN Hongwei1
Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism, in addition, the presence of elevated lactate levels in critically ill patients has important implications for prognosis and mortality. The paper reviews the clinical role of lactic acid and the potential treatments, elucidates the important role and prognostic significance of lactic acid and provides new thoughts for the therapies of severe diseases.
2018 Vol. 15 (3): 22-25 [Abstract] ( 316 ) HTML (1 KB)  PDF (510 KB)  ( 115 )
26 Research progress on correlation between persistent HR-HPV infection of cervix and vaginal microecology
LU Yu1 ZHAO Jianwu2
Persistent infections with cervical high risk human papilloma virus (HR-HPV) is a necessary but insufficient condition to cause cervical cancer and precancerous lesions. Vaginal microecology is highly correlated with occurrence and development of infectious diseases in female genital tract. It is crucial for vaginal microecology research to study normal microbial bacteria inside vagina. Vagina bacterial diversity increasing, lactobacillus quantity decreasing and bacterial vaginosis significantly increase risk of susceptible and persistent infection of cervical HR-HPV, so as to promote progress of cervical intraepithelial neoplasia and cervical cancer. Clinically, regulation of vaginal microecology shall be emphasized. Probably, restoration of vaginal microecology plays a role in indirectly promoting turning cervical HR-HPV infection to be negative.
2018 Vol. 15 (3): 26-29 [Abstract] ( 320 ) HTML (1 KB)  PDF (511 KB)  ( 536 )
30 The study on the fracture of radial microcephalus in the "triad" of the elbow joint
QIAO Songyi1,2 LUO Bin1,2 MENG Xiangqi2
The radial microcephalus plays a crucial role in the elbow joint and the treatment of the radial fracture in the "triad" of the elbow directly affects the stability of the elbow joint. By reviewing the literatures about the treatment of radial capitulum fracture in elbow "triad" at home and abroad in recent years, found that the views on the treatment of it is mainly surgery and conservative therapy. The surgical method is mainly internal fixation and radial small head replacement, while conservative treatment is mainly gypsum or splint and other external fixation treatment and early functional exercise. Both treatments have advantages and disadvantages, and most of the efficacy is satisfactory. This paper summarized the studies of the mechanism of the fracture of radial fracture in the "triad" of the elbow joint, the research and the treatment progress of the injury mechanism, so as to provide references to the treatment.
2018 Vol. 15 (3): 30-33 [Abstract] ( 276 ) HTML (1 KB)  PDF (511 KB)  ( 133 )
34 Clinical research progress in chronic kidney disease - mineral and bone disorder
LIU Guiping ZHANG Lin ZHANG Guoling▲
Chronic kidney disease (CKD) is one of the most important diseases threatening human health. Its incidence is high, its complications are numerous, and its consequences are serious. How to early diagnose and deal with all kinds of complications of CKD patients is an important and difficult task for clinical workers. Chronic kidney disease - mineral and bone disorder (CKD-MBD) is one of the complications of CKD. With the deep study of its pathophysiological mechanism and the continuous accumulation of evidence-based medicine research, the diagnosis and treatment of CKD-MBD have been paid more and more attention. This article reviews the latest research progress on the pathogenesis, clinical assessment and treatment measures of CKD-MBD, in order to provide a useful reference for improving the level of clinical diagnosis and treatment.
2018 Vol. 15 (3): 34-37 [Abstract] ( 251 ) HTML (1 KB)  PDF (511 KB)  ( 151 )
38 Analysis of the medical students′ cognitive status about elderly health
GAO Kui ZHANG Li′na▲ TU Hong LIU Xiaowei LI Ting XIAO Xiong
Objective To investigate the medical students′ cognitive status and job intention about elderly health, in order to provide some suggestions about elderly health education for medical college. Methods From March to June in 2016, 963 medical students in Sichuan Province were investigated and interviewed by self-made questionnaires, and the obtained data were analyzed. Results About 56.6% students lacked the knowledge of elderly health. 66.4% medical colleges didn′t give lectures on the elderly health, and only 17.6% medical students showed that they would be willing to work in the filed of elderly health. The analysis of variance showed that there were significant differences in gender, grade and specialty about the understanding of the elderly diseases (P < 0.05). There were statistically significant differences between the sexes in the cognitive status of elderly mental and elderly nursing (P < 0.05). Conclusion There are differences in gender, grade and specialty about the cognition of the elderly health. Medical studentsare generally less aware of the elderly health, and they are not willing to work in the field of geriatric health. The school should increase the input and guidance of education for geriatric health, so as to enhance the initiative of medical students in choosing careers. 
2018 Vol. 15 (3): 38-41 [Abstract] ( 665 ) HTML (1 KB)  PDF (514 KB)  ( 129 )
42 Investigation on the immune status of 330 patients with brucellic disease in non-pasturing area and high-risk factors of infection
GAO Jicheng1 MA Baoliang2▲ HU Xiaomei1 ZU Yonggang1
Objective To investigate the immune status of patients with brucellic disease in non-pasturing area and high-risk factors of infection. Methods From January 2008 to November 2016, 330 patients with brucellic disease in non-pasturing area received in Traditional Chinese Medicine Hospital of Langfang City were selected as the observation group, 330 healthy personnel with the same occupation at the same time were selected as the control group. Then the serum immunoglobulin, circulating immune complex and T lymphocyte subsets of observation group with different treatment effect were compared. The consist of gender, ages, nationality, work types, length of job, hygienic habit and contact with livestock situation of two groups were compared, and the relationship between those factors and infection of brucellic disease were analyzed by multivariate conditional Logistic regression. Results In the observation group, the serum immunoglobulin and the T lymphocyte subsets of cured cases in patients with brucellic disease were all lower than those of effective and ineffective patients, and circulating immune complex were significantly lower than those of effective and ineffective patients, with statistically significant differences (P < 0.05). The gender, age and ethnic composition of the two groups were not statistically significant (P > 0.05). There were statistically significant differences between the two groups of workers, working age, hygienic habits and contact with livestock (P < 0.05). The multivariate conditional Logistic regression showed that sales, length of job < 1 year, not washing hands by rules, not disinfectant application by rules, not sterilize the workplace by rules, drinking raw milk, eating sick and dead livestock, treatment of dead lambs, contacting with borted livestock or deliver livestock were all risk factors of infection (P < 0.05). Conclusion The immune status of patients with brucellic disease in non-pasturing area are worse, and the differences of patients with different prognosis are obvious, the work types, length of job, hygienic habit and contact with livestock situation are all the high-risk factors of infection, the monitoring and regulation of immune should be carried out according to the patients′ condition, and the prevention and control measures should be worked out according to the high-risk factors.
