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| The effect of Shenxiong Injection combined with Captopril on ventricular remodeling and serum brain natriuretic peptide in patients with myocardial infarction |
| XU Kai1 ZHAO Cunrui2 GUO Hong1 SUN Mu1 XIANG Zongxing1 CHEN Rufei1 JIA Junzheng1▲ |
1.Department of Cardiology, Baoji Hospital of Traditional Chinese Medicine, Shaanxi Province, Baoji 721000, China;
2.Department of Cardiology, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China |
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Abstract Objective To explore the effect of Shenxiong Injection combined with Captopril on ventricular remodeling and serum brain natriuretic peptide (BNP) in patients with myocardial infarction. Methods One hundred and forty patients with initial myocardial infarction in the Emergency Department in Baoji Hospital of Traditional Chinese Medicine from March 2016 to March 2017 were selected and randomly divided into combined group and control group according to random number table method, with 70 cases in each group. The control group was given Captopril, the combined group was given Shenxiong Injection on basis of the control group, for a month. The chemiluminescence method was used to measure the level of natriuretic peptide (BNP) in patients before treatment and after treatment for 7 and 14 days. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), ejection fraction (EF) were recorded with echocardiography before treatment and after treatment for 1 month. At the same time, the adverse reactions were statistically analyzed. Results After treatment for 1 month, LVEDV and LVESV in the control group were higher than those before treatment, and EF in the combined group was significantly higher than that before treatment, the differences were statistically significant (P ＜ 0.05). After treatment for 1 month, the levels of EF in combined group were significantly higher than those of control group (P ＜ 0.05). After treatment for 7, 14 days, the BNP levels of the two groups were all significantly lower than those before treatment (P ＜ 0.05), which of the combined group were lower than those of the control group, with statistically significant differences (P ＜ 0.05). No serious adverse reactions were observed in either group. Conclusion The combined application of Shenxiong Injection and Captopril can improve left ventricular remodeling and prognosis in patients with myocardial infarction, reduce the levels of serum BNP, with obvious effect and good safety.
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[1] 中华医学会心血管病学分会，中华心血管病杂志编辑委员会，中国循环杂志编辑委员会，等.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志，2001，29（12）：710-725.
[2] 李登云，杨利萍.冠心病患者血清BNP、VEGF、hs-CRP检测的临床意义[J].检验医学，2016，31（3）：205-208.
[3] 朱德才，麦一峰，马龙洲，等.重症心肌炎患者治疗中丙种球蛋白对心肌损伤与心功能及血清免疫学指标的影响分析[J].中华医院感染学杂志，2016，26（24）：5601-5603.
[4] Mutsuzaki H，Nakajima H，Nomura S，et al. Differences in placement of calcium phosphate-hybridized tendon grafts within the femoral bone tunnel during ACL reconstruction do not influence tendon-to-bone healing [J]. J Orthop Surg Res，2017，12（1）：80.
[5] Mizuno T，Egi K，Sakai K，et al. Minimally Circulatory-Assisted On-Pump Beating Coronary Artery Bypass Grafting for Patients With Complex Conditions for Off-Pump Surgery [J]. Artif Organs，2017，41（3）：233-241.
[6] Maslow J，Hutzler L，Slover J，et al. Etiology of Readmissions Following Orthopaedic Procedures and Medical Admissions. A Comparative Analysis [J]. Bull Hosp Jt Dis（2013），2015，73（4）：269-275.
[7] Sinaei F，Zendehdel K，Adili M，et al. Association Between Breast Reconstruction Surgery and Quality of Life in Iranian Breast Cancer Patients [J]. Acta Med Iran，2017，55（1）：35-41.
[8] Chi PC，Kuo JY，Chen CY，et al. Changes of Atrial Natriuretic Peptides after Defibrillation Threshold Testing Predicted Future Ventricular Arrhythmia Event [J]. Acta Cardiol Sin，2017，33（4）：401-409.
[9] Xu B，Xu H，Cao H，et al. Intermedin improves cardiac function and sympathetic neural remodeling in a rat model of post myocardial infarction heart failure [J]. Mol Med Rep，2017，16（2）：1723-1730.
