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| Investigation of the current situation of Neuroprotective Agents in six cities in China from 2012 to 2016 |
| WANG Huiyuan YANG Li ZHAO Zhigang |
| Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China |
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Abstract Objective Based on the investigation of the current situation and trend of the use of Neuroprotective Agents in six cities in China, to preliminarily evaluate the rationality of the use of Neuroprotective Agents, in order to provide the basic reference data for promoting the rational use of drugs. Methods The data were from sampling prescription of 84 samples of medical and health institutions at all levels in 6 cities (Beijing, Tianjin, Shanghai, Guangzhou, Hangzhou, Chengdu) in China collected in“The Hospital Prescriptions Cooperation Project” of Hospital Pharmacy Committee of Chinese Pharmaceutical Association from January 2012 to December 2016, and the patient′s medication situation was analyzed. Results During the five years, the sales amount of Neuroprotective Agents in six cities increased year by year. The ratio of men to women was about 5 to 4, with the patients aged between 1 and 118 years old, mainly in the 50 to 90 years old, accounting for 75.00%. The distribution of drug departments were mainly in neurology (24.92%), neurosurgery (11.17%), old cadre department (8.47%), emergency department (7.62%) and cardiology (5.33%).The original diagnosis accounted for the top five: cerebral infarction (3.17%), cerebral hemorrhage (1.45%), cerebrovascular disease (0.91%), head trauma (0.50%) and cerebral infarction sequel (0.41%). The amount and kind of drug sales in 2016, Neurotrophic Co-Stimulating (5.2 million yuan) > Membrane Stabilizer (5.1 million yuan) > Calcium Antagonists (2.8 million yuan) > Glutamate Release Inhibitors (2.6 million yuan). The top 5 drug consumption figures were respectively Ganglioside (3.9 million yuan), Mouse Nerve Growth Factor (3.3 million yuan), Butyl Phthalide (2.6 million yuan), Edaravone (2.2 million yuan), Cinepazide (2 million yuan). There was a wide variation in drug use among cities, and each region had its own tendency to use drugs. Conclusion In general, there are clinical abuses in the application of Neuroprotective Agents in six cities in China, which should be used rationally and economically on the basis of ensuring the efficacy and safety of drugs.
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