2018 Vol. 15 (3): 42-45 [Abstract] ( 266 ) HTML (1 KB)  PDF (493 KB)  ( 208 )
46 Investigation of the current situation of Neuroprotective Agents in six cities in China from 2012 to 2016
WANG Huiyuan YANG Li ZHAO Zhigang
Objective Based on the investigation of the current situation and trend of the use of Neuroprotective Agents in six cities in China, to preliminarily evaluate the rationality of the use of Neuroprotective Agents, in order to provide the basic reference data for promoting the rational use of drugs. Methods The data were from sampling prescription of 84 samples of medical and health institutions at all levels in 6 cities (Beijing, Tianjin, Shanghai, Guangzhou, Hangzhou, Chengdu) in China collected in“The Hospital Prescriptions Cooperation Project” of Hospital Pharmacy Committee of Chinese Pharmaceutical Association from January 2012 to December 2016, and the patient′s medication situation was analyzed. Results During the five years, the sales amount of Neuroprotective Agents in six cities increased year by year. The ratio of men to women was about 5 to 4, with the patients aged between 1 and 118 years old, mainly in the 50 to 90 years old, accounting for 75.00%. The distribution of drug departments were mainly in neurology (24.92%), neurosurgery (11.17%), old cadre department (8.47%), emergency department (7.62%) and cardiology (5.33%).The original diagnosis accounted for the top five: cerebral infarction (3.17%), cerebral hemorrhage (1.45%), cerebrovascular disease (0.91%), head trauma (0.50%) and cerebral infarction sequel (0.41%). The amount and kind of drug sales in 2016, Neurotrophic Co-Stimulating (5.2 million yuan) > Membrane Stabilizer (5.1 million yuan) > Calcium Antagonists (2.8 million yuan) > Glutamate Release Inhibitors (2.6 million yuan). The top 5 drug consumption figures were respectively Ganglioside (3.9 million yuan), Mouse Nerve Growth Factor (3.3 million yuan), Butyl Phthalide (2.6 million yuan), Edaravone (2.2 million yuan), Cinepazide (2 million yuan). There was a wide variation in drug use among cities, and each region had its own tendency to use drugs. Conclusion In general, there are clinical abuses in the application of Neuroprotective Agents in six cities in China, which should be used rationally and economically on the basis of ensuring the efficacy and safety of drugs.
2018 Vol. 15 (3): 46-51 [Abstract] ( 348 ) HTML (1 KB)  PDF (767 KB)  ( 165 )
52 The clinical effects of Selenious yeast tablets combined with Levothyroxine sodium in patients with hypothyroidism
LI Shan JIANG Min WANG Fen WANG Rui XIE Peifeng
Objective To explore the clinical effects of Selenious yeast tablets combined with Levothyroxine sodium in the treatment of hypothyroidism. Methods From April 2015 to April 2016, 80 cases of patients with hypothyroidism treated in Beijing University of Chinese Medicine Third Affiliated Hospital were selected as research objects and divided into the control group and the experimental group by random, double-blind and control method, with 40 cases in each group. The control group was treated with oral Levothyroxine sodium combined with placebo and the experimental group was treated with oral Selenious yeast tablets on the basis of Levothyroxine sodium. Both groups were treated for 6 months. The clinical efficacy, the levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free tetraiodothyronine (FT4), the adverse reactions and the patiens′ satisfaction in the two groups were compared. Results After treatment, the incidence of clinical efficacy in the experimental group was higher than that of control group, with statistically significant difference (P ＜ 0.05). After treatment, the TSH was lower, the FT3 and FT4 were higher than those of before treatment in the two groups, the indicators above in the experimental group improved much more remarkably, with statistically significant differences (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). The patiens′ satisfaction in the experimental group was higher than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion Selenious yeast tablets combined with Levothyroxine sodium is helpful to control the clinical symptoms in patients with hypothyroidism. It can improve the levels of thyroid hormone, promote the patiens′ satisfactton and has high safty. It is worthy of promotion and application.
2018 Vol. 15 (3): 52-55 [Abstract] ( 245 ) HTML (1 KB)  PDF (386 KB)  ( 91 )
56 Single versus double J ureteral stent placement for the management of recurrent benign ureteral stricture
LIU Jie WANG Wei LI Gang QIN Qingping ZHOU Yi YANG Jianwen LU Qihai YAO Yuan
Objective To explore the efficacy of single versus double J ureteral stent placement in the treatment of recurrent benign ureteral stricture. Methods From January 2012 to December 2016, 26 patients with recurrent benign ureteral stricture in the Department of Urology, Liuzhou General Hospital, Guangxi Zhuang Autonomous Region were selected as the research objects and divided into the single J ureteral stent group and the double J ureteral stent group by random number table. The clinical efficacy was compared between the two groups after stent placement. Before and after 3 months of stent placement, the levels of serum creatinine and hydronephrosis were compared between the two groups. Results After stent placement, the total effective rate in double J ureteral stent group was higher than that in single J ureteral stent group, but with no statistically significant difference (P ＞ 0.05). Before and after stent placement, there were no statistically significant differences in the levels of serum creatinine between the two groups and within groups (P ＞ 0.05). In the single J ureteral stent group, there was no statistically significant difference in hydronephrosis before and after stent placement (P ＞ 0.05), but after stent placement, that in the double J ureteral stent group was lower than that of before stent placement and that in the single J ureteral stents group, with statistically significant differences (P ＜ 0.05). Conclusion The efficacy and the drainage of double J ureteral stent placement in the treatment of recurrent benign ureteral stricture are better than those of single J ureteral stent placement. However, the long-term effects and mechanisms need to be further studied and verified by large samples.
2018 Vol. 15 (3): 56-59 [Abstract] ( 227 ) HTML (1 KB)  PDF (421 KB)  ( 206 )
60 Application value of serum anti-phospholipase A2 receptor antibody in the diagnosis of membranous nephropathy
WANG Xi
Objective To evaluate application value of serum anti-phospholipase A2 receptor antibody in the diagnosis of membranous nephropathy. Methods Fifty patients with membranous nephropathy treated with nephrology in Department of Nephrology, the Second People′s Hospital of Yunnan Province ("our hospital" for short) from July 2014 to August 2016 were selected as observation group. Fifty healthy subjects of our hospital Physical Examination Department were selected as control group. Serum anti-phospholipase A2 receptor antibody and a variety of biochemical immune indicators of the results between two groups were compared, the relationship between indicators were analyzed. Results The anti-phospholipase A2 antibody titer in observation group was higher than that in control group, TP and IgG in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in IgM, IgA, C3 and C4 between two groups (P > 0.05). The diagnostic sensitivity of anti-phospholipase A2 antibody to membranous nephropathy was 58.00%, specificity was 98.00%. There was a positive correlation between anti-phospholipase A2 antibody and TP, IgG and IgA (r = －3.954, －0.483, －0.286, P < 0.05), and positively correlated with C4 (r = 0.256, P < 0.05), and IgM and C3 did not show correlation (P > 0.05). Conclusion The technique of detecting anti-phospholipase A2 antibody by ELISA is maturing. The diagnosis of membranous nephropathy by anti-phospholipase A2 antibody detection is a good research direction, and ELISA can be used for quantitative detection of anti-phospholipase A2 antibody, and the change of condition for membranous nephropathy monitoring and treatment of the effectiveness of the assessment, but also has the role of auxiliary judgment.