[10] Chen CY，Lin HY，Chen YW，et al. Obesity-associated cardiac pathogenesis in broiler breeder hens：Pathological adaption of cardiac hypertrophy [J]. Poult Sci，2017，96（7）：2428-2437.
[11] Safi M，Bayat F，Ahmadi Z，et al. The change in NT-pro-BNP and post-PTMC echocardiography parameters in patients with mitral stenosis. A pilot study [J]. Rom J Intern Med，2017，55（2）：75-81.
[12] Hongyuan B，Xin D，Jingwen Z，et al. Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels were Negatively Regulated by Captopril in Volume-Overload Heart Failure Rats [J]. J Membr Biol，2016，249（4）：429-436.
[13] Sun W，Zhang H，Guo J，et al. Comparison of the Efficacy and Safety of Different ACE Inhibitors in Patients With Chronic Heart Failure：A PRISMA-Compliant Network Meta-Analysis [J]. Medicine（Baltimore），2016，95（6）：e2554.
[14] Zimmer J，Hawlitschek C，Rabald S，et al. Effects of late-onset and long-term captopril and nifedipine treatment in aged spontaneously hypertensive rats：Echocardiographic studies [J]. Hypertens Res，2015，38（11）：716-722.
[15] 褚庆民，吴伟，金政，等.急性ST段抬高型心肌梗死不同形态的机制及中医证型分布规律探讨[J].广州中医药大学学报，2017，34（3）：313-317.
[16] 张郑，杨黎，朱凯莉，等.丹参素冰片酯影响大鼠脑组织P-糖蛋白表达研究[J].中国药理学通报，2017，33（8）：1114-1119.
[17] 王冰瑶，吴晓燕，樊官伟，等.丹参素保护心血管系统的药理作用机制研究进展[J].中草药，2014，45（17）：2571-2575.
[18] 吕磊，郭华，张洁，等.糖原合酶激酶-3β在川芎嗪对心肌缺血再灌注损伤保护中的作用[J].东南大学学报：医学版，2016，35（6）：836-840.
[19] 王晓萍，彭军.川芎嗪联合小牛血去蛋白提取物治疗椎基底动脉供血不足的临床疗效研究[J].中国生化药物杂志，2016，36（2）：148-150.
[20] 张瑞，沈承武，闫根全，等.川芎嗪对大鼠心肌细胞氧糖剥夺/复氧损伤的保护作用及机制研究[J].中国生化药物杂志，2017，37（9）：10-13.
[21] 梁滨，王少鹏.丹参川芎嗪在急性心肌梗死中对左室舒张期内径和左室射血分数的影响[J].中国医药科学，2015， 5（5）：72-74.
[22] 杜亚康.参麦注射液配合瑞通立溶栓治疗前壁急性心肌梗死再灌注损伤的临床研究[J].陕西中医，2017，38（2）：171-173.
[23] 黄赞鸿，张惜铃.心型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用[J].现代医院，2017，17（10）：1545-1548.
[24] 王晓霞，郑艳芬，聂叶廷，等.丹参、参麦注射液对急性心肌梗死再灌注后脂蛋白相关磷脂酶A的影响[J].中西医结合心血管病电子杂志，2016，4（3）：30-32.
[25] 张璇，王培利，柴华，等.史大卓教授治疗急性心肌梗死的中医临床经验[J].世界中医药，2017，12（6）：1384-1387.
[26] 林晓烁，寇兰俊，潘国忠，等.中医序贯疗法改善急性心肌梗死患者介入术后心功能临床研究[J].中国药业，2017， 26（11）：34-37.
[27] 许峰，王怀龙.高敏肌钙蛋白T在急性心肌梗死诊断中的价值[J].现代医院，2017，17（5）：713-715.
[28] 林小茹，刘湘，鲁澄宇，等.丹参素和丹参酮ⅡA对大鼠弥漫性血管内凝血的影响[J].中成药，2016，38（12）：2673-2676.
[29] 柯健.参芎葡萄糖注射液对急性心肌梗死的保护作用及与6种常用注射剂配伍风险评估研究[D].广州：暨南大学，2016. |
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