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| The curative effect of three-dimensional intracavitary brachytherapy in the preoperative treatment of cervical cancer with stage ⅠB1 and ⅡA1 （3-4 cm in diameter） |
| DENG Lixia LIU Xinxin CHEN Bin LIU Sukun▲ |
| Department of Radiotherapy, Baoding First Central Hospital, Hebei Province, Baoding 071000, China |
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Abstract Objective To analyze the clinical efficacy of three-dimensional intracavitary brachytherapy in the treatment of cervical cancer with stage ⅠB1 and ⅡA1 (3-4 cm in diameter). Methods The cases of early cervical cancer (stage ⅠB1 and stage ⅡA1) treated in Baoding First Central Hospital from January 2014 to June 2016 were selected, who underwent laparoscopic radical hysterectomy. The patients were randomly divided into two groups, with 32 patients in each group, the observation group received three dimensional intracavitary radiotherapy guided by CT, followed by surgical treatment, while the control group was treated with radical hysterectomy. The general situation and treatment related indicators were observed and recorded. Results There was no significant difference between the two groups in mean age, body mass index, maximum diameter of cervical lesion, FIGO clinical stage and pathological type (P > 0.05). The blood loss in the observation group [(197.0±85.4) mL] was less than that in the control group [(253.8±112.1) mL], the diameter of the cervical lesion in the postoperative pathology [(1.9±0.5) cm] was smaller than that in the control group [(3.6±0.7) cm], and the cases of postoperative adjuvant radiotherapy and chemotherapy (9 cases) were less than the control group(17 cases), the differences were statistically significant (P ＜ 0.05). The average operation time [(169.2±49.3) min vs. (195.7±70.1) min], a verage length of stay [(16.4±3.9) d vs. (15.9±4.5) d] and complication rate [7 cases (21.9%) vs. 11 cases (34.4%)] between the two groups were not statistically significant (P > 0.05). Conclusion Three dimensional intracavitary radiotherapy can effectively reduce the volume of cervical lesions and be beneficial to the implementation of surgery. Meanwhile, it can reduce the risk factors of prognosis.
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