2018 Vol. 15 (3): 60-63 [Abstract] ( 287 ) HTML (1 KB)  PDF (420 KB)  ( 126 )
64 Meta-analysis of diagnostic value of sacroiliac joint ultrasound examination in ankylosing spondylitis
LYU Haoyuan1 WANG Qianjiang2 JIANG Xin3,4 ZHANG Chi5 XIAO Qiangbing3,4 LIU Caiping1 ZHENG Ren6 WEI Yi6
Objetive To evaluate the diagnostic value of sacroiliac joint ultrasound examination in ankylosing spondylitis (AS) and provide evidence for clinical diagnosis. Methods The databases of PubMed, EMbase, Cochrane Library, CNKI, China biology medicine disc, wangfang and VIP were retrieved about ultrasound diagnosis test of ultrasonographic examination for AS in sacroiliac joint. The retrieval time from database built to August 1th, 2017. Two reviewers independently screened and extracted literatures according to inclusion and exclusion criteria. The Revman 5.3 software was applied to assess the risk bias and then Meta-analysis was performed by using Meta-Disc 1.4 software. Results A total of 5 articles involving 350 patients were included. The results of heterogeneity test revealed that there was statistical heterogeneity among the results of the studies, random effects model was adopted for Meta-analysis. The results of Meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnosis odds ratio for ultrasound checking in sacroiliac joints diagnosis were 0.78 (95%CI: 0.74-0.82), 0.87 (95%CI:0.82-0.91), 5.71 (95%CI: 3.99-8.15), 0.25 (95%CI: 0.16-0.39), 27.79 (95%CI:11.18-69.06) respectively. The area under the SROC curve was 0.9298. Conclusion Ultrasound in diagnosis of sacroiliac joint in patients with AS is a good non-invasive method as a routine examination. Due to the limited quality and quantity of included samples, the above conclusion is needed to be validated by more high-quality studies.
2018 Vol. 15 (3): 64-69 [Abstract] ( 316 ) HTML (1 KB)  PDF (1371 KB)  ( 200 )
70 Effect of percutaneous endoscopic lumbar discectomy of ODI, good rate of MacNab and Lehmann lumbar function in patients with single-stage lumbar disc herniation
MI Panpan1 CHEN Shengle1 XU Yafang2 FAN Guofeng1▲
Objective To observe the clinical effect of percutaneous lumbar intervertebral disc resection in the treatment of patients with single-stage lumbar disc herniation and the clinical outcome of Oswestry disability index (ODI), good rate of MacNab and Lehmann lumbar function. Methods From January 2015 to April 2016, 102 patients with single-stage lumbar disc herniation in China National Petroleum Corporation Central Hospital were selected and divided into observation group and control group by random number table, with 51 patients in each group. The control group was treated with standard posterior push plate lumbar disc resection, while the observation group was treated with percutaneous intervertebral disc resection. The ODI, good rate of MacNab, Lehmann lumbar function between two groups after operation were compared. Results After operation, ODI in the observation group was lower than that in the control group, and the good rate of MacNab and Lehmann lumbar function in the observation group were better than those in the control group, with statistically significant difference (P < 0.05). Conclusion The treatment of single-stage lumbar disc herniation by percutaneous intervertebral disc resection can reduce the amount of bleeding in operation, decrease the incision of the operation, shorten the hospitalization time, and improve the curative effect and improve quality of life after the operation. Therefore, it is worthy of further clinical promotion.
2018 Vol. 15 (3): 70-72,92 [Abstract] ( 310 ) HTML (1 KB)  PDF (955 KB)  ( 107 )
73 Comparative analysis of the clinical effectiveness of conservative treatment and surgery in the treatment of senile type C3 distal radius fracture
LUO Yuancheng WANG Jing WANG Kui DIAO Jingming YANG Wei ZHU Bin
Objective To compare the efficacy between manipulative reduction combined with external fixation using the splint and open reduction combined with internal fixation using volar plates in the treatment of senile type C3 distal radius fracture. Methods From July 2009 to December 2016, 97 clinical data of patients with type C3 distal radius fracture aged above 65 years old that received treatments in the National Hospital of Enshi Autonomous Prefecture were analyzed retrospectively and divided into the conservation group (55 cases) and the surgery group (42 cases). The conservation group was treated with manipulative reduction combined with external fixation using the splint and the surgery group was treated with open reduction combined with internal fixation using volar plates. The average hospitalization expenses and average hospitalization time, incidence of complications, postoperative reduction condition, the condition of postoperative functional recovery and the patients′ satisfaction with the treatment were compared between the two groups. Results The hospitalization expenses was less and the hospitalization time was shorter in the conservation group than those of surgery group, with statistically significant differences (P ＜ 0.05). The incidence of complications in the conservation group (1.82%) was lower than that of surgery group (7.14%), but with no statistically significant difference (P ＞ 0.05). There were no statistically significant differences in the excellent rate of 1 d and 1 week Lidstrom scores between the two groups (P ＞ 0.05), but with statistically significant differences in 1 month and 6 month (P ＜ 0.05). The excellent rate of Dienst assessment of wrist joint function in the conservation group was 74.55% and of 88.10% in the surgery group, but with no statistically significant differences (P ＞ 0.05). The patients′ satisfaction in the conservation group(89.10%) was higher than that of surgery group(71.43%), with statistically significant difference(P ＜ 0.05). Conclusion Manipulative reduction combined with external fixation using the splint is the best treatment method for elderly patients who fail to tolerate the surgery, have little requirement for the treatment, or not willing to receive the surgery.
2018 Vol. 15 (3): 73-76 [Abstract] ( 323 ) HTML (1 KB)  PDF (614 KB)  ( 99 )
77 The short-term effect of arthroscopic debridement in treating gout arthritis of knee joint
DENG Zhicheng GUI Jingxiong▲
Objective To investigate the value of arthroscopic debridement in the treatment of gouty arthritis of knee joint. Methods The clinical data of 51 patients with gouty arthritis of knee joint treated in Southern Medical University Xiaolan Affiliated Hospital from January 2012 to December 2016 were analyzed retrospectively. The observation group (19 cases) was treated by medical intervention, drug treatment and arthroscopic debridement, while the control group (32 cases) were treated by medical intervention and drug treatment. The visual analogue score (VAS) score and Lysholm joint function score were compared between the two groups before and after treatment, and the rate of recurrence was estimated at 6 months after treatment. Results After treatment, the VAS and Lysholm scores in the two groups were improved (P < 0.05). One week after treatment, the VAS score in the observation group was better than that in the control group (P < 0.05). Two week after treatment, the VAS and Lysholm scores in the observation group were better than those in the control group (P < 0.05). And the recurrence rate of observation group was lower than that in the control group at 6 months after treatment (P < 0.05). Conclusion Arthroscopic debridement in treating gouty arthritis of knee joint can relieve pain, improve joint function, low recurrence rate, which can be used as effective means of medical intervention and drug treatment.
