330例非牧区布氏杆菌病患者免疫状态及感染高危因素调查

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Abstract Objective To investigate the immune status of patients with brucellic disease in non-pasturing area and high-risk factors of infection. Methods From January 2008 to November 2016, 330 patients with brucellic disease in non-pasturing area received in Traditional Chinese Medicine Hospital of Langfang City were selected as the observation group, 330 healthy personnel with the same occupation at the same time were selected as the control group. Then the serum immunoglobulin, circulating immune complex and T lymphocyte subsets of observation group with different treatment effect were compared. The consist of gender, ages, nationality, work types, length of job, hygienic habit and contact with livestock situation of two groups were compared, and the relationship between those factors and infection of brucellic disease were analyzed by multivariate conditional Logistic regression. Results In the observation group, the serum immunoglobulin and the T lymphocyte subsets of cured cases in patients with brucellic disease were all lower than those of effective and ineffective patients, and circulating immune complex were significantly lower than those of effective and ineffective patients, with statistically significant differences (P < 0.05). The gender, age and ethnic composition of the two groups were not statistically significant (P > 0.05). There were statistically significant differences between the two groups of workers, working age, hygienic habits and contact with livestock (P < 0.05). The multivariate conditional Logistic regression showed that sales, length of job < 1 year, not washing hands by rules, not disinfectant application by rules, not sterilize the workplace by rules, drinking raw milk, eating sick and dead livestock, treatment of dead lambs, contacting with borted livestock or deliver livestock were all risk factors of infection (P < 0.05). Conclusion The immune status of patients with brucellic disease in non-pasturing area are worse, and the differences of patients with different prognosis are obvious, the work types, length of job, hygienic habit and contact with livestock situation are all the high-risk factors of infection, the monitoring and regulation of immune should be carried out according to the patients′ condition, and the prevention and control measures should be worked out according to the high-risk factors.

Key words： Non-pasturing area Brucellic disease Immune status High-risk factors of infection

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	GAO Jicheng1 MA Baoliang2▲ HU Xiaomei1 ZU Yonggang1

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GAO Jicheng1 MA Baoliang2▲ HU Xiaomei1 ZU Yonggang1. Investigation on the immune status of 330 patients with brucellic disease in non-pasturing area and high-risk factors of infection[J]. 中国医药导报, 2018, 15(3): 42-45.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I3/42

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