2018 Vol. 15 (3): 77-80 [Abstract] ( 264 ) HTML (1 KB)  PDF (620 KB)  ( 126 )
81 Experience of treatment for postoperative infection of thoracolumbar spine without removing internal fixation
WANG Shaoqian WANG Hui▲ NIU Lei WEI Longyu
Objective To explore the feasibility of treating postoperative infection of thoracolumbar spine in the case of retaining internal fixation with a series of treatment methods, such as changing drugs, removing the lesion, expanding the drainage and using sensitive antibiotics. Methods The clinical data of 16 patients with postoperative infection of thoracolumbar spine treated in the Second People's Hospital of Hefei from January 2012 to May 2015 were analyzed retrospectively. In the case of retaining internal fixation, after a series of treatment methods, such as changing drugs, removing the lesion, expanding the drainage and using sensitive antibiotics, the wound healing was observed. The white blood cell (WBC) number, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and visual analogous scale (VAS) were analyzed and compared before and after treatment. Results All patients wound healing were well. Follow-up time was from 6 months to 2 years, and no case recurred. After treatment, the WBC number, ESR, CRP and VAS score were lower than those before treatment, with statistically significant difference (P < 0.05). Conclusion It is necessary to clearly diagnose the postoperative infection of thoracolumbar spine in the early stage, and actively take the active treatment, such as changing drugs, removing the lesion, washing the drainage, etc. In the case of retaining internal fixation, it can also achieve good curative effect.
2018 Vol. 15 (3): 81-84 [Abstract] ( 277 ) HTML (1 KB)  PDF (678 KB)  ( 146 )
85 Effects of vitamin D supplementation on bronchial asthma of different severity in children
WANG Zhihua
Objectives To explore the effects of vitamin D supplementation on symptoms of children with bronchial asthma of different severity and relevant mechanisms. Methods Ninety children with bronchial asthma were included from the Second Hospital of Chaoyang from January 2015 to January 2017. Random blocks design was used in this study, the children were assigned to mild (n = 30), moderate and severe attack (n = 60) groups, then they were assigned to the treatment and control subgroups with 45 for each with random number table. The children in the control group were treated with Salbutamol Sulfate Aerosol Inhalation and Fluticasone Propionate Aerosol, and the children received additionally oral vitamin D3 at dose of 800 U daily in the treatment group. All children were treated for 3 months. The childhood asthma control test was used to assess the state of illness of children with bronchial asthma at 3 months after treatment. In addition, serum levels of 25(OH)D3, specific IgE and eosinophil cationic protein were determined before and 3 months after treatment. Results Illness control rate and serum level of 25(OH)D3 in the children with mild attack in the treatment group were significantly higher than those of the control group, the differences were statistically significant (P < 0.05). Conversely, serum levels of specific IgE and eosinophil cationic protein in the children with mild attack in the treatment group were significantly lower than the control group (P < 0.05). Compared with before treatment, serum levels of 25(OH)D3 of children with bronchial asthma in each group was significantly decreased after treatment (P < 0.05) with the exception of mild attack children, but specific IgE and eosinophil cationic protein were significantly increased after treatment (P < 0.05). Conclusion Effects of vitamin D supplementation on symptoms of children with bronchial asthma of different severity are varied, those are more obvious in mild asthmatic attack children, and the underlying mechanisms may involve the increased serum level of 25(OH)D3 and the decreased serum levels of specific IgE and eosinophil cationic protein.
2018 Vol. 15 (3): 85-88 [Abstract] ( 273 ) HTML (1 KB)  PDF (573 KB)  ( 154 )
89 Application of planned cesarean section in the diagnosis and treatment of placenta accreta complicated with placenta previa
HE Xiangmei1 WANG Nan2 MA Xiwen1 QIN Fengxue1
Objective To analyze the clinical data of patients of placenta accreta complicated with placenta previa, and investigate the value of planned surgery in the diagnosis and treatment of these cases. Methods Sixty-four cases of placenta accreta complicated with placenta previa in Qinghai Provincial Traffic Hospital from January 2012 to December 2016 were selected. Patients were randomly divided into observation group and control group. The 33 cases of the observation group was treated with planned surgery and 31 cases of the the control group was treated with routine surgery. The operative time, postpartum hemorrhage, hospitalization cost and hospital stay day of two groups were analyzed and compared. Results The average operation time, hospitalization expenses and average hospitalization days  of the observation group were less than those of the control group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in postpartum hemorrhage between two groups (P ＞ 0.05). Conclusion The plan of surgery can improve the treatment efficiency, reduce the operation time and the average hospitalization days, reduce hospitalization expenses.
2018 Vol. 15 (3): 89-92 [Abstract] ( 242 ) HTML (1 KB)  PDF (594 KB)  ( 159 )
93 Effect of early comprehensive intervention on prevention of infantile eczema
LI Xiaorui1 SUN Lirong2 ZHU Lihong3
Objective To explore the effect of early comprehensive intervention in preventing infantile eczema. Methods From January to May in 2016, 340 infants born in People′s Hospital of Xinjiang Uygur Autonomous Region were included and divided into control group and observation group according random number table method, 170 patients in each group. Infants of two groups were followed up for 6 months. The control group was followed up by routine method, the observation group was treated with comprehensive nursing intervention on the basis of routine follow-up. Eczema infants of two groups were followed up with recording. The incidence of infantile eczema in both groups, the maximum duration of eczema, the severity of eczema, the short term effect of eczema was compared. Results Following-up until the infants were 6 months old, the incidence of eczema in the observation group was lower, the treatment effect was  more remarkable, the duration of eczema was shorter, the degree of eczema was slighter, compared with the control group, the differences were statistically significant (P < 0.05). Conclusion Early comprehensive nursing intervention can reduce the incidence of infantile eczema, to ensure the normal growth and development of infants.
2018 Vol. 15 (3): 93-96,106 [Abstract] ( 242 ) HTML (1 KB)  PDF (617 KB)  ( 120 )
97 A network Meta-analysis of the treatments for endometriosis after laparoscopy
ZHANG Wen DU Hao ZU Li YUAN Yuan▲ LI Ning
Objective To systematically evaluate the clinical efficacy of different treatment methods for endometriosis after laparoscopic surgery. Methods RCTs about endometriosis after laparoscopic surgery from 2007 to 2017 nearly ten years were searched in the database of PubMed， CNKI， CBM， VIP and Wanfang. Eligible RCTs were included and the quality of RCTs were evaluated. The data were extracted and the clinical efficacy of after laparoscopic surgery was Meta analyzed by Stata 14.0 and RevMan 5.3 software. And according to the effective rate of treatment， recurrence rate and pregnancy rate， the network Meta sequencing was ranked. Results A total of 13 RCTs were included in， including 1263 patients with endometriosis. The effective rate of laparoscopy combined with Chinese and Western medicine was higher than that of traditional Chinese medicine therapy and Western medicine therapy， the differences were statistically significant （P < 0.05）. There was no significant difference in the effective rate between simple western medicine and traditional Chinese medicine （P > 0.05）. According to the treatment efficiency， recurrence rate and pregnancy rate ranking order was the combination of Chinese and western， traditional Chinese medicine， western medicine and placebo. Conclusion The clinical curative effect of combined therapy of Chinese and Western in patients with endometriosis after the uterus is most prominent， can effectively improve the treatment efficiency of patients with endometriosis， reduce the recurrence rate and infertility rate. But there may be some selective bias to be included in the study， also need to provide more accurate basis to more high quality RCT.
2018 Vol. 15 (3): 97-101 [Abstract] ( 284 ) HTML (1 KB)  PDF (912 KB)  ( 145 )
102 The curative effect of three-dimensional intracavitary brachytherapy in the preoperative treatment of cervical cancer with stage ⅠB1 and ⅡA1 （3-4 cm in diameter）
DENG Lixia LIU Xinxin CHEN Bin LIU Sukun▲
Objective To analyze the clinical efficacy of three-dimensional intracavitary brachytherapy in the treatment of cervical cancer with stage ⅠB1 and ⅡA1 (3-4 cm in diameter). Methods The cases of early cervical cancer (stage ⅠB1 and stage ⅡA1) treated in Baoding First Central Hospital from January 2014 to June 2016 were selected, who underwent laparoscopic radical hysterectomy. The patients were randomly divided into two groups, with 32 patients in each group, the observation group received three dimensional intracavitary radiotherapy guided by CT, followed by surgical treatment, while the control group was treated with radical hysterectomy. The general situation and treatment related indicators were observed and recorded. Results There was no significant difference between the two groups in mean age, body mass index, maximum diameter of cervical lesion, FIGO clinical stage and pathological type (P > 0.05). The blood loss in the observation group [(197.0±85.4) mL] was less than that in the control group [(253.8±112.1) mL], the diameter of the cervical lesion in the postoperative pathology [(1.9±0.5) cm] was smaller than that in the control group [(3.6±0.7) cm], and the cases of postoperative adjuvant radiotherapy and chemotherapy (9 cases) were less than the control group(17 cases), the differences were statistically significant (P ＜ 0.05). The average operation time [(169.2±49.3) min vs. (195.7±70.1) min], a verage length of stay [(16.4±3.9) d vs. (15.9±4.5) d] and complication rate [7 cases (21.9%) vs. 11 cases (34.4%)] between the two groups were not statistically significant (P > 0.05). Conclusion Three dimensional intracavitary radiotherapy can effectively reduce the volume of cervical lesions and be beneficial to the implementation of surgery. Meanwhile, it can reduce the risk factors of prognosis.
2018 Vol. 15 (3): 102-106 [Abstract] ( 250 ) HTML (1 KB)  PDF (608 KB)  ( 125 )
107 Short-term effect of Xuezhikang Capsules combined with Valsartan on sclerotic stage of hypertensive retinopathy
LI Yanping1 LIU Sheng2
Objective To observe the short-term effect of Xuzhikang Capsules combined with Valsartan in the treatment of patients with hypertensive retinopathy. Methods The subjects in 60 cases with 106 eyes were from the Fourth People′s Hospital of Linfen from January 2012 to July 2015, and they were divided into control group and treatment group by random number table, with 30 cases in each group. The two groups were underwent routine treatment to ensure that the test was carried out with the patient′s blood pressure up to standard. The observation group was additionally treated with Xuezhikang Capsules. The clinical efficacy was evaluated at 8 weeks after treatment. Results After treatment, the systolic blood pressure in the two groups and diastolic blood pressure in the control group were decreased (P < 0.05). The cure rate and total efficiency of treatment group were higher than those of control group (P < 0.05). The mend matters of retinal arterial spasm and vascular wall reflex in treatment group were better than those in the control group (P < 0.05). Conclusion The short-term effect of Xuzhikang Capsules combined with Valsartan in treating vision, fundus angiography and hypertension on sclerotic stage of hypertensive retinopathy is better.
2018 Vol. 15 (3): 107-109,133 [Abstract] ( 284 ) HTML (1 KB)  PDF (774 KB)  ( 155 )
110 Changes of nasal physiological function and its clinical significance before and after nasal septum perforation surgery
QIAN Junyong MA Jing GUO Jinbao HU Zhibang
Objective To explore the changes of nasal physiological function and its clinical significance before and after nasal septum perforation(NSP) surgery. Methods From January 2014 to December 2016, 60 cases of NSP patients received surgery treatment in the Third People's Hospital of Changzhou City were selected and divided into the small perforation group (＜1 cm, 18 cases), the medium perforation group (1-2 cm, 26 cases) and the large perforation group (＞2 cm, 16 cases) according to the results of nasal endoscopic examination. The visual analogue scoring system (VAS) was uesd to evaluate the clinical symptoms among the three groups. The nasal resistance, nasal mucus mucociliary system clearance function and olfactory function before and after surgery were detected and compared. The Spearman correlation analysis was used to analyze the related factors of VAS. Results Before and after operation, there were significant differences in the VAS score, nasal resistance, nasal mucociliary transmission rate and olfactory threshold among the three groups (all P ＜ 0.05). After operation, the indicators above in the medium perforation group and the large perforation group were all better than those of before operation, with statistically significant differences (all P ＜ 0.05). There were no statistically significant differences in the indicators above in the small perforation group before and after operation (P ＞ 0.05). Spearman correlation analysis showed that the VAS score was positively correlated with nasal resistance and olfactory threshold, and negatively correlated with mucociliary transmission rate(P ＜ 0.05). Conclusion The nasal physiological function is closely related to the size of perforation in patients with NSP. The greater the perforation is, the worse the physiological function is and which can be improved by surgery treatment. However, non-surgical treatment may be consider in small perforation.
2018 Vol. 15 (3): 110-113 [Abstract] ( 285 ) HTML (1 KB)  PDF (501 KB)  ( 181 )
114 The study of the location of the mental canal by CBCT
ZHONG Fei
Objective To study the location of the mental foramen and the course of mental canal by cone-beam computed tomography (CBCT). Methods From January 2014 to May 2015, 50 healthy subjects from Department of Stomatology, The Third People′ Hospital of Zhenjiang City were collected. They were detected by CBCT, and the angle between the mental canal and the vertical curve, the location of the mental foramen, the distance from the superior border of the mental foramen to alveolar crest and the distance from the inferior border of the mental foramen to the inferior border of mandible were measured. Results There were 27 cases of mental foramen located at the bottom of the second bicuspid tooth root, accounted for 54.00%. The mean angle between the mental canal and the vertical curve was (46.0±2.3)°. The mean distance from the superior border of the mental foramen to alveolar crest was (16.88±1.44) mm, the mean distance from the inferior border of the mental foramen to the inferior border of mandible was (8.95±1.98) mm. The distance from the superior border of the mental foramen to alveolar crest was greater than the distance from the inferior border of the mental foramen to the inferior border of mandible (P < 0.05). Conclusion CBCT can accurately measure the position change of the mental formen. The mental foramen is mainly located in the root of the mandibular second premolar. The inferior alveolar nerve mostly comes from the mandibular second premolar forward, upward and outward through the mental foramen.
2018 Vol. 15 (3): 114-117 [Abstract] ( 307 ) HTML (1 KB)  PDF (615 KB)  ( 79 )
118 The effects of IL-17 and TGF-β1 on chronic periodontitis
LI Shengbai LUO Yi
Objective To investigate the expression levels of interleukin -17 (IL-17) and transforming growth factor beta 1 (TGF-β1) in gingival crevicular fluid (GCF) in patients with chronic periodontitis, in order to explore the role of both in the development and progression of chronic periodontitis. Methods From June 2015 to May 2017, 42 patients with chronic periodontitis diagnosed in Department of Stomatology of the First People's Hospital of Yibin were selected as the subjects. They were divided into moderate and severe chronic periodontitis group (group A, 22 cases) and mild chronic periodontitis group (group B, 20 cases) according to the oral condition. Another 20 patients who had periodontal health at the same period were selected as control group. The plaque index (PLI), bleeding index (BI), diagnostic depth (PD), bleeding (BOP), probing depth (PD), loss of attachment (AL) and levels of IL-17 and TGF-β1 in gingival crevicular fluid were detected. Results There were significant differences in the levels of PD, BOP, BI, PLI and amount of GCF in the groups (P < 0.05). The levels of IL-17 in gingival crevicular fluid of group A and B were higher than that of control group (P < 0.05). The level of IL-17 in gingival crevicular fluid of group A was higher than that of group B (P < 0.05). The level of TGF-β1 in gingival crevicular fluid of group B were higher than that of control group and group A(P < 0.05). The level of TGF-β1 in gingival crevicular fluid of group A was lower than that of control group(P < 0.05). The amount of GCF and the level of IL-17 in gingival crevicular fluid were positively correlated with the levels of PD, AL, BOP, BI and PLI (r=0.712-0.869, P < 0.05). The levels of TGF-β1 in gingival crevicular fluid were negatively correlated with PD, AL, BOP, BI and PLI in patients with chronic periodontitis (r=-0.702--839, P < 0.05); the levels of IL-17 in gingival crevicular fluid were negatively correlated with TGF-β1 levels in patients with chronic periodontitis (r=-0.817, P < 0.05). Conclusion The expression of IL-17 is closely related to the occurrence and development of chronic periodontitis, and it can reflect the extent of periodontal tissue destruction. TGF-β1 may play an immunosuppressive role in local tissues of chronic periodontitis.
2018 Vol. 15 (3): 118-121 [Abstract] ( 268 ) HTML (1 KB)  PDF (548 KB)  ( 134 )
122 Establishment of method for determination of the contents of hyperin in Huangdi Jixian Tablets
TIAN Mi CHEN Fang HE Jianchang
Objective To improve the quality standard of Huangdi Jixian Tablets, high performance liquid chromatography (HPLC) method was established to detect the contents of hyperin and the contents of heavy metal and arsenic salt in Huangdi Jiexian Tablets were detected. Methods Symmetry C18 (5 μm, 6 mm×150 mm) column was used. The mobile phase contained acetonitrile and 0.1% phosphoric acid (18∶82). The flow rate was 1.0 mL/min and the detection wavelength was 353 nm. The injection volume was 10 μL. In addition, the impurity of heavy metal and arsenic salt was also detected according to Chinese Pharmacopoeia (2010). Results Within the range from 2.0 to 100.0 μg/mL, hyperin presented an ideal linear relationship with the peak areas (R2 = 0.9998). The average recovery rate was 75.61%. Heavy metal was less than 10 parts per million and arsenic salt was less than 2 parts per million. These results conformed to the requirements of Chinese Pharmacopoeia (2010). Conclusion HPLC method for determining the content of hyperin is simple, with high sensitivity and good repeatability, which can be used for the content determination of hyperin in Huangdi Jixian Tablets. The contents of heavy metal and arsenic salt are conformed to the requirement, which provides evidence for the safety of clinical medication.
2018 Vol. 15 (3): 122-125 [Abstract] ( 263 ) HTML (1 KB)  PDF (528 KB)  ( 131 )
126 Determination on the contents of ethyl methanesulfonate in Levofloxacin Mesylate Tablets by gas chromatography-mass spectrometry
HOU Jinfeng LI Min QI Lin LI Wendong CHE Baoquan WANG Junqiu
Objective To establish a derivative gas chromatography-mass spectrometry (GC-MS) method for analyzing the contents of ethyl methanesulfonate (EMS) in Levofloxacin Mesylate Tablets. Methods Pre-column NaI-H2O derivating method was used, and the derivatives ethyl iodide and iodine butane were obtained from EMS and n-butyl methanesulfonate (BMS) derivatization. The derivatives were separated on a DB-WAX (0.32 mm×60 m, 0.25 μm) fused-silica capillary column firstly, and then detected by mass spectrometry under single ion monitoring (SIM) mode. The content of EMS was calculated by the area ratio of ethyl iodide to iodine butane. Results The method showed good linearity (r ＞ 0.9999) over the range of 2.5-150 ng/mL. The limit of detection was 0.5 ng/mL, the recovery was 100.5% (RSD = 1.2%) and the repeatability RSD was 0.6% (n = 6). The method also showed good robustness. No ethyl methanesulfonate was detected in one batch of API and three batches of tablets. Conclusion The method is sensitive, simple, accurate and rapid, and it can be used for the determination of genotoxic impurity EMS, which may be generated in the synthesis and preparation of Levofloxacin Mesylate.
2018 Vol. 15 (3): 126-129 [Abstract] ( 276 ) HTML (1 KB)  PDF (617 KB)  ( 266 )
130 The effect of Shenxiong Injection combined with Captopril on ventricular remodeling and serum brain natriuretic peptide in patients with myocardial infarction 
XU Kai1 ZHAO Cunrui2 GUO Hong1 SUN Mu1 XIANG Zongxing1 CHEN Rufei1 JIA Junzheng1▲
Objective To explore the effect of Shenxiong Injection combined with Captopril on ventricular remodeling and serum brain natriuretic peptide (BNP) in patients with myocardial infarction. Methods One hundred and forty patients with initial myocardial infarction in the Emergency Department in Baoji Hospital of Traditional Chinese Medicine from March 2016 to March 2017 were selected and randomly divided into combined group and control group according to random number table method, with 70 cases in each group. The control group was given Captopril, the combined group was given Shenxiong Injection on basis of the control group, for a month. The chemiluminescence method was used to measure the level of natriuretic peptide (BNP) in patients before treatment and after treatment for 7 and 14 days. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), ejection fraction (EF) were recorded with echocardiography before treatment and after treatment for 1 month. At the same time, the adverse reactions were statistically analyzed. Results After treatment for 1 month, LVEDV and LVESV in the control group were higher than those before treatment, and EF in the combined group was significantly higher than that before treatment, the differences were statistically significant (P ＜ 0.05). After treatment for 1 month, the levels of EF in combined group were significantly higher than those of control group (P ＜ 0.05). After treatment for 7, 14 days, the BNP levels of the two groups were all significantly lower than those before treatment (P ＜ 0.05), which of the combined group were lower than those of the control group, with statistically significant differences (P ＜ 0.05). No serious adverse reactions were observed in either group. Conclusion The combined application of Shenxiong Injection and Captopril can improve left ventricular remodeling and prognosis in patients with myocardial infarction, reduce the levels of serum BNP, with obvious effect and good safety.
2018 Vol. 15 (3): 130-133 [Abstract] ( 238 ) HTML (1 KB)  PDF (377 KB)  ( 219 )
134 The effect of different acupoints of electroacupuncture on myocardial function in rats with myocardial ischemia injury
ZHANG Li1 AI Xia2 PENG Ye3 LIU Baoyu4▲
Objective To explore the effect of different acupoints of electroacupuncture on myocardial function in rats with myocardial ischemia injury. Methods Sixty male Wistar rats were randomly divided into four groups by random number table method: normal group, model group, acupoint compatibility group, normal distribution group, with 15 rats in each group. Building methods: subcutaneous injection of Isoproterenol Hydrochloride (5 mL/kg) was given. Normal group: the same dose of 0.9% sodium chloride solution was injected, once a day, for one week. Model group was made the model. Acupoint compatibility group: the successful rats of the model were taken, and each day, the electric needle of the double “neiguan”, double “zusanli” and “guanyuan” were performed respectively for two weeks. Normal distribution group: "neiguan", double "shenmen" and "danzhong" were performed respectively, the followed method was as the same as the acupoint compatibility group. The changes of electrocardiogram in rats, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were observed. Results Compared with normal group, the heart rate (HR) in model group was accelerated significantly, and the amplitude of S-T segment was significantly enhanced, the differences were highly statistically significant (P ＜ 0.01). After the electroacupuncture intervention, the HR of the acupoints in the acupoint compatibility group and normal distribution group was decreased, and the amplitude of S-T was decreased, which had statistically significant differences compared with those of model group (P ＜ 0.05). Compared with the normal group, the activities of myocardial SOD and GSH-Px in the model group were decreased significantly, and the content of MDA was increased significantly, the differences were highly statistically significant (P ＜ 0.01). After the electroacupuncture intervention, the activities of SOD and GSH-Px of the myocardium of the rats in the acupoint compatibility group and normal distribution group were significantly increased, and the content of MDA was decreased,  which had statistically significant differences compared with those of model group (P ＜ 0.05). Compared with normal distribution group, the activities of myocardial SOD and GSH-Px in the acupoint compatibility group were significantly increased, and the content of MDA was decreased significantly, the differences were statistically significant (P ＜ 0.05). Conclusion Compatibility of acupuncture acupoints method has very good protection effect for myocardial ischemia, which can effectively reduce the myocardial cell degeneration and the myocardial tissue damage, and it can provide basis for clinical controlling the myocardial ischemic diseases with acupuncture.
2018 Vol. 15 (3): 134-137 [Abstract] ( 326 ) HTML (1 KB)  PDF (594 KB)  ( 180 )
138 The medication characteristics of Yang Xiaojun in treating myasthenia gravis
CHEN Chuchun YANG Xiaojun
By collecting the efficacious prescriptions of Professor Yang Xiaojun in treating myasthenia gravis and conducting statistical analysis, the medication characteristics of Yang Xiaojun in treating myasthenia gravis can be concluded: strengthening spleen and stomach, invigorating spleen and benefiting qi; making good use of Lingnan crude drug in accordance with local conditions; tonifying spleen and clearing damp in accordance with patient's individuality; treatment based on syndrome differentiation, add or subtract medicine according to different syndromes, which provide reference for traditional Chinese medicine in the treatment of myasthenia gravis.
2018 Vol. 15 (3): 138-141 [Abstract] ( 280 ) HTML (1 KB)  PDF (592 KB)  ( 141 )
142 Clinical experience of Professor Zhang Binghou in the treatment of refractory gout
WANG Jiajia1 ZHOU Jie1 DUAN Yanping1 WANG Zhiyu1 ZHAO Wenjing2
Clinical experience of Professor Zhang Binghou in the treatment of refractory gout is unique. The main causes he considered are improper diet and exogenous pathogenic factors invasion. The pathological factors of dampness-heat, toxic heat, blood stasis and turbidity toxin are involved in the pathogenesis. The body surface and meridian, bones and joints are the disease location. The spleen, stomach and kidney are the mainly involving zang-fu organs. The deficiency of spleen and kidney are the root cause of disease. His characteristics of clinical diagnosis and treatment for the disease are as followed: the syndrome and disease differentiation are combined, the treatment is by stages; the special drugs are chosen to dispel pathogenic factors; the insect drugs are chosen to dredge collateral; taking good care of daily life is to prevent recurrence.
2018 Vol. 15 (3): 142-144,149 [Abstract] ( 257 ) HTML (1 KB)  PDF (603 KB)  ( 179 )
145 Clinical study of Activating Qi and Resolving Stagnation Formula in the treatment of post-stroke depression
ZHUANG Xue
Objective To investigate the effect of Activating Qi and Resolving Stagnation Formula in the treatment of post-stroke depression. Methods One hundred and eight cases of patients with post-stroke depression in Dongguan People′s Hospital from September 2014 to May 2016 were selected and randomly divided into two groups by random number table method, with 54 cases in each group. The control group received Flupentixol and Melitracen Tablets, the observation group received Activating Qi and Resolving Stagnation Formula, both groups were treated for 8 weeks. The scores of Hamilton depression scale (HAMD), national institute of health stroke scale (NIHSS) and activities of daily living (ADL) were evaluated. The levels of neurotransmitter and neurocytokines were determined, and the clinical efficacy between the two groups was compared. Results Compared with before treatment, the scores of HAMD, NIHSS in the two groups after treatment were decreased, ADL scores were increased, the levels of serum 5-hydroxy tryptamine (5-HT) , noradrenaline (NE), dopamine (DA) were increased, the levels of 5-hydroxy indole acetic acid (5-HIAA) were decreased, and the levels of serum brain derived neurotrophic factor (BDNF), nerve growth factor (NGF) were increased (P ＜ 0.05). Compared with the control group, the scores of HAMD, NIHSS in the observation group after treatment were decreased, ADL scores were increased, the levels of serum 5-HT, NE and DA were increased, the levels of 5-HIAA were decreased, and the levels of serum BDNF and NGF were increased, the differences were statistically significant (P ＜ 0.05). The total effective rate of the control group (75.93%) was lower than that of observation group (90.74%), the difference was statistically significant (P ＜ 0.05). Conclusion Activating Qi and Resolving Stagnation Formula can relieve depression in patients with post-stroke depression, improve the ability of daily living and the neurotransmitter metabolism, which is worthy to be widely promoted.
2018 Vol. 15 (3): 145-149 [Abstract] ( 220 ) HTML (1 KB)  PDF (629 KB)  ( 76 )
150 Therapeutic effect of acupotomy lysis combined with Modified Taohong Siwu Decoction in treating postoperative dysfunction of hip joint
TIAN Yafeng YAO Xingbao YANG Gang YU Jian ZHU Yanfeng WEN Zhigang HAN Kun DONG Junge
Objective To observe the clinical curative effect of acupotomy lysis combined with Modified Taohong Siwu Decoction in the treatment of postoperative dysfunction of hip joint. Methods By using randomized parallel controlled method, all 72 patients with postoperative dysfunction of hip joint treated in Hebei Hospital of Traditional Chinese Medicine from December 2014 to December 2017 were randomly divided into control group and treatment group by random number table method, with 36 cases in each group. The treatment group was treated with the acupotomy lysis combined with Modified Taohong Siwu Decoction after 1 week of operation, and the control group was treated with local closure combined with Modified Taohong Siwu Decoction after 1 week of operation. The visual analogue scale (VAS), Harris score and range of motion (ROM) of hip joint before treatment and after treatment for 15 days in the two groups were recorded, and the clinical efficacy between the two groups was compared. Results After treatment for 15 d, the VAS scores of the two groups were all lower than those before treatment, and the VAS scores of treatment group were lower than that of control group, the differences were statistically significant (P ＜ 0.05). After treatment for 15 d, the Harris scores in the two groups were all higher than those before treatment, and the Harris scores of the treatment group were higher than those of control group, the differences were statistically significant (P ＜ 0.05). After treatment for 15 d, the ROM of hip joint in the two groups were bigger than those before treatment, and the ROM of hip joint in the treatment group was bigger than that of control group, the differences were statistically significant (P ＜ 0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Acupotomy lysis combined with Taohong Siwu Decoction in treating postoperative dysfunction of hip joint takes both manifestation and root cause seriously, which has the characteristics of convenience, effective and inexpensive, with small injury, less bleeding, simple and easy operation, effective curative effect. It is easy to be accepted by the majority of patients, and the efficacy is significantly better than that of local closure combined with Modified Taohong Siwu Decoction, thus it is worthy of clinical promotion and application.
2018 Vol. 15 (3): 150-154 [Abstract] ( 288 ) HTML (1 KB)  PDF (491 KB)  ( 111 )
155 Clinical effect of acupotomy therapy in the treatment of post-stroke spasm
DING Min FENG Hua JIN Changxu HE Weiqi WANG Huiguo XU Lei
Objective To observe the clinical effect of acupotomy therapy in the treatment of post-stroke spasm. Methods Seventy-nine patients with post-stroke spasm treated in Inpatient Ward and Outpatient Clinic of Acupuncture and Moxibustion in Wuxi Traditional Chinese Medicine Hospital from January 2016 to October 2017 were selected, and they were divided into two groups by random number table method, 40 patients of acupotomy group was given the treatment of acupotomy, 39 patients of control group were given rehabilitation therapy. The degree of limb spasm (modified Ashworth scale), the clinical spasticity index (CSI) and the conditions of motor function (simple Fugl-Meyer scale) of the two groups before and after treatment were observed. Results After treatment, the cure rate and total effective rate in the acupotomy group were all higher than those of the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the CSI scores of the two groups were lower than those before treatment, and the scores of simple Fugl-Meyer scale in the two groups were higher than those before treatment, and the CSI scores of the acupotomy group were lower than those of the control group, the scores of simple Fugl-Meyer scale of the acupotomy group were higher than those of the control group, the differences were all statistically significant (all P ＜ 0.05). Conclusion Acupotomy therapy in the treatment of post-stroke spasm has definite clinical effects, which is worthy of clinical application.
2018 Vol. 15 (3): 155-158 [Abstract] ( 284 ) HTML (1 KB)  PDF (477 KB)  ( 87 )
159 Treatment of exenatide of Prader-Willi syndrome complicated with metabolic syndrome：a case report
FANG Haining YU Fei▲
Prader-Willi syndrome is a genomic imprinting disease that is highly susceptible to childhood and adolescence obesity, multiplex syndromes of metabolic syndrome such as hypertension, hyperglycemia and dyslipidemia due to overfeeding and obesity will seriously affect the survival rate and quality of life of children. In this paper, a case of genetically diagnosed 9 years old Prader-Willi syndrome child complicated with metabolic syndrome is reported to analyse the data of blood pressure, body weight, biochemistry, liver imaging and sleep apnea monitoring before and after treatment of human glucagon like peptide -1 receptor agonist-exenatide, this child's appetite decreased and the satiety increased, body weight and body mass index decreased, blood pressure decreased and stable in the normal range, low density lipoprotein cholesterol decreased, high density lipoprotein cholesterol increased, the CT value of the liver increased, apnea hypoventilation index decreased and tolerance was good after 6 months of exenatide treatment. This study provides a new possibility for the treatment of such children.
2018 Vol. 15 (3): 159-162 [Abstract] ( 231 ) HTML (1 KB)  PDF (354 KB)  ( 201 )
163 Study on Chinese drug price reform direction based on international comparison
SONG Yan HAN Zhiyan SONG Kuimeng DOU Weijie
Effective price management is an important guarantee for improving the drug supply. In this study, the drug price regulation models in foreign countries were explored with the comparative method and criterion method in order to provide references for Chinese drug price reform. The findings showed that different countries carried out different models. Attention should be paid to learn the advantages in different drug administration models. Based on the international successful experiences, Chinese price reform should focus on four aspects: properly handling the relationships between government and market, reinforcing the drug price monitoring, cutting off the interests between medical suppliers and drug prices, strengthening the power of health insurance.
2018 Vol. 15 (3): 163-166 [Abstract] ( 248 ) HTML (1 KB)  PDF (549 KB)  ( 166 )
167 Referring to American experience to explore the establishment of the medical insurance system for health management in China
CHEN Xiuyan1 ZHANG Zehao1 XU Feng1 LI wenyuan2
With the development of national economy, the disease burden of chronic diseases is increasing and the medical expenses are rising. According to the practice of foreign medical expense controlling, to implement health management is an effective strategy to control the sharp rise of medical expenses. Referring to the development of the payment mode in American from the traditional fee-for-service to the efficient manage care and from the manage care to the burgeoning value-based reimbursement, China needs to change the existing medical insurance system to promote the development of health management. According to the practice of the payment reform of the American medical insurance, the value-based reimbursement which is based on the health improvement is more suitable for the long-term development of the health and medical career. China should jointly explore the health insurance system for health management from the government, commercial insurance agencies and medical institutions.
2018 Vol. 15 (3): 167-170 [Abstract] ( 254 ) HTML (1 KB)  PDF (552 KB)  ( 156 )
171 Digital design and implementation of computer laboratory in TCM Colleges
LI Xiaoyan LI Jingzhong
Digital construction is an important means to improve computer teaching and experimental level in traditional Chinese medicine colleges. This paper summarizes the main problems existing in the computer laboratory of traditional Chinese medicine colleges. In the digital construction, the network environment, desktop deployment, multimedia teaching, virtual experiment, resource sharing and integrated wiring are comprehensively designed and constructed. The training of students′ practical ability and innovation ability is enhanced, formed the teaching and practice of digital space for traditional Chinese medicine.
2018 Vol. 15 (3): 171-175 [Abstract] ( 241 ) HTML (1 KB)  PDF (838 KB)  ( 138 )
176 Effect evaluation and causal analysis of medication orders of PIVAS examination in a hospital
ZHOU Lijun1 SHEN Shaoqing1 WU Siyu2 LI Wai1 LIU Ping1
Objective To investigate the effectiveness of prescription checking, analyze the causes of problems and promote the rational medication in clinic, so as to provide references for the research of evidence-based pharmacy. Methods From November 2016 to March 2017, irrational drug use from pharmacy intravenous admixture service during the prescription checking were analyzed and the adverse events were followed up. Results A total of 1519 irrational medication orders, including improper solvent selection, inappropriate dosage and route of medication, incompatibility and so on, accounted for 2.2% in totally 69 046 medication orders. There was no adverse events occurred in 230 irrational medication orders. Conclusion The overall drug use in the hospital is relatively resonable, but some irrational drug use phenomenon still exist. It is necessary to further strengthen the apothecarys′ ability to review the medication orders and intervention should be further enforced. Meanwhile, partial off-label drug use should be deeply and rationally reflected.
2018 Vol. 15 (3): 176-180 [Abstract] ( 216 ) HTML (1 KB)  PDF (677 KB)  ( 136 )
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